ES8506601A1 - Benzamide derivatives - Google Patents
Benzamide derivativesInfo
- Publication number
- ES8506601A1 ES8506601A1 ES537046A ES537046A ES8506601A1 ES 8506601 A1 ES8506601 A1 ES 8506601A1 ES 537046 A ES537046 A ES 537046A ES 537046 A ES537046 A ES 537046A ES 8506601 A1 ES8506601 A1 ES 8506601A1
- Authority
- ES
- Spain
- Prior art keywords
- sulphamoyl
- lower alkyl
- hydrogen
- signifies
- dichloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Benzamides of the formula < IMAGE > wherein R<1> and R<2> each independently signify hydrogen, halogen, lower alkyl, lower alkoxy, cyano, trifluoromethyl, sulphamoyl, mono(lower alkyl)sulphamoyl or di(lower alkyl)sulphamoyl or R<1> and R<2> on adjacent carbon atoms together signify a methylenedioxy group, with the proviso that R<2> is different from hydrogen when R<1> signifies bromine in the 3-position, and their pharmaceutically usable acid addition salts have interesting monoamine oxidase inhibiting properties with low toxicity and can accordingly be used for the treatment of depressive states and Parkinsonism. Those compounds of formula I in which R<1> signifies halogen, cyano or trifluoromethyl in the para-position and R<2> signifies hydrogen or R<1> and R<2> together signify 2,4-dichloro, 3,4-dichloro or 3,4-methylenedioxy are novel these novel compounds can be manufactured according to methods known per se.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1150/83A CH653670A5 (en) | 1983-03-03 | 1983-03-03 | BENZAMIDE DERIVATIVES. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES537046A0 ES537046A0 (en) | 1985-08-16 |
ES8506601A1 true ES8506601A1 (en) | 1985-08-16 |
Family
ID=4203649
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES530230A Expired ES8504680A1 (en) | 1983-03-03 | 1984-03-02 | Benzamide derivatives |
ES537046A Expired ES8506601A1 (en) | 1983-03-03 | 1984-10-25 | Benzamide derivatives |
ES537045A Granted ES537045A0 (en) | 1983-03-03 | 1984-10-25 | A PROCEDURE FOR THE PREPARATION OF BENZAMIDE DERIVATIVES |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES530230A Expired ES8504680A1 (en) | 1983-03-03 | 1984-03-02 | Benzamide derivatives |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES537045A Granted ES537045A0 (en) | 1983-03-03 | 1984-10-25 | A PROCEDURE FOR THE PREPARATION OF BENZAMIDE DERIVATIVES |
Country Status (28)
Country | Link |
---|---|
JP (1) | JPS59167552A (en) |
KR (1) | KR910008202B1 (en) |
AR (1) | AR243155A1 (en) |
AT (1) | AT390948B (en) |
AU (2) | AU570431B2 (en) |
BE (1) | BE899059A (en) |
CA (1) | CA1252794A (en) |
CH (1) | CH653670A5 (en) |
DE (1) | DE3407654C2 (en) |
DK (1) | DK166382C (en) |
ES (3) | ES8504680A1 (en) |
FI (1) | FI79297C (en) |
FR (1) | FR2541996B1 (en) |
GB (1) | GB2135998B (en) |
GR (1) | GR81866B (en) |
HU (1) | HU193556B (en) |
IE (1) | IE57004B1 (en) |
IL (1) | IL71078A (en) |
IT (1) | IT1173365B (en) |
LU (1) | LU85231A1 (en) |
MC (1) | MC1568A1 (en) |
NL (1) | NL8400459A (en) |
NO (1) | NO165999C (en) |
NZ (1) | NZ207272A (en) |
PH (1) | PH19623A (en) |
PT (1) | PT78187B (en) |
SE (1) | SE466447B (en) |
ZA (1) | ZA841394B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1261335A (en) * | 1984-08-29 | 1989-09-26 | Hoffmann-La Roche Limited/Hoffmann-La Roche Limitee | Ethylenediamine monoamide derivatives |
US4772630A (en) * | 1984-11-23 | 1988-09-20 | Ciba-Geigy Corp. | Benzamides and their salts |
NZ219974A (en) * | 1986-04-22 | 1989-08-29 | Goedecke Ag | N-(2'-aminophenyl)-benzamide derivatives, process for their preparation and their use in the control of neoplastic diseases |
FR2642972B1 (en) * | 1989-02-14 | 1994-08-05 | Inst Nat Sante Rech Med | AGENTS FOR THE DIAGNOSIS AND TREATMENT OF MELANOMAS, HALOGENATED AROMATIC DERIVATIVES SUITABLE FOR USE AS SUCH AGENTS AND THEIR PREPARATION |
WO2014155184A1 (en) * | 2013-03-28 | 2014-10-02 | Rhenovia Pharma | Treatment for parkinson's disease |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3342679A (en) * | 1967-09-19 | Parts by weight of acid chloride to react with parts of amine in | ||
FR6557M (en) * | 1967-06-20 | 1968-12-23 | Ile De France | |
GB1455116A (en) * | 1972-12-15 | 1976-11-10 | Ici Ltd | Pharmaceutical compositions |
GB1520584A (en) * | 1975-04-02 | 1978-08-09 | Yamanouchi Pharma Co Ltd | 2 - alkoxy - 5 substituted benzamide derivatives and their use in pharmaceutical compositions |
DE2616486A1 (en) * | 1976-04-14 | 1977-11-03 | Basf Ag | Perylene tetracarboxylic acid diimide pigments - for use in paints, thermoplastics, etc. and as vat dyes |
CA1206964A (en) * | 1980-11-12 | 1986-07-02 | Nobuo Shinma | Tetra-substituted benzene derivatives |
DE3200258A1 (en) * | 1982-01-07 | 1983-07-21 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | SUBSTITUTED 1-BENZOYL-2-PHENYLIMINO IMIDAZOLIDINE, THE ACID ADDITION SALTS THEREOF, METHOD FOR THE PRODUCTION THEREOF AND THE MEDICINAL PRODUCTS CONTAINING THE SAME |
IL69997A0 (en) * | 1983-01-03 | 1984-01-31 | Miles Lab | Procainamide and n-acetylprocainamide immunogens,antibodies prepared therefrom,labeled conjugates,and the use of such antibodies and labeled conjugates in immunoassays |
US4808624A (en) * | 1984-06-28 | 1989-02-28 | Bristol-Myers Company | Pharmacologically active substituted benzamides |
-
1983
- 1983-03-03 CH CH1150/83A patent/CH653670A5/en not_active IP Right Cessation
-
1984
- 1984-01-13 CA CA000445296A patent/CA1252794A/en not_active Expired
- 1984-02-13 NL NL8400459A patent/NL8400459A/en not_active Application Discontinuation
- 1984-02-22 FI FI840734A patent/FI79297C/en not_active IP Right Cessation
- 1984-02-23 IT IT19778/84A patent/IT1173365B/en active
- 1984-02-24 NZ NZ207272A patent/NZ207272A/en unknown
- 1984-02-24 ZA ZA841394A patent/ZA841394B/en unknown
- 1984-02-27 HU HU84767A patent/HU193556B/en not_active IP Right Cessation
- 1984-02-27 AU AU25066/84A patent/AU570431B2/en not_active Ceased
- 1984-02-27 IL IL71078A patent/IL71078A/en not_active IP Right Cessation
- 1984-02-29 PH PH30315A patent/PH19623A/en unknown
- 1984-02-29 LU LU85231A patent/LU85231A1/en unknown
- 1984-02-29 DK DK147584A patent/DK166382C/en not_active IP Right Cessation
- 1984-03-01 FR FR8403219A patent/FR2541996B1/en not_active Expired
- 1984-03-01 JP JP59037410A patent/JPS59167552A/en active Granted
- 1984-03-01 MC MC841696A patent/MC1568A1/en unknown
- 1984-03-01 GR GR73975A patent/GR81866B/el unknown
- 1984-03-01 DE DE3407654A patent/DE3407654C2/en not_active Expired - Fee Related
- 1984-03-02 AT AT0072484A patent/AT390948B/en not_active IP Right Cessation
- 1984-03-02 IE IE512/84A patent/IE57004B1/en not_active IP Right Cessation
- 1984-03-02 BE BE0/212488A patent/BE899059A/en not_active IP Right Cessation
- 1984-03-02 GB GB08405486A patent/GB2135998B/en not_active Expired
- 1984-03-02 PT PT78187A patent/PT78187B/en not_active IP Right Cessation
- 1984-03-02 AR AR84295901A patent/AR243155A1/en active
- 1984-03-02 ES ES530230A patent/ES8504680A1/en not_active Expired
- 1984-03-02 SE SE8401190A patent/SE466447B/en not_active IP Right Cessation
- 1984-03-02 NO NO840797A patent/NO165999C/en unknown
- 1984-03-03 KR KR1019840001083A patent/KR910008202B1/en not_active IP Right Cessation
- 1984-10-25 ES ES537046A patent/ES8506601A1/en not_active Expired
- 1984-10-25 ES ES537045A patent/ES537045A0/en active Granted
-
1987
- 1987-12-24 AU AU83079/87A patent/AU609758B2/en not_active Ceased
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19971001 |