ES398109A1 - Pharmaceutical composition - Google Patents

Pharmaceutical composition

Info

Publication number
ES398109A1
ES398109A1 ES398109A ES398109A ES398109A1 ES 398109 A1 ES398109 A1 ES 398109A1 ES 398109 A ES398109 A ES 398109A ES 398109 A ES398109 A ES 398109A ES 398109 A1 ES398109 A1 ES 398109A1
Authority
ES
Spain
Prior art keywords
aqueous solution
local anesthetic
tetrodotoxin
pharmaceutical composition
aminoalcohilbenzoates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES398109A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astra USA Inc
Original Assignee
Astra Pharmaceutical Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharmaceutical Products Inc filed Critical Astra Pharmaceutical Products Inc
Publication of ES398109A1 publication Critical patent/ES398109A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A method for the preparation of a local anesthetic composition with prolonged duration of action, in the form of an aqueous solution intended for injection, characterized in that a compound with local anesthetic activity selected from the group consisting of aminoacyanilides, aminoalcohilbenzoates, cocaine, aminocarbamates, N-phenylamidines, N-aminoalcohilamides, amino ketones and aminoethers, in aqueous solution, are combined with 0.5 to 10, preferably 0.5 to 5 μg/ml of tetrodotoxin or 10 to 20 μg/ml of tetrodotoxin of deoxytetrodotoxin, and because the ph of the resulting aqueous solution containing the toxin and local anesthetic complex thus formed is adjusted to the desired value. (Machine-translation by Google Translate, not legally binding)
ES398109A 1971-01-26 1971-12-18 Pharmaceutical composition Expired ES398109A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10994271A 1971-01-26 1971-01-26

Publications (1)

Publication Number Publication Date
ES398109A1 true ES398109A1 (en) 1975-03-16

Family

ID=22330411

Family Applications (2)

Application Number Title Priority Date Filing Date
ES398108A Expired ES398108A1 (en) 1971-01-26 1971-12-18 Pharmaceutical composition
ES398109A Expired ES398109A1 (en) 1971-01-26 1971-12-18 Pharmaceutical composition

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES398108A Expired ES398108A1 (en) 1971-01-26 1971-12-18 Pharmaceutical composition

Country Status (18)

Country Link
AT (2) AT310938B (en)
AU (1) AU465875B2 (en)
BE (2) BE776769A (en)
BR (2) BR7108428D0 (en)
CA (2) CA986012A (en)
DD (2) DD96400A5 (en)
DE (2) DE2163055A1 (en)
DK (2) DK130389B (en)
ES (2) ES398108A1 (en)
FR (2) FR2123278B1 (en)
GB (1) GB1370904A (en)
HU (2) HU162185B (en)
IE (2) IE35937B1 (en)
LU (1) LU64664A1 (en)
NL (2) NL7117401A (en)
NO (2) NO135892C (en)
SE (2) SE391127B (en)
ZA (2) ZA718327B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4917894A (en) * 1988-06-29 1990-04-17 Beecham Inc. Rapid-onset long-duration oral anesthetic composition
AU6883798A (en) * 1997-04-02 1998-10-22 Regents Of The University Of California, The Method of anesthesia
AU7389098A (en) 1997-05-16 1998-12-08 Brigham And Women's Hospital Local anesthetic formulations
WO2007110221A1 (en) 2006-03-27 2007-10-04 Wex Pharmaceuticals Inc. Use of sodium channel blockers for the treatment of neuropathic pain developing as a consequence of chemotherapy
US8952152B2 (en) 2009-03-24 2015-02-10 Proteus S.A. Methods for purifying phycotoxins, pharmaceutical compositions containing purified phycotoxins, and methods of use thereof
RU2015143665A (en) 2013-03-15 2017-04-27 Дзе Чилдрен'З Медикал Сентер Корпорейшн COMBINED DRUGS OF NEOSAXITOXIN FOR PROLONGED LOCAL ANESTHESIA

Also Published As

Publication number Publication date
AU465875B2 (en) 1975-10-09
LU64664A1 (en) 1972-08-23
DE2163054B2 (en) 1978-06-01
FR2123278B1 (en) 1975-08-01
HU162185B (en) 1973-01-29
NO135892B (en) 1977-03-14
IE35910B1 (en) 1976-06-23
NO135891C (en) 1978-05-16
IE35937B1 (en) 1976-07-07
BE776768A (en) 1972-06-16
NL7117404A (en) 1972-07-28
ZA718327B (en) 1972-09-27
GB1370904A (en) 1974-10-16
NO135892C (en) 1978-05-16
DD96400A5 (en) 1973-03-20
CA983850A (en) 1976-02-17
DE2163054C3 (en) 1979-02-01
HU162347B (en) 1973-02-28
DE2163055A1 (en) 1972-10-12
SE391127B (en) 1977-02-07
CA986012A (en) 1976-03-23
IE35937L (en) 1972-07-26
FR2123277B1 (en) 1975-06-13
NO135891B (en) 1977-03-14
DE2163054A1 (en) 1974-05-02
BR7108428D0 (en) 1973-06-14
IE35910L (en) 1972-07-26
BR7108429D0 (en) 1973-06-14
ZA718326B (en) 1972-09-27
NL7117401A (en) 1972-07-28
DK131606C (en) 1976-01-12
FR2123278A1 (en) 1972-09-08
ES398108A1 (en) 1975-03-01
AT310938B (en) 1973-10-25
DD96144A5 (en) 1973-03-12
DK130389B (en) 1975-02-17
AU3710071A (en) 1973-06-28
AT310939B (en) 1973-10-25
SE391286B (en) 1977-02-14
DK131606B (en) 1975-08-11
FR2123277A1 (en) 1972-09-08
DK130389C (en) 1975-07-14
BE776769A (en) 1972-06-16
AU3710171A (en) 1973-06-28

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