ES2171040T3 - Derivados de esteres hidroxiaceticos y su utilizacion como intermediarios de sintesis. - Google Patents

Derivados de esteres hidroxiaceticos y su utilizacion como intermediarios de sintesis.

Info

Publication number
ES2171040T3
ES2171040T3 ES98946523T ES98946523T ES2171040T3 ES 2171040 T3 ES2171040 T3 ES 2171040T3 ES 98946523 T ES98946523 T ES 98946523T ES 98946523 T ES98946523 T ES 98946523T ES 2171040 T3 ES2171040 T3 ES 2171040T3
Authority
ES
Spain
Prior art keywords
derivatives
halogen atoms
esters
several
hydroxyacetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98946523T
Other languages
English (en)
Inventor
Andre Bousquet
Andree Musolino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Application granted granted Critical
Publication of ES2171040T3 publication Critical patent/ES2171040T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cephalosporin Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Derivados de ésteres (R)-sulfoniloxi-acéticos de fórmula general: OSO2 R1 (R) ( ) Cl j í Q Q Q QQ C C OCH3 j j j H O I en la que R1 representa un grupo bencilo, alquilo de C1-C4 eventualmente sustituido por uno o varios átomos de halógeno, o fenilo eventualmente sustituido por uno o varios átomos de halógeno o por uno o varios grupos alquilo, lineales o ramificados, de C1-C4 o por un grupo nitro.
ES98946523T 1997-10-06 1998-09-29 Derivados de esteres hidroxiaceticos y su utilizacion como intermediarios de sintesis. Expired - Lifetime ES2171040T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9712441A FR2769313B1 (fr) 1997-10-06 1997-10-06 Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese

Publications (1)

Publication Number Publication Date
ES2171040T3 true ES2171040T3 (es) 2002-08-16

Family

ID=9511879

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98946523T Expired - Lifetime ES2171040T3 (es) 1997-10-06 1998-09-29 Derivados de esteres hidroxiaceticos y su utilizacion como intermediarios de sintesis.

Country Status (15)

Country Link
US (3) US6573381B1 (es)
EP (1) EP1021449B1 (es)
JP (3) JP3827946B2 (es)
AT (1) ATE211476T1 (es)
AU (1) AU9354498A (es)
BR (1) BR9813022B1 (es)
CA (1) CA2306409C (es)
DE (1) DE69803397T2 (es)
DK (1) DK1021449T3 (es)
ES (1) ES2171040T3 (es)
FR (1) FR2769313B1 (es)
HU (1) HU226771B1 (es)
NO (1) NO325150B1 (es)
PT (1) PT1021449E (es)
WO (1) WO1999018110A1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002018357A1 (en) * 2000-08-29 2002-03-07 Rpg Life Sciences Limited A ONE-POT PROCESS FOR THE PREPARATION OF PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS OF 4, 5, 6, 7 - TETRAHYDROTHIENO (3,2-c) PYRIDINE DERIVATIVES HAVING ANTITHROMBOTIC ACTIVITY
US6495691B1 (en) 2001-07-06 2002-12-17 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
ES2316650T3 (es) * 2001-12-18 2009-04-16 Teva Pharmaceutical Industries Ltd. Polimorfos de hidrogenosulfato de clopidogrel.
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
ITMI20020933A1 (it) * 2002-05-03 2003-11-03 Danimite Dipharma S P A Procedimento per la sintesi di clopidogrel
US6800759B2 (en) 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
IL166593A0 (en) 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
ITMI20022228A1 (it) * 2002-10-21 2004-04-22 Dinamite Dipharma S P A Sali di clopidogrel con acidi alchil-solforici.
EP1603920A1 (en) 2003-03-12 2005-12-14 Cadila Healthcare Ltd. Polymorph and amorphous form of (s)-(+)-clopidogrel bisulfate
WO2004098593A1 (en) * 2003-05-05 2004-11-18 Hetero Drugs Limited Amorphous clopidogrel hydrogen sulfate composition
EP1680430B1 (en) 2003-11-03 2010-01-20 Cadila Healthcare Ltd. Processes for preparing form i of (s)-(+)- clopidogrel bisulfate
SI1589019T1 (sl) * 2004-04-20 2008-12-31 Ratiopharm Gmbh Stereoselektivni postopek za pripravo klopidogrela
CZ20041048A3 (cs) * 2004-10-18 2005-11-16 Zentiva, A. S Způsob výroby klopidogrelu
CN100406568C (zh) * 2005-02-18 2008-07-30 淮北市辉克药业有限公司 氯吡格雷新生产工艺
EP1902058A2 (en) * 2005-07-12 2008-03-26 RPG Life Sciences Limited A process for preparation of methyl-(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno(3,2-c)pyridine-5(4h)-acetic acid methyl ester or salts thereof having higher chiral purity and products thereof
CN101253271A (zh) * 2005-09-02 2008-08-27 第一精密化学株式会社 光学活性α-羟基羧酸的制造方法
KR101235117B1 (ko) 2005-12-26 2013-02-20 에스케이케미칼주식회사 광학분리에 의한 (ｓ)-(＋)-클로피도그렐의 제조방법
WO2007144729A1 (en) * 2006-06-13 2007-12-21 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of clopidogrel
WO2008004249A2 (en) * 2006-07-04 2008-01-10 Msn Laboratories Limited An improved process for the preparation of clopidogrel and its pharmaceutically acceptable salts
ATE494289T1 (de) * 2006-08-04 2011-01-15 Merz Pharma Gmbh & Co Kgaa Substituierte pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin
KR100834967B1 (ko) * 2006-08-11 2008-06-03 에스케이케미칼주식회사 여액의 라세미화 반응에 의한 ｓ-(＋)-클로피도그렐의고수율 제조방법
EP1980563A1 (en) 2007-04-09 2008-10-15 BATTULA, Srinivasa Reddy Procedure for the preparation of methyl (+)-(S)-Alpha-(O-chlorophenyl)-6,7-dihydrothieno-[3,2-C]pyridine-5(4H) acetate
BRPI0803101A2 (pt) * 2007-04-18 2014-04-22 Teva Pharma Processos melhores para preparação de clopidogrel
KR20160033792A (ko) 2007-04-27 2016-03-28 사이덱스 파마슈티칼스, 인크. 클로피도그렐 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형 및 사용 방법
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
KR100990949B1 (ko) 2008-06-09 2010-10-29 엔자이텍 주식회사 클로피도그렐 및 그의 유도체의 제조방법
US8236782B2 (en) 2009-05-13 2012-08-07 Cydex Pharmaceuticals, Inc. Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same
CN102863457B (zh) * 2010-02-02 2013-10-09 江苏威凯尔医药科技有限公司 光学活性2-羟基四氢噻吩并吡啶衍生物及其制备方法与在制药中的用途
CN102558138A (zh) * 2010-12-08 2012-07-11 湖北成田制药股份有限公司 2-卤代苯基-2-(2-噻吩乙氨基)乙酸酯类及其盐的制备方法
WO2012123958A1 (en) 2011-02-14 2012-09-20 Cadila Healthcare Limited Highly pure salts of clopidogrel free of genotoxic impurities
CN102351877B (zh) * 2011-08-12 2014-07-09 天津药物研究院 噻吩衍生物、其制备方法和用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2652575B1 (fr) 1989-09-29 1992-01-24 Sanofi Sa Procede de preparation d'acides alpha-bromo phenylacetiques.
US5189170A (en) 1989-09-29 1993-02-23 Sanofi Process for the preparation of phenylacetic derivatives of thieno-pyridines
FR2664276B1 (fr) * 1990-07-04 1992-10-23 Sanofi Sa Derive thienyl-2 glycidique, son procede de preparation et son utilisation comme intermediaire de synthese.
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
JPH06293729A (ja) * 1993-04-06 1994-10-21 Sankyo Co Ltd 光学活性カルボン酸誘導体
US5583147A (en) * 1994-03-23 1996-12-10 The Dupont Merck Pharmaceutical Company Amides for the treatment of atherosclerosis
FR2751540B1 (fr) * 1996-07-26 1998-10-16 Sanofi Sa Composition pharmaceutique antithrombotique
HU222283B1 (hu) * 1997-05-13 2003-05-28 Sanofi-Synthelabo Eljárás tieno[3,2-c]piridin-származékok előállítására

Also Published As

Publication number Publication date
NO20001736D0 (no) 2000-04-04
JP2009137989A (ja) 2009-06-25
CA2306409A1 (fr) 1999-04-15
PT1021449E (pt) 2002-06-28
NO20001736L (no) 2000-06-06
JP2006124398A (ja) 2006-05-18
DK1021449T3 (da) 2002-04-22
EP1021449A1 (fr) 2000-07-26
JP3827946B2 (ja) 2006-09-27
DE69803397T2 (de) 2002-08-29
NO325150B1 (no) 2008-02-11
US7153969B2 (en) 2006-12-26
US6894186B2 (en) 2005-05-17
HUP0004250A2 (hu) 2001-10-28
HU226771B1 (en) 2009-09-28
FR2769313B1 (fr) 2000-04-21
BR9813022B1 (pt) 2010-07-13
CA2306409C (fr) 2010-06-29
JP4264437B2 (ja) 2009-05-20
US20040260110A1 (en) 2004-12-23
DE69803397D1 (de) 2002-02-28
HUP0004250A3 (en) 2001-12-28
JP4903819B2 (ja) 2012-03-28
EP1021449B1 (fr) 2002-01-02
JP2001519353A (ja) 2001-10-23
FR2769313A1 (fr) 1999-04-09
WO1999018110A1 (fr) 1999-04-15
ATE211476T1 (de) 2002-01-15
US6573381B1 (en) 2003-06-03
AU9354498A (en) 1999-04-27
US20030208077A1 (en) 2003-11-06
BR9813022A (pt) 2000-08-15

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