EA200700387A1 - Гидраты и полиморфы 4-[[(7r)-8-циклопентил-7-этил-5,6,7,8-тетрагидро-5-метил-6-оксо-2-птеридинил]амино]-3-метокси-n-(1-метил-4-пиперидинил)бензамида, способы их получения и их применение в качестве лекарственных средств - Google Patents

Гидраты и полиморфы 4-[[(7r)-8-циклопентил-7-этил-5,6,7,8-тетрагидро-5-метил-6-оксо-2-птеридинил]амино]-3-метокси-n-(1-метил-4-пиперидинил)бензамида, способы их получения и их применение в качестве лекарственных средств

Info

Publication number
EA200700387A1
EA200700387A1 EA200700387A EA200700387A EA200700387A1 EA 200700387 A1 EA200700387 A1 EA 200700387A1 EA 200700387 A EA200700387 A EA 200700387A EA 200700387 A EA200700387 A EA 200700387A EA 200700387 A1 EA200700387 A1 EA 200700387A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methyl
pteridinyl
benzamide
piperidinyl
tetrahydro
Prior art date
Application number
EA200700387A
Other languages
English (en)
Other versions
EA011407B1 (ru
Inventor
Гюнтер Линц
Петер Зигер
Герд Ф. Крэмер
Вернер Ралль
Рольф Хертер
Маттиас Хоффманн
Рольф Шмид
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35311878&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200700387(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA200700387A1 publication Critical patent/EA200700387A1/ru
Publication of EA011407B1 publication Critical patent/EA011407B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems

Abstract

В заявке описаны новые гидраты и новые полиморфы 4-[[(7R)-8-циклопентил-7-этил-5,6,7,8-тетрагидро-5-метил-6-оксо-2-птеридинил]амино]-3-метокси-N-(1-метил-4-пиперидинил)бензамида, способы их получения и их применение в качестве лекарственных средств.
EA200700387A 2004-08-14 2005-08-11 Гидраты и полиморфы 4-[[(7r)-8-циклопентил-7-этил-5,6,7,8-тетрагидро-5-метил-6-оксо-2-птеридинил]амино]-3-метокси-n-(1-метил-4-пиперидинил)бензамида, способы их получения и их применение в качестве лекарственных средств EA011407B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04019366 2004-08-14
PCT/EP2005/008736 WO2006018222A1 (de) 2004-08-14 2005-08-11 Hydrate und polymorphe des 4-[[(7r)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-4-6-oxo-2-piperidinyl]amino]-3-methoxy-n-(1-methyl-4-piperidinyl)-benzamid, verfahren zu deren herstellung und deren verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
EA200700387A1 true EA200700387A1 (ru) 2007-08-31
EA011407B1 EA011407B1 (ru) 2009-02-27

Family

ID=35311878

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700387A EA011407B1 (ru) 2004-08-14 2005-08-11 Гидраты и полиморфы 4-[[(7r)-8-циклопентил-7-этил-5,6,7,8-тетрагидро-5-метил-6-оксо-2-птеридинил]амино]-3-метокси-n-(1-метил-4-пиперидинил)бензамида, способы их получения и их применение в качестве лекарственных средств

Country Status (19)

Country Link
US (3) US7728134B2 (ru)
EP (1) EP1778691A1 (ru)
JP (1) JP2008509953A (ru)
KR (1) KR101221864B1 (ru)
CN (1) CN101006090A (ru)
AR (1) AR052404A1 (ru)
AU (1) AU2005274340B2 (ru)
BR (1) BRPI0514351A2 (ru)
CA (1) CA2578098A1 (ru)
EA (1) EA011407B1 (ru)
EC (1) ECSP077249A (ru)
IL (1) IL181302A0 (ru)
MX (1) MX2007001854A (ru)
NO (1) NO20070752L (ru)
NZ (1) NZ553649A (ru)
PE (1) PE20060424A1 (ru)
TW (1) TWI370131B (ru)
UA (1) UA87865C2 (ru)
WO (1) WO2006018222A1 (ru)

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Also Published As

Publication number Publication date
US20090298840A1 (en) 2009-12-03
CN101006090A (zh) 2007-07-25
ECSP077249A (es) 2007-03-29
UA87865C2 (en) 2009-08-25
CA2578098A1 (en) 2006-02-23
AR052404A1 (es) 2007-03-21
AU2005274340A1 (en) 2006-02-23
IL181302A0 (en) 2007-07-04
TW200619220A (en) 2006-06-16
TWI370131B (en) 2012-08-11
NO20070752L (no) 2007-05-10
US20060035902A1 (en) 2006-02-16
WO2006018222A8 (de) 2006-06-15
KR101221864B1 (ko) 2013-01-14
WO2006018222A1 (de) 2006-02-23
EA011407B1 (ru) 2009-02-27
US8034816B2 (en) 2011-10-11
AU2005274340B2 (en) 2012-04-05
EP1778691A1 (de) 2007-05-02
MX2007001854A (es) 2007-03-28
JP2008509953A (ja) 2008-04-03
BRPI0514351A2 (pt) 2012-10-30
US7728134B2 (en) 2010-06-01
NZ553649A (en) 2010-11-26
PE20060424A1 (es) 2006-06-09
KR20070050967A (ko) 2007-05-16
US20090318457A1 (en) 2009-12-24
US8202867B2 (en) 2012-06-19

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