EA200600138A1 - Способ получения кристаллического полиморфа ингибитора агрегации тромбоцитов - Google Patents
Способ получения кристаллического полиморфа ингибитора агрегации тромбоцитовInfo
- Publication number
- EA200600138A1 EA200600138A1 EA200600138A EA200600138A EA200600138A1 EA 200600138 A1 EA200600138 A1 EA 200600138A1 EA 200600138 A EA200600138 A EA 200600138A EA 200600138 A EA200600138 A EA 200600138A EA 200600138 A1 EA200600138 A1 EA 200600138A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- inhibitor
- crystalline polymorph
- obtaining crystalline
- aggregation
- aggregation inhibitor
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 2
- 238000004220 aggregation Methods 0.000 title 1
- 230000002776 aggregation Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Настоящее изобретение относится к новому способу получения полиморфной формы 1 метил (S)-(+)-(2-хлорфенил)-2-(6,7-дигидро-4Н-тиено[3,2-с]пиридин-5-ил-ацетата гидросульфата формулы (I).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0302028A HU0302028D0 (en) | 2003-07-02 | 2003-07-02 | Process for the production of crystalline polymorphous form of an anticoagulant agent |
HU0401272A HU226773B1 (en) | 2004-06-23 | 2004-06-23 | Process for the production of clopidogrel hydrogensulfate polymorph 1 |
PCT/HU2004/000070 WO2005003139A1 (en) | 2003-07-02 | 2004-06-30 | Process for the preparation of crystalline polymorph of a platelet aggregation inhibitor drug |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200600138A1 true EA200600138A1 (ru) | 2006-08-25 |
EA010684B1 EA010684B1 (ru) | 2008-10-30 |
Family
ID=89985327
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200600138A EA010684B1 (ru) | 2003-07-02 | 2004-06-30 | Способ получения кристаллического полиморфа ингибитора агрегации тромбоцитов |
Country Status (14)
Country | Link |
---|---|
US (1) | US20070142637A1 (ru) |
EP (1) | EP1644381B1 (ru) |
JP (1) | JP4681545B2 (ru) |
KR (1) | KR101155679B1 (ru) |
CN (1) | CN1812993B (ru) |
AT (1) | ATE461201T1 (ru) |
BG (1) | BG109429A (ru) |
CA (1) | CA2530449C (ru) |
CZ (1) | CZ200641A3 (ru) |
DE (1) | DE602004026059D1 (ru) |
EA (1) | EA010684B1 (ru) |
PL (2) | PL378710A1 (ru) |
SK (1) | SK50102006A3 (ru) |
WO (1) | WO2005003139A1 (ru) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7999106B2 (en) | 2004-04-19 | 2011-08-16 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Processes for the preparation of clopidogrel hydrogen sulfate polymorphic form I |
EP1902058A2 (en) | 2005-07-12 | 2008-03-26 | RPG Life Sciences Limited | A process for preparation of methyl-(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno(3,2-c)pyridine-5(4h)-acetic acid methyl ester or salts thereof having higher chiral purity and products thereof |
US20090247569A1 (en) * | 2006-08-03 | 2009-10-01 | Claude Singer | Process for Preparing Clopidogrel Bisulphate |
WO2011010318A1 (en) * | 2009-07-23 | 2011-01-27 | Praveen Laboratories Private Limited | Process for the preparation of clopidogrel polymorphous form 1 using seed chrystals |
CN102070648A (zh) * | 2010-12-07 | 2011-05-25 | 天津红日药业股份有限公司 | I型硫酸氢氯吡格雷的制备方法 |
CN102702224A (zh) * | 2012-06-25 | 2012-10-03 | 山东齐都药业有限公司 | I型硫酸氢氯吡格雷的制备方法 |
CN107337683B (zh) * | 2017-08-16 | 2019-08-16 | 中荣凯特(北京)生物科技有限公司 | 一种噻吩并吡啶类衍生物硫酸氢盐的晶型ⅱ及其制备方法和应用 |
CN113121559B (zh) * | 2019-12-31 | 2023-08-29 | 惠州信立泰药业有限公司 | 一种高堆密度的ii型硫酸氢氯吡格雷球形结晶及制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2623810B2 (fr) * | 1987-02-17 | 1992-01-24 | Sanofi Sa | Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant |
FR2779726B1 (fr) * | 1998-06-15 | 2001-05-18 | Sanofi Sa | Forme polymorphe de l'hydrogenosulfate de clopidogrel |
CN100338068C (zh) * | 2001-01-24 | 2007-09-19 | 卡地拉健康护理有限公司 | 制备氯吡格雷的方法 |
GB0125708D0 (en) * | 2001-10-26 | 2001-12-19 | Generics Uk Ltd | Novel compounds and processes |
ES2316650T3 (es) * | 2001-12-18 | 2009-04-16 | Teva Pharmaceutical Industries Ltd. | Polimorfos de hidrogenosulfato de clopidogrel. |
-
2004
- 2004-06-30 CZ CZ20060041A patent/CZ200641A3/cs unknown
- 2004-06-30 DE DE602004026059T patent/DE602004026059D1/de not_active Expired - Fee Related
- 2004-06-30 US US10/563,133 patent/US20070142637A1/en not_active Abandoned
- 2004-06-30 AT AT04743729T patent/ATE461201T1/de not_active IP Right Cessation
- 2004-06-30 EP EP04743729A patent/EP1644381B1/en active Active
- 2004-06-30 CA CA2530449A patent/CA2530449C/en not_active Expired - Fee Related
- 2004-06-30 PL PL378710A patent/PL378710A1/pl not_active Application Discontinuation
- 2004-06-30 WO PCT/HU2004/000070 patent/WO2005003139A1/en active Application Filing
- 2004-06-30 EA EA200600138A patent/EA010684B1/ru not_active IP Right Cessation
- 2004-06-30 SK SK5010-2006A patent/SK50102006A3/sk unknown
- 2004-06-30 KR KR1020067000012A patent/KR101155679B1/ko not_active IP Right Cessation
- 2004-06-30 JP JP2006516497A patent/JP4681545B2/ja not_active Expired - Fee Related
- 2004-06-30 CN CN2004800181228A patent/CN1812993B/zh not_active Expired - Fee Related
- 2004-06-30 PL PL04743729T patent/PL1644381T3/pl unknown
-
2006
- 2006-02-02 BG BG109429A patent/BG109429A/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2007516167A (ja) | 2007-06-21 |
CZ200641A3 (cs) | 2006-05-17 |
CN1812993A (zh) | 2006-08-02 |
CA2530449A1 (en) | 2005-01-13 |
EP1644381B1 (en) | 2010-03-17 |
WO2005003139A1 (en) | 2005-01-13 |
US20070142637A1 (en) | 2007-06-21 |
KR101155679B1 (ko) | 2012-06-13 |
CA2530449C (en) | 2010-03-23 |
BG109429A (en) | 2006-10-31 |
PL378710A1 (pl) | 2006-05-15 |
KR20060026119A (ko) | 2006-03-22 |
EP1644381A1 (en) | 2006-04-12 |
JP4681545B2 (ja) | 2011-05-11 |
CN1812993B (zh) | 2011-06-29 |
ATE461201T1 (de) | 2010-04-15 |
EA010684B1 (ru) | 2008-10-30 |
PL1644381T3 (pl) | 2010-08-31 |
SK50102006A3 (sk) | 2006-05-04 |
DE602004026059D1 (de) | 2010-04-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200800886A1 (ru) | Способ получения 1-н-имидазо[4,5-с]пиридинов и их аналогов | |
EA200400491A1 (ru) | Полиморфная форма римонабанта, способ её получения и содержащие её фармацевтические композиции | |
RS53292B (en) | CRYSTAL FORMS 2-THIAZOLYL-4-HINOLINYL-OXY DERIVATIVES, POWERFUL HCV INHIBITOR | |
NO20054669L (no) | Substituerte kinobenzoxazinanaloger | |
EA200702670A1 (ru) | Препарат тиенопиридинового ингибитора агрегации тромбоцитов | |
CA2665931C (en) | Hydrobenzamide derivatives as inhibitors of hsp90 | |
MXPA05009969A (es) | Metodo para aislar la forma cristalina i de la 5-azacitidina. | |
EA200401025A1 (ru) | Полиморфы клопидогреля и их применение в качестве антитромботических соединений | |
EA200600621A1 (ru) | Производные тетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств | |
MX2009003257A (es) | Procedimiento para la sintesis de derivados de fenoxi diaminopirimidina. | |
TW200420541A (en) | Crystalline forms | |
BG109429A (en) | A METHOD FOR OBTAINING A CRYSTAL POLYMORPHIC FORMAN FOR INHIBITING TROMBOCYTE AGGREGATION | |
TW200635905A (en) | Processes for producing 4-aminoquinazolines | |
TW200612959A (en) | Method for preparing hydroxamic acids | |
EA200870038A1 (ru) | Способ получения аминов | |
NO20063111L (no) | Fremgangsmate for fremstilling av tiazolpyrimidiner | |
WO2004111008A3 (en) | Use of a compound of formula i for making a pharmaceutical composition | |
WO2005005394A3 (en) | Thiophenylaminoimidazolines as prostaglandin i2 antagonists | |
AR056805A1 (es) | Un proceso para oxidacion para la preparcion de n- (3- amino-1- ( ciclobutilmetil) -2,3- dioxopropil ) -3-(n-(( ter-butilamino) carbonil )-3- metil- l- valil) -6,6- dimetil-3- azabiciclo (3.1.0) hexano -2- carboxamida y compuestos ralacionados | |
EA200800200A1 (ru) | Способ получения кристаллического периндоприла | |
NO20052197L (no) | Fremgangsmate for fremstilling av pyrazol | |
EA200501527A1 (ru) | Способ получения полиморфа малеата розиглитазона | |
CY1112457T1 (el) | Χρωμανο- και θειοxρωμανο-3-υλο-1,3-διυδρο-ιμιδαζολια ως αναστολεις της ντοπαμινο-β-υδροξυλασης, και μεθοδοι παρασκευης αυτων | |
WO2005054175A3 (en) | New process for the preparation of nitrooxyderivatives of paracetamol | |
BG109428A (en) | METHOD FOR OBTAINING AMORPHIC FORM OF MEDICINES INHIBITION OF THERAPEUTIC AGGREGATION |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |