DE60236014D1 - METHOD FOR PRODUCING INSULIN COMPOUNDS - Google Patents

METHOD FOR PRODUCING INSULIN COMPOUNDS

Info

Publication number
DE60236014D1
DE60236014D1 DE60236014T DE60236014T DE60236014D1 DE 60236014 D1 DE60236014 D1 DE 60236014D1 DE 60236014 T DE60236014 T DE 60236014T DE 60236014 T DE60236014 T DE 60236014T DE 60236014 D1 DE60236014 D1 DE 60236014D1
Authority
DE
Germany
Prior art keywords
insulin compounds
producing insulin
compounds
insulin
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60236014T
Other languages
German (de)
Inventor
Are Bogsnes
Ingun Christiansen
Per Balschmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of DE60236014D1 publication Critical patent/DE60236014D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A preferred way of converting insulin precursors into insulin compounds is to perform an enzymatic peptide cleavage in an aqueous medium and, thereafter, without removal of the intermediate product formed, to add an amino acid ester or a peptide ester and an organic solvent so that the desired coupling takes place.
DE60236014T 2001-11-19 2002-11-15 METHOD FOR PRODUCING INSULIN COMPOUNDS Expired - Lifetime DE60236014D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200101716 2001-11-19
PCT/DK2002/000765 WO2003044210A2 (en) 2001-11-19 2002-11-15 Process for preparing insulin compounds

Publications (1)

Publication Number Publication Date
DE60236014D1 true DE60236014D1 (en) 2010-05-27

Family

ID=8160841

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60236014T Expired - Lifetime DE60236014D1 (en) 2001-11-19 2002-11-15 METHOD FOR PRODUCING INSULIN COMPOUNDS

Country Status (15)

Country Link
EP (1) EP1448786B1 (en)
JP (1) JP4404631B2 (en)
KR (1) KR100925381B1 (en)
CN (1) CN100424179C (en)
AT (1) ATE464390T1 (en)
AU (1) AU2002342597A1 (en)
BR (1) BR0213583A (en)
CA (1) CA2464616C (en)
DE (1) DE60236014D1 (en)
ES (1) ES2344448T3 (en)
HU (1) HU228934B1 (en)
IL (2) IL161358A0 (en)
PL (1) PL210437B1 (en)
RU (1) RU2376379C2 (en)
WO (1) WO2003044210A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006031955A1 (en) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Process for the preparation of dibasic B chain end insulin analogs
DE102006031962A1 (en) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidated insulin glargine
TW200902708A (en) * 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
RS56632B1 (en) 2008-10-17 2018-03-30 Sanofi Aventis Deutschland Combination of an insulin and a glp-1 agonist
KR20120055653A (en) * 2009-08-11 2012-05-31 바이오콘 리미티드 Chromatographic processes and purified compounds thereof
PT3345593T (en) 2009-11-13 2023-11-27 Sanofi Aventis Deutschland Pharmaceutical composition comprising despro36exendin-4(1-39)-lys6-nh2 and methionine
ES2855146T3 (en) 2009-11-13 2021-09-23 Sanofi Aventis Deutschland Pharmaceutical composition comprising a GLP-1 agonist, an insulin and methionine
HUE031181T2 (en) 2010-08-30 2017-06-28 Sanofi Aventis Deutschland Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
CN103917241A (en) 2011-08-29 2014-07-09 赛诺菲-安万特德国有限公司 Pharmaceutical combination for use in glycemic control in diabetes type 2 patients
AR087744A1 (en) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT OF A NEURODEGENERATIVE DISEASE
CN102703552B (en) * 2012-05-15 2014-10-29 山东阿华生物药业有限公司 Preparation method and products of recombinant human insulin
CN102816819B (en) * 2012-08-13 2014-10-29 山东阿华生物药业有限公司 Method for increasing yield of B30 threonine-deficient human insulin obtained by digestion conversion of human insulin precursor fusion protein
CN103305581B (en) * 2013-07-04 2015-05-27 珠海联邦制药股份有限公司 Preparation method of recombinant human insulin
EP3087192B1 (en) * 2013-12-23 2020-08-12 Biocon Biologics India Limited Method of production of human insulin methyl ester
JP6970615B2 (en) 2014-12-12 2021-11-24 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Insulin glargine / lixisenatide fixed ratio prescription
TWI748945B (en) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 Treatment type 2 diabetes mellitus patients
TW201705975A (en) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 Treatment of type 2 diabetes mellitus patients
KR20170036643A (en) * 2015-09-24 2017-04-03 한미약품 주식회사 Method of insulin production

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50892B1 (en) 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters
EP0088117B1 (en) 1981-09-15 1986-09-24 Nordisk Insulinlaboratorium Process for preparing human insulin or b-30 esters thereof
DE3262052D1 (en) 1981-08-10 1985-03-07 Nordisk Insulinlab Process for the enzymatic preparation of human insulin
DK149824C (en) 1982-01-22 1987-03-16 Carlsberg Biotechnology Ltd PROCEDURE FOR ENZYMATIC REPLACEMENT OF B-30 AMINO ACIDS IN INSULINES
EP0087238A1 (en) 1982-02-08 1983-08-31 Biogen N.V. Am improved method for preparing human insulin from non-human insulin
DK347086D0 (en) 1986-07-21 1986-07-21 Novo Industri As NOVEL PEPTIDES
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
IL84110A (en) * 1986-10-14 1992-11-15 Lilly Co Eli Process for transforming a human insulin precursor to a human insulin
DE10075034I1 (en) 1987-02-25 2001-05-23 Novo Nordisk As Insulin derivatives
US6011007A (en) 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
RO112873B1 (en) 1993-09-17 1998-01-30 Novo Nordisk As Insulin derivatives
JP4773023B2 (en) 1999-12-29 2011-09-14 ノボ ノルディスク アクティーゼルスカブ Method for producing insulin precursor and insulin precursor analogue
DE60044728D1 (en) 1999-12-29 2010-09-02 Novo Nordisk As METHOD FOR THE PRODUCTION OF INSULIN FORECASTS AND ANALOGS OF INSULIN PROCESSORS WITH IMPROVED FERMENTATION EXPORTS IN YEAST
DE60131969D1 (en) 2000-04-14 2008-01-31 Univ Maryland Biotech Inst IMPROVED THERMOSTABILITY AND TEMPERATURE RESISTANCE OF PROTEINS
WO2002079254A1 (en) 2001-03-29 2002-10-10 Janoff Edward N Human monoclonal antibodies against capsular polysaccharides of streptococcus pneumoniae

Also Published As

Publication number Publication date
CN1589328A (en) 2005-03-02
PL369447A1 (en) 2005-04-18
ES2344448T3 (en) 2010-08-27
BR0213583A (en) 2004-08-24
CA2464616A1 (en) 2003-05-30
RU2004118503A (en) 2005-06-10
CN100424179C (en) 2008-10-08
IL161358A (en) 2011-05-31
KR100925381B1 (en) 2009-11-09
EP1448786A2 (en) 2004-08-25
CA2464616C (en) 2012-07-24
HUP0500037A3 (en) 2010-01-28
KR20050044855A (en) 2005-05-13
PL210437B1 (en) 2012-01-31
ATE464390T1 (en) 2010-04-15
JP2005509687A (en) 2005-04-14
AU2002342597A1 (en) 2003-06-10
WO2003044210A2 (en) 2003-05-30
RU2376379C2 (en) 2009-12-20
WO2003044210A3 (en) 2004-03-25
AU2002342597A8 (en) 2003-06-10
EP1448786B1 (en) 2010-04-14
HUP0500037A2 (en) 2005-03-29
JP4404631B2 (en) 2010-01-27
IL161358A0 (en) 2004-09-27
HU228934B1 (en) 2013-06-28

Similar Documents

Publication Publication Date Title
ATE464390T1 (en) METHOD FOR PRODUCING INSULIN COMPOUNDS
ATE461270T1 (en) METHOD FOR PRODUCING L-AMINO ACIDS
DE60238745D1 (en) GLUCOSAMINE AND METHOD FOR PRODUCING GLUCOSAMINE FROM MICROBIAL BIOMASS
ATE323778T1 (en) METHOD FOR PRODUCING L-AMINO ACIDS USING STRAINS OF THE ENTEROBACTERIACEAE FAMILY
DE60028777D1 (en) PROCESS FOR THE PREPARATION OF 1,3-PROPANEDIOL BY A RECOMBINANT MICRO ORGANISM IN THE ABSENCE OF COENZYME B12
ATE488492T1 (en) METHOD FOR PRODUCING GABAPENTIN
DE60315014D1 (en) METHOD FOR PRODUCING SEQUENCE-SPECIFIC PROTEASES BY TARGETED EVOLUTION
DE50111897D1 (en) PROCESS FOR THE PRODUCTION OF ESTERS alpha, beta-unsaturated tartaric acids
ATE458066T1 (en) METHOD FOR PRODUCING SUBSTITUTED CARBOXYLIC ACID ESTERS USING ENZYMATIC HYDROLYSIS
DE50311645D1 (en) Process for the enzymatic preparation of enantiomerically enriched beta-amino acids
DE50304116D1 (en) Process for the enzymatic preparation of enantiomerically enriched beta-amino acids
DE50109832D1 (en) PROCESS FOR PREPARING ACETIC ACID
ATE285393T1 (en) METHOD FOR PRODUCING (R)-2-BROMO-3-PHENYLPROPIONIC ACID
ATE301637T1 (en) METHOD FOR PRODUCING N-PROTECTED AZETIDINE-2-CARBONIC ACIDS
DE50109809D1 (en) Process for the preparation of D- or L-menthol
ATE342873T1 (en) METHOD FOR PRODUCING LITHIUMAMIDE
ATA2852003A (en) METHOD FOR PRODUCING CHIRAL ALPHA HYDROXYCARBOXYLIC ACIDS BY ENZYMATIC HYDROLYSIS OF CHIRAL CYANHYDRINES
ATE223901T1 (en) METHOD FOR PRODUCING 5,7 DICHLORO-4-HYDROXYQUINOLINE
WO2004081220A3 (en) A process for enzymatically resolving an enantiomeric mixture of alpha-hydroxy acids
ATE423215T1 (en) METHOD FOR PRODUCING LYSOSPHINGOLIPIDS
DE60034699D1 (en) PROCESS FOR THE PRODUCTION OF FUMAGILLIN
ATE334963T1 (en) METHOD FOR PRODUCING 4 METHYLAMINO 4 PHENYLPIPERIDINE
DE60103565D1 (en) METHOD FOR PRODUCING 2-METHOXY-4-METHYL-6-METHYLAMINO-1,3,5-TRIAZINE
ATE296895T1 (en) METHOD FOR PRODUCING C4-C12 FATTY ACIDS
DE50109324D1 (en) METHOD FOR PRODUCING PHENYLENE-BIS-BENZIMIDAZOLE-TETRASULFONIC ACID-DINATRIUM SALT

Legal Events

Date Code Title Description
8364 No opposition during term of opposition