DE60236014D1 - Verfahren zur herstellung von insulinverbindungen - Google Patents

Verfahren zur herstellung von insulinverbindungen

Info

Publication number
DE60236014D1
DE60236014D1 DE60236014T DE60236014T DE60236014D1 DE 60236014 D1 DE60236014 D1 DE 60236014D1 DE 60236014 T DE60236014 T DE 60236014T DE 60236014 T DE60236014 T DE 60236014T DE 60236014 D1 DE60236014 D1 DE 60236014D1
Authority
DE
Germany
Prior art keywords
insulin compounds
producing insulin
compounds
insulin
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60236014T
Other languages
English (en)
Inventor
Are Bogsnes
Ingun Christiansen
Per Balschmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of DE60236014D1 publication Critical patent/DE60236014D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE60236014T 2001-11-19 2002-11-15 Verfahren zur herstellung von insulinverbindungen Expired - Lifetime DE60236014D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200101716 2001-11-19
PCT/DK2002/000765 WO2003044210A2 (en) 2001-11-19 2002-11-15 Process for preparing insulin compounds

Publications (1)

Publication Number Publication Date
DE60236014D1 true DE60236014D1 (de) 2010-05-27

Family

ID=8160841

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60236014T Expired - Lifetime DE60236014D1 (de) 2001-11-19 2002-11-15 Verfahren zur herstellung von insulinverbindungen

Country Status (15)

Country Link
EP (1) EP1448786B1 (de)
JP (1) JP4404631B2 (de)
KR (1) KR100925381B1 (de)
CN (1) CN100424179C (de)
AT (1) ATE464390T1 (de)
AU (1) AU2002342597A1 (de)
BR (1) BR0213583A (de)
CA (1) CA2464616C (de)
DE (1) DE60236014D1 (de)
ES (1) ES2344448T3 (de)
HU (1) HU228934B1 (de)
IL (2) IL161358A0 (de)
PL (1) PL210437B1 (de)
RU (1) RU2376379C2 (de)
WO (1) WO2003044210A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006031955A1 (de) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
DE102006031962A1 (de) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
TW200902708A (en) * 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
RS56632B1 (sr) 2008-10-17 2018-03-30 Sanofi Aventis Deutschland Kombinacija insulina i glp-1-agonista
KR20120055653A (ko) * 2009-08-11 2012-05-31 바이오콘 리미티드 크로마토그래피 방법 및 그의 정제된 화합물
PT3345593T (pt) 2009-11-13 2023-11-27 Sanofi Aventis Deutschland Composição farmacêutica compreendendo despro36exendina- 4(1-39)-lys6-nh2 e metionina
ES2855146T3 (es) 2009-11-13 2021-09-23 Sanofi Aventis Deutschland Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina
HUE031181T2 (en) 2010-08-30 2017-06-28 Sanofi Aventis Deutschland Use of AVE0010 for the manufacture of a medicament for the treatment of type 2 diabetes
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
CN103917241A (zh) 2011-08-29 2014-07-09 赛诺菲-安万特德国有限公司 用于2型糖尿病患者中的血糖控制的药物组合
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
CN102703552B (zh) * 2012-05-15 2014-10-29 山东阿华生物药业有限公司 重组人胰岛素的制备方法及其产品
CN102816819B (zh) * 2012-08-13 2014-10-29 山东阿华生物药业有限公司 提高人胰岛素前体融合蛋白酶切转换成b30缺苏氨酸人胰岛素产率的方法
CN103305581B (zh) * 2013-07-04 2015-05-27 珠海联邦制药股份有限公司 一种重组人胰岛素的制备方法
EP3087192B1 (de) * 2013-12-23 2020-08-12 Biocon Biologics India Limited Verfahren zur herstellung von humaninsulinmethylester
JP6970615B2 (ja) 2014-12-12 2021-11-24 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング インスリングラルギン／リキシセナチド固定比処方
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
KR20170036643A (ko) * 2015-09-24 2017-04-03 한미약품 주식회사 인슐린의 제조 방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50892B1 (en) 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters
EP0088117B1 (de) 1981-09-15 1986-09-24 Nordisk Insulinlaboratorium Verfahren zur herstellung von menschlichem insulin oder b-30-estern davon
DE3262052D1 (en) 1981-08-10 1985-03-07 Nordisk Insulinlab Process for the enzymatic preparation of human insulin
DK149824C (da) 1982-01-22 1987-03-16 Carlsberg Biotechnology Ltd Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner
EP0087238A1 (de) 1982-02-08 1983-08-31 Biogen N.V. Methode zur Herstellung von menschlichem Insulin aus nichtmenschlichem Insulin-
DK347086D0 (da) 1986-07-21 1986-07-21 Novo Industri As Novel peptides
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
IL84110A (en) * 1986-10-14 1992-11-15 Lilly Co Eli Process for transforming a human insulin precursor to a human insulin
DE10075034I1 (de) 1987-02-25 2001-05-23 Novo Nordisk As Insulinderivate
US6011007A (en) 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
RO112873B1 (ro) 1993-09-17 1998-01-30 Novo Nordisk As Derivati de insulina
JP4773023B2 (ja) 1999-12-29 2011-09-14 ノボ ノルディスク アクティーゼルスカブ インスリン前駆体及びインスリン前駆体類似体の製造方法
DE60044728D1 (de) 1999-12-29 2010-09-02 Novo Nordisk As VERFAHREN ZUR HERSTELLUNG VON INSULINVORLäUFERN UND ANALOGEN VON INSULINVORLÄUFERN MIT VERBESSERTER FERMENTATIONSAUSBEUTE IN HEFE
DE60131969D1 (de) 2000-04-14 2008-01-31 Univ Maryland Biotech Inst Verbesserte thermostabilität und temperaturresistenz von proteinen
WO2002079254A1 (en) 2001-03-29 2002-10-10 Janoff Edward N Human monoclonal antibodies against capsular polysaccharides of streptococcus pneumoniae

Also Published As

Publication number Publication date
CN1589328A (zh) 2005-03-02
PL369447A1 (en) 2005-04-18
ES2344448T3 (es) 2010-08-27
BR0213583A (pt) 2004-08-24
CA2464616A1 (en) 2003-05-30
RU2004118503A (ru) 2005-06-10
CN100424179C (zh) 2008-10-08
IL161358A (en) 2011-05-31
KR100925381B1 (ko) 2009-11-09
EP1448786A2 (de) 2004-08-25
CA2464616C (en) 2012-07-24
HUP0500037A3 (en) 2010-01-28
KR20050044855A (ko) 2005-05-13
PL210437B1 (pl) 2012-01-31
ATE464390T1 (de) 2010-04-15
JP2005509687A (ja) 2005-04-14
AU2002342597A1 (en) 2003-06-10
WO2003044210A2 (en) 2003-05-30
RU2376379C2 (ru) 2009-12-20
WO2003044210A3 (en) 2004-03-25
AU2002342597A8 (en) 2003-06-10
EP1448786B1 (de) 2010-04-14
HUP0500037A2 (hu) 2005-03-29
JP4404631B2 (ja) 2010-01-27
IL161358A0 (en) 2004-09-27
HU228934B1 (hu) 2013-06-28

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