DE602004029999D1 - Neue kristalline polymorphe von clopidogrel - Google Patents

Neue kristalline polymorphe von clopidogrel

Info

Publication number
DE602004029999D1
DE602004029999D1 DE602004029999T DE602004029999T DE602004029999D1 DE 602004029999 D1 DE602004029999 D1 DE 602004029999D1 DE 602004029999 T DE602004029999 T DE 602004029999T DE 602004029999 T DE602004029999 T DE 602004029999T DE 602004029999 D1 DE602004029999 D1 DE 602004029999D1
Authority
DE
Germany
Prior art keywords
forms
present
clopidogrel
relates
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004029999T
Other languages
English (en)
Inventor
Ramakrishnan Arul
Ajay Singh Rawat
Maheshkumar Gadakar
Rajesh Rao
Abhinay Pise
Jason Gray
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Generics UK Ltd
Original Assignee
Generics UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29226875&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602004029999(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Generics UK Ltd filed Critical Generics UK Ltd
Publication of DE602004029999D1 publication Critical patent/DE602004029999D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Liquid Crystal Substances (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE602004029999T 2003-09-11 2004-09-09 Neue kristalline polymorphe von clopidogrel Active DE602004029999D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0321256.0A GB0321256D0 (en) 2003-09-11 2003-09-11 Novel crystalline compounds
PCT/GB2004/003867 WO2005026174A1 (en) 2003-09-11 2004-09-09 Novel crystalline polymorphs of clopidogrel

Publications (1)

Publication Number Publication Date
DE602004029999D1 true DE602004029999D1 (de) 2010-12-23

Family

ID=29226875

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004029999T Active DE602004029999D1 (de) 2003-09-11 2004-09-09 Neue kristalline polymorphe von clopidogrel

Country Status (15)

Country Link
US (1) US7897613B2 (de)
EP (4) EP1772456B1 (de)
AT (1) ATE487725T1 (de)
AU (1) AU2004272337B2 (de)
CA (3) CA2536052C (de)
CY (1) CY1115917T1 (de)
DE (1) DE602004029999D1 (de)
DK (2) DK1772456T3 (de)
ES (2) ES2528198T3 (de)
GB (1) GB0321256D0 (de)
HU (1) HUE029256T2 (de)
PL (2) PL1772456T3 (de)
PT (1) PT1772456E (de)
SI (1) SI1772456T1 (de)
WO (1) WO2005026174A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1713812A1 (de) * 2004-01-13 2006-10-25 Zentiva, a.s. Neue kristalline formen von clopidogrel-hydrobromid und verfahren zu deren herstellung
CN1997648A (zh) * 2004-04-20 2007-07-11 赛诺菲-安万特 (+)－(S)－α－(2－氯苯基)－6,7－二氢噻吩并[3,2－C]吡啶－5(4H)乙酸甲酯氢溴酸盐，即氯吡格雷氢溴酸盐的多晶型物
BRPI0510008A (pt) 2004-04-20 2007-09-18 Sanofi Aventis sal de clopidogrel e formas polimórficas deste
WO2006018853A2 (en) 2004-08-19 2006-02-23 Hetero Drugs Limited Novel polymorphs of efavirenz
US20060154957A1 (en) * 2004-09-21 2006-07-13 Nina Finkelstein Crystalline clopidogrel hydrobromide and processes for preparation thereof
EP1674468A1 (de) * 2004-12-21 2006-06-28 Ratiopharm GmbH Polymorphe von Clopidogrel Hydrobromid
US7932391B2 (en) 2005-09-08 2011-04-26 Zhejiang Hauhai Pharmaceutical Co., Ltd. Method for the preparation of clopidogrel and its analogues of methyl-tetrahydrothieno[3,2-C]pyridine acetate
CN100417653C (zh) * 2005-09-08 2008-09-10 浙江华海药业股份有限公司 噻吩并四氢吡啶乙酸及其盐的制备方法
ES2584838T3 (es) * 2006-04-05 2016-09-29 Opko Health, Inc Sal clorhidrato de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-espiro[4.5]decán-2-ona y procedimiento de preparación de la misma
ITMI20062449A1 (it) * 2006-12-19 2008-06-20 Dipharma Spa Forma cristallina di rabeprazolo sodico
WO2008081473A2 (en) * 2006-12-29 2008-07-10 Cadila Healthcare Limited Process for preparing clopidogrel
EP1970054A3 (de) 2007-03-14 2009-06-03 Ranbaxy Laboratories Limited Clopidogrel-Tabletten
EP2107061A1 (de) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Herstellungsverfahren für optisch angereichertes Clopidogrel
CN105503870A (zh) * 2009-08-14 2016-04-20 欧科生医股份有限公司 神经激肽-1拮抗剂的静脉内制剂
WO2012123958A1 (en) 2011-02-14 2012-09-20 Cadila Healthcare Limited Highly pure salts of clopidogrel free of genotoxic impurities
US9233103B2 (en) 2011-03-25 2016-01-12 Takeda Pharmaceuticals U.S.A., Inc. Methods for treating heartburn, gastric bleeding or hemorrhage in patients receiving clopidogrel therapy
WO2012174731A1 (en) * 2011-06-24 2012-12-27 Cheng Haiyung Method and improved pharmaceutical composition for improving the absorption of an ester prodrug
TWI461215B (zh) * 2011-06-24 2014-11-21 Acenda Pharma Inc 用以改善酯類前驅藥吸收率的方法與改良之藥學組合物
ES2791417T3 (es) * 2013-02-06 2020-11-04 Jingjun Huang Composición farmacéutica estable de base libre de clopidogrel para administración oral y parenteral

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2530247B1 (fr) 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2623810B2 (fr) 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2652575B1 (fr) 1989-09-29 1992-01-24 Sanofi Sa Procede de preparation d'acides alpha-bromo phenylacetiques.
FR2664596B1 (fr) 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
MA23420A1 (fr) * 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
HU222283B1 (hu) 1997-05-13 2003-05-28 Sanofi-Synthelabo Eljárás tieno[3,2-c]piridin-származékok előállítására
HU225503B1 (en) 1997-05-13 2007-01-29 Sanofi Aventis Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them
HU225504B1 (en) 1997-05-13 2007-01-29 Sanofi Aventis Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
FR2779726B1 (fr) 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
HUP0200438A3 (en) * 2002-02-06 2003-10-28 Egis Gyogyszergyar Nyilvanosan Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
EP1713812A1 (de) 2004-01-13 2006-10-25 Zentiva, a.s. Neue kristalline formen von clopidogrel-hydrobromid und verfahren zu deren herstellung
CN1997648A (zh) 2004-04-20 2007-07-11 赛诺菲-安万特 (+)－(S)－α－(2－氯苯基)－6,7－二氢噻吩并[3,2－C]吡啶－5(4H)乙酸甲酯氢溴酸盐，即氯吡格雷氢溴酸盐的多晶型物

Also Published As

Publication number Publication date
CY1115917T1 (el) 2017-01-25
EP2149578A1 (de) 2010-02-03
ES2355729T3 (es) 2011-03-30
AU2004272337B2 (en) 2008-02-14
EP1772456A1 (de) 2007-04-11
US20070281964A1 (en) 2007-12-06
EP1618113B1 (de) 2010-11-10
AU2004272337A1 (en) 2005-03-24
CA2809750A1 (en) 2005-03-24
CA2536052C (en) 2013-06-25
ATE487725T1 (de) 2010-11-15
PL1772456T3 (pl) 2015-03-31
EP1618113A1 (de) 2006-01-25
ES2528198T3 (es) 2015-02-05
WO2005026174A1 (en) 2005-03-24
PL1837337T3 (pl) 2017-02-28
HUE029256T2 (en) 2017-02-28
GB0321256D0 (en) 2003-10-08
CA2810312A1 (en) 2005-03-24
EP1772456B1 (de) 2014-10-29
EP1837337A1 (de) 2007-09-26
DK1772456T3 (en) 2015-01-19
US7897613B2 (en) 2011-03-01
SI1772456T1 (sl) 2015-03-31
CA2536052A1 (en) 2005-03-24
PT1772456E (pt) 2015-02-06
EP1837337B1 (de) 2016-04-06
DK1618113T3 (da) 2011-02-07

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