CN1631361A - Application of alpha cyclo-alanine in the process for preparing medicine to treat cerebrovascular and cardiovascular disease - Google Patents
Application of alpha cyclo-alanine in the process for preparing medicine to treat cerebrovascular and cardiovascular disease Download PDFInfo
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- CN1631361A CN1631361A CN 200410010516 CN200410010516A CN1631361A CN 1631361 A CN1631361 A CN 1631361A CN 200410010516 CN200410010516 CN 200410010516 CN 200410010516 A CN200410010516 A CN 200410010516A CN 1631361 A CN1631361 A CN 1631361A
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Abstract
The invention relates to the use of 1-aminocyclopropanecarboxylic acid (ACPC) in preparing medicine for treating cerebrovascular and cardiovascular diseases, in particular the use in preparing medicament for treating hypertension, cerebrovascular thrombus and cerebral apoplexy.
Description
(1) technical field
The present invention relates to the new purposes of α-ring alanine (ACPC) in preparation treatment cardiovascular and cerebrovascular diseases medicament, especially the application in preparation prophylactic treatment vascular hypertension, cardiovascular and cerebrovascular vessel thrombosis, apoplexy disease drug and protection cerebrovascular, heart, renal drug.
(2) background technology
α-ring alanine (1-aminocyclopropanecarboxylic acid, ACPC) be the extraordinary aminoacid of natural non-albumen, be mainly used in the preparation bird feed additive at present, existing report α-ring alanine (ACPC) can be used for the spiritual class disease medicament of preparation treatment, as anxiety neurosis, depression etc., also there is not α-ring alanine to be applied to treat the relevant report of preparation cardiovascular and cerebrovascular diseases medicament.
(3) summary of the invention
The present invention promptly is for the new purposes of α-ring alanine (ACPC) at pharmaceutical field is provided, be the application of α-ring alanine (ACPC) in the preparation cardiovascular and cerebrovascular diseases medicament, the especially application in preparation treatment vascular hypertension, cardiovascular and cerebrovascular vessel thrombosis, apoplexy disease drug.
The technical solution used in the present invention is:
α-ring alanine (ACPC) is applied to preparation treatment cardiovascular and cerebrovascular diseases medicament.
Especially, described α-ring alanine is applied to preparation treatment vascular hypertension medicine, treatment cardiovascular and cerebrovascular vessel thrombosis medicine or control apoplexy disease drug.Experimental results show that; α-ring alanine (ACPC) can suppress increased blood pressure; improve the cerebral blood flow increasing amount; prevent cerebral hemorrhage; anti-hemostatic tube infraction, the prevention of brain apoplexy takes place, reduces the apoplexy mortality rate, and effective protection cranial nerve cell; protection heart and kidney are avoided cardiac hypertrophy and kidney sclerosis atrophy.
Described medicine also can contain pharmaceutical excipient or carrier.
α-ring alanine also uses jointly with other drug.
The beneficial effect of the application of α of the present invention-ring alanine in the preparation cardiovascular and cerebrovascular diseases medicament is mainly reflected in: (1) α-ring alanine can effectively be treated cardiovascular and cerebrovascular diseases such as vascular hypertension, cardiovascular and cerebrovascular vessel thrombosis, apoplexy disease, cerebrovascular, heart, kidney are effectively protected, had no side effect; (2) pharmacological action is clear and definite, for new medicament screen provides the foundation.
(4) description of drawings
Fig. 1 is administration SHR-SP rat Laser-Doppler blood-stream image after 1 month, and a left side be that α-ring alanine (ACPC) is treated group, and the right side is a control group;
Fig. 2 is dead rat of apoplexy and ACPC treatment survival rats brain picture, and A is a cerebral hemorrhage, and B is cerebral malacia (cerebral infarction), and C is cerebral malacia (hemorrhage merging), and D is slight cerebral thrombosis, and E is to ACPC, treats basic normal rat;
Fig. 3 compares for the SHR-SP rat heart, and right for contrasting, a left side is to the ACPC rat;
Fig. 4 compares for the SHR-SP rat kidney, and a left side is contrast, and right is to the ACPC rat.
(5) specific embodiment
The present invention is described further below in conjunction with specific embodiment:
Embodiment 1:SHR-SP rat pharmacological evaluation
(1) model and method:
20 of SHR-SP rats be divided into ACPC treatment group and matched group, 10 every group.α-ring alanine (ACPC) treatment group is pressed 50mg/kg (50mgACPC/ml distilled water) dosage lumbar injection (iP), and the matched group injection is with the distilled water of making a gesture of measuring.Day injection on every Fridays once a day.The blood pressure lowering of spontaneous generation hypertension, apoplexy rat, the effect of prevention of brain apoplexy are observed.
(2) testing index:
Weekly systolic pressure (SBP), diastolic pressure (DBP), the heart rate (HR) measured before the experiment, after the beginning.
Collect twenty-four-hour urine around the administration the, carry out the mensuration of excretions such as NO.
After around the administration, レ one ザ one De Star プ ラ one (Laser-Doppler) blood-stream image mensuration blood flow is seen Fig. 1.
Observe the incidence of apoplexy, the mortality rate of apoplexy.
Rat is dissected, and the extraction heart, brain, kidney carry out pathological analysis.
(3) result:
1. systolic pressure (SBP), two weeks are than matched group decline 24mg mercury column (P＜0.001) after α-ring alanine (ACPC) treatment group administration; Diastolic pressure (DBP), α-ring alanine (ACPC) treatment group is than matched group decline 16mg mercury column (P＜0.01); Heart rate (HR) does not have significant difference.
2. collect twenty-four-hour urine around the administration the, carry out the mensuration of excretions such as NO, 0.76 μ mol is organized in α-ring alanine (ACPC) treatment, matched group 1.36 μ mol, and about 50% (P＜0.05) descends.
3. cerebral blood flow measured value, α-ring alanine (ACPC) treatment group 1.5, matched group 1.2 increases by 25% (P＜0.05).
4. the incidence of apoplexy, judge according to the nerve action symptom (pain sensation sensitivity, limb paralysis etc.) of rat whether rat sends out disease, observation experiment begins the apoplexy of rat in back 100 days and sends out the symptom condition: 10 of matched groups are all sent out disease (100%), and α-2 of ring alanine (ACPC) treatment groups are sent out disease (20%).
5. the mortality rate of apoplexy, 10 of matched groups were all sent out disease death (100%) in 70-82 days, and 1 of α-ring alanine (ACPC) treatment group sent out disease death (10%) in 80 days, still survive after 100 days for all the other 9.
6. the heart, brain, kidney carry out pathological analysis, see that Fig. 2, Fig. 3, Fig. 4: Fig. 2 shows that α-ring alanine (ACPC) effectively prevents and treats apoplexy; Fig. 3 shows that α-ring alanine (ACPC) effectively protects heart, and heart is normal, the contrast cardiac hypertrophy; Fig. 4 shows that α-ring alanine (ACPC) effectively protects kidney, and kidney is normal, contrast kidney sclerosis atrophy.
Claims (6)
1. the application of α-ring alanine in preparation treatment cardiovascular and cerebrovascular diseases medicament.
2. the application of α as claimed in claim 1-ring alanine in preparation treatment cardiovascular and cerebrovascular diseases medicament is characterized in that described α-ring alanine is applied to preparation treatment vascular hypertension medicine.
3. the application of α as claimed in claim 1-ring alanine in preparation treatment cardiovascular and cerebrovascular diseases medicament is characterized in that described α-ring alanine is applied to preparation treatment cardiovascular and cerebrovascular vessel thrombosis medicine.
4. the application of α as claimed in claim 1-ring alanine in preparation treatment cardiovascular and cerebrovascular diseases medicament is characterized in that described α-ring alanine is applied to preparation control apoplexy disease drug.
5. as the application of the described α of one of claim 1～4-ring alanine in preparation treatment cardiovascular and cerebrovascular diseases medicament, it is characterized in that described medicine also contains pharmaceutical excipient or carrier.
6. as the application of the described α of one of claim 1～4-ring alanine in preparation treatment cardiovascular and cerebrovascular diseases medicament, it is characterized in that the described α of being applied as-ring alanine and other drug use jointly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100105160A CN1293868C (en) | 2004-12-29 | 2004-12-29 | Application of alpha cyclo-alanine in the process for preparing medicine to treat cerebrovascular and cardiovascular disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100105160A CN1293868C (en) | 2004-12-29 | 2004-12-29 | Application of alpha cyclo-alanine in the process for preparing medicine to treat cerebrovascular and cardiovascular disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1631361A true CN1631361A (en) | 2005-06-29 |
| CN1293868C CN1293868C (en) | 2007-01-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2004100105160A Expired - Fee Related CN1293868C (en) | 2004-12-29 | 2004-12-29 | Application of alpha cyclo-alanine in the process for preparing medicine to treat cerebrovascular and cardiovascular disease |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006082771A1 (en) * | 2005-02-02 | 2006-08-10 | Juridical Person, Suzuka University Of Medical Science | Preventive or therapeutic agent for stroke or sequelae of stroke comprising as main component 1-aminocyclopropanecarboxylic acid or the like |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2610430T3 (en) | 2001-12-17 | 2017-04-27 | Microsoft Technology Licensing, Llc | Default macroblock coding |
| US7724827B2 (en) | 2003-09-07 | 2010-05-25 | Microsoft Corporation | Multi-layer run level encoding and decoding |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS50142572A (en) * | 1974-04-25 | 1975-11-17 | ||
| WO1991001724A1 (en) * | 1989-07-27 | 1991-02-21 | G.D. Searle & Co. | Renal-selective prodrugs for the treatment of hypertension |
| US6017957A (en) * | 1989-08-08 | 2000-01-25 | The United States Of America As Represented By The Department Of Health And Human Services | Partial agonists of the strychnine insensitive glycine modulatory site of the N-methyl-D-aspartate receptor complex as neuropsychopharmacological agents |
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- 2004-12-29 CN CNB2004100105160A patent/CN1293868C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006082771A1 (en) * | 2005-02-02 | 2006-08-10 | Juridical Person, Suzuka University Of Medical Science | Preventive or therapeutic agent for stroke or sequelae of stroke comprising as main component 1-aminocyclopropanecarboxylic acid or the like |
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| CN1293868C (en) | 2007-01-10 |
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Granted publication date: 20070110 Termination date: 20100129 |