CN1281229C - Eye drop and its preparation - Google Patents
Eye drop and its preparation Download PDFInfo
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- CN1281229C CN1281229C CN 200310104091 CN200310104091A CN1281229C CN 1281229 C CN1281229 C CN 1281229C CN 200310104091 CN200310104091 CN 200310104091 CN 200310104091 A CN200310104091 A CN 200310104091A CN 1281229 C CN1281229 C CN 1281229C
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- injection
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- eye drops
- medicine
- eye drop
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Abstract
The present invention relates to eye drops and a preparation method thereof. The present invention is characterized in that the eye drops are preparations prepared by medicine with the volume percentage of 0.5 to 2 of 0.25% of mydriacyl eye drops, 2 to 8 of red sage root injections, 0.5 to 2 of gianossine triphosphate injections and 0.5 to 2 of inosine injections. The eye drops of the present invention use tropicamide as main components for being matched with other kinds of medicine for nourishing ouclar muscles, expanding blood vessels, etc., and have favorable effect on the treatment of functional myopia of youth. Compared with existing similar medicine, the present invention has the advantages of short mydriatic action time and quick recovery, overcomes the bad effect of 'mydriasis' on study and lives, and similarly has a better relaxation function to ciliary spasm Because medicine for nourishing ocular nerves and muscles and expanding blood vessels is compounded in the eye drops, the present invention has a better function to the improvement of functional myopia and the recovery of eyestrain.
Description
Technical field
The present invention relates to field of pharmaceutical technology, specifically treat external eye drip medicine eye drop of teenager functional myopia and preparation method thereof.
Background technology
Functional myopia is in teenager, and is especially common in 7～18 years old student, health had damaging effect, and teen-age studying and living is affected.If being used for the treatment of the drug main of teenager functional myopia at present is the eye drop of principal agent with the atropine, though obtain certain therapeutic effect, mydriatic action time is longer, makes troubles to living and studying.
Summary of the invention
The objective of the invention is to overcome the deficiency that prior art exists, a kind of good effect is provided, recovers fast, the little eye drop its preparation method of side effect.
Eye drop of the present invention is to contain the preparation that the medicament of following parts by volume is made:
0.25% N-ethyl-N-(.gamma.-picolyl)tropamide eye drop 0.5～2
Danshen root injection 2～8
Gianossine Triphosphate injection 0.5～2
Inosine injection 0.5～2
Except that above-mentioned medicament, also contain water for injection 980～997.
Its preparation method is: earlier Danshen root injection added in the water for injection, then adds 0.25% N-ethyl-N-(.gamma.-picolyl)tropamide eye drop and Gianossine Triphosphate injection and inosine injection more respectively, and adjust pH to 6.9～7.5, mixing, filtration, packing are promptly.
Eye drop of the present invention is a main component with the N-ethyl-N-(.gamma.-picolyl)tropamide, cooperates medicines such as other nutrition eye muscle and blood vessel dilating, in the treatment to the few functional myopia of green grass or young crops good effect is arranged.Compare with existing similar medicine, its mydriatic action time is short, recovers fast, has overcome " mydriasis " adverse effect to study and life, and ciliary spasm is had relexation preferably equally.Owing to be furnished with the medicine of nutrition ocular nerve, muscle and blood vessel dilating in this agent, the improvement of functional myopia and the recovery of eyestrain's disease all had better action.
Eye drop of the present invention is with functional myope 51 examples that die of teenager, age is 8～16 years old, vision 32 examples below 0.6 wherein, 0.6～1.0 19 example, administrated method: preceding 1 eye drip of sleeping every night, each 1～2, after the medication one month, vision restoration reaches 0.1 48 examples, and effective percentage reaches 94.1%, it is 29 examples that vision restoration reaches more than 0.1, and obvious effective rate is 56.9%.
Eye drop of the present invention clinic trial except that to functional myopia effectively, life-time service computation and other asthenopia disease with eyestrain crowd are all had good prevention effect.
The specific embodiment
Embodiment 1:
Choose crude drug: (milliliter)
0.25% N-ethyl-N-(.gamma.-picolyl)tropamide eye drop 0.5
Danshen root injection 2
Gianossine Triphosphate injection 0.5
Inosine injection 0.5
Water for injection 996.5
Preparation method: earlier Danshen root injection is added in the water for injection, then add 0.25% N-ethyl-N-(.gamma.-picolyl)tropamide eye drop and Gianossine Triphosphate injection and inosine injection more respectively, adjust pH to 6.9～7.5, mixing, filtration, packing are promptly.
Embodiment 2:
Choose crude drug: (milliliter)
0.25% N-ethyl-N-(.gamma.-picolyl)tropamide eye drop 1.5
Danshen root injection 6.5
Gianossine Triphosphate injection 1.5
Inosine injection 1.5
Water for injection 989
Press the method preparation of embodiment 1.
Embodiment 3:
Choose crude drug: (milliliter)
0.25% N-ethyl-N-(.gamma.-picolyl)tropamide eye drop 2
Danshen root injection 8
Gianossine Triphosphate injection 2
Inosine injection 2
Water for injection 986
Press the method preparation of embodiment 1.
Claims (2)
1, a kind of eye drop is characterized in that it being to contain the preparation that the medicament of following parts by volume is made:
0.25% N-ethyl-N-(.gamma.-picolyl)tropamide eye drop 0.5～2
Danshen root injection 2～8
Gianossine Triphosphate injection 0.5～2
Inosine injection 0.5～2
Water for injection 980～997.
2, press the preparation method of the described eye drop of claim 1, it is characterized in that earlier Danshen root injection being added in the water for injection, then add 0.25% N-ethyl-N-(.gamma.-picolyl)tropamide eye drop and Gianossine Triphosphate injection and inosine injection, adjust pH to 6.9～7.5 more respectively, mixing, filtration, packing are promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310104091 CN1281229C (en) | 2003-12-19 | 2003-12-19 | Eye drop and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310104091 CN1281229C (en) | 2003-12-19 | 2003-12-19 | Eye drop and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1628705A CN1628705A (en) | 2005-06-22 |
| CN1281229C true CN1281229C (en) | 2006-10-25 |
Family
ID=34842949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200310104091 Expired - Fee Related CN1281229C (en) | 2003-12-19 | 2003-12-19 | Eye drop and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1281229C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103159672A (en) * | 2012-07-16 | 2013-06-19 | 湖南尔文生物科技有限公司 | Preparation method of tropine amide |
| CN104127441B (en) * | 2014-08-19 | 2017-09-29 | 宁夏瑞视眼科研究所 | Eye drops of anti-kopiopia and preparation method thereof |
-
2003
- 2003-12-19 CN CN 200310104091 patent/CN1281229C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1628705A (en) | 2005-06-22 |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |