CN1137702C - Application of konjack and its extract in preparing medicinal composition - Google Patents

Application of konjack and its extract in preparing medicinal composition Download PDF

Info

Publication number
CN1137702C
CN1137702C CNB001194526A CN00119452A CN1137702C CN 1137702 C CN1137702 C CN 1137702C CN B001194526 A CNB001194526 A CN B001194526A CN 00119452 A CN00119452 A CN 00119452A CN 1137702 C CN1137702 C CN 1137702C
Authority
CN
China
Prior art keywords
extract
application
chinese herbal
herbal medicine
konjack
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB001194526A
Other languages
Chinese (zh)
Other versions
CN1291481A (en
Inventor
潘胜利
钱伏刚
王厄舟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fudan University
Original Assignee
Fudan University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fudan University filed Critical Fudan University
Priority to CNB001194526A priority Critical patent/CN1137702C/en
Publication of CN1291481A publication Critical patent/CN1291481A/en
Priority to AU2002213750A priority patent/AU2002213750A1/en
Priority to PCT/CN2001/001172 priority patent/WO2002022144A1/en
Application granted granted Critical
Publication of CN1137702C publication Critical patent/CN1137702C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides a Chinese herbal medicine, namely konjak, an extract thereof and a preparing process thereof. Meanwhile, the Chinese herbal medicine and the extract thereof can be made into tablets, injections, slow-release agents, capsules and compound preparations as raw medicinal materials. The present invention also relates to an application of the Chinese herbal medicine and the extract thereof on the treatment of depression.

Description

The application of Chinese herbal medicine Piper laetispicum C.DC. ethyl acetate extract in the spiritual class medicine of preparation
The invention relates to from the Chinese herbal medicine Piper laetispicum C.DC. and to extract active component and make medicine, be used to prevent and treat depression and mental disorder disease.
Progress along with the epoch, the rhythm and pace of moving things of work is constantly accelerated, and ((Alzheimer) become one of 5 big diseases of world today's harm humans health for the depression that the intense strain that causes because of operating pressure causes, mental disorder and the presenile dementia that therefore causes.The World Health Organization (WHO) reveals that spiritual disease is brought white elephant to human society.Ministry of Health of China confirms that also mental disorder ranks first, and has surpassed illness such as cardiovascular and cerebrovascular vessel, respiratory system and malignant tumor in the rank of the total burden of China's disease.
Kawakawa (Kavakava) is the fashionable in the last few years natural health-care medicine in states such as America and Europe and Japan.Be used for relaxation of tension emotion, calmness and antidepressant etc.Its plant origin is the piper methysticum (Piper methysticum Forst) that grows in South Pacific Ocean island country.
It is revealed that kawakawa also has unsatisfactory part in clinical treatment, the medicine of excavating antidepressant and treatment mental disorder disease in China's natural drug has formed the research focus.
The purpose of this invention is to provide Chinese herbal medicine Piper laetispicum C.DC. Piper laetispicum C.DC and its extract and preparation method thereof.
Another object of the present invention is with the raw material of said extracted thing as pharmaceutical preparation.
A further object of the invention provides Chinese herbal medicine Piper laetispicum C.DC. and the application of extract in preparation treatment depression and mental disorder disease medicament thereof.
Piper laetispicum C.DC. Piper laetispicum C.DC is Piperaceae (Piperaceae) Piper (Piper L.) plant, is distributed in China Guangdong and south Guangxi and Hainan Province.At source, be used for the treatment of traumatic injury, swelling and pain due to blood stasis as the promoting blood circulation and detumescence analgesic.The present invention discovers the analgesia of extract tool, calmness and the antidepressant effect of its alcohol extraction ethyl acetate extraction of Da Ye.Aspect antidepressant effect, stronger 2～3 times especially than external like product kawakawa (Kavakava).
The present invention prepares the Piper laetispicum C.DC. extract by following method.
Get Piper laetispicum C.DC. root coarse powder and add 8 times of amount 95% alcohol refluxs 2 times, each 1 hour, filter, merging filtrate is evaporated to dried, add 3 times of amount ethyl acetate extractions 3 times again, combining extraction liquid, be evaporated to dried, khaki thick solid content, yield 3.17%, main component are lactone and glycoside.
Piper laetispicum C.DC. of the present invention and extract thereof can be used as medicine material and make preparations such as capsule, tablet, injection, oral liquid, slow releasing agent.The result proves through zoopery, and the big leaf extract of the present invention (POS) has tangible antidepressant effect and calm, analgesic activity to mice.
Animal experiment method of the present invention and result are as follows:
This experiment is a U.S. Nutratech. company product with the kawakawa that compares.The Piper laetispicum C.DC. extract is with 2% Tween 80 preparation.
Laboratory animal: Kunming mouse, male, 22～25g, 8 every group.
Experimental technique:
Antidepressant: forced swimming method.The mice random packet conformed 1 day.In the 2nd day gastric infusion.Half an hour after the administration, to put in the vial of diameter 10cm, high 30cm, depth of water 15cm, water temperature can only be tested 1 time by 24 ℃ of every mices.Spaced-apart between mice during experiment.When mice is put in the vial, begin to move about desperately, it is motionless just to keep afloat when " despair ".In stopwatch record 6 minutes, back 4 minutes continuous dead times.
Sedation: wear lattice walking method.Half an hour after the mouse stomach administration, put diameter 35cm, high 15cm, the bottom is decorated with in the case of 5cm * 5cm grid.Allow mice case endoadaptation environment 3 minutes earlier, observe the lattice number that mice walked then in 5 minutes.
Analgesic activity: acetic acid twisting method.Half an hour after the mouse stomach administration, lumbar injection 1% acetic acid 0.1ml/10g body weight.Observe the 1st time and turn round the number of times that body takes place to turn round in back 10 minutes body.
Matched group is irritated stomach with equivalent 2% Tween 80 aqueous solution.
Experimental result adopts t method of inspection statistical data.
Table 1 antidepressant effect (forced swimming method)
Group dosage mg/kg moves time min
Matched group 2.87 ± 0.17
PDS 120 1.41±0.34**
PDS 60 1.55±0.41**
PDS 30 2.24±0.33
Kavakava 120 1.80±0.28**
Kavakava 60 2.71±0.16
Table 2 sedation (wearing lattice walking method)
Group dosage mg/kg wears lattice walking number
Matched group 170.25 ± 7.53
PDS 120 116.88±5.96 **
PDS 60 162.13±12.86
PDS 30 170.13±15.06
Kavakava 120 138.13±12.56 *
Kavakava 60 167.38±8.70
Table 3 analgesic activity (acetic acid twisting method)
Group dosage mg/kg turns round the body number
Matched group 29.25 ± 2.61
PDS 120 10.38±1.44 ***
PDS 60 19.13±2.82 *
PDS 30 20.34±2.18 *
Kavakava 120 14.25±2.47 **
Kavakava 60 16.25±0.90 **
*P＜0.05 **P＜0.01 ***P＜0.001

Claims (2)

1, the application of Chinese herbal medicine Piper laetispicum C.DC. ethyl acetate extract in preparation treatment mental disorder disease medicament compositions.
2, the application of Chinese herbal medicine Piper laetispicum C.DC. ethyl acetate extract in preparation treatment depression pharmaceutical composition.
CNB001194526A 2000-07-14 2000-07-14 Application of konjack and its extract in preparing medicinal composition Expired - Fee Related CN1137702C (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CNB001194526A CN1137702C (en) 2000-07-14 2000-07-14 Application of konjack and its extract in preparing medicinal composition
AU2002213750A AU2002213750A1 (en) 2000-07-14 2001-07-12 The uses of chinese herb piper laetispicum c. dc and its extract for the preparation of pharmaceutical composition
PCT/CN2001/001172 WO2002022144A1 (en) 2000-07-14 2001-07-12 The uses of chinese herb piper laetispicum c. dc and its extract for the preparation of pharmaceutical composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNB001194526A CN1137702C (en) 2000-07-14 2000-07-14 Application of konjack and its extract in preparing medicinal composition

Publications (2)

Publication Number Publication Date
CN1291481A CN1291481A (en) 2001-04-18
CN1137702C true CN1137702C (en) 2004-02-11

Family

ID=4587697

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB001194526A Expired - Fee Related CN1137702C (en) 2000-07-14 2000-07-14 Application of konjack and its extract in preparing medicinal composition

Country Status (3)

Country Link
CN (1) CN1137702C (en)
AU (1) AU2002213750A1 (en)
WO (1) WO2002022144A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100436407C (en) * 2003-03-20 2008-11-26 蒋毅 Preparation of piper laetispicum effective part and its use in medical therapy and health field
CN100356940C (en) 2004-12-01 2007-12-26 蒋毅 Method for preparing piper laetispicum extract, extract and its use
CN102475746B (en) * 2010-11-23 2015-05-06 天士力制药集团股份有限公司 Preparation method of piper laetispicum active ingredient
CN103063789B (en) * 2011-10-19 2016-06-08 天士力制药集团股份有限公司 The liquid phase analysis method of 12 amide alkaloids in detection great Ye simultaneously
CN107837301B (en) * 2017-11-01 2021-05-28 苏州颐华生物医药技术股份有限公司 Piper laetispicum extract and preparation method and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2757506C2 (en) * 1977-12-22 1980-02-14 Haarmann & Reimer Gmbh, 3450 Holzminden Process for the preparation of Piperonylidencrotonsaureamiden

Also Published As

Publication number Publication date
WO2002022144A1 (en) 2002-03-21
AU2002213750A1 (en) 2002-03-26
CN1291481A (en) 2001-04-18

Similar Documents

Publication Publication Date Title
CN1210047C (en) Medicine for treating common cold and preparation method
CN108785357A (en) A kind of masticinic acid and myrrh terpene compatible composition and its preparation method and application
CN1137702C (en) Application of konjack and its extract in preparing medicinal composition
CN103435692B (en) The application of ginseng candies albumen in the medicine and protective foods for the treatment of senile dementia
CN107744571B (en) Pharmaceutical composition for improving vascular endothelial dysfunction and preparation method and application thereof
CN1857622A (en) Medicine composition and preparation containing effective components of gastrodia tuber and Chuanxiong rhizome
CN106176748B (en) Norisoboldine is preparing the purposes in anti-depression drug
CN1839855A (en) Ginsenoside F1 medicinal uses
WO2013056508A1 (en) Pharmaceutical composition regulating blood fat and preparation process thereof
CN1430967A (en) Naringin used in preparing medicine for curing acute and chronic bronchitis
CN101698094B (en) Distillate for treating white vein diseases and preparation method thereof
CN1313499C (en) Sargassum polysaccharide, its preparation method and use
CN1686514A (en) Chinese medicinal preparation for treating anxietas, depression and its production method
CN1244334C (en) Novel use of traditional Chinese medicine rabdosia rubeseens and Isodon longitubus
CN101032524A (en) Application of martianus dermestoides in producing oxygen-deficient resisting medicine or healthy food and the preparing method
CN110538232A (en) Anti-depression compound preparation and preparation method thereof
CN1895477A (en) Antidespressant and its preparation
CN105311387B (en) Application of compound rhizoma Gymnadeniae pills in preparation of medicine for treating essential tremor
CN103755692A (en) Compound, preparation method and application thereof, pharmaceutical composition and preparation
CN1201775C (en) Medicine for treating insomnia-sleeping particle and preparation thereof
CN1234380C (en) Fracture setting medicine powder and its prepn process
CN1546143A (en) Luyang kidney yang strengthening Chinese traditional medicinal formula and its preparation
CN109078067B (en) Traditional Chinese medicine composition for treating stiff and hypokinetic Parkinson disease and application thereof
CN1724036A (en) Medicine for improving internal secreting melatonin, and application of its related herb medicine
CN101366731A (en) Propolis flavone, preparation method and uses in treating diabetes

Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20040211

Termination date: 20110714