CN113117260A - Focused ultrasound device and focused ultrasound device control method - Google Patents
Focused ultrasound device and focused ultrasound device control method Download PDFInfo
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- A61N7/00—Ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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Abstract
The invention provides a focused ultrasound device and a control method thereof, which can solve the problem of poor safety of the existing focused ultrasound treatment equipment. The focusing ultrasonic device comprises a focusing ultrasonic transducer, a continuous wave driving source, a pulse signal instrument and a controller, wherein: the focused ultrasonic transducer is used for emitting continuous ultrasonic waves for multiple times under the driving of the continuous wave driving source so as to ablate tissues in a focus area; in any one or more gaps between two adjacent continuous ultrasonic waves, transmitting pulse ultrasonic waves to tissues in a focal region under the driving of a pulse signal instrument, and sending received echo signals to the pulse signal instrument; the controller is respectively connected with the continuous wave driving source and the pulse signal instrument and is used for controlling the focused ultrasonic transducer to emit continuous ultrasonic waves and pulse ultrasonic waves; the controller is also used for acquiring one or more groups of echo signals through the pulse signal instrument and determining the change rule of the echo signals according to the fluctuation state of the echo signals.
Description
Technical Field
The invention belongs to the technical field of high-intensity focused ultrasound treatment, and particularly relates to a focused ultrasound device and a control method of the focused ultrasound device.
Background
The High Intensity Focused Ultrasound (HIFU) technology is widely used for treating benign and malignant tumors such as liver cancer, breast cancer, kidney cancer, bone tumor, uterine fibroid, and the like, and focuses Ultrasound on a lesion site in a human body by using the focusability and penetrability of the Ultrasound, so that High energy density mechanical energy of a focal region is converted into heat energy, and the lesion tissue is coagulative and necrotic (also called ultrasonic thermal ablation); meanwhile, the ultrasonic energy on the acoustic channel is lower, so that the surrounding of the lesion tissue and the normal tissue on the acoustic channel can be ensured not to be influenced or the influence can be accepted.
At present, in the process of an ablation tumor operation by using a high-intensity focused ultrasound device, the gray level change of a B ultrasonic image is mainly relied on to perform necrosis evaluation on a focal region tissue and evaluate the safety of a normal tissue around the focal region according to the clinical experience of a doctor, because the gray level change of the B ultrasonic image is not obvious in the process of tumor tissue necrosis, and when a strong echo appears on the B ultrasonic image, the tumor tissue is usually treated excessively, so that the surrounding normal tissue is damaged, and the damaged tissue blocks the ultrasonic wave from passing through the focal region to reach a back field (a region where the ultrasonic wave reaches after passing through the focal region in a human body) normal tissue. Therefore, the above method for evaluating the safety of the normal tissue around the focal region by the clinical experience of the doctor cannot effectively or timely determine whether the normal tissue around the focal region (especially the back field of the focal region) is damaged.
In addition, in the training process of the focused ultrasound ablation surgical system, since a clinical plan is often required to be made according to the experience of a doctor, and whether normal tissues around a focus area are damaged or not is also required to be judged by the experience of the doctor in the surgery, the training cost of the doctor is increased, and the surgery treatment time is also prolonged.
Disclosure of Invention
The invention at least partially solves the problem of poor safety of the existing focused ultrasound treatment equipment, and provides a focused ultrasound device and a focused ultrasound device control method which can judge whether normal tissues outside a focus area are damaged.
The technical scheme adopted by the invention is that the focused ultrasound device comprises a focused ultrasound transducer, a continuous wave driving source, a pulse signal instrument and a controller, wherein:
the focusing ultrasonic transducer is respectively connected with a continuous wave driving source and the pulse signal instrument; the focused ultrasonic transducer is used for emitting continuous ultrasonic waves for multiple times under the driving of the continuous wave driving source so as to ablate tissues in a focus area; and in any one or more gaps between two adjacent continuous ultrasonic waves, the focused ultrasonic transducer emits pulse ultrasonic waves to the tissues in the focal domain under the driving of the pulse signal instrument and sends the received echo signals to the pulse signal instrument;
the controller is respectively connected with the continuous wave driving source and the pulse signal instrument and is used for controlling the focused ultrasonic transducer to emit the continuous ultrasonic waves and the pulse ultrasonic waves; the controller is also used for acquiring one or more groups of echo signals through the pulse signal instrument and determining the change rule of the echo signals according to the fluctuation state of the echo signals.
Optionally, in each gap, the pulse signal instrument transmits a plurality of pulse signals to the focused ultrasound transducer, the controller acquires a plurality of echo signals through the pulse signal instrument, determines an average amplitude according to the plurality of echo signals, and determines a change rule of the echo signals according to a fluctuation state of the average amplitude.
Optionally, the controller extracts a target echo signal reflected by a target region tissue outside a focal region according to all the echo signals, determines a target average amplitude according to the target echo signal, and determines a change rule of the target echo signal according to a fluctuation state of the target average amplitude.
Optionally, the pulse signal generator further comprises a signal processor, wherein the signal processor is arranged between the controller and the pulse signal generator;
and the controller controls the signal processor to acquire all echo signals from the pulse signal instrument, and performs noise reduction, filtering and spectrum analysis on all the echo signals to extract the target echo signal.
Optionally, the system further comprises an alarm connected with the controller;
the controller determines the difference value between the real-time average amplitude value in the current gap and the average amplitude value in the previous gap, and controls the alarm to give an alarm according to the difference value.
Optionally, the controller controls the alarm to send out a first alarm when the difference is greater than a first preset threshold;
and the controller controls the alarm to send out a second alarm when the difference value is greater than a second preset threshold value, wherein the second preset threshold value is greater than the first preset threshold value.
Optionally, a memory is also included;
the memory is connected with the controller and used for sequentially storing the echo signals in each gap and determining and storing the average amplitude of the echo signals.
Optionally, the ultrasonic focusing device further comprises an impedance matcher, wherein the impedance matcher is arranged between the focused ultrasonic transducer and the continuous wave driving source, and is used for changing load impedance to match with the impedance of the continuous wave driving source and tuning the working frequency of the focused ultrasonic transducer.
Optionally, the pulse signal instrument is connected in parallel with the continuous wave driving source and both connected with the impedance matcher;
still include high voltage isolator, high voltage isolator set up in the continuous wave driving source with between the pulse signal appearance to prevent the power transmission of continuous wave driving source to the pulse signal appearance.
The technical problem of the present invention is solved, and in another aspect, the technical solution is a method for controlling a focused ultrasound apparatus, which is applied to the focused ultrasound apparatus, and includes:
controlling the focused ultrasound transducer to emit continuous ultrasonic waves for multiple times to ablate tissue within a focal zone;
controlling the focused ultrasonic transducer to emit pulse ultrasonic waves to tissues in the focal region in any one or more gaps between two adjacent continuous ultrasonic waves, and controlling the focused ultrasonic transducer to send received echo signals to a pulse signal instrument;
and acquiring the echo signal through the pulse signal instrument, and determining the change rule of the echo signal according to the fluctuation state of the echo signal.
Optionally, the controlling the focused ultrasound transducer to emit pulsed ultrasound waves to the tissue in the focal region in one or more gaps of any two adjacent consecutive ultrasound waves comprises:
in each gap, controlling the pulse signal instrument to transmit a plurality of pulse signals to the focused ultrasonic transducer so as to drive the focused ultrasonic transducer to transmit pulse ultrasonic waves to tissues in the focal region for a plurality of times;
the obtaining of the echo signal by the pulse signal instrument and the determining of the change law of the echo signal according to the fluctuation state of the echo signal include:
and acquiring a plurality of echo signals through the pulse signal instrument, determining an average amplitude according to the echo signals, and determining a change rule of the echo signals according to a fluctuation state of the average amplitude.
Optionally, the determining a change rule of the echo signal according to the fluctuation state of the average amplitude includes:
and determining the difference value between the real-time average amplitude value in the current gap and the average amplitude value in the previous gap, and sending out an alarm according to the difference value.
Optionally, the sending an alarm according to the difference includes:
if the difference value is larger than a first preset threshold value, a first alarm is sent out; and if the difference value is greater than a second preset threshold value, sending a second alarm, wherein the second preset threshold value is greater than the first preset threshold value.
The invention has the following beneficial effects:
the focused ultrasound device provided by the invention is provided with a focused ultrasound transducer, a continuous wave driving source, a pulse signal instrument and a controller, and can intermittently transmit continuous ultrasonic waves for multiple times so as to melt tissues in a focal region of the focused ultrasound transducer; the ultrasonic wave generator is also provided with a pulse signal instrument which can emit and receive pulse signals, the focused ultrasonic transducer can be driven to emit the pulse ultrasonic waves in the gap of any two adjacent continuous ultrasonic waves, the focused ultrasonic transducer can receive echo signals of the pulse ultrasonic waves with obvious intensity and send the echo signals to the pulse signal instrument by utilizing the advantages of high signal-to-noise ratio, focusing and the like of the pulse signals, the controller can acquire the echo signals from the pulse signal instrument, determine the change rule of the echo signals according to the fluctuation state of the echo signals and then judge whether normal tissues outside a focus area are damaged or not according to the change rule of the echo signals,
thereby reminding the doctor whether the normal tissue outside the focal area is damaged or not.
Drawings
Fig. 1 is a schematic structural view of an ultrasonic transducer device according to an embodiment of the present invention;
fig. 2 is a flow chart of a control method of the focused ultrasound device.
Detailed Description
Reference will now be made in detail to the present application, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar parts or parts having the same or similar functions throughout. In addition, if a detailed description of the known art is not necessary for illustrating the features of the present application, it is omitted. The embodiments described below with reference to the drawings are exemplary only for the purpose of explaining the present application and are not to be construed as limiting the present application.
It will be understood by those within the art that, unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.
As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be understood that when an element is referred to as being "connected" or "coupled" to another element, it can be directly connected or coupled to the other element or intervening elements may also be present. Further, "connected" or "coupled" as used herein may include wirelessly connected or wirelessly coupled. As used herein, the term "and/or" includes all or any element and all combinations of one or more of the associated listed items.
The following describes the technical solutions of the present application and how to solve the above technical problems in specific embodiments with reference to the accompanying drawings.
The present embodiment provides a focused ultrasound device, which can ablate a tissue 70 (e.g., a human tissue, for convenience of description, the following tissues can be understood as human tissues) located in a focal region thereof, and during an ablation process, continuous ultrasound for ablation can be intermittently emitted for multiple times, and pulse ultrasound can be emitted in a gap between any two adjacent continuous ultrasound, and a change rule of an echo signal is determined according to a fluctuation state of the received echo signal, and then whether a normal tissue outside the focal region is damaged can be determined according to the change rule of the echo signal.
As shown in fig. 1, the focused ultrasound apparatus of the present embodiment includes a focused ultrasound transducer 30, a continuous wave driving source 40, a pulse signal generator 20, and a controller 10, wherein:
a focused ultrasound transducer 30 connected to the continuous wave drive source 40 and the pulse signal generator 20, respectively, wherein the connection here and below may include a connection via a transmission line and/or a signal connection; the focused ultrasonic transducer 30 is used for emitting continuous ultrasonic waves for a plurality of times under the driving of the continuous wave driving source 40 so as to ablate the tissue 70 in the focal region; and in any one or more gaps between two adjacent continuous ultrasonic waves, the focused ultrasonic transducer 30 transmits pulse ultrasonic waves to the tissue 70 in the focal region under the driving of the pulse signal instrument 20, and transmits the received echo signals to the pulse signal instrument 20.
The pulse signal meter 20 transmits pulse signals to the focused ultrasound transducer 30, each pulse signal drives the focused ultrasound transducer 30 to transmit a plurality of pulse ultrasonic waves to a focal region thereof, and a plurality of echoes reflected by tissues in and out of the focal region reach the surface of the focused ultrasound transducer 30, are received by the focused ultrasound transducer 30 in an overlapping manner, and are transmitted to the pulse signal meter 20 in an echo signal manner.
A controller 10 connected to the continuous wave driving source 40 and the pulse signal generator 20, respectively, for controlling the focused ultrasonic transducer 30 to emit continuous ultrasonic waves and pulse ultrasonic waves; the controller 10 is further configured to acquire one or more sets of echo signals through the pulse signal generator 20, and determine a variation law of the echo signals according to a fluctuation state of the echo signals.
The focused ultrasound device provided by the embodiment is provided with a focused ultrasound transducer 30, a continuous wave driving source 40 and a controller 10, and can intermittently emit continuous ultrasonic waves for multiple times so as to ablate a tissue 70 located in a focal region of the focused ultrasound transducer 30; the ultrasonic diagnostic device is also provided with a pulse signal instrument 20 which can transmit and receive pulse signals, the focused ultrasonic transducer 30 can be driven to transmit the pulse ultrasonic waves at the gap between any two adjacent continuous ultrasonic waves, the focused ultrasonic transducer 30 can receive echo signals of the pulse ultrasonic waves with obvious intensity and send the echo signals to the pulse signal instrument 20 by utilizing the advantages of high signal-to-noise ratio, focusing and the like of the pulse ultrasonic waves, the controller 10 can acquire the echo signals from the pulse signal instrument 20, determine the change rule of the echo signals according to the fluctuation state of the echo signals, and then judge whether normal tissues outside a focal domain are damaged or not according to the change rule of the echo signals, so that whether normal tissues outside the focal domain are damaged or not is reminded for a doctor.
It should be noted that, in the present embodiment, the specific structures of the focused ultrasound transducer 30, the continuous wave driving source 40, the pulse signal generator 20 and the controller 10 are not particularly limited, as long as the focused ultrasound device can achieve the above ablation and can determine whether normal tissues outside the focal domain are damaged. The controller 10 may be an upper computer having processing functions such as data processing and graphic analysis.
In one embodiment, in each gap, the pulse signal generator 20 emits a plurality of pulse signals to the focused ultrasound transducer 30, and the controller 10 obtains a plurality of echo signals through the pulse signal generator 20, determines an average amplitude (i.e., amplitude or peak value) according to the plurality of echo signals, and determines a variation law of the echo signals according to a fluctuation state of the average amplitude. Specifically, the number of the pulse signals can be but is not limited to 2-4, so that the accuracy of the device for detecting the echo signals can be improved, the change rule of the echo signals can be conveniently determined, the accuracy of judging normal tissues outside a focus domain is improved, and the conditions that the amplitude of the echo signals is small, the detection is difficult, the judgment is wrong and the like due to signal attenuation are avoided. The amplitude of the echo signal can be presented on the display interface of the controller 10 in a digital or graphic manner, so that the doctor can visually see the amplitude of the echo signal, and the judgment result of the focused ultrasound device can be verified and evaluated conveniently.
It should be noted that, in this embodiment, the amplitude of the echo signal is not limited, and the change rule of the echo signal may also be determined by the energy value of the echo signal or the fluctuation state of other indexes.
In a specific embodiment, in the practical application process, according to the propagation characteristic of the ultrasonic energy, when the tumor tissue is over-treated, the tissue tends to be damaged more easily, so the controller 10 may extract the echo signal reflected by the tissue in the back field of the focal region according to all the echo signals, and may be regarded as the target echo signal, and then determine the target average amplitude according to the target echo signal, and determine the change rule of the target echo signal according to the fluctuation state of the target average amplitude. The tissue of the back field of the focal region may be regarded as the tissue of the target region outside the focal region, but it should be noted that the target region outside the focal region may not be limited to the back field of the focal region, but may also be the front field of the focal region, and similarly, the echo signal reflected by the tissue of the front field of the focal region may also be extracted from all the echo signals.
Specifically, the focused ultrasound device may further include a signal processor (not shown in the figure) disposed between the controller 10 and the pulse signal generator 20; the controller 10 controls the signal processor to acquire all echo signals from the pulse signal instrument 20, and performs noise reduction, filtering, spectrum analysis and the like on all echo signals according to the characteristics of the front field or the rear field of the focal domain (for example, the front field of the focal domain has the characteristics of short propagation distance, small attenuation, short return time and the like, and the rear field of the focal domain has the characteristics of long propagation distance, large attenuation, short return time and the like), so as to extract target echo signals reflected by tissues of the front field or the rear field of the focal domain. It should be noted that the present embodiment does not limit the specific structure of the signal processor as long as it can achieve the above-described signal processing function.
In one embodiment, the focused ultrasound device may further include an alarm (not shown), which is connected to the controller 10; the controller 10 determines the difference between the real-time average amplitude in the current gap and the average amplitude in the previous gap, and controls the alarm to give an alarm according to the difference, so that a doctor can conveniently judge whether the normal tissue of the front field or the back field of the focal region is damaged, and the doctor is reminded whether the normal tissue of the front field or the back field of the focal region is damaged. Further, a focus area front field or back field normal tissue safety evaluation mechanism can be established, so that in the ablation process, when the focus area front field or back field normal tissue is about to be damaged, an alarm is given out, and the safety of the focus area front field or back field normal tissue is early warned. It should be noted that the present embodiment does not limit the specific structure of the alarm, as long as the alarm function is realized.
Specifically, taking the focal region back field area as an example, in the ablation process, theoretically, the average amplitude of the echo signal acquired by the controller 10 each time is substantially unchanged, and when the difference value is greater than a first preset threshold value, that is, the amplitude of the echo signal is suddenly increased, the tissue of the focal region back field may be damaged at this time, the controller 10 controls the alarm to send a suggestive first alarm, so that the tissue damage of the focal region back field can be warned to remind a doctor to end ablation, or the position of the focused ultrasound transducer 30 is adjusted in time, so as to perform accurate treatment on the tumor tissue. Further, the controller 10 may control the alarm to issue a second alarm with a higher severity when the difference is greater than a second preset threshold, where the second preset threshold is greater than the first preset threshold, and the tissue of the field behind the possible focal region is already damaged. The specific form of the alarm can be one or more of sound, light and electricity. It should be noted that, the specific values of the first preset threshold and the second preset threshold are not limited in this embodiment, different values may be set for different human bodies and different tissues, and theoretically, the real-time average amplitude is obviously increased compared with the previous average amplitude.
In one embodiment, the focused ultrasound device further comprises a memory (not shown); the memory is connected to the controller 10 for sequentially storing the plurality of echo signals in each gap and determining and storing an average amplitude of the plurality of echo signals. Therefore, the average amplitudes of the echo signals are cached conveniently, so that the signal processor can process all the echo signals, the echo signals which are not processed by the signal processor in time are prevented from being lost, and the historical data can be inquired and traced conveniently.
In one embodiment, the focused ultrasound apparatus may further include an impedance matching unit 50, where the impedance matching unit 50 is disposed between the focused ultrasound transducer 30 and the continuous wave driving source 40, and is configured to change a load impedance to match an impedance of the continuous wave driving source 40, and tune an operating frequency of the focused ultrasound transducer 30, so that the continuous wave driving source 40 and the pulse signal generator 20 can drive the focused ultrasound transducer 30 to emit corresponding ultrasound waves.
In one embodiment, the pulse signal instrument 20 may be connected to the impedance matching box 50 after being connected in parallel with the continuous wave driving source 40, such that when the continuous wave driving source 40 emits the continuous wave signal, a portion of the power is transmitted to the impedance matching box 50, and another portion of the power is transmitted to the pulse signal instrument 20, in order to prevent the portion of the power from being transmitted to the pulse signal instrument 20 (so as to prevent the pulse signal instrument 20 from being burned out by the high power of the continuous wave driving source 40), a high voltage isolation switch 60 may be disposed between the continuous wave driving source 40 and the pulse signal instrument 20, so as to prevent the power of the continuous wave driving source 40 from being transmitted to the pulse signal instrument 20.
Based on the same inventive concept, this embodiment further provides a control method of a focused ultrasound apparatus, which is applied to the above focused ultrasound apparatus, as shown in fig. 2, and is a flowchart of the control method of the focused ultrasound apparatus, where the method may include the following steps:
step S1, the focused ultrasound transducer 30 is controlled to emit continuous ultrasound waves a plurality of times to ablate the tissue 70 within the focal zone.
In step S1, in practical application, after the focal region of the focused ultrasound transducer 30 is located in the tissue 70 to be ablated, the continuous wave driving source 40 is activated by the controller 10, and the continuous wave driving source 40 transmits a continuous wave signal to the focused ultrasound transducer 30 to drive the focused ultrasound transducer 30 to transmit continuous ultrasound waves for multiple times, so as to ablate the tissue 70 in the focal region.
Step S2, in any one or more gaps between two adjacent continuous ultrasonic waves, controlling the focused ultrasonic transducer 30 to emit pulsed ultrasonic waves to the tissue 70 in the focal region, and controlling the focused ultrasonic transducer 30 to send the received echo signals to the pulse signal generator 20.
And step S3, acquiring the echo signal by the pulse signal instrument 20, and determining a change rule of the echo signal according to the fluctuation state of the echo signal.
In practical applications, the steps S2 and S3 may be performed after N (N is greater than 1) ablations are performed, and the physician empirically confirms that the ablation is completed. In the interval between two adjacent continuous ultrasonic waves, when step S2 needs to be executed, the pulse signal generator 20 may be activated by the controller 10, the pulse signal generator 20 may transmit a plurality of pulse signals to the focused ultrasound transducer 30, each pulse signal may drive the focused ultrasound transducer 30 to transmit a plurality of pulse ultrasonic waves, and a plurality of echoes reflected by the tissues in and out of the focal region reach the surface of the focused ultrasound transducer 30, and are received by the focused ultrasound transducer 30 in a superposition manner, and are transmitted to the pulse signal generator 20 in the form of echo signals. Then, the controller 10 may acquire one or more sets of echo signals through the pulse signal generator 20, and determine the change rule of the echo signals according to the fluctuation state of the echo signals.
It should be noted that, the above steps S2 and S3 are executed in the order described, but the steps S2 and S1 have no absolute execution order, and may be understood as being performed alternately, and after the step S1 is executed partially, step S2 and step S3 are executed, and then step S1 may be executed again (the controller 10 may not execute step S1 again according to the change rule of the echo signal), and the above steps are executed in a loop until the ablation is finished or the controller 10 determines that the change rule of the echo signal has a sudden change, and so on.
In one embodiment, controlling the focused ultrasound transducer 30 to emit pulsed ultrasound waves to the tissue 70 in the focal region in any one or more gaps between two adjacent consecutive ultrasound waves includes:
in each gap, controlling the pulse signal generator 20 to emit a plurality of pulse signals to the focused ultrasound transducer 30 so as to drive the focused ultrasound transducer 30 to emit pulsed ultrasonic waves to the tissue 70 in the focal region for a plurality of times;
the pulse signal instrument 20 acquires the echo signal, and determines the change rule of the echo signal according to the fluctuation state of the echo signal, including:
a plurality of echo signals are acquired by the pulse signal instrument 20, and an average amplitude value is determined according to the plurality of echo signals, and a change rule of the echo signal is determined according to a fluctuation state of the average amplitude value.
In one embodiment, the determining the change rule of the echo signal according to the fluctuation state of the average amplitude includes the following steps: and determining the difference value of the real-time average amplitude value in the current gap and the average amplitude value in the previous gap, and sending an alarm according to the difference value.
In one embodiment, the issuing of the alarm according to the difference comprises: if the difference value is larger than a first preset threshold value, a first alarm is sent out; and if the difference value is greater than a second preset threshold value, sending a second alarm, wherein the second preset threshold value is greater than the first preset threshold value.
The specific implementation process of the foregoing specific embodiment may refer to an embodiment of the apparatus, and is not described herein again.
The control method of the focused ultrasound device can at least realize the following beneficial effects:
by applying the control method of the focused ultrasound device, continuous ultrasonic waves can be emitted intermittently for a plurality of times so as to ablate the tissue 70 in the focal region of the focused ultrasound transducer 30; and in any one or more gaps between two adjacent continuous ultrasonic waves, the focused ultrasonic transducer 30 can be driven to emit pulse ultrasonic waves, by utilizing the advantages of the pulse signals, such as high signal-to-noise ratio and focusing, the focused ultrasonic transducer 30 can receive echo signals of the pulse ultrasonic waves with obvious intensity and send the echo signals to the pulse signal instrument 20, and the controller 10 can acquire the echo signals from the pulse signal instrument 20 and determine the change rule of the echo signals according to the fluctuation state of the echo signals.
In the description of the present application, it is to be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience in describing the present application and simplifying the description, but do not indicate or imply that the referred device or element must have a particular orientation, be constructed in a particular orientation, and be operated, and thus should not be construed as limiting the present application.
The terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, "a plurality" means two or more unless otherwise specified.
In the description of the present application, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood in a specific case by those of ordinary skill in the art.
In the description herein, particular features, structures, materials, or characteristics may be combined in any suitable manner in any one or more embodiments or examples.
The foregoing is only a partial embodiment of the present application, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present application, and these modifications and decorations should also be regarded as the protection scope of the present application.
Claims (13)
1. A focused ultrasound device, comprising a focused ultrasound transducer, a continuous wave drive source, a pulse signal meter, and a controller, wherein:
the focusing ultrasonic transducer is respectively connected with a continuous wave driving source and the pulse signal instrument; the focused ultrasonic transducer is used for emitting continuous ultrasonic waves for multiple times under the driving of the continuous wave driving source so as to ablate tissues in a focus area; and in any one or more gaps between two adjacent continuous ultrasonic waves, the focused ultrasonic transducer emits pulse ultrasonic waves to the tissues in the focal domain under the driving of the pulse signal instrument and sends the received echo signals to the pulse signal instrument;
the controller is respectively connected with the continuous wave driving source and the pulse signal instrument and is used for controlling the focused ultrasonic transducer to emit the continuous ultrasonic waves and the pulse ultrasonic waves; the controller is also used for acquiring one or more groups of echo signals through the pulse signal instrument and determining the change rule of the echo signals according to the fluctuation state of the echo signals.
2. The focused ultrasound device as claimed in claim 1, wherein the pulse signal generator emits a plurality of pulse signals to the focused ultrasound transducer in each gap, and the controller acquires a plurality of echo signals through the pulse signal generator, determines an average amplitude value according to the plurality of echo signals, and determines a variation law of the echo signals according to a fluctuation state of the average amplitude value.
3. The focused ultrasound device as claimed in claim 2, wherein the controller extracts a target echo signal reflected by a tissue in a target region out of a focal region according to all the echo signals, determines a target average amplitude according to the target echo signal, and determines a change rule of the target echo signal according to a fluctuation state of the target average amplitude.
4. The focused ultrasound device according to claim 3, further comprising a signal processor disposed between the controller and the pulse signal generator;
and the controller controls the signal processor to acquire all echo signals from the pulse signal instrument, and performs noise reduction, filtering and spectrum analysis on all the echo signals to extract the target echo signal.
5. The focused ultrasound device according to any of claims 2-4, further comprising an alarm connected to the controller;
the controller determines the difference value between the real-time average amplitude value in the current gap and the average amplitude value in the previous gap, and controls the alarm to give an alarm according to the difference value.
6. The focused ultrasound apparatus according to claim 5, wherein the controller controls the alarm to issue a first alarm when the difference is greater than a first preset threshold;
and the controller controls the alarm to send out a second alarm when the difference value is greater than a second preset threshold value, wherein the second preset threshold value is greater than the first preset threshold value.
7. The focused ultrasound device according to any of claims 2 to 4, further comprising a memory;
the memory is connected with the controller and used for sequentially storing the echo signals in each gap and determining and storing the average amplitude of the echo signals.
8. The focused ultrasound device according to any of claims 1-4, further comprising an impedance matcher disposed between the focused ultrasound transducer and the continuous wave drive source for varying a load impedance to match an impedance of the continuous wave drive source and tune an operating frequency of the focused ultrasound transducer.
9. The focused ultrasound device according to claim 8, wherein the pulse signal generator is connected in parallel with the continuous wave driving source and both connected to the impedance matcher;
still include high voltage isolator, high voltage isolator set up in the continuous wave driving source with between the pulse signal appearance to prevent the power transmission of continuous wave driving source to the pulse signal appearance.
10. A control method of a focused ultrasound device, which is applied to the focused ultrasound device according to any one of claims 1 to 9, comprising:
controlling the focused ultrasound transducer to emit continuous ultrasonic waves for multiple times to ablate tissue within a focal zone;
controlling the focused ultrasonic transducer to emit pulse ultrasonic waves to tissues in the focal region in any one or more gaps between two adjacent continuous ultrasonic waves, and controlling the focused ultrasonic transducer to send received echo signals to a pulse signal instrument;
and acquiring the echo signal through the pulse signal instrument, and determining the change rule of the echo signal according to the fluctuation state of the echo signal.
11. The focused ultrasound device control method according to claim 10, wherein the controlling the focused ultrasound transducer to emit pulsed ultrasound waves to the tissue in the focal region at one or more gaps of any two adjacent consecutive ultrasound waves comprises:
in each gap, controlling the pulse signal instrument to transmit a plurality of pulse signals to the focused ultrasonic transducer so as to drive the focused ultrasonic transducer to transmit pulse ultrasonic waves to tissues in the focal region for a plurality of times;
the obtaining of the echo signal by the pulse signal instrument and the determining of the change law of the echo signal according to the fluctuation state of the echo signal include:
and acquiring a plurality of echo signals through the pulse signal instrument, determining an average amplitude according to the echo signals, and determining a change rule of the echo signals according to a fluctuation state of the average amplitude.
12. The focused ultrasound device control method according to claim 10, wherein the determining the change law of the echo signal according to the fluctuation state of the average amplitude comprises:
and determining the difference value between the real-time average amplitude value in the current gap and the average amplitude value in the previous gap, and sending out an alarm according to the difference value.
13. The focused ultrasound device control method according to claim 11, wherein the issuing an alarm according to the difference comprises:
if the difference value is larger than a first preset threshold value, a first alarm is sent out; and if the difference value is greater than a second preset threshold value, sending a second alarm, wherein the second preset threshold value is greater than the first preset threshold value.
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