CN112244760A - Imaging device for realizing function of anterior segment OCT integrated biological measuring instrument based on beam splitter prism - Google Patents
Imaging device for realizing function of anterior segment OCT integrated biological measuring instrument based on beam splitter prism Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/102—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
Abstract
An imaging device for realizing the function of integrating an anterior segment OCT (optical coherence tomography) with a biological measuring instrument based on a beam splitter prism divides a reference arm light into two beams through the beam splitter prism, and when a movable shielding plate is positioned at a first position, the reference arm light of the first beam can be shielded, so that only a second plane reflector can reflect and interfere with a sample arm, and the anterior segment of an eye can be imaged independently; when the movable shielding plate is located at the second position, the first plane reflector and the second plane reflector can reflect and interfere with the sample arm and image in the same image, so that the purpose that the positions of the cornea and the retina are still relatively fixed in the process of involuntary movement of the eyeball is achieved, the interference of factors such as eye movement on numerical values is reduced, the accuracy of eye axis measurement is improved, and especially, special crowds such as nystagmus and Alzheimer's disease can be watched in patients with poor watching.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to an imaging device for realizing the function of an anterior segment OCT (optical coherence tomography) integrated biological measuring instrument based on a beam splitter prism.
Background
Optical Coherence Tomography (OCT) is a novel imaging technique based on the principle of low coherence optical interference, has the characteristics of high resolution, fast scanning imaging, non-contact and nondestructive detection, and the like, and is widely applied to the field of medical imaging. The spectral domain OCT utilizes a spectrometer detection system to obtain interference spectral signals, and depth information is obtained by a Fourier transform method, so that the imaging speed and the imaging sensitivity are further improved. Spectral domain OCT is an important ophthalmic optical imaging technique.
Currently, ophthalmic imaging OCT is classified into anterior segment OCT and fundus OCT according to the difference of imaging objects. The imaging range of anterior segment OCT, including cornea, anterior chamber, iris and lens, is limited by the technology, and OCT can perform high resolution imaging at mm-order thickness, but cannot achieve a large Z-axis scanning range. OCT imaging in the whole eye range, namely, the measurement of the anterior segment of the eye and the function of a biological measuring instrument such as an ocular axis and the like simultaneously and accurately has important value in the clinical and research fields of ophthalmology.
Currently, eyeball biometry enters the optical biometry era of 0.01mm from the ultrasonic biometry era of about 0.1mm in resolution, various optical biometers are widely applied to clinic, and mainly adopted measuring technologies comprise partial optical coherence based technologies, such as Carl Zeiss IOLMASter 500 and Nidek AL-Scan, optical low coherence reflection, such as Haag-Streit Lenstar LS900 and Suoer SW-9000; optically low coherence interference, such as Topcon Aladdin, Tomey CASIA SS-1000, Tomey CASIA 2. The above measurements all highly depend on the fixation coordination of the patients, and patients with partial retinal detachment, aphakic eyes filled with silicone oil, vitreous hematonystagmus, alzheimer's disease and the like have more complex and variable intraocular structures than normal eyes due to the disordered intraocular structures and poor eye fixation. When the conventional eye axis is measured, the measurement result is easy to misread the detached retina, the bleeding organic membrane and other interfaces or cause large errors due to eye movement.
Disclosure of Invention
In order to overcome the defects of the background art, the invention provides an imaging device for realizing the function of an anterior segment OCT integrated biological measuring instrument based on a beam splitter prism.
The technical scheme adopted by the invention is as follows: an imaging device for realizing the function of an anterior segment OCT integrated biological measuring instrument based on a beam splitter prism comprises a control center, a light source, an optical fiber coupler, a reference arm, a sample arm and a spectrometer; the reference arm comprises a first collimating mirror, a beam splitter prism, a first plane reflector, a second plane reflector and a movable shielding plate; the reference arm light is split by the splitting prism and then divided into a first beam of reference arm light and a second beam of reference arm light, the first plane reflector is arranged on a light path of the first beam of reference arm light, the first beam of reference arm light can vertically irradiate the first plane reflector, the second plane reflector is arranged on a light path of the second beam of reference arm light, and the second beam of reference arm light can vertically irradiate the second plane reflector; the movable shielding plate is movably arranged between the beam splitter prism and the first plane reflector and is provided with a first position for blocking the first beam of reference arm light so that the first beam of reference arm light cannot reach the first plane reflector and a second position for not blocking the first beam of reference arm light so that the first beam of reference arm light can reach the first plane reflector for reflection.
The distance from the reference arm light to the second plane reflector is the same as the distance from the sample arm light to the front segment of human eyes, and the distance from the reference arm light to the first plane reflector is the same as the distance from the sample arm light to the rear segment of human eyes.
The movable shielding plate is rotatably arranged.
The reference arm further comprises an electric translation table, and the first plane reflector is fixedly arranged on the electric translation table and can do linear reciprocating motion along the direction of the first beam of reference arm light.
And a grating ruler is arranged on the electric translation platform.
The sample arm comprises a second collimating lens, a first vibrating lens, a first lens, a second vibrating lens and a third lens, and light rays of the sample arm can sequentially pass through the second collimating lens, the first vibrating lens, the first lens, the second vibrating lens and the third lens and then enter human eyes.
The sample arm also comprises a human eye tracking sighting target system, and the human eye tracking sighting target system comprises a sighting target, a fourth lens, a tracking camera, a semi-transmitting and semi-reflecting mirror and a hot mirror; the sighting target corresponds to the human eyes through the fourth lens, the semi-transparent semi-reflective mirror and the hot mirror, the tracking camera corresponds to the human eyes through the semi-transparent semi-reflective mirror and the hot mirror, and the third lens corresponds to the human eyes through the hot mirror.
The invention has the beneficial effects that: by adopting the scheme, the reference arm light is divided into two beams by the beam splitter prism, and when the movable shielding plate is positioned at the first position, the first beam of reference arm light can be shielded, so that only the second plane reflector can reflect and interfere with the sample arm, and the independent imaging of the anterior segment of the eye is realized; when the movable shielding plate is located at the second position, the first plane reflector and the second plane reflector can reflect and interfere with the sample arm and image in the same image, so that the purpose that the positions of the cornea and the retina are still relatively fixed in the process of involuntary movement of the eyeball is achieved, the interference of factors such as eye movement on numerical values is reduced, the accuracy of eye axis measurement is improved, and especially, special crowds such as nystagmus and Alzheimer's disease can be watched in patients with poor watching.
Drawings
Fig. 1 is a schematic structural diagram of an imaging device for implementing the function of an anterior segment OCT integrated with a biometric apparatus based on a beam splitter prism according to an embodiment of the present invention.
Fig. 2 is a schematic structural diagram of a reference arm when a movable shielding plate is in a first position according to an embodiment of the present invention.
Fig. 3 is a schematic structural diagram of a reference arm when a movable shielding plate is at a second position according to an embodiment of the invention.
FIG. 4 is a schematic structural diagram of a sample arm according to an embodiment of the present invention.
FIG. 5 is a schematic diagram of a spectrometer according to an embodiment of the present invention.
FIG. 6 is an image of an OCT image when the movable shielding plate is at the second position according to an embodiment of the invention (the left image is an optical model eye, and the right image is a real human eye).
FIG. 7 is a schematic structural diagram of a reference arm according to a second embodiment of the present invention.
Fig. 8 is a schematic structural diagram of three reference arms according to an embodiment of the present invention.
Detailed Description
The embodiments of the invention will be further described with reference to the accompanying drawings in which:
example one
As shown in fig. 1-5, an imaging device for implementing the function of an anterior segment OCT integrated with a biometric apparatus based on a beam splitter prism includes a control center 1, a light source 2, a fiber coupler 3, a reference arm 4, a sample arm 5 and a spectrometer 6.
The control center 1 may adopt a computer, and is mainly used for controlling actions and analyzing and processing images.
The light source 2 is used for outputting light beams, and an SLD light source with the central wavelength of 840-880nm and the bandwidth of 45nm can be adopted.
The optical fiber coupler 3 can adopt a 2X2 optical fiber coupler which is arranged corresponding to the light source 2, the optical fiber coupler 3 can divide the light beam output by the light source 2 into two parts, one part is a reference arm light beam and enters the reference arm 4, the other part is a sample arm light beam and enters the sample arm 5, and meanwhile, the reflected reference arm light beam and the sample arm light beam can be interfered.
The reference arm 4 comprises a first collimating mirror 41, a beam splitting prism 42, a first plane mirror 43, a second plane mirror 44 and a movable shielding plate 45, the reference arm light rays horizontally exit through the first collimating mirror 41 and enter the beam splitting prism 42, the beam splitting prism 42 can adopt a half-transmitting half-reflecting mirror, the reference arm light rays are divided into a first beam of reference arm light rays and a second beam of reference arm light rays, the first beam of reference arm light rays completely passes through the beam splitting prism 42, the second beam of reference arm light rays are reflected out at an angle of 45 degrees, the first beam of reference arm light rays and the second beam of reference arm light rays are vertically distributed at an angle of 90 degrees, the first plane mirror 43 is arranged behind the beam splitting prism 42, the first beam of reference arm light rays can vertically enter the first plane mirror 43 after passing through the beam splitting prism 42 and are reflected, the second plane mirror 44 is arranged at the side edge of the beam splitting prism 42, the second beam of reference arm light is refracted by the beam splitter prism 42 and then can vertically enter the second plane mirror 44 to be reflected, the movable shielding plate 45 is movably arranged between the beam splitter prism 42 and the first plane mirror 43 and has a first position for blocking the first beam of reference arm light so that the first beam of reference arm light cannot reach the first plane mirror 43 and a second position for unblocking the first beam of reference arm light so that the first beam of reference arm light can reach the first plane mirror 43. The movable shielding plate 45 can be rotatably arranged by adopting a miniature electric hinge, is connected with the control center 1, and is controlled by the control center 1.
Of course, the beam splitter prism 42 is not limited to half-mirror, and different proportions may be selected according to actual requirements.
The sample arm 5 comprises a second collimating lens 51, a first vibrating lens 52, a first lens 53, a second lens 54, a second vibrating lens 55 and a third lens 56, and sample arm light rays are emitted in parallel through the second collimating lens 51 and then enter human eyes after sequentially passing through the first vibrating lens 52, the first lens 53, the second lens 54, the second vibrating lens 55 and the third lens 56; the first galvanometer 52 and the second galvanometer 55 can bend the light of the sample arm, the focal lengths of the first lens 53 and the second lens 54 are the same, so that 4F imaging of the scanning galvanometer is realized, optical distortion is reduced, and the third lens 56 is used for focal length adjustment, so that the focal length of the light of the sample arm can fall on a part required by imaging.
In addition, the sample arm 5 further includes a human eye tracking sighting target system 7, and the human eye tracking sighting target system 7 includes a sighting target 71, a fourth lens 72, a tracking camera 73, a half mirror 74 and a hot mirror 75; the sighting target 71 corresponds to the human eyes through the fourth lens 72, the half mirror 74 and the hot mirror 75, the tracking camera 73 corresponds to the human eyes through the half mirror 74 and the hot mirror 75, the third lens 56 corresponds to the human eyes through the hot mirror 75, and the use convenience of the instrument and the matching degree of a patient can be further improved through the human eye tracking sighting target system 7.
The spectrometer 6 comprises a third collimating mirror 61, a grating 62, a lens 63 and a camera 64, the spectrometer 6 is arranged corresponding to the optical fiber coupler 3, reflected reference arm light and sample arm light enter the spectrometer 6 after being interfered by the optical fiber coupler 3, the reference arm light and the sample arm light are collected by the camera 64 after being focused by the third collimating mirror 61, the grating 62 and the lens 63 in sequence, the camera 64 is connected with the control center 1, the collected signals can be transmitted to the control center 1, and the control center 1 performs subsequent image analysis and processing.
The distance from the reference arm light to the second plane mirror 44 is the same as the distance from the sample arm light to the anterior segment of the human eye, and the distance from the reference arm light to the first plane mirror 43 is the same as the distance from the sample arm light to the posterior segment of the human eye.
When the movable shielding plate 45 is at the first position, the first beam of reference arm light is shielded by the movable shielding plate 45 and cannot enter the first plane reflector 43 for reflection, only the second beam of reference arm light enters the second plane reflector 44 for reflection and interferes with the reflected sample arm light, and because the optical path difference of the second plane reflector 44 is matched with the anterior segment of the human eye, the anterior segment of the eye can be imaged independently.
When the movable shielding plate 45 is at the second position, the first beam of reference arm light enters the first plane reflector 43 for reflection, the second beam of reference arm light enters the second plane reflector 44 for reflection, the two beams of reference arm light can be respectively reflected to interfere with the sample arm light, and the second plane reflector 44 and the first plane reflector 43 are respectively matched with the optical path difference between the anterior segment of the human eye and the posterior segment of the human eye, so that the anterior segment of the human eye and the posterior segment of the human eye can be simultaneously imaged in the same image.
The imaging process of the imaging device for realizing the function of the anterior segment OCT integrated biological measuring instrument based on the beam splitter prism is as follows:
anterior segment OCT mode
The movable shielding plate 45 is at the first position, the light source 2 emits light, the light is divided into two after passing through the optical fiber coupler 3, one of the light is sample arm light, the sample arm light passes through the second collimating mirror 51, the first vibrating mirror 52, the first lens 53, the second lens 54, the second vibrating mirror 55 and the third lens 56 in sequence and enters human eyes to form reflected light and returns to the optical fiber coupler 3 according to the original path, the other light is reference arm light, the reference arm light passes through the first collimating mirror 41 and then exits in parallel, the reference arm light passes through the beam splitter prism 42 and is divided into two, the first reference arm light is shielded by the movable shielding plate 45, the second reference arm light enters the second plane reflector 44 and then reflects to form reflected light and returns to the optical fiber coupler 3 according to the original path, here, the reflected light of the sample arm light interferes with the reference arm light and enters the spectrometer 6 and passes through the third collimating mirror 61, the third lens 61 and the second lens 56 in sequence and the spectrometer 6, After the light is split by the grating 62 and focused by the lens 63, the light is collected by the camera 64, the collected signal is transmitted to the control center 1 by the camera 64, and the subsequent image analysis and processing are performed by the control center 1.
Biometric apparatus imaging mode
The movable shielding plate 45 is at the second position, the light source 2 emits light, the light is divided into two after passing through the optical fiber coupler 3, one of the light is sample arm light, the sample arm light passes through the second collimating mirror 51, the first vibrating mirror 52, the first lens 53, the second lens 54, the second vibrating mirror 55 and the third lens 56 in sequence and enters human eyes to form reflected light and returns to the optical fiber coupler 3 according to the original path, the other is reference arm light, the reference arm light passes through the first collimating mirror 41 and then exits in parallel, the reference arm light passes through the beam splitter prism 42 and is divided into two, the first reference arm light enters the first plane reflector 43 and then reflects to form reflected light and returns to the optical fiber coupler 3 according to the original path, the second reference arm light enters the second plane reflector 44 and then reflects to form reflected light and returns to the optical fiber coupler 3 according to the original path, and the reflected light of the sample arm light and the two reference arm light interfere respectively, then, the light enters the spectrometer 6, and is collected by the camera 64 after sequentially passing through the third collimating lens 61, the grating 62 for light splitting, and the lens 63 for focusing, the camera 64 transmits the collected signals to the control center 1, and the control center 1 performs subsequent image analysis and processing.
As shown in fig. 6, the left image is an optical model eye, and the right image is a real human eye, which can clearly image the anterior surface of the cornea, the posterior surface of the cornea, the iris, the retina, and the like in the imaging mode of the biometric apparatus. Then calculating the distance between cornea and retina in the image, and adding the optical path difference and refractive index conversion in the reference arm to calculate the axis value of eye
By adopting the scheme, the movable shielding plate 45 can be positioned at the first position or the second position by controlling the action of the movable shielding plate, so that the movable shielding plate has two imaging function modes of an anterior segment OCT mode and a biological measuring instrument imaging mode, when the movable shielding plate is positioned at the biological measuring instrument imaging mode, the anterior segment and the posterior segment of the eye can be imaged in the same image at the same time, and the purpose that the positions of a cornea and a retina are still relatively fixed in the process of involuntary movement of eyeballs is achieved, so that the interference of factors such as eye movement on numerical values is reduced, the accuracy of eye axis measurement is improved, and especially, special crowds such as nystagmus and Alzheimer's disease in patients with poor fixation are achieved.
Example two
The second embodiment is substantially the same as the first embodiment, except that the reference arm 4 further comprises a motorized translation stage 46 capable of linear reciprocating motion along the direction of the light of the first beam of reference arm.
As shown in fig. 7, the first plane mirror 43 is mounted on an electric translation stage, the electric translation stage 46 is connected to the control center 1, and the control center 1 can control the electric translation stage 46 to move, so as to drive the first plane mirror 43 to perform a linear reciprocating motion.
By the design of the electric translation stage 46, the inherent mode of the fixed design of the original plane mirror is abandoned, so that the inherent measurement range limitation of the OCT system is eliminated, and the ocular axis measurement in a larger depth range is realized.
EXAMPLE III
The third embodiment is substantially the same as the first embodiment, except that the reference arm 4 further includes an electric translation stage 46 capable of performing linear reciprocating motion along the direction of the first beam of reference arm light, and a grating scale 47 is disposed on the electric translation stage 46.
As shown in fig. 8, the first plane mirror 43 is mounted on an electric translation stage, the electric translation stage 46 and the grating scale 47 are connected to the control center 1, and the control center 1 can control the electric translation stage 46 to move, so as to drive the first plane mirror 43 to perform a linear reciprocating motion.
In addition to the capability of performing eye axis measurement over a larger depth range, the grating ruler in cooperation with the electric translation stage 46 can perform closed-loop automatic control, and the absolute positioning accuracy can reach micron level, thereby performing high-accuracy biological measurement.
In the description of the present invention, it should be noted that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the referred imaging device or element must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art. In addition, in the description of the present invention, "a plurality" means two or more unless otherwise specified.
The skilled person should understand that: although the invention has been described in terms of the above specific embodiments, the inventive concept is not limited thereto and any modification applying the inventive concept is intended to be included within the scope of the patent claims.
Claims (7)
1. An imaging device for realizing the function of an anterior segment OCT (optical coherence tomography) integrated biological measuring instrument based on a beam splitter prism comprises a control center (1), a light source (2), an optical fiber coupler (3), a reference arm (4), a sample arm (5) and a spectrometer (6);
the method is characterized in that: the reference arm (4) comprises a first collimating mirror (41), a beam splitter prism (42), a first plane reflecting mirror (43), a second plane reflecting mirror (44) and a movable shielding plate (45); the reference arm light is split into a first beam of reference arm light and a second beam of reference arm light by a splitting prism (42), the first plane reflector (43) is arranged on the light path of the first beam of reference arm light, the first beam of reference arm light can enter the first plane reflector (43), the second plane reflector (44) is arranged on the light path of the second beam of reference arm light, and the second beam of reference arm light can enter the second plane reflector (44);
the movable shielding plate (45) is movably arranged between the beam splitter prism (42) and the first plane reflector (43), and is provided with a first position for blocking the first beam of reference arm light rays so that the first beam of reference arm light rays cannot reach the first plane reflector (43) and a second position for unblocking the first beam of reference arm light rays so that the first beam of reference arm light rays can reach the first plane reflector (43) for reflection.
2. The imaging device for realizing anterior segment OCT integrated biometric function based on the beam splitter prism as claimed in claim 1, wherein: the distance from the reference arm light to the second plane reflector (44) is the same as the distance from the sample arm light to the front segment of the human eye, and the distance from the reference arm light to the first plane reflector (43) is the same as the distance from the sample arm light to the back segment of the human eye.
3. The imaging device for realizing anterior segment OCT integrated biometric function based on the beam splitter prism as claimed in claim 1, wherein: the movable shielding plate (45) is rotatably arranged.
4. The imaging device for realizing anterior segment OCT integrated biometric function based on the beam splitter prism as claimed in claim 1, wherein: the reference arm (4) further comprises an electric translation table (46), and the first plane reflecting mirror (43) is fixedly mounted on the electric translation table (45) and can do linear reciprocating motion along the direction of the first beam of reference arm light.
5. The imaging device for realizing anterior segment OCT integrated biometric function based on the beam splitter prism as claimed in claim 4, wherein: and a grating ruler (46) is arranged on the electric translation table (45).
6. The imaging device for realizing anterior segment OCT integrated biometric function based on the beam splitter prism as claimed in claim 1, wherein: the sample arm (5) comprises a second collimating lens (51), a first galvanometer (52), a first lens (53), a second lens (54), a second galvanometer (55) and a third lens (56), and light rays of the sample arm can sequentially pass through the second collimating lens (51), the first galvanometer (52), the first lens (53), the second lens (54), the second galvanometer (55) and the third lens (56) and then enter human eyes.
7. The imaging device for realizing the function of the anterior segment OCT integrated biomeeter based on the beam splitter prism as claimed in claim 6: the sample arm (5) further comprises a human eye tracking sighting target system (7), and the human eye tracking sighting target system (7) comprises a sighting target (71), a fourth lens (72), a tracking camera (73), a half-transmitting and half-reflecting mirror (74) and a hot mirror (75); the sighting target (71) corresponds to the human eyes through a fourth lens (72), a semi-transparent and semi-reflective mirror (74) and a hot mirror (75), the tracking camera (73) corresponds to the human eyes through the semi-transparent and semi-reflective mirror (74) and the hot mirror (75), and the third lens (56) corresponds to the human eyes through the hot mirror (75).
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| CN202011037937.8A CN112244760A (en) | 2020-09-28 | 2020-09-28 | Imaging device for realizing function of anterior segment OCT integrated biological measuring instrument based on beam splitter prism |
| PCT/CN2020/124350 WO2022062049A1 (en) | 2020-09-28 | 2020-10-28 | Beam splitter-based imaging device integrating anterior segment oct and biometer functions |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113267142A (en) * | 2021-05-17 | 2021-08-17 | 东北大学秦皇岛分校 | Surface contour imaging device and imaging method |
| CN113267142B (en) * | 2021-05-17 | 2022-08-19 | 东北大学秦皇岛分校 | Surface contour imaging device and imaging method |
| CN114916905A (en) * | 2022-05-10 | 2022-08-19 | 北京神光少年科技有限公司 | Myopia growth prediction method |
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