CN110211465B - Immune antibody teaching intelligent device - Google Patents
Immune antibody teaching intelligent device Download PDFInfo
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- CN110211465B CN110211465B CN201910547688.8A CN201910547688A CN110211465B CN 110211465 B CN110211465 B CN 110211465B CN 201910547688 A CN201910547688 A CN 201910547688A CN 110211465 B CN110211465 B CN 110211465B
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- domain
- disulfide bond
- immune antibody
- structural domain
- inter
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- 238000010586 diagram Methods 0.000 description 6
- 238000013461 design Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- RBORURQQJIQWBS-QVRNUERCSA-N (4ar,6r,7r,7as)-6-(6-amino-8-bromopurin-9-yl)-2-hydroxy-2-sulfanylidene-4a,6,7,7a-tetrahydro-4h-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol Chemical compound C([C@H]1O2)OP(O)(=S)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1Br RBORURQQJIQWBS-QVRNUERCSA-N 0.000 description 2
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 125000002228 disulfide group Chemical group 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 210000001503 joint Anatomy 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
- G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
- G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
-
- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
- G09B5/00—Electrically-operated educational appliances
- G09B5/04—Electrically-operated educational appliances with audible presentation of the material to be studied
Abstract
The invention discloses an immune antibody teaching intelligent device which comprises a plurality of structural domain components, inter-chain disulfide bonds and disulfide bonds, wherein a memory stores coded signals of the structural domain components, a processor reads the coded signals in the memory and sends the coded signals to a contact pair, and meanwhile, the processor detects signals of the contact pair and makes judgment so as to control a loudspeaker to emit sound. The inter-chain disulfide bond and the disulfide bond are used for connecting the structural domain parts and transmitting signals sent by the processors in the structural domain parts, and when the two structural domain parts are spliced with each other or spliced through the inter-chain disulfide bond and the disulfide bond, the processors in the structural domain parts receive coded signals of each other and judge whether the splicing mode is correct or not, so that the loudspeaker is controlled to send corresponding sound. The structure of the immune antibody model is displayed to students by using specific real objects, so that the understanding of the structure of the immune antibody by the students is enhanced, and the teaching of the immune antibody is not abstracted.
Description
Technical Field
The invention relates to a teaching model, in particular to a teaching model for antibody teaching.
Background
The section of the antibody is the important part of basic knowledge of the immunological test, the structure, the functional area and the functions of each functional area of the antibody are knowledge points required to be mastered, the mastering capability of the students in the universities and colleges is limited, the learning enthusiasm is not very high, and the mere characters and pictures are not enough in image, so that a plurality of students can learn the antibody and still feel foggy in clouds, and the understanding of the subsequent knowledge is influenced. The basic structure of the antibody is composed of 4 polypeptide chains, the polypeptide chains are linked by disulfide bonds with different numbers to form a Y-shaped structure, the polypeptide chains are composed of two structural domains VH, CH1, CH2, CH3, CL and VL, and inter-chain disulfide bonds exist in the inter-structural chain parts.
In the present teaching, the basic structure of the antibody is mainly spoken, or some PPT pictures or drawings are assisted, the structural characteristics of the antibody cannot be displayed to students in a specific image, most students can only imagine a three-dimensional antibody through the brain, but different imagines of people are different, and one person can recognize the antibody structure, although the structure is almost the same, the structure is always different, so that the students cannot communicate with each other conveniently or even with errors, and even cannot recognize the antibody through two-dimensional antibody images.
Disclosure of Invention
In order to solve the problem that students are difficult to understand and master the basic structure of immune antibodies and the functions of functional areas due to abstraction and improve learning interest, the invention provides an intelligent immune antibody teaching device, which designs six structural domains VH, CH1, CH2, CH3, CL and VL into a unified structural domain part, wherein a power supply, a memory, a processor, a loudspeaker and a plurality of contact pairs are arranged in the structural domain part, the memory stores coding signals of the structural domain part and represents one of the six structural domains VH, CH1, CH2, CH3, CL and VL, and the processor reads the coding signals in the memory and sends the coding signals to the contact pairs, and simultaneously detects signals of the contact pairs and makes judgment so as to control the loudspeaker to emit sound. The inter-chain disulfide bond and the disulfide bond are used for connecting the structural domain parts and transmitting signals sent by the processors in the structural domain parts, when the two structural domain parts are spliced with each other or spliced through the inter-chain disulfide bond and the disulfide bond, the processors in the structural domain parts receive coded signals of each other and judge whether the splicing mode is correct or not, and then the loudspeaker is controlled to send corresponding sounds, so that students are guided to splice the whole immune antibody model correctly step by step.
The invention has the advantages that students can deepen the impression of different structural domain parts by assembling the structural domain parts by hands, thereby deepen the memory and understanding of the basic structure of the immune antibody, enabling the immune antibody teaching to be not abstract any more, enabling the students to understand and master the basic structure and related knowledge of the immune antibody more easily, and improving the learning enthusiasm of the students.
Drawings
FIG. 1 is a structural diagram of a domain component;
FIG. 2 is a schematic diagram of circuitry and components within a domain component;
FIG. 3 is a schematic diagram of an inter-chain disulfide structure and circuit;
FIG. 4 is a schematic diagram of a disulfide bond structure and circuit;
FIG. 5 is a basic structural diagram of an immune antibody.
Detailed Description
The immune antibody basic structure comprises six structural domains VH, CH1, CH2, CH3, CL and VL, and inter-chain disulfide bonds and disulfide bonds for connecting different structural domains, the six structural domains are arranged in a specific mode and are connected by the inter-chain disulfide bonds and the disulfide bonds to form a Y-shaped structure, in order to enable students to better remember and understand the immune antibody basic structure in a splicing mode, the six structural domains VH, CH1, CH2, CH3, CL and VL are designed into unified structural domain parts, the different structural domain parts are distinguished through labels, a plurality of structural domain splicing combinations can be formed like building blocks through the design, so that the students can try continuously and repeatedly, and only when the students splice the immune antibody model correctly, the students can prompt the completion of splicing.
Domain part structure as shown in figure 1 domain part 1 comprises a tag 101, a number of notches 102 and a flange 103. The label 101 is labeled with one of the six domain markers VH, CH1, CH2, CH3, CL and VL for distinguishing between the different domains in the design of the unified domain component 1. The notches 102 and the flanges 103 are arranged on the periphery of the structural domain part 1, the flanges 103 are in concave-convex fit with the notches 102, and the flanges 103 can be inserted into the notches 102, so that butt joint between the structural domain parts 1 is facilitated, and the fastening function between the structural domain parts can be achieved.
The domain part shown in fig. 2 is provided with a circuit and its components schematic, and the domain part 1 is provided with a power supply 109, a memory 107, a processor 106, a speaker 108 and a number of contact pairs 110. The power supply 109 provides the power required by the processor 106, the memory 107 and the speaker 108. The contact pairs 110 are disposed within the slots 102 and flanges 103 shown in fig. 1, with each slot 102 and flange 103 having a corresponding contact pair 110. The memory 107 stores an encoded signal of the domain component 1, which encoded signal represents one of the six domains VH, CH1, CH2, CH3, CL and VL, which encoded signal can be read from the memory 107 by the processor 106 and sent to the other domain component 1 via the contact pair 110 connected to the processor and finally received by the processor 106 in the other domain component 1. After the processor 106 receives the coded signals sent by the other domain components 1, the coded signals are received from the notch 102 or the contact pairs 110 of the flange 103, and whether the splicing between the domain components is correct or not is comprehensively judged, if the splicing is correct, the processor 106 controls the loudspeaker 108 to send out a correct spliced prompt tone, and if the splicing is incorrect, the processor 106 controls the loudspeaker 108 to send out a failed spliced prompt tone, so that students try to splice the domain components 1 marked by other labels again.
As shown in fig. 3, the inter-chain disulfide bond structure and circuit schematic, the inter-chain disulfide bond 2 has a straight shape, which is provided with two flanges 103 and two contact pairs 110. The contact pairs 110 are disposed within the flanges 103, and each flange 103 has a corresponding contact pair 110. There is a circuit connection between the two contact pairs 110. The flange 103 of the inter-chain disulfide 2 can be inserted into any one of the notches 102 in the domain members 1 as in fig. 1, while the contact pairs 110 in the inter-chain disulfide 2 and the contact pairs 110 in the domain members 1 are in contact with each other, forming a circuit connection that serves to transfer the encoded signals between the domain members 1.
As shown in FIG. 4, which is a schematic diagram of a disulfide bond structure and circuit, disulfide bond 3 has an "H" shape with four flanges 103 and four contact pairs 110. The contact pairs 110 are disposed within the flanges 103, and each flange 103 has a corresponding contact pair 110. The four flanges 103 in the disulfide bond 3 are located at the four corners of the "H" shape, the two flanges 103 on the left side are in one group, and at the same time, there is a circuit connection between the two corresponding contacts 110, and similarly, the two flanges 103 on the right side are in the other group, and there is a circuit connection between the two corresponding contacts 110. The flange 103 of the disulfide bond 3 can be inserted into any one of the notches 102 in the domain members 1 as in fig. 1, while the contact pairs 110 in the disulfide bond 3 and the contact pairs 110 in the domain members 1 are in contact with each other, forming a circuit connection that serves to transfer the coded signals between the domain members 1.
The basic structure of an immune antibody is shown in FIG. 5. The basic structure 100 of an immune antibody has twelve domain members 1, two interchain disulfide bonds 2 and one disulfide bond 3. The tag 101 of domain part 1 is labeled with VH, CH1, CH2, CH3, CL and VL symbols, and each symbol is two, representing two, twelve domains each, of the six domains VH, CH1, CH2, CH3, CL and VL, respectively. The formation of the domain members 1, interchain disulfide bonds 2 and disulfide bonds 3 with different tag symbols in a specific arrangement as shown in FIG. 3 represents successful completion of the splicing of the basic structure of the immune antibody. The processor 106 in the structural domain component 1 continuously judges when the students continuously try to splice, and prompts the students to correctly splice the structural domain components 1 which are adjacent or are connected through the inter-chain disulfide bonds 2/disulfide bonds 3 through the loudspeaker 108, so that the students are led to finish splicing of the immune antibody basic structure step by step, when the splicing is finished, the processors 106 in all the structural domain components 1 communicate through the contact pairs 110, and judge whether the number of the structural domain components 1 is correct or not and whether the mutual direct position relationship is correct or not, if the number of the structural domain components 1 and the mutual direct position relationship are correct or not, the processor 106 controls the loudspeaker 108 to send a prompt tone that the immune antibody basic structure is successfully spliced.
In this embodiment, by enabling students to assemble the structural domain component 1 by hand, correct or failure prompts are performed in the assembling process of the structural domain component 1, so that the students are guided to complete successful assembling of the immune antibody basic structure model 100 step by step, so that not only is the learning enthusiasm of the students improved, but also the immune antibody teaching is not abstract any more, the students can understand and master the basic structure and related knowledge of the immune antibody more easily, and the students can learn and understand the basic structure of the immune antibody further.
The above description is only of the preferred embodiments of the present invention and is not intended to limit the present invention, but various modifications and variations can be made to the present invention by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (4)
1. An immune antibody teaching intelligent device is characterized by comprising a plurality of structural domain components (1), inter-chain disulfide bonds (2) and disulfide bonds (3);
the structure domain component (1) is internally provided with a power supply (109), a memory (107), a processor (106), a loudspeaker (108) and a plurality of contact pairs (110), the power supply (109) provides electric energy required by the processor (106), the memory (107) and the loudspeaker (108), the memory (107) stores coding signals of the structure domain component (1), the processor (106) reads the coding signals in the memory (107) and sends the coding signals to the contact pairs (110), and meanwhile, the processor (106) detects the signals of the contact pairs (110) and makes judgment so as to control the loudspeaker (108) to emit sound;
the inter-chain disulfide bond (2) is provided with two contact pairs (110) which are communicated with each other;
the disulfide bond (3) is provided with two groups of four contact pairs (110) which are communicated with each other;
the inter-chain disulfide bond (2) and the disulfide bond (3) are used for connecting the structural domain component (1), transmitting signals sent by the processor (106) in the structural domain component (1), and assembling the immune antibody basic structure (100).
2. An immune antibody teaching intelligent device according to claim 1 characterized in that domain part (1) further comprises a tag (101), a number of notches (102) and a flange (103), tag (101) being fixed outside domain part (1), tag (101) identifying one of "VL", "VH", "CL", "CH 1", "CH 2" and "CH 3"; a notch (102) and a flange (103) are provided around the domain parts (1), the flange (103) being insertable into the notch (102) for connection between the domain parts (1).
3. An immune antibody teaching intelligent device according to claim 2 characterized in that the interchain disulfide bond (2) is further provided with two flanges (103), the flanges (103) being insertable into any one of the notches (102) in the domain part (1) for connecting the domain part (1).
4. An immune antibody teaching intelligent device according to claim 2 characterized in that the disulfide bond (3) is further provided with four flanges (103), the flanges (103) being insertable into any one of the slots (102) of the domain member (1) for connecting the domain member (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910547688.8A CN110211465B (en) | 2019-06-24 | 2019-06-24 | Immune antibody teaching intelligent device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910547688.8A CN110211465B (en) | 2019-06-24 | 2019-06-24 | Immune antibody teaching intelligent device |
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| Publication Number | Publication Date |
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| CN110211465A CN110211465A (en) | 2019-09-06 |
| CN110211465B true CN110211465B (en) | 2024-02-06 |
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| CN201910547688.8A Active CN110211465B (en) | 2019-06-24 | 2019-06-24 | Immune antibody teaching intelligent device |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1256277A (en) * | 1968-04-22 | 1971-12-08 | Burroughs Corp | Data processing apparatus |
| CN101561880A (en) * | 2009-05-11 | 2009-10-21 | 华北电力大学（保定） | Pattern recognition method based on immune antibody network |
| CN210244804U (en) * | 2019-06-24 | 2020-04-03 | 漳州卫生职业学院 | Immune antibody teaching intelligent device |
-
2019
- 2019-06-24 CN CN201910547688.8A patent/CN110211465B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1256277A (en) * | 1968-04-22 | 1971-12-08 | Burroughs Corp | Data processing apparatus |
| CN101561880A (en) * | 2009-05-11 | 2009-10-21 | 华北电力大学（保定） | Pattern recognition method based on immune antibody network |
| CN101655911A (en) * | 2009-05-11 | 2010-02-24 | 华北电力大学（保定） | Mode identification method based on immune antibody network |
| CN210244804U (en) * | 2019-06-24 | 2020-04-03 | 漳州卫生职业学院 | Immune antibody teaching intelligent device |
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| CN110211465A (en) | 2019-09-06 |
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