CN108096429A - A kind of mouth sprays for alleviating oral peculiar smell and preparation method thereof - Google Patents

A kind of mouth sprays for alleviating oral peculiar smell and preparation method thereof Download PDF

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Publication number
CN108096429A
CN108096429A CN201711434145.2A CN201711434145A CN108096429A CN 108096429 A CN108096429 A CN 108096429A CN 201711434145 A CN201711434145 A CN 201711434145A CN 108096429 A CN108096429 A CN 108096429A
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cloves
extracting solution
peculiar smell
chinese cassia
cassia tree
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CN201711434145.2A
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Chinese (zh)
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庞庆华
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays

Abstract

The present invention discloses a kind of mouth sprays for alleviating oral peculiar smell and preparation method thereof, which is characterized in that is produced by the Raw material processing of following parts by weight：Carboxymethyl chitosan 0.1% 5%, sodium acid carbonate 0.1% 0.8%, vitamin C 0.1% 0.5%, Aloe Vera Gel 2% 5%, food flavor 0.2% 0.5%, preservative 0.1% 0.3%, borneol 0.3% 0.5%, ethyl alcohol 5% 8%, Chinese cassia tree extracting solution 2% 8%, cloves extracting solution 2% 8%, naringin 0.1% 1% and distilled water surplus, wherein Chinese cassia tree extracting solution and cloves extracting solution are by being obtained after Chinese cassia tree is flowed back and concentrated with cloves.A kind of mouth sprays for alleviation oral peculiar smell that the present invention is produced, it can effectively kill except the bacterium in oral cavity, oral peculiar smell is reduced from source, the healing of the inflammation wound caused by oral inflammation can be effectively facilitated, intraoral salivary secretion can also be promoted simultaneously, the a variety of enzymes being rich in saliva using human body itself carry out oral cavity sterilizing, and the mouth sprays that the present invention is produced are non-stimulated when in use, with obvious effects.

Description

A kind of mouth sprays for alleviating oral peculiar smell and preparation method thereof
Technical field
The invention belongs to pharmaceutical technology field, specifically, being related to a kind of mouth sprays for alleviating oral peculiar smell and its preparation Method.
Background technology
Oral peculiar smell is a kind of oral disease, and almost everyone has a degree of oral peculiar smell, causes oral peculiar smell The reason for, also has very much, wherein being grown with oral inflammation and oral bacteria for main cause, the serious patient of oral peculiar smell can be right The people on oneself and periphery impacts, and severe patient can even influence normally exchange and the normal life of patient.
In order to alleviate oral peculiar smell, people can usually use the product of mouthwash etc, but during this kind of product use Usage amount it is larger, product itself usually has heavier irritation taste, have the user of oral cavity breakage using when have it is strong Strong excitement, this kind of product need to pay attention to cannot swallow when in use, and more inconvenient, pot life system is more, in order to It provides one kind to be convenient for carrying, can use whenever and wherever possible, counterpart intracavitary is fully killed while oral peculiar smell is alleviated immediately The product of bacterium treatment, the present invention provides following technical schemes.
The content of the invention
It is an object of the invention to provide a kind of mouth sprays for alleviating oral peculiar smell and preparation method thereof.
The purpose of the present invention can be achieved through the following technical solutions：
A kind of mouth sprays for alleviating oral peculiar smell, are produced by following Raw material processing：
Carboxymethyl chitosan, sodium acid carbonate, vitamin C, Aloe Vera Gel, food flavor, preservative, borneol, ethyl alcohol, distillation Water, Chinese cassia tree extracting solution, cloves extracting solution and naringin.
Specifically, it is produced by the Raw material processing of following parts by weight：Carboxymethyl chitosan 0.1%-5%, sodium acid carbonate 0.1%-0.8%, vitamin C 0.1%-0.5%, Aloe Vera Gel 2%-5%, food flavor 0.2%-0.5%, preservative 0.1%-0.3%, borneol 0.3%-0.5%, ethyl alcohol 5%-8%, Chinese cassia tree extracting solution 2%-8%, cloves extracting solution 2%-8%, Naringin 0.1%-1% and distilled water surplus.
Further, the food flavor is natural essence.
Further, the preservative for benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, calcium propionate, benzene prick amide, Mixture more than one or both of benzalkonium chloride.
Further, the preparation method of the Chinese cassia tree extracting solution is：
After Chinese cassia tree is taken to be ground into powder, reflux operation 2-3h, meat are carried out with being immersed after multilayer gauze wrapped in absolute ethyl alcohol The w/v (g/ml) of cassia lignea flour end and absolute ethyl alcohol is 1:3-5 after reflux, is filtered to remove residue, further concentrates Afterwards with activated carbon adsorption pigment and smell specific to Chinese cassia tree, concentrate, the Chinese cassia tree powder of original addition and the weight of concentrate are obtained It is 2 to measure volume ratio (g/ml):1.
Further, the preparation method of the cloves extracting solution is：
After cloves is taken to be ground into powder, reflux operation 2-3h, fourth are carried out with being immersed after multilayer gauze wrapped in absolute ethyl alcohol The w/v (g/ml) of face powder end and absolute ethyl alcohol is 1:3-5 after reflux, is filtered to remove residue, further concentrates Afterwards with activated carbon adsorption pigment and smell specific to cloves, concentrate, the cloves powder of original addition and the weight of concentrate are obtained It is 1 to measure volume ratio (g/ml):1.
A kind of preparation method for the mouth sprays for alleviating oral peculiar smell, includes the following steps：
(1) borneol is added in naringin in ethyl alcohol and dissolved, after dissolving, continuously add Chinese cassia tree extracting solution and fourth Fragrant extracting solution, stirs and evenly mixs, and obtains mixed liquor A；
(2) carboxymethyl chitosan, sodium acid carbonate, vitamin C and Aloe Vera Gel are added in distilled water and dissolves mixing, mixed Close liquid B；
(3) obtained mixed liquor A in above-mentioned steps with mixed liquid B is mixed evenly, adds in edible perfume wherein Essence and preservative, are mixed evenly, sterilization obtains finished product.
The tender activity that can effectively inhibit bacteria of carboxymethyl chitosan added in the present invention, and can be selective Height inhibit the growth of Streptococcus oralis, while will not other beneficial bacterias be generated with apparent effect；By institute of the present invention It states in mouth sprays added with ethyl alcohol, when use can generate oral cavity certain stimulation, by adding Aloe Vera Gel and naringin Sedation can be played, reduces excitement caused by ethyl alcohol；Naringin, Chinese cassia tree extracting solution and cloves extracting solution are effectively Sterilization, bacteriostasis, can from source reduce oral peculiar smell；By adding sodium acid carbonate, oral cavity acid-base value is improved, is conducive to The healing acceleration of oral inflammation wound.
Beneficial effects of the present invention：A kind of mouth sprays for alleviation oral peculiar smell that the present invention is produced, can effectively kill Except the bacterium in oral cavity, oral peculiar smell is reduced from source, promotes the healing of the inflammation wound caused by oral inflammation, while can Promote saliva of buccal cavity secretion, sterilizing is carried out to oral cavity using a variety of enzymes being rich in human saliva, when use is non-stimulated.
Specific embodiment
The technical solution in the embodiment of the present invention will be clearly and completely described below, it is clear that described implementation Example is only part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common All other embodiment that technical staff is obtained without creative efforts belongs to the model that the present invention protects It encloses.
Embodiment 1：
A kind of mouth sprays for alleviating oral peculiar smell, are produced by following Raw material processing：
Carboxymethyl chitosan, sodium acid carbonate, vitamin C, Aloe Vera Gel, food flavor, sorbic acid, borneol, ethyl alcohol, distillation Water, Chinese cassia tree extracting solution, cloves extracting solution and naringin.
Specifically, it is produced by the Raw material processing of following parts by weight：Carboxymethyl chitosan 3%, sodium acid carbonate 0.4%, dimension life Plain C0.2%, Aloe Vera Gel 4%, food flavor 0.3%, sorbic acid 0.2%, borneol 0.4%, ethyl alcohol 5%, Chinese cassia tree extracting solution 3%, Cloves extracting solution 5%, naringin 0.6% and distilled water surplus.
Further, the food flavor is natural essence.
Further, the preparation method of the Chinese cassia tree extracting solution is：
After Chinese cassia tree is taken to be ground into powder, reflux operation 3h, Chinese cassia tree are carried out with being immersed after multilayer gauze wrapped in absolute ethyl alcohol The w/v of powder and absolute ethyl alcohol (g/ml) is 1:4, after reflux, residue is filtered to remove, is further used after concentration Activated carbon adsorption pigment and smell specific to Chinese cassia tree, obtain concentrate, the Chinese cassia tree powder of original addition and the weighing body of concentrate Product is 2 than (g/ml):1.
Further, the preparation method of the cloves extracting solution is：
After cloves is taken to be ground into powder, reflux operation 3h, cloves are carried out with being immersed after multilayer gauze wrapped in absolute ethyl alcohol The w/v of powder and absolute ethyl alcohol (g/ml) is 1:4, after reflux, residue is filtered to remove, is further used after concentration Activated carbon adsorption pigment and smell specific to cloves, obtain concentrate, the cloves powder of original addition and the weighing body of concentrate Product is 1 than (g/ml):1.
A kind of preparation method for the mouth sprays for alleviating oral peculiar smell, includes the following steps：
(1) borneol is added in naringin in ethyl alcohol and dissolved, after dissolving, continuously add Chinese cassia tree extracting solution and fourth Fragrant extracting solution, stirs and evenly mixs, and obtains mixed liquor A；
(2) carboxymethyl chitosan, sodium acid carbonate, vitamin C and Aloe Vera Gel are added in distilled water and dissolves mixing, mixed Close liquid B；
(3) obtained mixed liquor A in above-mentioned steps with mixed liquid B is mixed evenly, adds in edible perfume wherein Essence and sorbic acid, are mixed evenly, sterilization obtains finished product.
Embodiment 2：
A kind of mouth sprays for alleviating oral peculiar smell, are produced by following Raw material processing：
Carboxymethyl chitosan, sodium acid carbonate, vitamin C, Aloe Vera Gel, food flavor, calcium propionate, borneol, ethyl alcohol, distillation Water, Chinese cassia tree extracting solution, cloves extracting solution and naringin.
Specifically, it is produced by the Raw material processing of following parts by weight：Carboxymethyl chitosan 5%, sodium acid carbonate 0.6%, dimension life Plain C0.5%, Aloe Vera Gel 3%, food flavor 0.3%, calcium propionate 0.1%, borneol 0.3%, ethyl alcohol 5%, Chinese cassia tree extracting solution 2%, Cloves extracting solution 4%, naringin 0.4% and distilled water surplus.
Further, the food flavor is natural essence.
Further, the preparation method of the Chinese cassia tree extracting solution is：
After Chinese cassia tree is taken to be ground into powder, reflux operation 2.5h, meat are carried out with being immersed after multilayer gauze wrapped in absolute ethyl alcohol The w/v (g/ml) of cassia lignea flour end and absolute ethyl alcohol is 1:5, after reflux, residue is filtered to remove, further after concentration The smell specific to activated carbon adsorption pigment and Chinese cassia tree obtains concentrate, the Chinese cassia tree powder of original addition and the weight of concentrate Volume ratio (g/ml) is 2:1.
Further, the preparation method of the cloves extracting solution is：
After cloves is taken to be ground into powder, reflux operation 2.5h, fourth are carried out with being immersed after multilayer gauze wrapped in absolute ethyl alcohol The w/v (g/ml) of face powder end and absolute ethyl alcohol is 1:5, after reflux, residue is filtered to remove, further after concentration The smell specific to activated carbon adsorption pigment and cloves obtains concentrate, the cloves powder of original addition and the weight of concentrate Volume ratio (g/ml) is 1:1.
A kind of preparation method for the mouth sprays for alleviating oral peculiar smell, includes the following steps：
(1) borneol is added in naringin in ethyl alcohol and dissolved, after dissolving, continuously add Chinese cassia tree extracting solution and fourth Fragrant extracting solution, stirs and evenly mixs, and obtains mixed liquor A；
(2) carboxymethyl chitosan, sodium acid carbonate, vitamin C and Aloe Vera Gel are added in distilled water and dissolves mixing, mixed Close liquid B；
(3) obtained mixed liquor A in above-mentioned steps with mixed liquid B is mixed evenly, adds in edible perfume wherein Essence and calcium propionate, are mixed evenly, sterilization obtains finished product.
Present invention disclosed above preferred embodiment is only intended to help to illustrate the present invention.There is no detailed for preferred embodiment All details are described, are not limited the invention to the specific embodiments described.Obviously, according to the content of this specification, It can make many modifications and variations.This specification is chosen and specifically describes these embodiments, is in order to preferably explain the present invention Principle and practical application so that skilled artisan can be best understood by and utilize the present invention.The present invention is only It is limited by claims and its four corner and equivalent.

Claims (6)

1. a kind of mouth sprays for alleviating oral peculiar smell, which is characterized in that produced by the Raw material processing of following parts by weight：Carboxymethyl Chitosan 0.1%-5%, sodium acid carbonate 0.1%-0.8%, vitamin C 0.1%-0.5%, Aloe Vera Gel 2%-5%, food flavor 0.2%-0.5%, preservative 0.1%-0.3%, borneol 0.3%-0.5%, ethyl alcohol 5%-8%, Chinese cassia tree extracting solution 2%-8%, Cloves extracting solution 2%-8%, naringin 0.1%-1% and distilled water surplus.
2. a kind of mouth sprays for alleviating oral peculiar smell according to claim 1, which is characterized in that the food flavor is Natural essence.
3. a kind of mouth sprays for alleviating oral peculiar smell according to claim 1, which is characterized in that the preservative is benzene Formic acid, sodium benzoate, sorbic acid, potassium sorbate, calcium propionate, benzene are pricked more than one or both of amide, benzalkonium chloride mixed Close object.
A kind of 4. mouth sprays for alleviating oral peculiar smell according to claim 1, which is characterized in that the Chinese cassia tree extracting solution Preparation method be：
After Chinese cassia tree is taken to be ground into powder, reflux operation 2-3h, ground cinnamon are carried out with being immersed after multilayer gauze wrapped in absolute ethyl alcohol The w/v of end and absolute ethyl alcohol is 1:3-5 after reflux, is filtered to remove residue, further uses activated carbon after concentration Adsorpting pigment and smell specific to Chinese cassia tree, obtain concentrate, and the Chinese cassia tree powder of original addition and the w/v of concentrate are 2:1。
A kind of 5. mouth sprays for alleviating oral peculiar smell according to claim 1, which is characterized in that the cloves extracting solution Preparation method be：
After cloves is taken to be ground into powder, reflux operation 2-3h, Ground Cloves are carried out with being immersed after multilayer gauze wrapped in absolute ethyl alcohol The w/v of end and absolute ethyl alcohol is 1:3-5 after reflux, is filtered to remove residue, further uses activated carbon after concentration Adsorpting pigment and smell specific to cloves, obtain concentrate, and the cloves powder of original addition and the w/v of concentrate are 1:1。
6. a kind of preparation method for the mouth sprays for alleviating oral peculiar smell, which is characterized in that include the following steps：
(1) borneol is added in naringin in ethyl alcohol and dissolved, after dissolving, continuously added Chinese cassia tree extracting solution and carried with cloves Liquid is taken, is stirred and evenly mixed, obtains mixed liquor A；
(2) carboxymethyl chitosan, sodium acid carbonate, vitamin C and Aloe Vera Gel are added in distilled water and dissolves mixing, obtain mixed liquor B；
(3) obtained mixed liquor A in above-mentioned steps is mixed evenly with mixed liquid B, wherein add in food flavor with Preservative is mixed evenly, and sterilization obtains finished product.
CN201711434145.2A 2017-12-26 2017-12-26 A kind of mouth sprays for alleviating oral peculiar smell and preparation method thereof Withdrawn CN108096429A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200077090A (en) * 2018-12-20 2020-06-30 동의대학교 산학협력단 Composition for prevention or treatment of dental disease comprising an extract of cinnamon
CN111358746A (en) * 2020-04-30 2020-07-03 云南风联科技有限公司 Plant lemon-flavored oral cavity atomized liquid and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1149491A (en) * 1996-06-17 1997-05-14 郭恒盛 Traditional Chinese medicine spray preparation for curing and clearing oral peculiar smell and its making technology
CN102085370A (en) * 2011-01-28 2011-06-08 武汉耦合医学科技有限责任公司 Oral spray for inflammatory diseases of oral cavity and preparation method thereof
CN106466482A (en) * 2015-08-20 2017-03-01 康多宝医疗健康产品（湖南）有限公司 A kind of compositionss of prevention, treatment or suppression membrane disease and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1149491A (en) * 1996-06-17 1997-05-14 郭恒盛 Traditional Chinese medicine spray preparation for curing and clearing oral peculiar smell and its making technology
CN102085370A (en) * 2011-01-28 2011-06-08 武汉耦合医学科技有限责任公司 Oral spray for inflammatory diseases of oral cavity and preparation method thereof
CN106466482A (en) * 2015-08-20 2017-03-01 康多宝医疗健康产品（湖南）有限公司 A kind of compositionss of prevention, treatment or suppression membrane disease and preparation method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200077090A (en) * 2018-12-20 2020-06-30 동의대학교 산학협력단 Composition for prevention or treatment of dental disease comprising an extract of cinnamon
KR102141623B1 (en) 2018-12-20 2020-08-05 동의대학교 산학협력단 Composition for prevention or treatment of dental disease comprising an extract of cinnamon
CN111358746A (en) * 2020-04-30 2020-07-03 云南风联科技有限公司 Plant lemon-flavored oral cavity atomized liquid and preparation method thereof

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