CN104887581B - A kind of oral care composition and preparation method thereof - Google Patents
A kind of oral care composition and preparation method thereof Download PDFInfo
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Abstract
The present invention discloses a kind of oral care composition and preparation method thereof, includes the component of following masses percentage：Aloe gel juice 14.35~99%, B family vitamin 0.001~0.15%, essential oil 0.001~5%, sorbefacient 0.001~8%, surfactant and solubilizer 0.1~15%.The water soluble ingredient in B family vitamin and sorbefacient is added in Aloe gel juice during preparation, and is uniformly mixed to obtain mixed liquor；Added after the water insoluble ingredients in essential oil and sorbefacient are carried out into emulsification solubilising with surfactant and solubilizer in mixed liquor, and stirring or homogeneous, that is, obtain oral care composition.The oral care composition of the present invention can prevent, alleviate and mitigate all kinds of oral inflammations, promote the healing of the surface of a wound, accelerate the maintenance of mucous membrane of mouth, extend its residence time in the oral cavity, improve its utilization rate, extend the time of its efficacy exertion.
Description
Technical field
It is more particularly to a kind of that there is cleaning oral cavity the present invention relates to a kind of oral care composition and preparation method thereof, delay
Solve oral cavity, the multi-function oral care composition of gum nonspecific inflammation symptom.
Background technology
Oral care product in the market is mainly toothpaste, mouthwash, and it is more simply to clean oral cavity or pure and fresh
Based on the basic nursings such as implication.With the improvement of people ' s living standards and the continuous pursuit to U.S., oral health turn into people
Focus of attention, occur various effect type oral care products on the market.
Toothpaste is especially inconvenient when going out because it needs to coordinate toothbrush, cup and clear water when in use, and has when in oral cavity
During the surface of a wound, the stimulation of toothbrush can also aggravate pain and the deterioration of site of injury.Mouthwash carries as one kind, is easy to use, will not
Bring because the surface of a wound caused by toothbrush friction deteriorates, the oral care product of the pain increased problem, increasingly by consumers in general
Like, especially both effectiveness mouthwash.Being presently available for, which improves oral problem the effect of property mouthwash, mainly includes two classes：
(1) mouthwash using the extract solution that single or a variety of Chinese medicine composition compounds as main component；(2) using chemical antiphlogistic as mainly into
The mouthwash divided.(1) class Traditional-Chinese-medicine-type mouthwash complex process, production cost is high, and color is deep, flavour of a drug weight, to the outer of product
See and mouthfeel has a great influence, and be possible to that in the extraction process of active ingredient of Chinese herbs a large amount of organic solvents can be introduced, influence people
Body health.The mouthwash of (2) class chemical drugs formulation, long-term use can cause the drug-fast problem of microorganism.
In addition, mouthwash is when in use, typically it is contained in intraoral, agitates two cheeks and lip, make mouthwash in oral cavity
Inside fully contacted with tooth, gum, and each position in oral cavity is repeatedly rinsed using waterpower, spued after 30 seconds~1 minute.Because gargling
Saliva residence time in mouth is shorter, the problem of effective ingredient draws are less, and utilization rate is low be present.
The content of the invention
The time is utilized for increase mouthwash, avoids traditional Chinese medicine ingredients poor taste, the problems such as chemical agent is harmful, this
Invention provides a kind of oral care composition and preparation method thereof, and it makes, and simple, utilization rate of active components is high, safe,
Cleanable oral cavity, alleviate oral cavity, the multi-function oral care composition of gum nonspecific inflammation symptom.
The present invention is realized by following technical proposal：A kind of oral care composition, it is characterised in that including following masses
The component of percentage：
Aloe gel juice 14.35~99%, B family vitamin 0.001~0.15%,
Essential oil 0.001~5%, sorbefacient 0.001~8%,
Surfactant and solubilizer 0.1~15%.
The Aloe gel juice is made by the following steps：
A, aloe leaf cleaned, removed the peel, squeezed the juice, sterilized, digested, plate-frame filtering be made soluble solid be 0.5~
1.25% asparagus juice；
B, by the ︰ 1 of Lu Hui juice ︰ macroporous anion exchange resin=20~25 volume ratio, asparagus juice obtained by step A is passed through
Macroporous anion exchange resin column, 20~30min of time of contact is controlled, that is, obtain removing anthraquinone, the Aloe Vera Gel juice of pigment；
C, Aloe Vera Gel juice obtained by step B is concentrated with the reverse osmosis membrane that molecular cut off is 18, collects concentrate, i.e.,
Obtain Aloe gel juice.
The B family vitamin be vitamin B1, vitamin B2, vitamin B6, one or both of vitamin B12 with
On.
The essential oil includes parent essential oil and the derived essential oil separated from parent essential oil, is thymol, folium eucalypti
Oily element, gaultherolin, menthol, tea tree ethereal oil, cinnamon essential oil, citral, clove seed essential oil, citronellol, fragrant Chinese holly leaf essential oil
One or both of more than.
The sorbefacient is made up of taste stimulation agent, heat sensitizer and film forming agent.
The taste stimulation agent is more than one or both of salt, phosphoric acid, organic food acids.
Organic food acids are lactic acid or citric acid.
The heat sensitizer is vanillyl alcohol n-butyl ether, zingiberol, vanillyl alcohol isobutyl ether, vanillyl alcohol n-propyl ether, vanillyl alcohol
Isopropyl base ether, vanillyl alcohol n-amino ether, vanillyl alcohol methyl ether, vanillyl alcohol isoamyl ether, vanillyl alcohol n-hexyl ether, vanillyl alcohol second
It is more than one or both of ether, salad oil, zingerone, capsaicine.
The film forming agent is sodium alginate, xanthans, carboxymethyl cellulose, hydroxy propyl cellulose, hydroxybutyl fiber
Element, Hydroxypropyl ethyl cellulose, methylethylcellulose, hydroxypropyl methyl cellulose, carrageenan, microcrystalline cellulose, shell gather
It is more than one or both of sugar.
Further, the mass ratio of the taste stimulation agent, heat sensitizer and film forming agent is (0.06~2):(0.001~1):
(0.01~5).
The surfactant is the single or compound nonionic surfactant that HLB value is 8-18, including tween system
It is more than one or both of row, Span series, rilanit special, APG, cithrol.
The TWEEN Series are more than one or both of Tween-20, Tween-60, Tween-80.
The Span series are more than one or both of Arlacel-20, Arlacel-60, Arlacel-80.
The rilanit special is one or both of Cremophor RH40, PEG-60 rilanit specials.
The APG is the APG that atomic number of alkyl carbon is 10-14.
The solubilizer is alcohols solubilizer, including one or both of propane diols, ethanol, butanediol, polyethylene glycol
More than.
Further, the oral care composition also includes water, accounts for the 0~50% of oral care composition quality.
Further, the oral care composition also includes natural anti-inflammatory anti-allergic agent, such as Flos Lonicerae extractive solution, the root of herbaceous peony
Extract solution, ginger extract solution, radix glycyrrhizae and its derivative (such as dipotassium glycyrrhizinate).Account for the 0~5% of oral care composition quality.
Further, in order to extend the resting period of oral care composition involved in the present invention, it is also comprising appropriate
Preservative.Account for the 0~1% of oral care composition quality.
Further, in order to improve the mouthfeel of oral care composition involved in the present invention, it also includes appropriate sweet tea
Taste agent, sweetener are selected from least one of Aspartame, saccharin sodium, xylitol.Account for oral care composition quality 0~
0.5%.
Further, oral care composition involved in the present invention may also include complementary composition, such as pH adjusting agent, chela
Mixture, spices, antioxidant.Account for the 0~1% of oral care composition quality.
Another object of the present invention is to provide a kind of preparation method of oral care composition, by following each step：
(1) component of following mass percent is pressed：
Aloe gel juice 14.35~99%, B family vitamin 0.001~0.15%,
Essential oil 0.001~5%, sorbefacient 0.001~8%,
Surfactant and solubilizer 0.1~15%；
(2) water soluble ingredient in the B family vitamin and sorbefacient in step (1) is added in Aloe gel juice,
And it is uniformly mixed to obtain mixed liquor；
(3) by the water insoluble ingredients surfactant and solubilising in the essential oil and sorbefacient in step (1)
Agent is added in mixed liquor obtained by step (1) after carrying out emulsification solubilising, and stirring or homogeneous, that is, obtains oral care composition.
Water, natural anti-inflammatory anti-allergic agent, preservative, sweet taste are added on demand after stirring or homogeneous in the step (3)
One or more in agent, complementary composition.
The pharmacological action of oral care composition provided by the invention：Aloe polysaccharide in Aloe gel juice can strengthen immune
System, promotion organization Cortical fiber increase, there is provided cell nutrients, promote cell metabolism, help cell repair, so as to promote
Wound healing, reparation mucous membrane of mouth in oral cavity.B family vitamin can maintain the health of skin and muscle, promote immune system and god
Through system, promote cell growth and division.Essential oil has antimicrobial acivity, can suppress the formation of bacterial plaque and gingivitis.Reed
Luxuriant growth gel juice, B family vitamin and essential oil three synergy, effectively can prevent and mitigate oral inflammation (as mitigation gingivitis,
Angular stomatitis, canker sore etc.), wound repairing, mitigate pain, accelerate the maintenance of mucous membrane of mouth, improve oral environment.Absorption enhancement
Taste stimulation agent in agent can stimulate the human body sense of taste, promote salivary secretion, maintain cavity interior moistening, be advantageous to oozing for active matter
Absorb thoroughly；Heat sensitizer can provide warmth sensation in cavity interior, promote oral cavity when using the oral care composition rinse oral cavity
Interior microcirculation, promote active ingredient draws.Both collective effects, for the oral care composition use provide one it is relatively wet
The oral environment of heat, to promote the quick absorption of its active ingredient.Film forming agent in sorbefacient can not only improve oral cavity
The viscosity of care composition, increase it containing time of contact when gargling with oral cavity wall, tongue and gum etc., and can be in oral cavity
One layer of temporary film of middle formation, strengthens the adhesiveness of active component in the oral cavity in oral care composition, extends activity
Composition plays the time of function.Three's collective effect in sorbefacient, active ingredient in the oral care composition can be improved
Utilization rate, extend time of its efficacy exertion, so that it preferably protects the health of one's mouth.In addition, the taste in sorbefacient
Feel stimulant, the human body sense of taste can be stimulated, promote salivary secretion, the self-cleaning of cavity interior, sterilizing function is given full play to,
With other functional component collective effects in oral care composition, can faster, preferably recover oral health.Surfactant
And solubilizer is mainly used in the water insoluble ingredients in emulsification, solubilized oral care composition, while strengthens it and clean oral cavity
Effect.
The advantages of present invention possesses and effect：Oral care composition involved in the present invention makes simple, active ingredient
Utilization rate is high, can clean oral cavity, alleviates oral cavity, gum nonspecific inflammation symptom, Aloe gel juice, B races dimension contained by it
Raw element, essential oil collective effect can prevent, alleviate and mitigate all kinds of oral inflammations in oral cavity, promote the healing of the surface of a wound, accelerate oral cavity
The maintenance of mucous membrane；Sorbefacient contained by it can increase Aloe gel juice, B family vitamin, essential oil containing when gargling and in oral cavity
The adhesion of wall, tongue etc., extend its residence time in the oral cavity, improve its utilization rate, extend the time of its efficacy exertion.
Embodiment
The present invention is specifically described below by embodiment.
Embodiment 1
(1) component of according to the form below and content are stocked up：
| Component | Content % |
| Aloe gel juice | 55.00% |
| Vitamin B1 | 0.02% |
| Vitamin B2 | 0.01% |
| Thymol | 0.10% |
| Cineole | 0.002% |
| Gaultherolin | 0.01% |
| Menthol | 0.01% |
| Salt | 0.60% |
| Vanillyl alcohol n-butyl ether | 0.01% |
| Xanthans | 0.10% |
| Tween-20 | 0.03% |
| Polyethylene glycol -12- hydroxy stearic acids | 2.50% |
| Ethanol | 2.00% |
| Water | 37.658% |
| Dipotassium glycyrrhizinate | 0.25% |
| Preservative | 1% |
| Xylitol | 0.2% |
| PH adjusting agent | 0.5% |
Wherein, Aloe gel juice is made by the following steps：
A, aloe leaf cleaned, removed the peel, squeezed the juice, sterilized, digested, soluble solid is made as 1% in plate-frame filtering
Asparagus juice；
B, by the ︰ 1 of Lu Hui juice ︰ macroporous anion exchange resins=25 volume ratio, asparagus juice obtained by step A is passed through into macropore
Anion-exchange resin column, time of contact 20min is controlled, that is, obtain removing anthraquinone, the Aloe Vera Gel juice of pigment；
C, Aloe Vera Gel juice obtained by step B is concentrated with the reverse osmosis membrane that molecular cut off is 18, collects concentrate, i.e.,
Obtain Aloe gel juice；
(2) water soluble ingredient in the B family vitamin and sorbefacient in step (1) is added in Aloe gel juice,
And it is uniformly mixed to obtain mixed liquor；
(3) by the water insoluble ingredients surfactant and solubilising in the essential oil and sorbefacient in step (1)
Agent is added in mixed liquor obtained by step (1) after carrying out emulsification solubilising, and stirring or homogeneous, adds water, natural anti-inflammatory antiallergy
Agent, preservative, sweetener, complementary composition, that is, obtain oral care composition.
Embodiment 2
(1) component of according to the form below and content are stocked up：
| Composition | Content % |
| Aloe gel juice | 82.77% |
| Vitamin B1 | 0.01% |
| Vitamin B2 | 0.01% |
| Vitamin B12 | 0.005% |
| Cinnamon essential oil | 0.25% |
| Thymol | 0.20% |
| Gaultherolin | 0.005% |
| Tea tree ethereal oil | 0.10% |
| Salt | 0.40% |
| Vanillyl alcohol n-butyl ether | 0.10% |
| Sodium alginate | 0.25% |
| Tween-20 | 0.40% |
| Polyethylene glycol -12- hydroxy stearic acids | 8.00% |
| Ethanol | 5.00% |
| Flos Lonicerae extractive solution | 0.50% |
| Preservative | 0.50% |
| Aspartame | 0.50% |
| PH adjusting agent | 1% |
Wherein, Aloe gel juice is made by the following steps：
A, aloe leaf cleaned, removed the peel, squeezed the juice, sterilized, digested, soluble solid is made as 1.25% in plate-frame filtering
Asparagus juice；
B, by the ︰ 1 of Lu Hui juice ︰ macroporous anion exchange resins=22 volume ratio, asparagus juice obtained by step A is passed through into macropore
Anion-exchange resin column, time of contact 25min is controlled, that is, obtain removing anthraquinone, the Aloe Vera Gel juice of pigment；
C, Aloe Vera Gel juice obtained by step B is concentrated with the reverse osmosis membrane that molecular cut off is 18, collects concentrate, i.e.,
Obtain Aloe gel juice；
(2) water soluble ingredient in the B family vitamin and sorbefacient in step (1) is added in Aloe gel juice,
And it is uniformly mixed to obtain mixed liquor；
(3) by the water insoluble ingredients surfactant and solubilising in the essential oil and sorbefacient in step (1)
Agent is added in mixed liquor obtained by step (1) after carrying out emulsification solubilising, and is stirred or homogeneous, add natural anti-inflammatory anti-allergic agent,
Preservative, sweetener, complementary composition, that is, obtain oral care composition.
Embodiment 3
(1) component of according to the form below and content are stocked up：
| Composition | Content % |
| Aloe gel juice | 99% |
| Vitamin B1 | 0.05% |
| Vitamin B6 | 0.05% |
| Citral | 0.13% |
| Lactic acid | 0.1% |
| Zingiberol | 0.02% |
| Carboxymethyl cellulose | 0.1% |
| Arlacel-20 | 0.05% |
| Tween-20 | 0.35% |
| Propane diols | 0.15% |
Wherein, Aloe gel juice is made by the following steps：
A, aloe leaf cleaned, removed the peel, squeezed the juice, sterilized, digested, soluble solid is made as 0.5% in plate-frame filtering
Asparagus juice；
B, by the ︰ 1 of Lu Hui juice ︰ macroporous anion exchange resins=20 volume ratio, asparagus juice obtained by step A is passed through into macropore
Anion-exchange resin column, time of contact 30min is controlled, that is, obtain removing anthraquinone, the Aloe Vera Gel juice of pigment；
C, Aloe Vera Gel juice obtained by step B is concentrated with the reverse osmosis membrane that molecular cut off is 18, collects concentrate, i.e.,
Obtain Aloe gel juice；
(2) water soluble ingredient in the B family vitamin and sorbefacient in step (1) is added in Aloe gel juice,
And it is uniformly mixed to obtain mixed liquor；
(3) by the water insoluble ingredients surfactant and solubilising in the essential oil and sorbefacient in step (1)
Agent is added in mixed liquor obtained by step (1) after carrying out emulsification solubilising, and stirring or homogeneous, that is, obtains oral care composition.
Embodiment 4
(1) component of according to the form below and content are stocked up：
Wherein, Aloe gel juice is made by the following steps：
A, aloe leaf cleaned, removed the peel, squeezed the juice, sterilized, digested, soluble solid is made as 1.25% in plate-frame filtering
Asparagus juice；
B, by the ︰ 1 of Lu Hui juice ︰ macroporous anion exchange resins=22 volume ratio, asparagus juice obtained by step A is passed through into macropore
Anion-exchange resin column, time of contact 25min is controlled, that is, obtain removing anthraquinone, the Aloe Vera Gel juice of pigment；
C, Aloe Vera Gel juice obtained by step B is concentrated with the reverse osmosis membrane that molecular cut off is 18, collects concentrate, i.e.,
Obtain Aloe gel juice；
(2) water soluble ingredient in the B family vitamin and sorbefacient in step (1) is added in Aloe gel juice,
And it is uniformly mixed to obtain mixed liquor；
(3) by the water insoluble ingredients surfactant and solubilising in the essential oil and sorbefacient in step (1)
Agent is added in mixed liquor obtained by step (1) after carrying out emulsification solubilising, and stirring or homogeneous, adds water, natural anti-inflammatory antiallergy
Agent, preservative, sweetener, complementary composition, that is, obtain oral care composition.
Embodiment 5
(1) component of according to the form below and content are stocked up：
| Component | Content % |
| Aloe gel juice | 72.609% |
| Vitamin B2 | 0.001% |
| Thymol | 0.08% |
| Phosphoric acid | 0.1% |
| Zingerone | 0.0003% |
| Methylethylcellulose | 0.03% |
| Chitosan | 0.02% |
| PEG-60 rilanit specials | 0.03% |
| Cithrol | 2.50% |
| Ethanol | 2.00% |
| Water | 20.9297% |
| Dipotassium glycyrrhizinate | 0.8% |
| Preservative | 0.3% |
| Xylitol | 0.2% |
| Spices | 0.2% |
| Antioxidant | 0.2% |
Wherein, Aloe gel juice is made by the following steps：
A, aloe leaf cleaned, removed the peel, squeezed the juice, sterilized, digested, soluble solid is made as 1% in plate-frame filtering
Asparagus juice；
B, by the ︰ 1 of Lu Hui juice ︰ macroporous anion exchange resins=25 volume ratio, asparagus juice obtained by step A is passed through into macropore
Anion-exchange resin column, time of contact 20min is controlled, that is, obtain removing anthraquinone, the Aloe Vera Gel juice of pigment；
C, Aloe Vera Gel juice obtained by step B is concentrated with the reverse osmosis membrane that molecular cut off is 18, collects concentrate, i.e.,
Obtain Aloe gel juice；
(2) water soluble ingredient in the B family vitamin and sorbefacient in step (1) is added in Aloe gel juice,
And it is uniformly mixed to obtain mixed liquor；
(3) by the water insoluble ingredients surfactant and solubilising in the essential oil and sorbefacient in step (1)
Agent is added in mixed liquor obtained by step (1) after carrying out emulsification solubilising, and stirring or homogeneous, adds water, natural anti-inflammatory antiallergy
Agent, preservative, sweetener, complementary composition, that is, obtain oral care composition.
In addition, those skilled in the art can also the claims in the present invention scope of disclosure and spirit in do other forms and
Various modifications, addition and replacement in details.Certainly, these various modifications, addition and replacements for being made according to present invention spirit
Deng change, should all be included within scope of the present invention.
Comparative example 1：Using traditional Chinese medicine ingredients compounding extract solution as main component mouthwash, traditional Chinese medicine ingredients be mainly peppermint,
Honeysuckle, chrysanthemum.
Comparative example 2：Mouthwash using chemical antiphlogistic as main component, the antiphlogistic mainly have metronidazole, hydrogen peroxide group
Into.
The clinical observation of oral care composition prevention and treatment mouth disease obtained by the various embodiments described above：
First, patient is grouped：120 patients of inclusive criteria will be met, random point 3 groups, wherein the first treatment group 40, its
Middle male 20, female 20,9~70 years old age；Second treatment group 40, wherein man 20, female 20,9~70 years old age.Control
Group 40, wherein man 20, female 20；9~70 years old age.Three groups of ages, sex, the course of disease and cardinal symptom through statistics at
Reason, no significant difference (P>0.05), there is comparativity.
Inclusive criteria：(1) all kinds of oral inflammations；(2) oral peculiar smell person.
2nd, treatment method
Treatment group：The oral care composition 5-20ml of gained in Example 1-5, after gargling -5 minutes 30 seconds, spue.
It can be used 1-5 times daily according to being actually needed.
First control group：Commercial products 5-20ml selected by comparative example 1 is taken, after gargling -5 minutes 30 seconds, is spued.According to reality
Need to can be used 1-5 times daily.
Second control group：Commercial products 5-20ml selected by comparative example 2 is taken, after gargling -5 minutes 30 seconds, is spued.According to reality
Need to can be used 1-5 times daily.
4th, result
Treatment group is 95% to the effective percentage of all kinds of oral inflammations, and the effective percentage to oral peculiar smell person is 99%.
First control group is 60% to the effective percentage of all kinds of oral inflammations, and the effective percentage to oral peculiar smell person is 79%.
Second control group is 82% to the effective percentage of all kinds of oral inflammations, and the effective percentage to oral peculiar smell person is 31%.
Analyzed through Ridit, P<0.05, treatment group is better than control group.
5th, conclusion
Oral care composition therapeutic action provided by the invention is better than control group, and simply, safely, have no side effect, nothing
Pain, it is the convenient treatment method for preventing and treating all kinds of common oral diseases.
In summary, oral care composition provided by the invention promotes the healing of the surface of a wound, accelerates the maintenance of mucous membrane of mouth
The effect of, oral cavity is cleaned, alleviates oral cavity, gum nonspecific inflammation symptom, extends its residence time in the oral cavity, improve it
Utilization rate, extend the time of its efficacy exertion.With good anti-inflammatory, analgesia, cleaning action, can promote mucous membrane of mouth reparation,
Fresh breath, there is prevention and treatment effect well to gingivitis, canker sore, halitosis, lichen planus of mouth, can reach guarantor
Hold the purpose of oral health.It is without any side effects and in good taste, suitable for long-term use, avoid traditional mouthwash flavour of a drug weight,
A large amount of organic solvents are introduced, influence health, the problems such as long-term use can cause the resistance to the action of a drug of microorganism, and safely, effectively.
Under attached model case：
1st, certain female, 32 years old.With swelling and aching of gum.Contained every time using the oral care composition of embodiment 1 after gargling about 30 seconds,
Spue.Contain daily and gargle 3 times.After 2 days, feel that swelling and aching of gum has been alleviated, be continuing with the oral cavity of embodiment 1 daily afterwards
Care composition is eliminated containing gargling 1-2 times using sensation swelling and aching of gum after 5 days.
2nd, certain man, 53 years old.Suffer from canker sore, canker sore is located at lower lip and the tip of the tongue, and it is big to there are about soybean grain, drinks water and has a meal
When have obvious pain, canker sore has continued 3 days.Just start using the oral care composition of embodiment 2 to contain every time and gargled
After about 1-2min, spue.Contain daily and gargle 5 times.It is obviously improved using feels pain sense after 4 days.It is continuing with implementing daily afterwards
The oral care composition of example 2 is disappeared containing gargling 1-3 times using canker sore after 1 month.
3rd, certain female, 45 years old.Suffer from lichen planus of mouth, tongue, which has, slightly to fester.The oral care group of embodiment 2 is used every time
Compound spues containing after gargling about 3-5min.Contain daily and gargle 5 times.It is obviously improved, is used continuously 6 months using feels pain sense after 4 days
Symptom disappears substantially afterwards.
4th, certain man, 36 years old.With canker sore, there is a peculiar smell in oral cavity, and for canker sore positioned at sublingual, it is big to there are about the grain of rice, with
Pain.Spued every time using the oral care composition of embodiment 1 containing after gargling 1min.Contain daily and gargle 3 times.After 5 days, pain
Pain is obviously improved, and is substantially eliminated using canker sore after 1 month, and oral peculiar smell makes moderate progress, after being used continuously 6 weeks, mouth
Cavity foreign flavor substantially eliminates.
Claims (9)
1. a kind of oral care composition, it is characterised in that include the component of following masses percentage：
Aloe gel juice 14.35~99%, B family vitamin 0.001~0.15%,
Essential oil 0.001~5%, sorbefacient 0.001~8%,
Surfactant and solubilizer 0.1~15%；
The sorbefacient is made up of taste stimulation agent, heat sensitizer and film forming agent；
The taste stimulation agent is more than one or both of salt, phosphoric acid, organic food acids, wherein organic food acids are breast
Acid or citric acid；
The heat sensitizer is vanillyl alcohol n-butyl ether, zingiberol, vanillyl alcohol isobutyl ether, vanillyl alcohol n-propyl ether, vanillyl alcohol isopropyl
Base base ether, vanillyl alcohol n-amino ether, vanillyl alcohol methyl ether, vanillyl alcohol isoamyl ether, vanillyl alcohol n-hexyl ether, vanillyl alcohol ethyl ether, ginger
It is more than one or both of alkene phenol, zingerone, capsaicine；
The film forming agent is sodium alginate, xanthans, carboxymethyl cellulose, hydroxy propyl cellulose, hydroxybutyl cellulose, hydroxyl
In ethyl cellulose, methylethylcellulose, hydroxypropyl methyl cellulose, carrageenan, microcrystalline cellulose, chitosan
It is one or more kinds of；
The mass ratio of the taste stimulation agent, heat sensitizer and film forming agent is 0.06~2:0.001~1:0.01~5.
2. oral care composition according to claim 1, it is characterised in that：The Aloe gel juice passes through the following steps
It is made：
A, aloe leaf cleaned, removed the peel, squeezed the juice, sterilized, digested, soluble solid is made as 0.5~1.25% in plate-frame filtering
Asparagus juice；
B, by the ︰ 1 of Lu Hui juice ︰ macroporous anion exchange resin=20~25 volume ratio, asparagus juice obtained by step A is passed through into macropore
Anion-exchange resin column, 20~30min of time of contact is controlled, that is, obtain removing anthraquinone, the Aloe Vera Gel juice of pigment；
C, Aloe Vera Gel juice obtained by step B is concentrated with the reverse osmosis membrane that molecular cut off is 18, collects concentrate, that is, obtain
Aloe gel juice.
3. oral care composition according to claim 1, it is characterised in that：The B family vitamin is vitamin B1, dimension
It is more than one or both of raw plain B2, vitamin B6, vitamin B12.
4. oral care composition according to claim 1, it is characterised in that：The essential oil includes parent essential oil and from mother
The derived essential oil separated in body essential oil, it is thymol, cineole, gaultherolin, menthol, tea tree ethereal oil, meat
It is more than one or both of osmanthus essential oil, citral, clove seed essential oil, citronellol, fragrant Chinese holly leaf essential oil.
5. oral care composition according to claim 1, it is characterised in that：The surfactant is that HLB value is 8-
18 single or compound nonionic surfactant, including it is TWEEN Series, Span series, rilanit special, APG, poly-
It is more than one or both of glycol fatty acid ester；Wherein TWEEN Series are one in Tween-20, Tween-60, Tween-80
Kind is two or more；Span series are more than one or both of Arlacel-20, Arlacel-60, Arlacel-80；Rilanit special is
One or both of Cremophor RH40, PEG-60 rilanit specials；APG is that atomic number of alkyl carbon is 10-14
APG.
6. oral care composition according to claim 1, it is characterised in that：The solubilizer is alcohols solubilizer, bag
Include more than one or both of propane diols, ethanol, butanediol, polyethylene glycol.
7. oral care composition according to claim 1, it is characterised in that：The oral care composition also includes
Water, account for the 0~50% of oral care composition quality；The oral care composition also includes natural anti-inflammatory anti-allergic agent, accounts for mouth
The 0~5% of chamber care composition quality；The oral care composition also includes preservative, accounts for oral care composition quality
0~1%；The oral care composition also includes sweetener, sweetener in Aspartame, saccharin sodium, xylitol at least
One kind, account for the 0~0.5% of oral care composition quality.
8. a kind of preparation method of oral care composition as claimed in claim 1, it is characterised in that pass through following each step：
（1）Stocked up by the component of following mass percent：
Aloe gel juice 14.35~99%, B family vitamin 0.001~0.15%,
Essential oil 0.001~5%, sorbefacient 0.001~8%,
Surfactant and solubilizer 0.1~15%；
（2）By step（1）In B family vitamin and sorbefacient in water soluble ingredient add in Aloe gel juice, and stir
Mix to be well mixed and obtain mixed liquor；
（3）By step（1）In essential oil and sorbefacient in water insoluble ingredients surfactant and solubilizer enter
After row emulsification solubilising, step is added to（2）In gained mixed liquor, and stirring or homogeneous, that is, obtain oral care composition.
9. preparation method according to claim 8, it is characterised in that：The step（3）In stirring or homogeneous after on demand
Ask add water, natural anti-inflammatory anti-allergic agent, preservative, sweetener, in one or more.
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| CN105168927A (en) * | 2015-09-24 | 2015-12-23 | 王栩 | Medicine and atomized liquid for treating oral lichen planus and preparation method |
| CN105456132A (en) * | 2015-12-28 | 2016-04-06 | 肇庆迪彩日化科技有限公司 | Composition of plant extracts and application of composition |
| CN105726408A (en) * | 2016-03-28 | 2016-07-06 | 北京世纪鸿成商贸有限公司 | Tooth gel |
| CN106177269A (en) * | 2016-07-07 | 2016-12-07 | 万苏晨 | The pharmaceutical composition of quick curing oral keritonocytes, preparation method and application |
| CN106265383A (en) * | 2016-10-14 | 2017-01-04 | 柳州环山科技有限公司 | A kind of child's collutory and preparation method thereof |
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| CN106562921B (en) * | 2016-11-02 | 2020-11-24 | 李浩然 | A liquid oral composition containing Chinese medicinal active substances and tea tree essential oil |
| CN107375024B (en) * | 2017-07-04 | 2020-02-14 | 广东丸美生物技术股份有限公司 | Stable one-phase solubilization method |
| CN107595750B (en) * | 2017-07-28 | 2020-07-14 | Dj健康产业集团 | Active anti-inflammation toothpaste |
| EP3459368A1 (en) * | 2017-09-20 | 2019-03-27 | Geophyt S.r.L. | Food integrator for antineoplastic therapies |
| CN108096486B (en) * | 2018-01-25 | 2020-05-26 | 北京斯利安药业有限公司 | Composition, oral film and preparation method thereof |
| CN108379432A (en) * | 2018-04-18 | 2018-08-10 | 佛山科学技术学院 | It is a kind of to be used to treat gel of various focusing depths represented and preparation method thereof |
| CN111467365A (en) * | 2019-01-24 | 2020-07-31 | 开封九福来生物技术有限公司 | Oral instant film agent containing dendrobium polysaccharide and preparation method thereof |
| CN111000871A (en) * | 2020-01-18 | 2020-04-14 | 杭州倍荣生物科技有限公司 | Oral cavity spray and preparation method thereof |
| CN111166711A (en) * | 2020-03-05 | 2020-05-19 | 珠海市尼诺生物科技有限公司 | Sterilizing mouthwash |
| CN111728905A (en) * | 2020-06-02 | 2020-10-02 | 福州安得尔卫生技术开发有限公司 | Plant gargle |
| CN112694622B (en) * | 2020-12-29 | 2022-11-29 | 山东鲁台农业科技有限公司 | Temperature-sensitive aloe arborescens-chitosan-poly (N-isopropylacrylamide) gel |
| CN114652647A (en) * | 2022-02-14 | 2022-06-24 | 西安医学院 | Mouthwash for preventing decayed teeth and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297735A (en) * | 1999-12-02 | 2001-06-06 | 马贵龄 | Aloe toothpaste |
| CN100408024C (en) * | 2006-03-10 | 2008-08-06 | 贵州宏宇药业有限公司 | Oral cavity cleaning bacteriostat and its preparing process |
| CN101249056B (en) * | 2008-01-11 | 2011-06-29 | 美晨集团股份有限公司 | Anti-inflammation gargle water and method of preparing the same |
| AU2011308857B2 (en) * | 2010-10-01 | 2015-11-05 | The Procter & Gamble Company | Oral care compositions with improved flavor |
| CN104693314B (en) * | 2015-03-16 | 2017-03-22 | 云南万绿生物股份有限公司 | Processing method for 2000: 1 aloe gel dry powder |
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