CN105213216B - A kind of natural disaccharide antibacterial shield tooth gargle and preparation method thereof - Google Patents
A kind of natural disaccharide antibacterial shield tooth gargle and preparation method thereof Download PDFInfo
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- CN105213216B CN105213216B CN201510732243.9A CN201510732243A CN105213216B CN 105213216 B CN105213216 B CN 105213216B CN 201510732243 A CN201510732243 A CN 201510732243A CN 105213216 B CN105213216 B CN 105213216B
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- gargle
- nmf
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The invention discloses a kind of natural disaccharide antibacterial shield tooth gargle and preparation method thereof.The effective ingredient of the gargle is chitosan and flaxseed gum, and caries preventive agent is stannous fluoride and xylitol, in addition to NMF, inorganic salts, peppermint oil and purified water.Its preparation method is to take purified water, adds chitosan and flaxseed gum according to quantity, and heating makes dissolving；It is to be cooled, caries preventive agent is added, then adds NMF, inorganic salts, peppermint oil, purified water is added to full dose, product is obtained after determining pH value.The present invention has significant antibacterial shield tooth effect.This product can extend the time that oral cavity keeps moistening due to adding NMF；Mitigate patient's pain caused by dry.Preparation method of the present invention is simple, and cost is cheap, and durable antibacterial effect is effective, and human body is had no toxic side effect, comfortable taste.
Description
Technical field
The invention belongs to medical health product field, more particularly to a kind of natural disaccharide antibacterial shield tooth gargle and its preparation side
Method.
Background technology
In recent years, the incidence of disease of stomatopathy is high, with the raising of living standards of the people and health perception, oral disease
Preventing and treating and the protection of tooth are more and more important, traditional oral care means for being brushed teeth using toothpaste exist in-convenience in use, clearly
Reason not in time, not thoroughly, to tooth have abrasion etc. drawback, it is difficult to meet the oral cleaning requirement of people.
Mouth disease is a kind of common disease, is mainly shown as gingivitis, bacterial plaque, canker sore, periodontitis, dispute life
The symptoms such as sore, halitosis.After harmful bacteria enters blood caused by mouth disease, different degrees of shadow can be produced to whole body health
Ring, or even the Important cause of disease as some general diseases.Modern medicine study shows, mouth disease and internal system, painstaking effort
Guard system and respiratory system etc. have close relationship.People also already prevent oral cavity disease by various oral care products
The generation of disease.At present, the major product in terms of detergents and cosmetic oral care can be divided into toothpaste, gargle and flavorants,
These products mainly play cleaning tooth, tooth-whitening, remove dental plaque, kill oral cavity harmful bacteria, pre- anti-caries, fresh breath etc.
Effect, while the treatment to some mouth diseases such as such as various focusing depths representeds also functions to certain positive role.Also some other is such as
The chewing gum of foodstuff, edible implication cleaning sheet etc. also have more or less prevention effect.
Gargle is generally seated in portable Packaging Bottle, can entered at any time as a kind of emerging oral cavity cleaning and nursing product
Exercise and use, thoroughly overcome oral care not in time, toothpaste in-convenience in use, the cleaning drawback such as not thorough, it cleans oral cavity, pre-
The effect such as anti-caries and periodontitis is significantly stronger than conventional toothpaste, and then very popular in recent years.It is made in the present invention
Before, the product such as existing water soluble chitosan gargle, Tea Polyphenols gargle clinically uses, but because of itself fungistatic effect list
One, it is higher to concentration requirement, or need to be acted synergistically with high concentration ethanol and get to fungistatic effect, so that narrow antimicrobial spectrum, is used
Effect is poor, and mouthfeel is bad, the reasons such as patient is difficult to receive, and causes to be difficult to popularization and application.Chinese patent CN102274150 is public
A kind of gargle using chitosan and extractive of flax seed for active ingredient has been opened, using extractive of flax seed retentiveness by force
Feature, the mouthfeel of gargle is improved, the time that oral cavity keeps moistening can be extended, but the technical scheme can not be fully solved mouth
Chamber antibacterial and shield tooth two large problems.Therefore, it is good there is an urgent need to a kind of retentiveness, can broad-spectrum antiseptic, durable antibacterial effect has
Imitate and have protective effect to tooth, while also human body is had no toxic side effect, the gargle of comfortable taste.
Stannous fluoride is professional composition of the dentist in clinical long-term use, is food and medicine Surveillance Authority of the U.S. (FDA)
The composition that can effectively mitigate gingivitis of accreditation.It has extensive suppression to various types of bacteriums, particularly Periodontal Pathogens
Effect, and can last for hours.By suppressing the generation of bacterium toxic metabolic products (such as hydrogen sulfide), stannous fluoride is to gum
Inflammatory reaction also has certain antagonism.But stannous fluoride is a kind of extremely unstable material, soluble in water and oxygen
Change, it is stated that in the market only has Crest to spend for 15 years just successfully by stannous fluoride stable components among toothpaste.
The content of the invention
It is an object of the invention to overcome the deficiencies of the prior art and provide one kind containing natural antibacterial ingredient, without synthesis
Essence, retentiveness is good, can broad-spectrum antiseptic, durable antibacterial effect is effective, and human body is had no toxic side effect, and comfortable taste is gargled
Liquid；Meanwhile the present invention also provides a kind of preparation method of the gargle.
The present invention takes following technical scheme：A kind of natural disaccharide antimicrobial mouthwash, its effective ingredient is chitosan and Asia
Numb seed glue.To obtain more preferable effect, also include NMF, inorganic salts, peppermint oil, caries preventive agent and purifying in the gargle
Water.Its constituent mass percentage composition is：
Chitosan：0.1~1%
Flaxseed gum：0.1~1%
Caries preventive agent：0.05~0.1%
NMF：1~10%
Inorganic salts：0.5~1.5%
Peppermint oil：0.01~0.05%
Surplus is purified water,
Wherein described caries preventive agent is stannous fluoride or the mixture of stannous fluoride and xylitol.
The preparation method of above-mentioned natural disaccharide antimicrobial mouthwash, comprises the following steps：
(1) flaxseed gum is added in dissolution kettle, with water-swellable 8~24 hours of purifying, then added into dissolution kettle
Chitosan, insulating box is opened, the stirring at low speed 0.5~1 hour in the case where temperature is T=60~70 DEG C, until chitosan and linseed
Glue all dissolves, and filters off the removal of impurity；
(2) it is 5.0~6.5 with the pH value of acetic acid regulating step (1) resulting solution；
(3) caries preventive agent is added into step (2) resulting solution, regulation temperature is T=30~40 DEG C, continues to be stirred
It is even；
(4) NMF, inorganic salts, peppermint oil are added into step (3) resulting solution, keeping temperature is 30~40 DEG C, after
It is continuous to be uniformly mixed；
(5) obtained gargle is delivered into the next step packing, after detection meets product standard, packed, made
Into finished product.
Further, the NMF described in above-mentioned preparation method is one in sorbierite, glycerine, polyethylene glycol, propane diols
Kind is several.
Further, the inorganic salts described in above-mentioned preparation method are sodium chloride and calcium chloride mixture, and sodium chloride and chlorine
The mass ratio for changing calcium is 2：1.
Beneficial effects of the present invention are as follows：
1. preventing decayed tooth shield tooth effect is notable：Stannous fluoride is easily decomposed and aoxidized in water, but is but had in gluey system good
Good stand-up, this is also the reason for Crest toothpaste can successfully add stannous fluoride.It is of the invention to be found in many experiments,
Using chitosan-flaxseed gum system, chitosan can adsorb stannous ion, and flaxseed gum is combined into hydration with large quantity of moisture
Thing, reduce the chance that stannous fluoride directly reacts with hydrone, stannous ion can be effectively retained, to avoid other
Component has an impact to stannous fluoride, and the present invention is final to determine that chitosan-flaxseed gum solution is first made, and adjusts pH value and be
5.0~6.5, the caries preventive agent containing stannous fluoride is then added under the conditions of 30~40 DEG C of lower temperature, due to substantial amounts of moisture
Son combines to form hydration material with flaxseed gum, and stannous fluoride is combined with chitosan, therefore reduces stannous fluoride
Decomposition and oxidation, in the final product retain 80-100ppm stannous ion play preventing decayed tooth shield tooth effect.
2. natural component, broad-spectrum antiseptic：The chitosan and flaxseed gum of the present invention belongs to natural antimicrobial substance, and raw material is wide
General, structure is clear and definite, and cost is cheap, and chitosan and flaxseed gum have Synergistic antimicrobial effect, relative to other single chitosans
Class gargle has excellent fungistatic effect.
3. comfortable taste：The present invention can extend the time that oral cavity keeps moistening due to adding NMF；Mitigate patient because
Pain caused by mouthfeel.
It is 4. safe and effective：Preparation method of the present invention is simple, and antibacterial shield tooth effect is persistently effective, and human body is had no toxic side effect,
Comfortable taste.
Embodiment
Below by way of specific embodiment further illustrate technical scheme, but technical scheme not with
Embodiment is limited.
Embodiment 1：
A kind of preparation method of natural disaccharide antibacterial shield tooth gargle, comprises the following steps：
(1) 0.5% flaxseed gum is added in dissolution kettle, with purifying water-swellable 8~24 hours, then to dissolution kettle
The chitosan of middle addition 0.5%, opens insulating box, the stirring at low speed 0.5~1 hour in the case where temperature is T=60~70 DEG C, until shell
Glycan and flaxseed gum all dissolve, and filter off the removal of impurity；
(2) it is 5.0~6.5 with the pH value of acetic acid regulating step (1) resulting solution；
(3) 0.1% stannous fluoride is added into step (2) resulting solution, regulation temperature is T=30~40 DEG C, is continued
It is uniformly mixed；
(4) into step (3) resulting solution add 5% sorbierite, 0.5% sodium chloride/calcium chloride, 0.01% it is thin
Lotus oil, keeping temperature are 30~40 DEG C, continue to be uniformly mixed；
(5) by obtained gargle deliver to the next step packing, detect product in stannous ion content be 80~
100ppm, after meeting product standard, packed, finished product is made.
Embodiment 2：
A kind of preparation method of natural disaccharide antibacterial shield tooth gargle, comprises the following steps：
(1) 0.5% flaxseed gum is added in dissolution kettle, with purifying water-swellable 8~24 hours, then to dissolution kettle
The chitosan of middle addition 1%, opens insulating box, the stirring at low speed 0.5~1 hour in the case where temperature is T=60~70 DEG C, until shell gathers
Sugar and flaxseed gum all dissolve, and filter off the removal of impurity；
(2) it is 5.0~6.5 with the pH value of acetic acid regulating step (1) resulting solution；
(3) 0.05% stannous fluoride and 0.05% xylitol is added into step (2) resulting solution, regulation temperature is
T=30~40 DEG C, continue to be uniformly mixed；
(4) into step (3) resulting solution add 5% sorbierite, 0.5% sodium chloride/calcium chloride, 0.01% it is thin
Lotus oil, keeping temperature are 30~40 DEG C, continue to be uniformly mixed；
(5) by obtained gargle deliver to the next step packing, detect product in stannous ion content be 80~
100ppm, after meeting product standard, packed, finished product is made.
Clinical test results show：Embodiment product can significantly reduce the bacterial population in oral cavity during Clinical practice,
Suppress the growth of bacterium, reduce calcareous dissolution in tooth, reduce carious tooth incidence.The natural disaccharide antibacterial shield tooth of the present invention is gargled
Liquid energy quickly kills the pathogenic bacteria for causing periodontitis, gingivitis, canker sore, bacterial plaque, dental hemorrhage, halitosis, protects firming tooth, peace
It is Atoxic, non-stimulated, have no side effect, do not develop immunity to drugs, be novel mouth sterilization, sterilizing clean-keeping articles for use.
A kind of natural disaccharide antibacterial shield tooth gargle provided by the present invention and preparation method thereof has been carried out in detail above
Introduce.The principle and embodiment of the present invention are set forth herein by embodiment, it is described above to be only intended to
Help to understand method and its core concept of the invention.It should be pointed out that for those skilled in the art,
Without departing from the principles of the invention, some improvement and modification can also be carried out to the present invention, these are improved and modification also falls
Enter in the protection domain of the claims in the present invention.
Claims (2)
1. a kind of natural disaccharide antibacterial shield tooth gargle, its constituent mass percentage composition are：
Chitosan：0.1~1%
Flaxseed gum：0.1~1%
Caries preventive agent：0.05~0.1%
NMF：1~10%
Inorganic salts：0.5~1.5%
Peppermint oil：0.01~0.05%
Surplus is purified water,
Its preparation method comprises the following steps：
(1) flaxseed gum is added in dissolution kettle, with water-swellable 8~24 hours of purifying, shell is then added into dissolution kettle and is gathered
Sugar, insulating box is opened, the stirring at low speed 0.5~1 hour in the case where temperature is T=60~70 DEG C, until chitosan and flaxseed gum are complete
Portion dissolves, and filters off the removal of impurity；
(2) it is 5.0~6.5 with the pH value of acetic acid regulating step (1) resulting solution；
(3) caries preventive agent is added into step (2) resulting solution, regulation temperature is T=30~40 DEG C, continues to be uniformly mixed；
(4) NMF, inorganic salts, peppermint oil are added into step (3) resulting solution, keeping temperature is 30~40 DEG C, continues to stir
Mix well mixed；
(5) obtained gargle is delivered into the next step packing, after detection meets product standard, is packed, be made into
Product；
Characterized in that, the caries preventive agent is stannous fluoride or the mixture of stannous fluoride and xylitol, the inorganic salts are chlorine
Change the mixture of sodium and calcium chloride, and the mass ratio of sodium chloride and calcium chloride is 2：1.
2. natural disaccharide antibacterial shield tooth gargle according to claim 1, it is characterised in that the NMF is sorbierite, sweet
One or more in oil, polyethylene glycol, propane diols.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510732243.9A CN105213216B (en) | 2015-11-02 | 2015-11-02 | A kind of natural disaccharide antibacterial shield tooth gargle and preparation method thereof |
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| CN201510732243.9A CN105213216B (en) | 2015-11-02 | 2015-11-02 | A kind of natural disaccharide antibacterial shield tooth gargle and preparation method thereof |
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| CN105213216B true CN105213216B (en) | 2017-12-08 |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074192B (en) * | 2016-07-01 | 2019-08-06 | 好来化工(中山)有限公司 | Oxidation resistant oral care composition |
| CN115844765A (en) * | 2022-11-25 | 2023-03-28 | 重庆医科大学附属口腔医院 | Antibacterial and anti-caries oral care composition and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1034130A (en) * | 1988-07-23 | 1989-07-26 | 吴海元 | Child's preventing decayed tooth health gargle and method for making |
| CN102274150A (en) * | 2011-08-12 | 2011-12-14 | 山东赛克赛斯药业科技有限公司 | Gargle for relieving thirsty symptom and preparation method thereof |
| CN102512345A (en) * | 2011-12-28 | 2012-06-27 | 美晨集团股份有限公司 | Natural antibacterial gargle and preparation method thereof |
| CN104434699A (en) * | 2014-12-18 | 2015-03-25 | 东莞市阿比亚能源科技有限公司 | Tooth washing liquid |
-
2015
- 2015-11-02 CN CN201510732243.9A patent/CN105213216B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1034130A (en) * | 1988-07-23 | 1989-07-26 | 吴海元 | Child's preventing decayed tooth health gargle and method for making |
| CN102274150A (en) * | 2011-08-12 | 2011-12-14 | 山东赛克赛斯药业科技有限公司 | Gargle for relieving thirsty symptom and preparation method thereof |
| CN102512345A (en) * | 2011-12-28 | 2012-06-27 | 美晨集团股份有限公司 | Natural antibacterial gargle and preparation method thereof |
| CN104434699A (en) * | 2014-12-18 | 2015-03-25 | 东莞市阿比亚能源科技有限公司 | Tooth washing liquid |
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| CN105213216A (en) | 2016-01-06 |
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