CN107715211A - A kind of plasma exchange loading photochemical virus inactivation device and its application apparatus - Google Patents
A kind of plasma exchange loading photochemical virus inactivation device and its application apparatus Download PDFInfo
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- 241001597008 Nomeidae Species 0.000 claims abstract description 112
- 210000004369 blood Anatomy 0.000 claims abstract description 64
- 239000008280 blood Substances 0.000 claims abstract description 64
- 239000012530 fluid Substances 0.000 claims abstract description 47
- 238000001802 infusion Methods 0.000 claims abstract description 41
- 210000004027 cell Anatomy 0.000 claims abstract description 15
- 238000005286 illumination Methods 0.000 claims description 22
- 229910001220 stainless steel Inorganic materials 0.000 claims description 21
- 239000010935 stainless steel Substances 0.000 claims description 21
- 230000002572 peristaltic effect Effects 0.000 claims description 16
- 239000003795 chemical substances by application Substances 0.000 claims description 9
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- 102000008100 Human Serum Albumin Human genes 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3601—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3643—Priming, rinsing before or after use
- A61M1/3644—Mode of operation
- A61M1/3646—Expelling the residual body fluid after use, e.g. back to the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3687—Chemical treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3692—Washing or rinsing blood or blood constituents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0415—Plasma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/15—Detection of leaks
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- External Artificial Organs (AREA)
Abstract
The present invention provides a kind of plasma exchange loading photochemical virus inactivation device and its application apparatus, including：Derivant mixed cell, the blood plasma in spite of illness for plasma exchange pattern to be filtered out are mixed with derivant, and the mixed blood plasma with derivant is sent into photoinactivation unit；Photoinactivation unit, for being irradiated to the blood plasma with derivant, inactivation of virus is completed, and the blood plasma after inactivation is sent into derivant removal unit；Derivant removal unit, for the derivant remained in the blood plasma after inactivation to be filtered out, remove the blood plasma after derivant and be used for fluid infusion.Membrane plasma separation method and photoinactivation method are combined by the present invention first, can make blood continual carry out blood-plasma virus killing in cyclic process in vitro.
Description
Technical field
The present invention relates to the blood cleaning equipment of technical field of medical instruments, in particular it relates to a kind of plasma exchange (PE)
Load the device and its application apparatus of photoinactivation.
Background technology
Blood purification is outside the blood lead body by patient, removes some of which morbid substance, and purification blood is controlled with reaching
Treat the purpose of disease.Plasma exchange PE is a kind of pattern of blood purification, and the blood of patient is passed through transducer potector lead body by it
Outside, the blood plasma of patient is separated from whole blood by membrane plasma separation method and discarded, then supplement the fresh cold of equivalent
Freeze the fluid infusion such as blood plasma or human serum albumin, so can to remove the various metabolic toxicities and virulence factor of patient's body, so as to
Reach therapeutic purposes.Plasma exchange PE can not only remove in vivo in, the metabolic toxicities of small molecule, also remove albumen, immune
The macromolecular substances such as compound, thus it is all good more than haemodialysis, blood filtering, blood perfusion to the clearance rate of harmful substance.
Supplement the necessary materials such as the albumin lacked in vivo, clotting factor again simultaneously, preferably instead of some functions of liver.Light
Chemical inactivation of virus is to be destroyed the structure of virus protein by chemical means, allows virus that may be present in blood plasma to lose
Infection, pathogenic and fertility.Shanghai Blood Center is used to inactivate potential virus, guarantee blood in photoinactivation technology
It is more ripe on secure context.
In view of PE can only discard the blood plasma of patient, and photoinactivation technology can destroy viral protein structures in blood plasma
Reach the purpose for the treatment of, the present invention devises a kind of device of plasma exchange (PE) loading photoinactivation.
Through retrieval, Publication No. CN104399135A Chinese invention patent application, the patent provides one kind to be used for blood
The processing unit of inactivation of virus is starched, but the method that the patent isolates blood plasma in blood is centrifugal plasma partition method, i.e.,
By supercentrifuge, blood plasma is separated from blood.Therefore the stability requirement to equipment is high, the weight weight of equipment,
Volume is big, is unfavorable for the movement of equipment.
The content of the invention
For in the prior art the defects of, it is an object of the invention to provide a kind of plasma exchange load photoinactivation
Device and its application apparatus, membrane plasma separation method and photoinactivation method are combined first, blood can be made in vitro
Continual carry out blood-plasma virus killing in cyclic process.
To achieve the above object, the present invention uses following technical scheme：
According to the first object of the present invention, there is provided a kind of plasma exchange loads photochemical virus inactivation device, including：
Derivant mixed cell, the blood plasma in spite of illness for plasma exchange pattern to be filtered out mix with derivant, and after mixing
Blood plasma with derivant be sent into photoinactivation unit；
Photoinactivation unit, for being irradiated to the blood plasma with derivant, inactivation of virus is completed, and
Blood plasma after inactivation is sent into derivant removal unit so that photoinactivation goes out for the continual photochemical virus of dynamic
It is living；
Derivant removal unit, for the derivant remained in the blood plasma after inactivation to be filtered out, after removing derivant
Blood plasma is used for fluid infusion.
Preferably, the derivant mixed cell, including blood plasma pump, derivant pump and stainless steel, the blood plasma pump, institute
State derivant pump and be all connected with the stainless steel, wherein the blood plasma in spite of illness that the blood plasma pump filters out plasma exchange pattern is pumped into institute
The input of stainless steel is stated, the derivant pump is used for the input that derivant is pumped into the stainless steel, the mixing
The output end of container connects the photoinactivation unit, and the blood plasma that derivant is carried after mixing is inputted into the photochemistry
Inactivation of virus unit.
It is highly preferred that the blood plasma pump and the derivant pump, wherein by blood plasma and derivant by setting ratio, flow pump
Enter the stainless steel.
It is further preferred that the blood plasma pump and the derivant pump are peristaltic pump, its range of flow is 0-200ml/
Min, when inputting the stainless steel, the input speed of derivant is the 1% of blood plasma input speed in spite of illness.
Preferably, the photoinactivation unit, including blood plasma containing component and illumination part, the blood plasma accommodate
Part connects the output end from the derivant mixed cell, and the blood plasma with derivant is in the blood plasma containing component
Flowing, while flowing, the illumination part is irradiated to the blood plasma with derivant, realizes that photochemical virus goes out
It is living.
It is highly preferred that the blood plasma containing component is a blood plasma plate, the blood plasma plate is provided with plasma inlet and plasma outlet port,
The plasma inlet connects the derivant mixed cell, and the plasma outlet port connects the derivant removal unit, the blood
Starch between entrance and plasma outlet port as the pipeline for plasma flow.
It is highly preferred that the illumination part includes lighting box, light source, the light source is arranged in the lighting box, described
Light source is located at the both sides of the blood plasma containing component.
It is further preferred that the light source is illumination lamp plate, the illumination lamp plate is divided into two pieces up and down, and centre is provided with institute
The mouth that is included in of blood plasma plate is stated, the distance of both sides to the illumination lamp plate of the blood plasma plate is equal.
Preferably, the derivant removal unit further connects fluid replacing unit, and the fluid replacing unit will remove derivant
Blood plasma afterwards inputs human body after venous chambers.
Preferably, described device further comprises that blood plasma filters unit, and the unit is separated blood samples of patients, filters out band
Sick blood plasma, and blood plasma is sent into the derivant mixed cell in spite of illness by this.
According to the second object of the present invention, there is provided a kind of application apparatus for including said apparatus, the equipment are integrated
Design.Specifically, the equipment includes：
Apparatus body, main body of the apparatus body as carrying miscellaneous part；
The photoinactivation unit of the apparatus body side is arranged at, for being irradiated to blood plasma, completes disease
Poison inactivation；
Arteriovenous kettle support member, blood plasma pass filter support member, fluid infusion and the induction being arranged on the apparatus body
Agent container support member, it is respectively used to place arteriovenous kettle, blood plasma pass filter, fluid infusion and induction agent container；The blood plasma filtration
Device position is less than the arteriovenous kettle, and the arteriovenous kettle position is less than the fluid infusion and induction agent container；
The master controller being arranged on the apparatus body, the master controller are arranged on the top of the apparatus body；
For controlling the rotating speed of all pumps, sensor signal is received, starts illumination and realizes the control of whole system；
The leakage blood detection part being arranged on the apparatus body, the leakage blood detection part are located at the photochemical virus
Inactivate near unit；And
It is arranged at multiple peristaltic pumps on the apparatus body.
Preferably, the apparatus body side is provided with metering module, and the metering module is arranged on the photochemical virus
Inactivate the lower section of unit.
Preferably, the apparatus body is provided with side door and side door attracting device, and the photochemistry is accommodated in the side door
Inactivation of virus unit, the metering module, the leakage blood detection part, and the side door is closed by the side door attracting device
Close.
Compared with prior art, the present invention has following beneficial effect：
The present invention is that blood plasma is separated from whole blood the blood of patient to by membrane plasma separation method, by compacted
Dynamic pump and Membrane Plasma Separator can be achieved, and the requirement for equipment just substantially reduces.
Processing of the present invention for blood plasma is dynamic, and the blood of patient is continuously extracted into membrane type blood plasma by peristaltic pump
Separator isolates blood plasma, and blood plasma is continuously inactivated into area of illumination.
The present invention uses LED, is more concentrated stably compared to fluorescent lamp LED frequency of light wave, light decay performance is smaller.And mesh
Preceding product on the market is only that the band virus blood plasma that will be separated is discarded and do not processed, or blood plasma is taken out individually with special
Equipment carries out processing recycling, and the present invention is combined with membrane plasma separation method and the design of photoinactivation method
Device, can be achieved to filter out the uninterrupted process of blood plasma and plasma treatment, substantially increase treatment effeciency, and cost reduces.
Brief description of the drawings
The detailed description made by reading with reference to the following drawings to non-limiting example, further feature of the invention,
Objects and advantages will become more apparent upon：
Fig. 1 is existing plasma exchange pattern schematic diagram；
In Fig. 1：Blood sampling pressure monitoring 101, anticoagulant pump 102, blood peristaltic pump 103, artery kettle 104, membrane separator
105th, venous chambers 106, bubble detector 107, leakage blood detector 108, folder valve 109, human body 110, blood plasma pressure monitoring 111, blood
Slurry outlet leakage blood detector 112, warmer 113, blood plasma pump 114, fluid infusion pump 115, plasma bags 116, fluid infusion bag 117, fluid infusion gas
Steep detector 118, metering module 119；
Fig. 2 is the schematic diagram that plasma exchange loads photochemical virus inactivation device in preferred embodiment of the present invention；
In Fig. 2：Take a blood sample pressure monitoring 201, anticoagulant pump 202, peristaltic pump 203, artery kettle 204, membrane separator 205,
Venous chambers 206, bubble detector 207, leakage blood detector 208, folder valve 209, human body 210, blood plasma pressure monitoring 211, leakage blood examination
Know device 212, warmer 213, blood plasma pump 214, fluid infusion pump 215, plasma bags 216, fluid infusion bag 217, fluid infusion bubble detector 218,
Metering module 219, derivant bag 220, derivant pump 221, blood plasma derivant mixed bag 222, key light source plate 223, blood plasma plate
224th, secondary light source plate 225, derivant remove 226；
Fig. 3 is illumination part-structure schematic diagram in one embodiment of the invention；
In Fig. 3：Lighting box bottom plate 41, lighting box side blood plasma plate Inlet cover plate 42, blood plasma plate 43, illumination lamp plate 44, light
According to case side panel 45, lighting box front panel 46；
Fig. 4 is blood plasma plate scheme of installation in one embodiment of the invention；
In Fig. 4：Blood plasma plate 43, illumination lamp plate 44；
Fig. 5 is blood plasma plate structure schematic diagram in one embodiment of the invention；
In Fig. 5：Plasma inlet 51, plasma outlet port 52；
Fig. 6 is the structural representation that plasma exchange loads photochemical virus inactivation device in one embodiment of the invention；
In Fig. 6：Universal wheel 1, exhausted bath box 2, cabinet 3, membrane separator support 4, main folder valve protection cover 5, anticoagulant pump 6,
Press from both sides valve 7, arteriovenous kettle support 8, pressure monitoring mouth 9, peristaltic pump 10, master controller 11, fluid infusion and derivant bag bracket 12, blood plasma
Pump 13, derivant pump 14, fluid infusion pump 15, handle 16, side door 17, photoinactivation unit 18, blood leakage detector 19, folder valve
20th, side door attracting device 21, metering module 22.
Embodiment
With reference to specific embodiment, the present invention is described in detail.Following examples will be helpful to the technology of this area
Personnel further understand the present invention, but the invention is not limited in any way.It should be pointed out that the ordinary skill to this area
For personnel, without departing from the inventive concept of the premise, various modifications and improvements can be made.These belong to the present invention
Protection domain.
As shown in figure 1, existing plasma exchange pattern schematic diagram, wherein：Peristaltic pump 103 draws blood from human body artery, leads to
The pressure of monitoring blood sampling in real time of blood sampling pressure monitoring mouth 101 is crossed, anticoagulant pump 102, which is pumped into anti-coagulants, prevents blood clotting, and blood leads to
Enter artery kettle 104 after crossing 103 and monitor angiosthenia, entered by blood after artery kettle from the upper end of membrane separator 105, film
First delivery outlet of formula separator 105 enters blood plasma kettle 111 and monitors blood plasma pressure, and blood plasma pump 114 is by the blood plasma in spite of illness of patient from film
Second delivery outlet of formula separator 105 detected whether to introduce plasma bags 116 after piping failure by leaking blood detector 112, together
When another branch into the balanced flow of metering module 119.Fluid infusion pump 115 is by the fresh frozen plasma of equivalent or the white egg of people's blood simultaneously
The branch of fluid infusion bag 117 1 such as white flows through bubble detector 118 after warmer 113 is warmed to human body normal temperature and has detected whether gas
The lower end of membrane separator 105 is introduced after bubble with the defeated the Huis' body of the blood for having filtered off blood plasma in spite of illness, it is another to branch into
The real time measure of metering module 119, for balanced flow；The blood for filtering off blood plasma in spite of illness is supervised into venous chambers 106 together with fluid infusion
The detection bubble of bubble detector 107 is flowed into after survey vein pressure and whether the detection pipeline of leakage blood detector 108 is damaged, subsequently enters folder
Valve 109, the effect of folder valve 109 are to open or blind off a line, if bubble detector or leakage blood detector 112 detect abnormal feelings
Condition, folder valve are closed, and are avoided abnormal blood from flowing into human body and are produced malpractice.Blood and fluid infusion reach treatment after flowing back to human body
Purpose.
As shown in Fig. 2 plasma exchange loads the schematic diagram of photochemical virus inactivation device in preferred embodiment of the present invention, its
Include derivant mixed cell, photoinactivation unit and derivant removal unit, blood plasma containing component and illumination
Part forms photoinactivation unit, for being irradiated to the blood plasma with derivant, completes inactivation of virus, and
Blood plasma after inactivation is sent into derivant removal unit.Specifically：
The blood plasma containing component connects the output end from the derivant mixed cell, the blood plasma with derivant
Flowed in the blood plasma containing component, while flowing, the illumination part is carried out to the blood plasma with derivant
Irradiation, realizes photoinactivation.
The derivant removal unit, is connected with photoinactivation unit, for will be residual in the blood plasma after inactivation
The derivant stayed filters out, and removes the blood plasma after derivant and is used for fluid infusion.
In the preferred embodiment of part, the derivant removal unit further connects fluid replacing unit, the fluid replacing unit
Blood plasma after removal derivant is inputted into human body after venous chambers.It is of course also possible to it is arranged as required to fluid infusion situation.
In the preferred embodiment of part, described device further comprises that blood plasma filters unit, and the unit enters blood samples of patients
Row separation, blood plasma in spite of illness is filtered out, and blood plasma is sent into the derivant mixed cell in spite of illness by this.
In the derivant mixed cell：The blood plasma pump 214, the derivant pump 221 are all connected with the stainless steel
222, wherein the blood plasma in spite of illness that the blood plasma pump 214 filters out plasma exchange pattern is pumped into the input of the stainless steel 222,
The derivant pump 221 is used for the input that derivant is pumped into the stainless steel 222, the output of the stainless steel 222
End connects the photoinactivation unit, and the blood plasma that derivant is carried after mixing is inputted into the photoinactivation list
Member.
Shown in reference picture 2, it is same as in figure 1 to filter out the process of blood plasma, is no longer described in detail, and difference is that blood plasma pump 214 will be filtered
The blood plasma gone out is pumped into plasma bags 216, the derivant in derivant bag 220 is pumped out to stainless steel 222 and blood by derivant pump 221
Slurry mixing, the blood plasma plate 224 that the mixed blood plasma with derivant is sent into photoinactivation unit, blood plasma plate 224
Both sides key light source plate 223 and fill-in light source plate 225 are housed, the mixed blood plasma with derivant is in photoinactivation
Carry out flowing into after photoinactivation in unit derivant removal device 226 will residual derivant remove after with fluid infusion together flow back to people
Body completes therapeutic process.
Blood plasma pump 214 of the present invention and the derivant pump 221, can be by blood plasma and derivant by setting ratio, stream
Speed is pumped into the stainless steel 222.For example in a preferred embodiment, the blood plasma pump 214 and the derivant pump 221 are
Peristaltic pump, its range of flow are 0-200ml/min, and when inputting the stainless steel 222, the input speed of derivant is in spite of illness
The 1% of blood plasma input speed.Experiment shows, while the blood plasma and derivant hybrid energy of this ratio reach the effect of inactivation preferably
The derivant of residual is minimum.
As shown in Figure 3-4, in some embodiments：
The blood plasma containing component is a blood plasma plate 224；
The illumination part includes lighting box, light source, and the light source is arranged in the lighting box, and the light source is located at institute
State the both sides of blood plasma containing component；
The light source is LED light illuminator, and the illumination lamp plate is divided into two pieces up and down, and centre is provided with being included in for the blood plasma plate
Mouthful, the distance of both sides to the illumination lamp plate of the blood plasma plate is equal.
As shown in Figure 3-4, lighting box includes：Lighting box bottom plate 41, lighting box side blood plasma plate Inlet cover plate 42, blood plasma plate
43rd, illumination lamp plate 44, lighting box side panel 45, according to case front panel 46.
As shown in figure 5, the blood plasma plate 224 is provided with plasma inlet 51 and plasma outlet port 52, the plasma inlet 51 connects
The derivant mixed cell, the plasma outlet port 52 connect the derivant removal unit, and the plasma inlet and blood plasma go out
It is the pipeline for plasma flow between mouthful.The pipeline can use various shapes, be the bent of ordered arrangement described in Fig. 5
Shape, wherein thering is multiple straight tubes and multiple bend pipes to form.
In some embodiments, blood plasma plate 224 is put into the centre of two blocks of fluorescent tube plates, and apart from the distance of every piece of fluorescent tube lower end
For 3mm.Certainly, it can also be in other embodiments other distances.
In some embodiments, the gross thickness of blood plasma plate 224 is 5mm, and centre is provided with the part of hollow out, and the part of hollow out is used for
The flowing of blood plasma, its thickness are 1mm.Certainly, it can also be in other embodiments other thickness.
Based on the preferred embodiment of the present invention described in above-mentioned Fig. 2, its overall process is different from shown in Fig. 1, wherein：Wriggle
Pump 203 draws blood from human body, by artery kettle and monitors angiosthenia, and blood enters from the upper end of blood plasma filtration unit, blood plasma
The blood plasma in spite of illness that displacement patternses filter out does not discard directly, by the different flow velocity of blood plasma pump 214 and derivant pump 221 by blood plasma and
Derivant is added in stainless steel in proportion, then the blood plasma that derivant is carried in stainless steel 222 is pumped into blood plasma containing component,
And illumination part is irradiated to it and completes viral inactivation steps, there is residual derivant in the blood plasma after irradiation, because
The blood plasma that this blood plasma containing component comes out will also enter derivant removal unit and filter out the derivant of residual, remaining blood plasma with
Enter venous chambers with fluid infusion, detect its vein pressure, finally return that human body, complete whole PE loadings photoinactivation
Therapeutic process.
As shown in fig. 6, the embodiment of a concrete application equipment for said apparatus of the present invention, the equipment are integrated
Design, the equipment include：
Apparatus body, main body of the apparatus body as carrying miscellaneous part；
The photoinactivation unit of the apparatus body side is arranged at, for being irradiated to blood plasma, completes disease
Poison inactivation；
Arteriovenous kettle support member, blood plasma pass filter support member, fluid infusion and the induction being arranged on the apparatus body
Agent container support member, it is respectively used to place arteriovenous kettle, blood plasma pass filter, fluid infusion and induction agent container；The blood plasma filtration
Device position is less than the arteriovenous kettle, and the arteriovenous kettle position is less than the fluid infusion and induction agent container；The arteriovenous kettle
The blood plasma pass filter branch that support member, blood plasma pass filter support member, fluid infusion and derivant container support part correspond in Fig. 6
Frame 4, arteriovenous kettle support 8, fluid infusion and derivant bag bracket 12；
The master controller 11 being arranged on the apparatus body, the master controller 11 are arranged on the upper of the apparatus body
Portion；The rotating speed of all pumps (anticoagulant pump 6, peristaltic pump 10, blood plasma pump 13, derivant pump 14, fluid infusion pump 15) is controlled, receives sensing
Device (blood leakage detector 19 etc.) signal, start illumination program and realize the control of whole system；
The leakage blood detection part i.e. blood leakage detector 19 being arranged on the apparatus body, the leakage blood detection part are located at
Near the photoinactivation unit；And
It is arranged at multiple peristaltic pumps 10 on the apparatus body.
In Fig. 6：Peristaltic pump 10 is prevented outside blood of human body lead body, anti-coagulants is pumped into external blood by anticoagulant pump 6
Hemostatic Oral Liquid solidifies, and blood plasma pump 13 draws the blood plasma in spite of illness filtered out, and fluid infusion pump 15 is by fresh blood plasma or other nutritional ingredient pumps
Enter blood.
On the basis of above-described embodiment, the apparatus body bottom is provided with universal wheel 1, facilitates the movement of integration apparatus.
On the basis of above-described embodiment, the apparatus body bottom is provided with exhausted bath box 2, and the exhausted bath box is positioned at described universal
Between wheel 1.
On the basis of above-described embodiment, the apparatus body bottom is provided with cabinet 3, and the cabinet 3 is located at the universal wheel 1
Top.
On the basis of above-described embodiment, the middle part of the apparatus body is provided with main folder valve protection cover 5, anticoagulant pump 6, folder valve
7th, arteriovenous kettle support 8, pressure monitoring mouth 9.Main folder valve protection cover 5 includes main folder valve, bubble detector and leakage blood detector 19,
Wherein main folder valve is used to cut-off pipeline, and bubble detector 19 detects whether have bubble in blood, and leakage blood detector 19 detects pipeline
It is whether damaged；The effect of anticoagulant pump 6 is that anti-coagulants is pumped into external blood to prevent blood clotting；Folder valve 7, which plays, cut-offs pipeline
Effect；Arteriovenous kettle support 8 is used to place artery and vein kettle；Pressure monitoring mouth 9 is used for the pressure for measuring pipeline.
The side of the apparatus body is additionally provided with folder valve 20, and the folder valve 20 is close to the photoinactivation unit, folder
Valve 20 is used to turn off blood plasma road pipeline when leaking blood detector 19 and detecting pipeline breakage, has avoided contact with the blood plasma of air again
Utilize.
On the basis of above-described embodiment, the top of the apparatus body is provided with peristaltic pump 10, master controller 11, fluid infusion and lured
Agent bag bracket 12, blood plasma pump 13, derivant pump 14, fluid infusion pump 15, handle 16 are led, peristaltic pump 10 draws blood from human body artery
Go out, master controller 11 controls the rotating speed of all pumps, receives sensor signal, starts illumination program and realizes the control of whole system
System, fluid infusion and derivant pan straddle 12 are used to hang fluid infusion bag and derivant bag, and blood plasma pump 13 is used to draw the blood plasma filtered out,
Derivant pump 14 is used to derivant being pumped into stainless steel, and fluid infusion pump 15 is used to fluid infusion being pumped into human body, and handle 16 is machine
Handrail, for equipment move.
On the basis of above-described embodiment, the apparatus body side is provided with metering module 22, and the metering module 22 is set
In the lower section of the photoinactivation unit 18.Metering module 22 is mainly to measure blood plasma and the fluid infusion that blood plasma pump pumps out
Weight, data are used for the calculating and adjustment of flow equilibrium, and the blood plasma for ensureing to filter out and the fluid infusion being pumped into are set according to operator
Parameter swap.
On the basis of above-described embodiment, the apparatus body is provided with side door 17 and side door attracting device 21, the side door
The photoinactivation unit 18, the metering module 22, blood leakage detector 19 are accommodated in 17, and the side door passes through
The side door attracting device 21 is closed.
The present invention is combined with the device of membrane plasma separation method and the design of photoinactivation method, by patient's
Blood separates blood plasma by membrane plasma separation method from whole blood, passes through peristaltic pump and Membrane Plasma Separator
Realize, the requirement for equipment just substantially reduces.
Dynamic processing mode is used in the present invention, the blood of patient is continuously extracted into membrane type blood plasma point by peristaltic pump
Blood plasma is isolated from device, blood plasma is continuously inactivated into area of illumination.Further, the present invention uses LED, compared to glimmering
Light lamp LED frequency of light wave is more concentrated stably, and light decay performance is smaller.
The application apparatus designed in the present invention, membrane plasma separation method and photoinactivation method are combined first,
Using integrated design, it is moved easily.
The above-mentioned preferred structure for the present invention elaborates, but the invention is not limited in above-mentioned specific implementation
Mode, in the case where above-mentioned preferred structure does not conflict, they individually or can be used in any combination, and this has no effect on the present invention
Substantive content.
In foregoing description of the present invention, it is to be understood that term " on ", " under ", "front", "rear", "left", "right", " perpendicular
Directly ", the orientation of the instruction such as " level ", " top ", " bottom ", " interior ", " outer " or position relationship are based on orientation shown in the drawings or position
Relation is put, the present invention is for only for ease of and simplifies description, rather than indicates or imply that signified device or element there must be spy
Fixed orientation, with specific azimuth configuration and operation, therefore be not considered as limiting the invention.
Although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of changes, modification can be carried out to these embodiments, replace without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (10)
1. a kind of plasma exchange loads photochemical virus inactivation device, it is characterised in that including：
Derivant mixed cell, the blood plasma in spite of illness for plasma exchange pattern to be filtered out mixes with derivant, and mixed band
The blood plasma for having derivant is sent into photoinactivation unit；
Photoinactivation unit, for being irradiated to the blood plasma with derivant, inactivation of virus is completed, and will go out
Blood plasma after work is sent into derivant removal unit so that photoinactivation is the continual photoinactivation of dynamic；
Derivant removal unit, for the derivant remained in the blood plasma after inactivation to be filtered out, remove the blood plasma after derivant
For fluid infusion.
2. plasma exchange according to claim 1 loads photochemical virus inactivation device, it is characterised in that the derivant
Mixed cell, including blood plasma pump, derivant pump and stainless steel, the blood plasma pump, the derivant pump are all connected with the mixing
Container, wherein the blood plasma in spite of illness that the blood plasma pump filters out plasma exchange pattern is pumped into the input of the stainless steel, it is described
Derivant pump is used for the input that derivant is pumped into the stainless steel, and the output end connection of the stainless steel is described photochemical
Inactivation of virus unit is learned, the blood plasma that derivant is carried after mixing is inputted into the photoinactivation unit.
3. plasma exchange according to claim 2 loads photochemical virus inactivation device, it is characterised in that the blood plasma pump
With the derivant pump, wherein blood plasma and derivant are pumped into the stainless steel by setting ratio, flow velocity.
4. plasma exchange according to claim 1 loads photochemical virus inactivation device, it is characterised in that the photochemistry
Inactivation of virus unit, including blood plasma containing component and illumination part, the blood plasma containing component connection mix from the derivant
The output end of unit, the blood plasma with derivant flow in the blood plasma containing component, while flowing, the light
The blood plasma with derivant is irradiated according to part, realizes photoinactivation.
5. plasma exchange according to claim 4 loads photochemical virus inactivation device, it is characterised in that the blood plasma holds
Part of receiving is a blood plasma plate, and the blood plasma plate is provided with plasma inlet and plasma outlet port, and the plasma inlet connects the derivant
Mixed cell, the plasma outlet port connect the derivant removal unit, are blood supply between the plasma inlet and plasma outlet port
Starch the pipeline of flowing.
6. plasma exchange according to claim 5 loads photochemical virus inactivation device, it is characterised in that the illumination portion
Part includes lighting box, light source, and the light source is arranged in the lighting box, and the light source is located at the two of the blood plasma containing component
Side.
7. plasma exchange according to claim 6 loads photochemical virus inactivation device, it is characterised in that the light source is
LED light illuminator, the illumination lamp are divided into two pieces up and down, and centre is included in mouth, the both sides of the blood plasma plate provided with the blood plasma plate
Distance to fluorescent tube is equal.
8. the plasma exchange loading photochemical virus inactivation device according to claim any one of 1-7, it is characterised in that institute
State derivant removal unit and further connect fluid replacing unit, the fluid replacing unit is by the blood plasma after removing derivant after venous chambers
Input human body.
9. the plasma exchange loading photochemical virus inactivation device according to claim any one of 1-7, it is characterised in that institute
To state device and further comprise that blood plasma filters unit, the unit is separated blood samples of patients, filters out blood plasma in spite of illness, and by this in spite of illness
Blood plasma is sent into the derivant mixed cell.
A kind of 10. application apparatus using any one of claim 1-9 device, it is characterised in that：The equipment is integrated to be set
Meter, including：
Apparatus body, main body of the apparatus body as carrying miscellaneous part；
It is arranged at the photoinactivation unit of the apparatus body side；
Arteriovenous kettle support member, blood plasma pass filter support member, fluid infusion and the derivant being arranged on the apparatus body hold
Device support member, it is respectively used to place arteriovenous kettle, blood plasma pass filter, fluid infusion and induction agent container；The blood plasma pass filter position
Set low in the arteriovenous kettle, the arteriovenous kettle position is less than the fluid infusion and induction agent container；
The master controller being arranged on the apparatus body, the master controller are arranged on the top of the apparatus body；
The leakage blood detection part being arranged on the apparatus body, the leakage blood detection part are located at the photoinactivation
Near unit；And
It is arranged at multiple peristaltic pumps on the apparatus body.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711055147.0A CN107715211A (en) | 2017-11-01 | 2017-11-01 | A kind of plasma exchange loading photochemical virus inactivation device and its application apparatus |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711055147.0A CN107715211A (en) | 2017-11-01 | 2017-11-01 | A kind of plasma exchange loading photochemical virus inactivation device and its application apparatus |
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| CN107715211A true CN107715211A (en) | 2018-02-23 |
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ID=61203660
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| CN201711055147.0A Pending CN107715211A (en) | 2017-11-01 | 2017-11-01 | A kind of plasma exchange loading photochemical virus inactivation device and its application apparatus |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110101928A (en) * | 2019-05-29 | 2019-08-09 | 刘忠英 | One kind is in body closed loop sterilizing installation |
| CN111481764A (en) * | 2020-05-12 | 2020-08-04 | 上海慧勤医疗器械有限公司 | Virus inactivation device and method for blood extracorporeal circulation |
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Application publication date: 20180223 |