CN110101928A - One kind is in body closed loop sterilizing installation - Google Patents
One kind is in body closed loop sterilizing installation Download PDFInfo
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- CN110101928A CN110101928A CN201910458503.6A CN201910458503A CN110101928A CN 110101928 A CN110101928 A CN 110101928A CN 201910458503 A CN201910458503 A CN 201910458503A CN 110101928 A CN110101928 A CN 110101928A
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- 230000001954 sterilising effect Effects 0.000 title claims abstract description 38
- 238000009434 installation Methods 0.000 title claims abstract description 36
- 210000004369 blood Anatomy 0.000 claims abstract description 111
- 239000008280 blood Substances 0.000 claims abstract description 111
- 238000005286 illumination Methods 0.000 claims abstract description 59
- 238000010992 reflux Methods 0.000 claims abstract description 35
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 17
- 239000000463 material Substances 0.000 claims abstract description 13
- 230000005855 radiation Effects 0.000 claims description 30
- 239000011324 bead Substances 0.000 claims description 28
- 230000005540 biological transmission Effects 0.000 claims description 12
- 230000017531 blood circulation Effects 0.000 claims description 12
- 238000005192 partition Methods 0.000 claims description 9
- 238000005119 centrifugation Methods 0.000 claims description 6
- 238000007599 discharging Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 8
- 230000004087 circulation Effects 0.000 abstract description 3
- 230000009885 systemic effect Effects 0.000 abstract description 3
- 210000004027 cell Anatomy 0.000 description 33
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- 241000700605 Viruses Species 0.000 description 8
- 239000003504 photosensitizing agent Substances 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 7
- 210000002381 plasma Anatomy 0.000 description 7
- 238000010241 blood sampling Methods 0.000 description 6
- 238000013461 design Methods 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 5
- 239000000654 additive Substances 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
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- 230000000840 anti-viral effect Effects 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
- A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
Abstract
The invention discloses one kind in body closed loop sterilizing installation, including blood-taking device, cell centrifugal separating device, illumination bactericidal unit, refluxing device and medicine-filling device；Illumination bactericidal unit includes illumination apparatus and device to be illuminated, and device to be illuminated is made of translucent material；Blood-taking device is connect by the first pipeline with cell centrifugal separating device；Cell centrifugal separating device is configurable for for blood being divided into non-treatment part and part to be treated；Cell centrifugal separating device is connect by the second pipeline with refluxing device；Cell centrifugal separating device also passes through third pipeline and connect with device to be illuminated, and device to be illuminated is configurable for receiving part to be treated, and illumination apparatus is configurable for treating received part to be treated in irradiation unit and carries out light irradiation；Device to be illuminated also passes through the 4th pipeline and connect with refluxing device；Medicine-filling device and third piping connection.A technical effect of the invention is the circulation irradiation treatment being able to achieve to systemic blood.
Description
Technical field
The present invention relates to medical instruments fields, more particularly it relates to which one kind is in body closed loop sterilizing installation.
Background technique
In daily life, human body is likely to infect bacterium or virus due to various reasons, to draw
It sends out disease various, the life of people even can be also injured when serious.Currently, common treatment method are as follows: use antibiotics
Drug carries out antibacterial therapy, either, carries out antiviral therapy using antiviral class drug.But drug therapy mostly can band
Carry out certain side effect, and body can also generate certain drug resistance after long-time service drug.Therefore, unsuitable large dosage or long
Time is treated using drug.In addition, for some superbacterias existing for hospital, at present still without more effective antibacterial
Drug effectively treats it.
With the fast development of medical science and technology, blood light therapy is had been more and more widely used.Specifically, be from
Human body acquires a certain amount of blood in vitro, and collected blood is transported in blood radiation therapeutical apparatus and receives ultraviolet lighting
Penetrate treatment, after completion to be treated again again by blood recovery into the human body.Although compared with drug therapy, blood light therapy
With apparent advantage, but it is found in long-term application there is also certain problems: first, this method can only be to few
The blood of amount is treated, and therapeutic effect is often very undesirable；Second, this mode is intermittent treatment, is needed and body
It separates, due to being external treatment again again in defeated ex vivo, operates more troublesome, and be easy to draw in this course
It sends out blood pollution or infection, safety is lower.It antivirus device or is set as it can be seen that being highly desirable to study new sterilizing or going out
It is standby.
Summary of the invention
It is an object of the present invention to provide a kind of new solutions in body closed loop sterilizing installation.
According to an aspect of the invention, there is provided a kind of be centrifuged in body closed loop sterilizing installation, including blood-taking device, cell
Separator, illumination bactericidal unit and refluxing device；The illumination bactericidal unit includes illumination apparatus and device to be illuminated, described
Device to be illuminated is made of translucent material；
The blood-taking device is connect by the first pipeline with the cell centrifugal separating device；
The cell centrifugal separating device is configurable for for blood being divided into non-treatment part and part to be treated；It is described
Cell centrifugal separating device is connect by the second pipeline with the refluxing device；The cell centrifugal separating device also passes through third
Pipeline is connect with the device to be illuminated, and the device to be illuminated is configurable for receiving the part to be treated, the light
It is configurable for carrying out light irradiation to part to be treated received in the device to be illuminated according to device；
The device to be illuminated also passes through the 4th pipeline and connect with the refluxing device；
It further include medicine-filling device, the medicine-filling device and the third piping connection.
Optionally, the blood-taking device, cell centrifugal separating device, illumination apparatus, refluxing device respectively with control device
Connection.
Optionally, described further includes collection device in body closed loop sterilizing installation, and the collection device is connected to described
On three pipelines；
The collection device has inlet, and the inlet is connect with the medicine-filling device, and the collection device is matched
It is set to: for collecting the part to be treated in the blood isolated through the cell centrifugal separating device in advance.
Optionally, the medicine-filling device is syringe；Either,
The medicine-filling device is killer injecting pump, and the killer injecting pump is connect with control device.
Optionally, the illumination apparatus includes two lamp plates being oppositely arranged, in two opposite faces of described two lamp plates
Multiple radiation sources are provided at least one face；
The device to be illuminated is arranged between described two lamp plates.
Optionally, the device to be illuminated is blood bag；
It further include swing mechanism, the swing mechanism is made of translucent material, and the blood bag is arranged in the swing mechanism
On；
The radiation source is lamp bead or fluorescent tube.
Optionally, the device to be illuminated is blood box；
The blood box includes flat box body, and the blood flow passage of light transmission is provided in the box body；
The radiation source is lamp bead, the shape phase of multiple lamp beads arrangement mode and the blood flow passage on lamp plate
Match.
Optionally, the device to be illuminated is blood box；
The blood box includes flat box body, and feed inlet, discharge port, the box body are respectively arranged on the box body
Multiple partitions are inside provided with, the intracorporal space of box is divided into multiple accommodating cavities by the multiple partition, and each accommodating cavity is provided with
The feeding branches mouth being connected to the feed inlet, each accommodating cavity are additionally provided with the discharging bifurcations being connected to the discharge port；
The radiation source is lamp bead, and multiple lamp beads are arranged on lamp plate in multiple lines and multiple rows, and the lamp bead of adjacent rows is in
Mutually stagger setting；Either,
The radiation source is fluorescent tube, and multiple fluorescent tubes are arranged successively on lamp plate, forms an at least bank light pipe.
Optionally, the device to be illuminated is blood transfusion pipeline, and the blood transfusion pipeline protrudes between described two lamp plates
One section is in flat structure.
Optionally, the illumination apparatus includes the cylinder shell of both ends open, on the inner wall of the cylinder shell
It is evenly arranged with multiple radiation sources；
The inside of the cylinder shell is arranged in the device to be illuminated.
Optionally, the device to be illuminated is transducer potector.
Optionally, the device to be illuminated is transducer potector, and wherein one section of cross sectional dimensions is greater than the transducer potector
The outer wall of the cross sectional dimensions at this section of both ends, and shunting body is provided in the section, the inner wall of transducer potector and shunting body it
Between form flow manifold；
The shunting body is made of translucent material, and the shunting body is configured as: when part to be treated enters blood tube
In road, for flowing through part to be treated along the flow manifold.
Optionally, the shunting body is hollow structure.
Optionally, flow control pump is provided on the transducer potector, the flow control pump is connect with control device.
Optionally, cylinder shell is mounted on the transducer potector by bayonet lock or hinge and is provided with the shunting body
On one section.
Optionally, the outside of the blood-taking device and the refluxing device is respectively arranged with pressure sensor, the pressure
Sensor is connect with control device.
Optionally, the cell centrifugal separating device is connected with component detection apparatus, the component detection apparatus and control
Device connection, the component detection apparatus are configured as: are detected under the control of the control device through cell centrifugation point
Type from each section that device is isolated, purity and stratification state.
Optionally, the refluxing device is also respectively connected with ultrasonic bubble sensor, liquid supply device, the ultrasonic bubble sensing
Device, liquid supply device are connect with control device.
It is provided in an embodiment of the present invention to form closed-loop system with human body when in use in body closed loop sterilizing installation, it should
Can be continued working in body closed-loop device, after the separation of special component to systemic blood, can it is continuous, targetedly to it
In part to be treated carry out photoradiation treatment, have the characteristics that therapeutic effect it is good with it is high-efficient, can effectively eliminate in blood
Bacterium, virus, and the other adaptable illnesss for the treatment of.Entire Curing circumstance safety, is avoided that the generation of infection conditions.It is somebody's turn to do
The structure of body closed loop sterilizing installation is simple, operates also more convenient.
By referring to the drawings to the detailed description of exemplary embodiment of the present invention, other feature of the invention and its
Advantage will become apparent.
Detailed description of the invention
It is combined in the description and the attached drawing for constituting part of specification shows the embodiment of the present invention, and even
With its explanation together principle for explaining the present invention.
Fig. 1 be it is provided in an embodiment of the present invention the first body closed loop sterilizing installation structural schematic diagram.
Fig. 2 is the second provided in an embodiment of the present invention structural schematic diagram in body closed loop sterilizing installation.
Fig. 3 be it is provided in an embodiment of the present invention the third body closed loop sterilizing installation structural schematic diagram.
Fig. 4 is the 4th kind of structural schematic diagram in body closed loop sterilizing installation provided in an embodiment of the present invention.
Fig. 5 is the structural schematic diagram of the first illumination bactericidal unit provided in an embodiment of the present invention.
Fig. 6 is the structural schematic diagram of second of illumination bactericidal unit provided in an embodiment of the present invention.
Fig. 7 is the structural schematic diagram of the third illumination bactericidal unit provided in an embodiment of the present invention.
Fig. 8 is the structural exploded view of a kind of blood box and corresponding lamp plate provided in an embodiment of the present invention.
Fig. 9 is the structural exploded view of another blood box and corresponding lamp plate provided in an embodiment of the present invention.
Figure 10 is the structural schematic diagram of the 4th kind of illumination bactericidal unit provided in an embodiment of the present invention.
Figure 11 is the partial enlargement diagram of Figure 10.
Figure 12 is the structural schematic diagram of the 5th kind of illumination bactericidal unit provided in an embodiment of the present invention.
Figure 13 is the side view of Figure 12.
Figure 14 is the schematic diagram of internal structure of Figure 12.
Figure 15 is a kind of structural schematic diagram of transducer potector provided in an embodiment of the present invention.
Figure 16 is the structural schematic diagram of another transducer potector provided in an embodiment of the present invention.
Figure 17 is the side view of Figure 15.
Figure 18 is a kind of side view of illumination apparatus provided in an embodiment of the present invention.
Figure 19 is the side view of another illumination apparatus provided in an embodiment of the present invention.
Description of symbols:
1- blood-taking device, 2- cell centrifugal separating device, 3- device to be illuminated, 301- blood flow passage, 302- shunting body,
303- feed inlet, 304- discharge port, 305- feeding branches mouth, 306- discharging bifurcations, 307- flow control pump, 308- shunt stream
Road, 4- illumination apparatus, 401- lamp plate, 402- radiation source, 403- cylinder shell, 404- bayonet lock, 405- hinge, 5- feed back dress
It sets, 6- control device, 7- killer injecting pump, the first pipeline of 8-, the second pipeline of 9-, 10- third pipeline, the 4th pipeline of 11-, 12- pressure
Sensor, 13- anti-coagulants adding set, 14- liquid supply device, 15- ultrasonic bubble sensor, 16- component detection apparatus, 17- are received
Acquisition means, 18- syringe, 19- swing mechanism.
Specific embodiment
Carry out the various exemplary embodiments of detailed description of the present invention now with reference to attached drawing.It should also be noted that unless in addition having
Body explanation, the unlimited system of component and the positioned opposite of step, numerical expression and the numerical value otherwise illustrated in these embodiments is originally
The range of invention.
Be to the description only actually of at least one exemplary embodiment below it is illustrative, never as to the present invention
And its application or any restrictions used.
Technology, method and apparatus known to person of ordinary skill in the relevant may be not discussed in detail, but suitable
In the case of, the technology, method and apparatus should be considered as part of specification.
It is shown here and discuss all examples in, any occurrence should be construed as merely illustratively, without
It is as limitation.Therefore, other examples of exemplary embodiment can have different values.
It should also be noted that similar label and letter indicate similar terms in following attached drawing, therefore, once a certain Xiang Yi
It is defined in a attached drawing, then in subsequent attached drawing does not need that it is further discussed.
It is provided in an embodiment of the present invention to form closed-loop system with body when in use in body closed loop sterilizing installation, it should
It can be carried out continuously work in body closed loop sterilizing installation, can be used for carrying out the blood of entire patient continuous circulation light irradiation and control
It treats, to inactivate bacterium, virus and other adaptable illnesss therein, Curing circumstance is safe and reliable, can effectively avoid blood
The case where liquid inductance contaminates.It should be noted that in the present invention, it is described refer to " in body " be joined together to form one with body
Body." closed loop " refers to that entire blood processing apparatus and body form a closed system, invades to avoid external bacterium etc.,
It avoids infection and causes danger.In addition, provided in an embodiment of the present invention can be applied to human body, animal body in body closed loop sterilizing installation
Deng the invention is not limited in this regard.
Refering to what is shown in Fig. 1, it is provided in an embodiment of the present invention in body closed loop sterilizing installation, it includes at least: blood-taking device 1,
Cell centrifugal separating device 2, illumination bactericidal unit, refluxing device 5 and medicine-filling device.It is, of course, also possible to include control device
6, to realize the automation control to whole equipment.
Blood-taking device 1 of the invention may include the those skilled in the art such as blood taking needle, blood sampling pump, filter and heparin tube
Component known to member, no longer illustrates herein.In the present invention, refering to what is shown in Fig. 1, blood-taking device 1 can pass through the first pipe
Road 8 is connect with cell centrifugal separating device 2, at this point, the blood extracted from body can be through first under the action of taking a blood sample pump
Pipeline 8 is transported in cell centrifugal separating device 2.That is, blood-taking device 1 is used to extract blood from body and by extraction
Blood is sent into cell centrifugal separating device 2.Also, it in order to realize the automation control run to blood-taking device 1, can will adopt
Blood device 1 is linked together by Communication Control line with control device 6, it can is opened by the realization of control device 6 blood-taking device 1
The control of the operations such as dynamic, stopping.
Cell centrifugal separating device 2 of the invention is mainly based upon centrifuge separation principle and carries out separating treatment to blood, with
Blood is divided into different parts.In the present invention, cell centrifugal separating device 2 be for by blood be divided into non-treatment part and
Part to be treated, in order to be treated for the part to be treated isolated, to inactivate bacterium therein, virus.It is specific next
It says, for bacterium, it is present in the blood plasma of blood, may be not present in intracellular, therefore, can pass through cell centrifugation point
The blood plasma in blood is separately separated out from device 2, it is independent by illumination bactericidal unit again later as part to be treated
Photoradiation treatment is carried out to blood plasma, bacterium present in blood plasma can be eliminated.And for virus, in blood plasma and karyocyte
It is inside likely to exist, therefore, blood plasma, karyocyte can be isolated from blood by centrifuge separation, later again by light
Photoradiation treatment is carried out to blood plasma, the karyocyte isolated according to bactericidal unit, to inactivate virus contained therein.
Wherein, cell centrifugal separating device 2 can be linked together by Communication Control line and control device 6, it can
2 centrifugal separation processes of cell centrifugal separating device are reasonably controlled by the realization of control device 6.
In addition, it is necessary to explanation, cell centrifugal separating device 2 of the invention be by centrifugal principle to blood constituent into
Row separation, eccentric part for example can be centrifugal pan, centrifugation bag, Centrifuge Cup etc., can flexible choice as the case may be, this
Invention to this with no restriction.
Refering to what is shown in Fig. 1, illumination bactericidal unit of the invention comprising there are an illumination apparatus 4 and device to be illuminated 3, and to
Irradiation unit 3 is whole to be made of translucent material.Specifically, illumination apparatus 4 can produce the photograph of predetermined strength and duration
Treatment light is penetrated, which can be used for carrying out photoradiation treatment.And device 3 to be illuminated can be used for receiving through cell centrifugation point
Part to be treated in the blood isolated from device 2.It is made since device 3 to be illuminated is whole using translucent material, because
This, the irradiation treatment light that illumination apparatus 4 is launched can carry out light to the part to be treated of its inside through device 3 to be illuminated
Irradiation treatment sterilizes to the part to be treated in blood, virus treated of going out.
Wherein, the irradiation treatment light that illumination apparatus 4 is launched can select UVA, any one in UVB, UVC, visible light
Kind or its all combination, can flexible choice as the case may be, the invention is not limited in this regard.
Wherein, illumination apparatus 4 can be linked together by Communication Control line and control device 6, it can be filled by control
Intensity of illumination and the time etc. for setting 6 pairs of illumination apparatus 4 are reasonably controlled.Specifically, control device 6 can be according to treatment
It is required that the irradiation time and exposure intensity etc. to illumination apparatus 4 control.In fact, carrying out light irradiation in illumination apparatus 4
In the process, irradiation energy J (unit, joule)=W*t, wherein W is irradiation power, and t is irradiation time.It should be noted that
During carrying out photoradiation treatment using illumination apparatus 4, specific irradiation energy J (irradiation joule), specific shot are selected
Wavelength can prevent from causing to damage to karyocyte in this way in inactivation of viruses.
In the present invention, cell centrifugal separating device 2 can be connect by the second pipeline 9 with refluxing device 5, and being used for will be from blood
The non-treatment part isolated in liquid directly through the second pipeline 9 be sent into refluxing device 5, and by refluxing device 5 feed back in vivo, with
Realize a cyclic process.Also, cell centrifugal separating device 2 is also connect by third pipeline 10 with device 3 to be illuminated, wait shine
Injection device 3 is connect by the 4th pipeline 11 with refluxing device 5.At this point it is possible to which the part to be treated isolated from blood is passed through
Third pipeline 10 is sent into device 3 to be illuminated, is treated the part to be treated in irradiation unit 3 by illumination apparatus 4 and is carried out light irradiation
It treats, is sent to refluxing device 5 again after photoradiation treatment to be done, and sent back in vivo, to realize another by refluxing device 5
Cyclic process.The above whole process can be carried out continuously, specifically can basis until systemic blood is treated one time or multipass
Actual conditions are adjusted flexibly, the invention is not limited in this regard.
Wherein, it when the treatment part isolated is sent into device 3 to be illuminated by cell centrifugal separating device 2, needs by infusing
Medicine device simultaneous implantation photosensitizer or relevant therapeutic agent into third pipeline 10.Photosensitizer or phase are used in treatment
The therapeutic agent of pass can enhance therapeutic effect.For example, can be using the vitamin B2 having no toxic side effect, but whether need to match
Composite medicine by clinic according to circumstances determine, the invention is not limited in this regard.
It is provided in an embodiment of the present invention in body closed loop sterilizing installation with reference to shown in Fig. 2 and Fig. 3, it can also include collecting
Device 17.Wherein, collection device 17 can connect or be arranged in the of connection cell centrifugal separating device 2 and device to be illuminated 3
On three pipelines 10.
Collection device 17 has inlet, which can connect with medicine-filling device.Medicine-filling device can be by photosensitizer
Or relevant therapeutic agent is injected into collection device 17 through inlet.The blood isolated through cell centrifugal separating device 2
In part to be treated can first be transported in collection device 17 and be collected, after accumulation reaches certain capacity, filled by injection
It sets and photosensitizer (perhaps drug) is injected into collection device 10 to photosensitizer (or drug) and part to be treated by inlet
It is sufficiently mixed and then will be mixed with and be sent into device 3 to be illuminated to the part to be treated of photosensitizer (or drug), and by illumination
Device 4 carries out photoradiation treatment, is sent to refluxing device 5 by the 4th pipeline 11 after the completion of photoradiation treatment, finally defeated to return to body
It is interior.
After the part to be treated collected in collection device 17 is all transported to device 3 to be illuminated, it is then turned at this time
Illumination apparatus 4.In this manner, after the part to be treated in collection device 17 fully inputs device 3 to be illuminated, then to
The part to be treated that input is newly isolated in collection device 17.Which has the characteristics that easy to control, simple.
By during fractional transmission to be treated to device 3 to be illuminated, transmission speed can be filled collection device 17 by control
6 are set to be determined according to the irradiation energy and exposure intensity of illumination apparatus 4.
Collection device 17 such as can be storage bag or storage pool with the device of store function, in use can be with
Flexible choice as needed, the invention is not limited in this regard.
Optionally, refering to what is shown in Fig. 1, provided in an embodiment of the present invention can also be not provided with receiving in body closed loop sterilizing installation
Acquisition means 17, at this point, the part to be treated in the blood isolated through cell centrifugal separating device 2 is on one side to device 3 to be illuminated
Transmission, the part to be treated transmitted on one side by 4 Duis of illumination apparatus carry out photoradiation treatment, i.e. transmission and the same stepping of photoradiation treatment
Row.When by the way of being irradiated while transmitting, the irradiation time t=L/v of illumination apparatus 4, wherein L is device 3 to be illuminated
Conveying length, v are transmission speed.Which has the characteristics that therapeutic efficiency is high.
With reference to shown in Fig. 1 and Fig. 2, medicine-filling device of the invention can use killer injecting pump 7, which can pass through
Communication Control line is connect with control device 6.Under the control of control device 6, killer injecting pump 7 injected into collection device 17 it is photosensitive
When agent (or drug), it may be implemented to transmit part to be treated to collection device 17 with cell centrifugal separating device 2 in time
Synchronization.Moreover, the amount of injected photosensitizer (or drug) accurate can control.Above whole process may be implemented automatically
Processing, precision is higher, and operation is very easy.
Refering to what is shown in Fig. 3, medicine-filling device of the invention may be syringe 18.By manual operation syringe 18, pass through
Syringe 18 can inject photosensitizer (perhaps drug) in third pipeline 10 or injection collection device 17, specifically can root
According to whether collection device 17 being arranged and flexible setting.
Wherein, refluxing device 5 may include the those skilled in the art such as blood transfusion needle, blood transfusion apparatus, filter and blood transfusion pipeline
Component known to member, no longer illustrates herein.Refluxing device 5 is matched with blood-taking device 1 and be may be implemented in body closed loop cycle
Process.Also, it, can in the present invention, in order to realize the automation control run to refluxing device 5 (such as starting or stopping)
Refluxing device 5 to be connect by Communication Control line with control device 6, realized by control device 6 to the worked of refluxing device 5
Cheng Jinhang is rationally controlled.
In the present invention, it can be realized by control device 6 and be sterilized to blood-taking device 1, cell centrifugal separating device 2, illumination
Device and refluxing device 5 etc. are controlled accordingly respectively.It can make to have certainly in body closed loop sterilizing installation by the design
The characteristics of dynamicization controls.Wherein, optionally, control device 6 can have display device, and user can pass through operation display dress
It sets to control and observe working condition of each component etc..Wherein, display device for example can be this fields such as touching display screen
Display device known to technical staff, the invention is not limited in this regard.
In addition, single needle mould can also be used refering to what is shown in Fig. 4, provided in an embodiment of the present invention in body closed loop sterilizing installation
Formula merges blood-taking device 1 and refluxing device 5.At this point it is possible to be handed over by the control of control device 6 blood sampling with feedback
For progress.Specifically: a needle can be used, which can serve as blood taking needle, can also act as blood transfusion needle.The needle is connected
Pipeline will not feed back blood to internal when from internal blood sampling, i.e., blood sampling and blood transfusion are that timesharing works, and will not be generated
Mutual interference phenomenon.When blood was collected, blood sampling pump is controlled by control device 6 and is operated, while controlling feedback pump
Stop working (or small flow).When feeding back blood, controlling the stalling of blood sampling pump by control device 6, (flow is 0 when stopping, quite
It is closed in pipeline, while controlling the operating of feedback pump).Wherein, take a blood sample pump flow be greater than feed back pump discharge when, blood is outside from needle
Stream, on the contrary it is flowed to internal.
It should be noted that first pipeline 8, the second pipeline 9, third pipeline 10, the 4th pipeline 11 are all made of this
Hose known to the technical staff of field, in order to the conveying of blood.Also, the size of these above-mentioned pipelines can according to need spirit
Adjustment living, the invention is not limited in this regard.
Illumination bactericidal unit of the invention, structure is simple, various, can be suitble to a variety of demands.The illumination bactericidal unit packet
Include illumination apparatus 4 and device to be illuminated 3.
Illumination apparatus 4 of the invention, may include shell, and multiple radiation sources are provided on the inner wall of the shell
402, irradiation treatment light is launched by radiation source 402, to realize photoradiation treatment.Radiation source 402 therein can be selected
Any one in UVA, UVB, UVC, visible light or its all combination.When in use, it is outer to be arranged on this for device 3 to be illuminated
The inside of shell, in order to which radiation source 402 can be irradiated to device 3 to be illuminated, so as to treat the portion to be treated in irradiation unit 3
Divide and carries out photoradiation treatment.
It should be noted that the shell of illumination apparatus 4 can have various structures, it in the application can be according to the actual situation
Flexible choice.The setting quantity and arrangement mode of radiation source 402, which also can according to need, to be adjusted flexibly.In addition, radiation source
402 can be arranged directly on the inner wall of shell, can also be embedded into the inner wall of shell, then be protected using the housing of light transmission
Come.
Refering to what is shown in Fig. 5, a kind of structure of illumination apparatus 4 are as follows: including shell, which includes two lamps being oppositely arranged
Plate 401.It is evenly arranged with multiple radiation sources 402 respectively on two opposite faces of two lamp plates 401.3 quilt of device to be illuminated
It is arranged between two lamp plates 401.At this point, the radiation source 402 on two lamp plates 401 can treat the upper and lower of irradiation unit 3
Face carries out light irradiation.It can be so that the illuminated uniform light of device to be illuminated 3, so as to so that interior using light irradiation simultaneously up and down
The part to be treated in portion uniformly receives good photoradiation treatment.It should be noted that it is opposite to be also possible to two lamp plates 401
It is uniformly arranged multiple radiation sources 402 on the face of any of two faces, that is, forms the mode of machine glazing irradiation.
Wherein, radiation source 402 can be lamp bead or fluorescent tube, can flexibly adjust according to actual needs in a particular application
It is whole.
When the shell of illumination apparatus 4 is two lamp plates 401 being oppositely arranged, device 3 to be illuminated can be used below
A kind of structure.
Optionally, device 3 to be illuminated is the blood bag made of translucent material.Refering to what is shown in Fig. 6, in order to make to receive in blood bag
Collection part to be treated can uniform light, i.e., received light energy is identical, and swing mechanism 19 can be added for it.At this point,
The radiation source for irradiating blood bag can use lamp bead, can also use fluorescent tube, and lamp bead or fluorescent tube are in uniform on lamp plate 401
Distribution, such as it is arranged in the shape of matrix.Specifically, swing mechanism 19 can use oscillating deck, when in use that blood bag is direct
Placing flat is on oscillating deck.It should be noted that in order to be able to achieve good translucent effect, swing mechanism 19 can be used
Such as the material production that the translucency such as quartz are good, naturally it is also possible to it is other translucent materials well known to those skilled in the art, this
Invention to this with no restriction.
Optionally, refering to what is shown in Fig. 7, device to be illuminated 3 is the blood box of flat structure.The blood box at least has
Two different structures.The blood box of two kinds of different structures further explained below.
In the specific embodiment of the present invention, refering to what is shown in Fig. 8, blood box includes flat box body, and
The blood flow passage 301 of light transmission is provided in the box body.At this point, radiation source 402 can choose using lamp bead, and multiple lamp beads exist
Arrangement mode should match with the shape of the blood flow passage 301 on lamp plate 401.Wherein, the blood flow passage 301 in blood box has
Have certain width and wall be very thin, translucency is fine, convenient for light shining wherein, realize to flowed in blood flow passage to
Treatment part carries out photoradiation treatment.Wherein, the shape by multiple lamp beads along blood flow passage 301 is arranged, and is conducive to be directed at blood
Runner 301 carries out abundant photoradiation treatment, can make full use of luminous energy, avoids the waste of luminous energy.Certainly, multiple lamp beads are in lamp plate
Can also be using other arrangement modes, such as the evenly distributed formation rectangular of multiple lamp beads etc. on 401, it can be according to specific need
It is adjusted flexibly, as long as lamp bead is enable to be irradiated in blood flow passage 301.
It in another embodiment of the invention, should refering to what is shown in Fig. 9, blood box includes flat box body
It is respectively arranged with feed inlet 303, discharge port 304 on box body, and is provided with multiple partitions in the box body, multiple partitions are used for will
The intracorporal space of box is divided into multiple accommodating cavities, wherein each accommodating cavity is provided with the feeding branches mouth being connected to feed inlet 303
305, and each accommodating cavity is additionally provided with the discharging bifurcations 306 being connected to discharge port 304.At this point, radiation source 402 can be adopted
With lamp bead, fluorescent tube can also be used.Specifically: when using lamp bead, multiple lamp beads are arranged on lamp plate 401 in multiple lines and multiple rows
Cloth, and the lamp bead of two adjacent rows is in mutually stagger setting, to make full use of luminous energy.When using fluorescent tube, multiple fluorescent tubes are in lamp
It being arranged successively on plate, forms a row or multi-row fluorescent tube, certain fluorescent tube can also need to be arranged in other shapes according to irradiation,
Such as rectangle etc..
Enter in blood box when from the part to be treated isolated in blood by feed inlet 303, since part to be treated is
Fluid can be entered in different accommodating cavities by each feeding branches mouth 305.Since fluid flow area becomes larger, light
Area also just increase.In the present embodiment, turning can be set on partition, which designs according to fluid curve, can be with
For water conservancy diversion, convenient for pushing fluid out, dead angle is formed to prevent.In addition, it is preferred that multiple partitions are in blood box
It is equidistant to be uniformly arranged, at this point, the bore away from the close feeding branches mouth 305 of feed inlet 303 is less than remote feeding branches mouth 305
From one end close apart from feed inlet to remote one end, bore becomes larger for bore, i.e. feeding branches mouth, is conducive to fluid respectively to each
Circulation in a accommodating cavity improves light exposure treatment effect so as to which partial-partition to be treated is carried out photoradiation treatment.
Optionally, device 3 to be illuminated is blood transfusion pipeline.When being irradiated treatment, which is extend into two
Between lamp plate 401.At this point, row irradiation is respectively arranged in the position for corresponding to blood transfusion pipeline on opposite two faces of two lamp plates 401
Light source 402.Which simplifies the structure of illumination apparatus 4.
With reference to shown in Figure 10 and Figure 11, when using blood transfusion pipeline, blood transfusion pipeline can be protruded into illumination apparatus 4,
Flat structure is made in one section extend between two lamp plates 401, to increase light-receiving area, appropriate can mention in this way
High photoradiation treatment effect.Wherein it is possible to which blood conduit is directly processed into flat structure.Either, using the side of extruding
The part that formula makes blood transfusion pipeline need to receive irradiation forms flat structure.It should be noted that the blood transfusion usual material ratio of pipeline
It is softer, when carrying out extrusion process to it, directly it can be squeezed using two lamp plates 401, naturally it is also possible to use
Other fashion of extrusion.And the recovery for pipeline deformation of transfusing blood in order to prevent, the support frame of light transmission can be set in blood transfusion pipeline,
While not influencing light transmission, blood transfusion tube road can be made to keep flat.
With reference to shown in Figure 12-Figure 14, a kind of structure of illumination apparatus 4 are as follows: including shell, shell is the circle of both ends open
Tubular shell 403, at this point, multiple radiation sources 402 are uniformly arranged on the inner wall of cylinder shell 403.Under this structure,
Device 3 to be illuminated protrudes into the inside of cylinder shell 403, such as can be arranged along the central axis of cylinder shell 403, i.e., logical
Device 3 to be illuminated can be wrapped up by crossing cylinder shell 403, so that device to be illuminated 3 receives in cylinder shell 403
The light of radiation source 402 irradiates.Wherein, radiation source 402 can be lamp bead, or fluorescent tube, it can be as the case may be
Flexible choice.
When the shell of illumination apparatus 4 is cylinder-like structure, in order to cooperate its structure, device 3 to be illuminated can be selected general
Logical transducer potector, cross sectional shape can be circle, ellipse etc., the invention is not limited in this regard.
But usual transducer potector is thinner, internal diameter is about 1.5-4mm, carries out light irradiation to it by illumination apparatus 4
When, light-receiving area is smaller, and it is undesirable to will lead to photoradiation treatment effect.And in order to increase light-receiving area, improve light irradiation effect
Fruit can be by the way of increasing transducer potector radius.In a specific embodiment, with reference to shown in Figure 15-Figure 17, blood
Wherein one section of cross sectional dimensions is greater than the cross sectional dimensions at this section of both ends to liquid pipeline, and is provided in this section of transducer potector
Shunting body 302, at this point, foring flow manifold 308 between the inner wall of transducer potector and the outer wall of shunting body 302.
Wherein, shunting body 302 includes shunting body shell, has cavity, as hollow structure in the shunting body shell.And
And 302 entirety of shunting body is made of translucent material, the irradiation treatment light that illumination apparatus 4 can be made to launch passes through.Shunting body
302 are configured as: entering in transducer potector when from the part to be treated isolated in blood, part to be treated is fluid, can be used
In flowing through part to be treated along flow manifold, even if part to be treated passes through close to the wall surface of transducer potector.When using light
When carrying out light irradiation to it according to device 4, have that light-receiving area is big and light more evenly the characteristics of.Certainly, shunting body 302
It can be solid construction, only for hollow structure, heavier-weight.In a particular application, it can according to need spirit
Adjustment living.
It should be noted that the outer shape of shunting body shell should facilitate to flow through fluid smoothly.I.e. in reality
While now shunting, good diversion function is also had both, is advantageously implemented no dead angle flowing.With reference to shown in Figure 15 and 16, shunt
The shape of body shell body can be cubic, tapered cylinder shape etc., and wherein tapered cylinder refers to that both ends form triangular shape
Cylindrical body.
In order to keep transducer potector stable the cylinder shell 403 that illumination apparatus 4 is set inside, can be using will justify
Tubular shell 403 is fixed on the mode on transducer potector to be illuminated.With reference to shown in Figure 18, cylinder shell 403 can be set
Two semicircular structures are calculated as, and bayonet lock 404 is respectively set in the junction of two semicircular structures, pass through a pair of of bayonet lock
404 are connected to cylinder shell 403 on transducer potector.With reference to shown in Figure 19, can also be designed as cylinder shell 403 can
Cylinder shell 403 is mounted on transducer potector after opening by the structure of folding, is fixed later by hinge 405.On
Stating two ways can according to need flexible choice, the invention is not limited in this regard.It should be noted that when using such as Figure 18 and
When this mode in Figure 19, the lamp bead on the inner wall of cylinder shell 403 can add lampshade；It is of course also possible to not add
Lampshade, i.e. lamp bead direct out irradiation.
In addition, flow control pump 307 can also be arranged on transducer potector with reference to shown in Figure 16.The flow control pump 307
It can be connect by Communication Control line with control device 6.Flow control pump 307 can be controlled by control device 6, with
Control is input to the flow velocity of fluid in transducer potector.
It is provided in an embodiment of the present invention in body closed loop sterilizing installation with reference to shown in Fig. 1-Fig. 4, it can also add including anti-coagulants
Feeder apparatus 13.Wherein, which is configured as: can add anti-coagulants into blood-taking device 1.It is specific next
It says, it, can by addition anti-coagulants when blood-taking device 1, which extracts blood, to be sent into the first pipeline 8 and start to be recycled
To prevent the blood clotting handled, to can guarantee going on smoothly for entire blood circulation process.It should be noted that anti-
The additive amount of solidifying agent can according to need flexible control, the invention is not limited in this regard.
Wherein, anti-coagulants adding set 13 can be directly joined together with blood-taking device 1.Certainly, anti-coagulants addition dress
Setting 13 can also be connect by pipeline with blood-taking device 1.The addition of anti-coagulants may be implemented in both modes, is specifically answering
It, can flexible choice according to the actual situation in.
Also, anti-coagulants adding set 13 can also be connect by Communication Control line with control device 6.The design can be real
Existing control of the control device 6 to anti-coagulants adding set 13, it can control anti-coagulants adding set 13 adds anti-into blood
Solidifying agent, or stop adding anti-coagulants into blood.That is, anti-coagulants can be added by the realization of control device 6
It automatically controls, this mode operates more convenient, is also easy to control additive amount.Certainly, anti-coagulants adding set 13 can also
Not connect with control device 6, at this point it is possible to using the addition and additive amount that manually control anti-coagulants.In a particular application
It can according to need flexible choice, the invention is not limited in this regard.
It is provided in an embodiment of the present invention in body closed loop sterilizing installation with reference to shown in Fig. 1-Fig. 4, it further include pressure sensor
12.Specifically, pressure sensor 12 can be respectively arranged in the outside of blood-taking device 1 and refluxing device 5.Pressure sensor
12 are connect by Communication Control line with control device 6.And in order to realize accurate pressure detecting, pressure sensor 12 is being arranged
When be intended to close to corresponding pipeline.
Wherein, be arranged in the pressure sensor 12 outside blood-taking device 1 for detect take a blood sample end, such as blood-taking device in adopt
Pressure condition in the pressure condition of blood vessel, and the first pipeline 8 for being connect with blood-taking device 1.Likewise, setting is feeding back dress
It sets the pressure sensor 12 outside 5 and is used to detect the pressure condition transfused blood in pipeline in reinfusion end, such as refluxing device 5, and
Pressure condition in the second pipeline 9 being connect with refluxing device 5 and the 4th pipeline 11.It may determine that needle (example by pressure detecting
Such as blood taking needle, blood transfusion needle) and corresponding pipeline whether generate blocking.Once blocking, it is easy to cause overpressure abnormal,
Cause dangerous.
It should be noted that there are many setting positions of pressure sensor 12, however it is not limited to the mode in above-described embodiment.
Such as: pressure sensor 12 is separately positioned on corresponding pipeline.Either, pressure sensor 12 is arranged and is managed accordingly
Inside road.It can be adjusted flexibly according to the actual situation, the invention is not limited in this regard.In addition, setting for pressure sensor 12
It sets the quantity present invention to be also not especially limited, can according to need the suitable quantity of flexible choice.
Also, each pressure sensor 12 can be connect by communication control line with control device 6.The design can be real
Existing control of the control device 6 to pressure sensor 12, it can control pressure sensing 8 starts pressure detecting on suitable opportunity,
Pressure sensor 12 can certainly be controlled without pressure detecting.
It is provided in an embodiment of the present invention in body closed loop sterilizing installation with reference to shown in Fig. 1-Fig. 4, it can also include composition detection
Device 16.Component detection apparatus 16 can be connect by detection line or Communication Control line with cell centrifugal separating device 2, ingredient
Detection device 16 is also connect by detection line or Communication Control line with control device 6.Wherein, component detection apparatus 16 is configured
Are as follows: ingredient and purity of each section isolated through cell centrifugal separating device 2 etc. are detected under the control of control device 6, and
And the component detection apparatus 16 can also the ingredient separation process to cell centrifugal separating device 2 control so that different
Ingredient can form good stratification state, be conducive to extract different ingredients respectively.That is, when cell centrifugation point
When blood being divided into different ingredients from device 2, stratification state, the kind of each ingredient can detecte out by component detection apparatus 16
Class and purity.It is provided with or without it should be noted that component detection apparatus 16 can according to need selection.
It is provided in an embodiment of the present invention in body closed loop sterilizing installation with reference to shown in Fig. 1-Fig. 4, it further include ultrasonic bubble sensing
Device 15, the ultrasonic bubble sensor 15 are located at one end where refluxing device 5.The ultrasonic bubble sensor 15 and refluxing device 5
Connection.Specifically, ultrasonic bubble sensor 15 be using ultrasound detection feed back blood in whether contain bubble, once detection
It will stop immediately to internal feedback blood and alarm containing bubble into blood, otherwise blood enters in body and can endanger
Danger.
Also, ultrasonic bubble sensor 15 is also connect by Communication Control line with control device 6.The design may be implemented to control
Control of the device 6 processed to ultrasonic bubble sensor 15, it can control ultrasonic bubble sensor 15 starts on suitable opportunity to be examined
It surveys, naturally it is also possible to control ultrasonic bubble sensor 15 without detection.That is, may be implemented pair by control device 6
The automation control of ultrasonic bubble sensor 15.
It is provided in an embodiment of the present invention in body closed loop sterilizing installation with reference to shown in Fig. 1-Fig. 4, it can also include liquid supply device
14.The liquid supply device 14 is configured as: when feeding back blood, the interior carry out fluid infusion into blood, such as can be to internal Replacement Battalion
Nutrient solution or drug etc..Wherein, liquid supply device 14 can be connect by liquid supplementation pipe with refluxing device 5.Certainly, liquid supply device 14 can also
To be combined together with refluxing device 5.The two ways may be implemented to add nutrient solution or medicine into the blood of feedback
Object.
Also, liquid supply device 14 can be connect by Communication Control line with control device 6.Control dress may be implemented in the design
The control of 6 pairs of liquid supply devices 14 is set, to realize the automation of fluid infusion.
It should be noted that the anti-coagulants adding set 13 and liquid supply device 14 in the present invention can use dedicated pump,
It runs or stops to be controlled by control device 6.Pressure sensor 12, ultrasonic bubble sensor in the present invention
15, component detection apparatus 16 is also controlled by control device 6, realizes the automation of operation.
Although some specific embodiments of the invention are described in detail by example, the skill of this field
Art personnel it should be understood that example above merely to being illustrated, the range being not intended to be limiting of the invention.The skill of this field
Art personnel are it should be understood that can without departing from the scope and spirit of the present invention modify to above embodiments.This hair
Bright range is defined by the following claims.
Claims (10)
1. one kind is in body closed loop sterilizing installation, which is characterized in that including blood-taking device, cell centrifugal separating device, illumination sterilizing
Device and refluxing device；The illumination bactericidal unit includes illumination apparatus and device to be illuminated, and the device to be illuminated is by light transmission
Material is made；
The blood-taking device is connect by the first pipeline with the cell centrifugal separating device；
The cell centrifugal separating device is configurable for for blood being divided into non-treatment part and part to be treated；The cell
Centrifugal separating device is connect by the second pipeline with the refluxing device；The cell centrifugal separating device also passes through third pipeline
It is connect with the device to be illuminated, the device to be illuminated is configurable for receiving the part to be treated, the illumination dress
It sets and is configurable for carrying out light irradiation to part to be treated received in the device to be illuminated；
The device to be illuminated also passes through the 4th pipeline and connect with the refluxing device；
It further include medicine-filling device, the medicine-filling device and the third piping connection.
2. according to claim 1 in body closed loop sterilizing installation, which is characterized in that the blood-taking device, cell centrifugation point
It is connect respectively with control device from device, illumination apparatus, refluxing device.
3. according to claim 1 in body closed loop sterilizing installation, which is characterized in that it further include collection device, the collection
Device is connected on the third pipeline；
The collection device has inlet, and the inlet is connect with the medicine-filling device, and the collection device is configured as:
For collecting the part to be treated in the blood isolated through the cell centrifugal separating device in advance.
4. according to claim 1 in body closed loop sterilizing installation, which is characterized in that the medicine-filling device is syringe；Or
Person is,
The medicine-filling device is killer injecting pump, and the killer injecting pump is connect with control device.
5. according to claim 1 in body closed loop sterilizing installation, which is characterized in that the illumination apparatus includes two opposite
The lamp plate of setting is provided with multiple radiation sources at least one face in two opposite faces of described two lamp plates；
The device to be illuminated is arranged between described two lamp plates.
6. according to claim 5 in body closed loop sterilizing installation, which is characterized in that the device to be illuminated is blood bag；
It further include swing mechanism, the swing mechanism is made of translucent material, and the blood bag is arranged on the swing mechanism；
The radiation source is lamp bead or fluorescent tube.
7. according to claim 5 in body closed loop sterilizing installation, which is characterized in that the device to be illuminated is blood box；
The blood box includes flat box body, and the blood flow passage of light transmission is provided in the box body；
The radiation source is lamp bead, and multiple lamp beads shape of arrangement mode and the blood flow passage on lamp plate matches.
8. according to claim 5 in body closed loop sterilizing installation, which is characterized in that the device to be illuminated is blood box；
The blood box includes flat box body, and feed inlet, discharge port are respectively arranged on the box body, is set in the box body
Multiple partitions are equipped with, the intracorporal space of box is divided into multiple accommodating cavities by the multiple partition, and each accommodating cavity is provided with and institute
The feeding branches mouth of feed inlet connection is stated, each accommodating cavity is additionally provided with the discharging bifurcations being connected to the discharge port；
The radiation source is lamp bead, and multiple lamp beads are arranged on lamp plate in multiple lines and multiple rows, and the lamp bead of adjacent rows is in mutual
It is arranged in a staggered manner；Either,
The radiation source is fluorescent tube, and multiple fluorescent tubes are arranged successively on lamp plate, forms an at least bank light pipe.
9. according to claim 5 in body closed loop sterilizing installation, which is characterized in that the device to be illuminated is blood transfusion tube
Road, and the blood transfusion pipeline protrudes into one section between described two lamp plates in flat structure.
10. according to claim 1 in body closed loop sterilizing installation, which is characterized in that the illumination apparatus includes that both ends are opened
The cylinder shell of mouth, is evenly arranged with multiple radiation sources on the inner wall of the cylinder shell；
The inside of the cylinder shell is arranged in the device to be illuminated.
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| CN201910458503.6A CN110101928A (en) | 2019-05-29 | 2019-05-29 | One kind is in body closed loop sterilizing installation |
| PCT/CN2019/124726 WO2020238150A1 (en) | 2019-05-29 | 2019-12-12 | In-vivo closed-loop sterilization apparatus |
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| CN201910458503.6A CN110101928A (en) | 2019-05-29 | 2019-05-29 | One kind is in body closed loop sterilizing installation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020238150A1 (en) * | 2019-05-29 | 2020-12-03 | 刘忠英 | In-vivo closed-loop sterilization apparatus |
| CN113350598A (en) * | 2021-04-07 | 2021-09-07 | 刘成一 | Extracorporeal circulation treatment apparatus |
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Also Published As
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| WO2020238150A1 (en) | 2020-12-03 |
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