CN107692977A - A kind of micro- angiographic imaging system of double mode optics based on OCT - Google Patents
A kind of micro- angiographic imaging system of double mode optics based on OCT Download PDFInfo
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- CN107692977A CN107692977A CN201711041270.7A CN201711041270A CN107692977A CN 107692977 A CN107692977 A CN 107692977A CN 201711041270 A CN201711041270 A CN 201711041270A CN 107692977 A CN107692977 A CN 107692977A
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- 238000003384 imaging method Methods 0.000 title claims abstract description 61
- 230000003287 optical effect Effects 0.000 claims description 65
- 230000005540 biological transmission Effects 0.000 claims description 34
- 230000001427 coherent effect Effects 0.000 claims description 9
- 230000011514 reflex Effects 0.000 claims description 2
- 238000001514 detection method Methods 0.000 abstract description 16
- 230000009977 dual effect Effects 0.000 abstract description 3
- 238000012014 optical coherence tomography Methods 0.000 description 25
- 230000003321 amplification Effects 0.000 description 6
- 238000003199 nucleic acid amplification method Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000009738 saturating Methods 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 210000001768 subcellular fraction Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0073—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by tomography, i.e. reconstruction of 3D images from 2D projections
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
Abstract
A kind of micro- angiographic imaging system of double mode optics based on OCT, it is characterised in that：It includes light source, instruction light, circulator, coupler, adjustable reference arm, adjustable sample arm, spectrometer, capture card and computer；The superiority of the present invention：Dual mode system of the present invention can make doctor position focal area more rapidly to be scanned, saved detection time in clinical detection, while improve the degree of accuracy of detection, greatly improve the practicality of the micro- angiographic imaging system of optics based on OCT.
Description
Technical field
The present invention relates to a kind of imaging system, more particularly to a kind of micro- angiographic imaging system of double mode optics based on OCT.
Background technology
Optical coherence tomography（Optical Coherence Tomography, abbreviation OCT）It is a kind of new life
Thing medical optics imaging mode, it can carry out the noninvasive imaging in body to sample.Due to its high-resolution, non-intruding and
The advantages that radiationless, had a wide range of applications in many fields, there is good development prospect.OCT can realize micron
Level axial resolution（<10 μm）, high accuracy depth image is provided for internal subcellular fraction biologicall test.Another of OCT technology is heavy
It is its highly scalable imaging depth, i.e. depth bounds to want characteristic.The depth bounds of most common commercial OCT systems is usual
It is most of to be applied to retina and endoscopic imaging for 2 to 4mm.
Medically, the technology for based on tissue blood flow detection diagnose some diseases also functions to the work of ever more important
With.Laser speckle blood current imaging technology, Doppler's OCT blood flow detections technology, the angiographic imaging based on OCT.Wherein, blood vessel
Contrast imaging comes constructing function 3D blood vessel imagings or blood by measuring the amplitudes of OCT signals, the change of phase and complex values
Perfusion figure.It is reported that angiographic imaging reaches higher sensitivity in the slower capillary of flow velocity.Angiogram
Method has been successfully applied to the imaging of human body skin microcirculatory vascular.But the areas imaging of angiographic imaging is smaller, generally only
There are several square millimeters.And in clinical detection, doctor needs just determine focal area by repeated detection.Also, if
Focal area scope is larger, then needs Multiple-Scan to splice, and reduces the accuracy of scanning, increases scanning result error.Institute
Vascular tissue in the larger visual field can be first detected to be badly in need of a kind of system, then fast positioning is scanned to focal area.
The present invention proposes a kind of micro- angiographic imaging system of double mode optics based on OCT, by using length in sample arm
Focal length lenses realize wide area mode；High resolution mode is realized using amplifying lens.Sample arm and ginseng are controlled by computer simultaneously
Arm is examined, is switched fast both of which.
For example, a kind of double space carrier frequency technique extension OCT image depth is mentioned in patent document 201510390567.9
Method and system, two sets of scanning galvanometer systems are respectively provided with set of system to scan the image of different depth, still
The cost of system has been significantly greatly increased in two sets of galvanometers, and to the light source in requisition for larger luminous power, further increases cost.This
Lens have only been changed in invention in sample arm, realize Double-mode imaging for different scanning area, its object is to examined in medical science
In disconnected, the accuracy and practical performance of system scanning are greatly improved.In patent document 201620806921.1, tear open for convenience
A kind of OCT reference arms self-checking device that machine is reconstituted and invented, is adjusted using speculum is installed on into console.And this
Invention is to realize the adjustable reference arm set by Double-mode imaging, and is controlled completely with computer, more convenient,
It is accurate and quick.
The content of the invention
It is an object of the invention to provide a kind of micro- angiographic imaging system of double mode optics based on OCT, it can solve the problem that
The deficiencies in the prior art, the areas imaging of current angiographic imaging is smaller, generally only several square millimeters, and is examined in clinic
In survey, doctor needs just determine focal area by repeated detection；The dual mode system of the present invention can in clinical detection
So that doctor positions more rapidly focal area and is scanned, detection time is saved, while improve the degree of accuracy of detection, pole
The big practicality for improving the micro- angiographic imaging system of optics based on OCT.
Technical scheme：A kind of micro- angiographic imaging system of double mode optics based on OCT, it is characterised in that：It
Including light source, instruction light, circulator, coupler, adjustable reference arm, adjustable sample arm, spectrometer, capture card and calculating
Machine；The optical signal for the scanning laser that the light source is sent respectively enters adjustable reference arm after circulator and coupler and can
Sample arm is adjusted, the light returned from adjustable reference arm and adjustable sample arm interferes in coupler, forms coherent light；
The coherent light of return is by circulator by spectrometer collection；The spectrometer collection optical signal, and optical signal is converted to simulation
Signal；The capture card gathers analog signal, and is transferred to computer；The computer carry out signal transacting, system imaging and
System controls；The adjustable sample arm includes realizing the long-focus lens of wide area mode and realizes that the amplification of high resolution mode is saturating
Mirror；The adjustable reference arm include respectively from the wide area mode and high resolution mode of the adjustable sample arm corresponding to it is different
Light path pattern；The adjustable reference arm and adjustable sample arm control row mode of going forward side by side to change by computer；The instruction
Light respectively enters adjustable reference arm and adjustable sample arm by coupler.
The centre wavelength of the light source is 1310 nm, with a width of 60 nm.
The instruction light uses 660 nm feux rouges, and the effect of instruction is provided for scan position.
The optical signal that the light source is sent is divided into two-way by circulator and coupler, and 10% light enters adjustable reference
Arm, 90% light enter adjustable sample arm.
The long-focus lens and amplifying lens of the adjustable sample arm are arranged on electronic rotation frame；The electronic rotation
Frame is arranged on electric bracket；The electronic rotation frame passes through the electrical motor driven that is controlled by computer；During wide area mode, rotation
Pivoted frame rotates, and makes scanning optical transport to the center of long-focus lens, and lens are vertical with optical transmission direction；High resolution mode
When, swivel mount rotation, make scanning optical transport to the center of amplifying lens, and lens are vertical with optical transmission direction.
The focal length of the long-focus lens is 75mm, and the multiplication factor of amplifying lens is 10 times.
The adjustable reference arm includes collimater, convex lens I, plane mirror I corresponding with convex lens I, convex lens
IIth, plane mirror II corresponding with convex lens II and electric reflector mirror baffle plate；The electric reflector mirror baffle plate passes through by calculating
The electrical motor driven of machine control changes reflection angle, and the light of different angle respectively enters the center of convex lens I or convex lens II
Position, lens are vertical with optical transmission direction.
When the adjustable sample arm is in wide area mode, electric reflector mirror baffle plate is controlled by computer in electro-motor
It is lower horizontal and do not block the optical transport of reference arm, the light of collimater is all transferred to the center of convex lens I, and convex lens I with
Optical transmission direction is vertical, and the wide area imaging pattern of system is realized with this；When adjustable sample arm is in high resolution mode, electric reverse
Penetrating mirror baffle plate, speculum baffle plate and optical transmission direction under motor control are in 45 ° of angles by computer, make what collimater was emitted
Light all reflexes to the center of convex lens II by speculum baffle plate, and convex lens II are vertical with optical transmission direction, scans marked area
Domain, the high resolution mode of system is realized with this.
The adjustable reference arm includes collimater, convex lens I, plane mirror I corresponding with convex lens I, convex lens
IIth, corresponding with convex lens II plane mirror II and electro-motor；The collimater passes through the electronic horse that is controlled by computer
Change the direction of emergent light up to driving, the light of different directions respectively enters the center of convex lens I or convex lens II, lens with
Optical transmission direction is vertical.
When the adjustable sample arm is in wide area mode, collimater rotates under electric motor control, makes emergent light
The center of convex lens I is transferred to, and convex lens I are vertical with optical transmission direction, and the wide area imaging pattern of system is realized with this；It is adjustable
When section sample arm is in high resolution mode, collimater rotates under electric motor control, emergent light is all transferred to convex lens
The center of mirror II, and convex lens II are vertical with optical transmission direction, scan tab area, and the high resolution mode of system is realized with this.
The adjustable reference arm includes collimater, convex lens I, plane mirror I corresponding with convex lens I, electricity and slided
Support and fixed small rack；The convex lens I and plane mirror I are fixedly mounted on electric sliding support；The collimater with
Fixed small rack is fixedly mounted；The electric sliding support by the electrical motor driven that is controlled by computer change convex lens I and
The distance between plane mirror I and collimater；The emergent light of the collimater enters the center of convex lens I, convex lens I
It is vertical with optical transmission direction.
When the adjustable sample arm is in wide area mode, electric sliding support is under electric motor control to away from collimation
Device direction is moved, and drives convex lens I and plane mirror I to reach relevant position, makes outgoing optical transport to the center of convex lens I,
And convex lens I are vertical with optical transmission direction, sample arm and the light of reference arm return are interfered, the wide area of system is realized with this
Pattern；When adjustable sample arm is in high resolution mode, electric sliding support moves to collimater direction under electric motor control
It is dynamic, drive convex lens I and plane mirror I to reach relevant position, make outgoing optical transport to the center of convex lens I, and convex lens I
It is vertical with optical transmission direction, tab area is scanned, the high resolution mode of system is realized with this.
The adjustable reference arm include collimater, convex lens I, plane mirror I corresponding with convex lens I and it is electronic can
The light delay device of tune；The collimater is connected with electronic adjustable light delay device, is inputted in electronic adjustable light delay device different
Value control the light path of reference arm；The emergent light of the collimater enters the center of convex lens I, and convex lens I pass with light
Defeated direction is vertical.
When the adjustable sample arm is in wide area mode, a fixed value A is inputted in electronic adjustable light delay device,
Change reference arm light path, the wide area mode of system is realized with this；When adjustable sample arm is in high resolution mode, electronic adjustable
Light delay device in input another fixed value B, change reference arm light path, scan tab area, the high score of system is realized with this
Distinguish pattern.
The wide area mode, scanning range are maximum up to 750mm2（25mm×30mm）；Under wide area mode, system is laterally divided
Resolution is 24.8 μm；Under high resolution mode, the lateral resolution of system is up to 6 μm.
The superiority of the present invention：
1st, the present invention provides a kind of micro- angiographic imaging system of double mode optics based on OCT.Dual mode system is in clinical detection
Doctor can be made to position focal area more rapidly to be scanned, saved detection time, while improve the degree of accuracy of detection,
Greatly improve the practicality of the micro- angiographic imaging system of optics based on OCT.
2nd, long-focus lens is used in sample arm, then system scanning range becomes big, realizes wide area mode；In sample arm
Middle to use amplifying lens, then the resolution ratio of system imaging improves, and realizes high resolution mode.And with the focal length of lens in sample arm
Change, the light path of sample arm changes.In order to realize the coherent imaging of sample arm and reference arm return light, the light of sample arm
Journey needs to be adjusted accordingly.The present invention controls adjustable sample arm and adjustable reference arm with computer, makes system can be with
It is switched fast both of which, practicality of the increase system in clinical detection.
3rd, the present invention controls sample arm and reference arm simultaneously by computer, makes the switching of both of which more quick.And
And system is using visible ray as instruction light, make system in both modes can it is quick to interest region, be accurately positioned.
Brief description of the drawings
Fig. 1 is a kind of structured flowchart of the micro- angiographic imaging system of double mode optics based on OCT involved by the present invention；
Fig. 2 is a kind of structural representation of the micro- angiographic imaging system embodiment one of double mode optics based on OCT involved by the present invention：
Fig. 3 is a kind of structural representation of the micro- angiographic imaging system embodiment two of double mode optics based on OCT involved by the present invention：
Fig. 4 is a kind of structural representation of the micro- angiographic imaging system embodiment three of double mode optics based on OCT involved by the present invention；
Fig. 5 is a kind of structural representation of the micro- angiographic imaging system example IV of double mode optics based on OCT involved by the present invention.
Wherein, 1 is light source, and 2 be instruction light, and 3 be circulator, and 4 be coupler, and 5 be adjustable reference arm, and 6 be adjustable
Sample arm, 7 be spectrometer, and 8 be capture card, and 9 be computer, and 10 be collimater, and 11 be convex lens I, and 12 be plane mirror I,
13 be convex lens II, and 14 be that plane mirror II 14,15 is electric reflector mirror baffle plate, and 16 be long-focus lens, and 17 is saturating for amplification
Mirror, 18 be electronic rotation frame, and 19 be electric bracket, and 20 be electro-motor, and 21 be electric sliding support, and 22 be to fix small rack, 23
For electronic adjustable light delay device.
Embodiment
The present invention is described in further detail below in conjunction with specific embodiment.It is it should be appreciated that described herein specific
Embodiment only to explain the present invention, is not intended to limit the present invention.
As shown in figure 1, the present invention is a kind of micro- angiographic imaging system of double mode optics based on OCT.Including light source 1；Refer to
Show light 2；Circulator 3；Coupler 4；Adjustable reference arm 5；Adjustable sample arm 6；Spectrometer 7；Capture card 8；Computer 9.Light
Source 1：Centre wavelength is 1310 nm, and with a width of 60 nm, effect is to send scanning laser.Indicate light 2：It is general to use 660 nm's
Feux rouges, the effect of instruction is provided for scan position.Circulator 3：The coherent light of return is set not return to light only by spectrometer collection
Source.Coupler 4：Make the light 10 that light source is sent：90 respectively enter reference arm and sample arm.Motorized adjustment reference arm 5：Various ways
Motorized adjustment reference arm light path.Adjustable sample arm 6：Electronic switch sample arm lens.Spectrometer 7：Optical signal is gathered, and light
Signal is converted to analog signal.Capture card 8：Analog signal is gathered, and is transferred to computer.Computer 9：Signal transacting, system
Imaging, system control.
The optical signal that light source 1 is sent is divided into two-way by circulator 3 and coupler 4, and 10% light enters adjustable reference arm
5,90% light enters adjustable sample arm 6.The light returned from adjustable sample arm 6 and adjustable reference arm 5 is in coupler 4
Interfere, form coherent light；Coherent light is gathered by circulator by spectrometer 7, and is converted to analog signal；Analog signal
The collected collection of card 8, and be transferred in computer 9；Computer is demodulated to signal, is imaged.In adjustable sample arm 6
Using long-focus lens 16, then the change of system scanning range is big, realizes wide area mode；Amplification is used in adjustable sample arm 6
The resolution ratio raising of lens 17, then system imaging, realizes high resolution mode.And with the focal length of lens in adjustable sample arm 6
Change, the light path of adjustable sample arm 6 changes.In order to realize adjustable sample arm 6 and the adjustable return light of reference arm 5
Coherent imaging, the light path of adjustable reference arm 5 needs to be adjusted accordingly.The present invention controls adjustable sample with computer
Arm 6 and adjustable reference arm 5, system is set to be switched fast both of which, practicality of the increase system in clinical detection.
Embodiment one：As shown in Fig. 2 two differences of adjustable reference arm 5 are realized using electric reflector mirror baffle plate 15
Light path.Adjustable reference arm 5 includes collimater 10, convex lens I 11, plane mirror I 12 corresponding with convex lens I 11, convex lens
Mirror II 13, plane mirror II 14 corresponding with convex lens II 13 and electric reflector mirror baffle plate 15.Adjustable sample arm 6 includes：
Focal length be 75mm long-focus lens 16, the amplifying lens 17 of multiplication factor × 10, electronic rotation frame 18, electric bracket 19.Can
Regulation sample arm 6 and adjustable reference arm 5 are connected with the electro-motor controlled by computer 9 respectively, are carried out using computer 9
Control to adjust.
First, into wide area mode, then it can adjust swivel mount 18 in sample arm 6 and turn clockwise, arrive scanning optical transport
The center of long-focus lens 16, and long-focus lens 16 is vertical with optical transmission direction.Meanwhile electricity in adjustable reference arm 5
Dynamic speculum baffle plate 15 by computer 9 under electro-motor control it is horizontal and do not block the optical transport of adjustable reference arm 5, make
The light of collimater 10 is all transferred in convex lens I 11.Realize the wide area imaging pattern of system with this, scanning range maximum is reachable
750mm2（25mm×30mm）.Then, region of interest is marked out with mouse, into high resolution mode, then swivel mount 18 is counterclockwise
Rotation, makes scanning optical transport to the center of amplifying lens 17, and amplifying lens 17 is vertical with optical transmission direction.Meanwhile join
Examine in arm, electric reflector mirror baffle plate 15 and optical transmission direction are in 45 ° of angles under motor control, pass through the light that collimater is emitted
Electric reflector mirror baffle plate 15 is all reflexed in convex lens II 13, then scanning range is that mouse marks scope, and system is realized with this
High resolution mode.Under wide area mode, system lateral resolution is 24.8 μm；And under high resolution mode, the transverse direction point of system
Resolution is up to 6 μm.
Embodiment two：As shown in figure 3, realize the two of reference arm differences by changing the direction of the emergent light of collimater 10
Light path.Adjustable reference arm 5 includes collimater 10, convex lens I 11, plane mirror I 12 corresponding with convex lens I 11, convex lens
Mirror II 13, plane mirror II 14 corresponding with convex lens II 13 and electro-motor 20.Adjustable sample arm 6 includes：Focal length is
75mm long-focus lens 16, the amplifying lens 17 of multiplication factor × 10, electronic rotation frame 18, electric bracket 19.Adjustable sample
Product arm 6 and adjustable reference arm 5 are connected with the electro-motor controlled by computer 9 respectively, are controlled also with computer 9
System regulation.
First, into wide area mode, then swivel mount 18 turns clockwise in sample arm, makes scanning optical transport saturating to long-focus
The center of mirror 16, and long-focus lens 16 is vertical with optical transmission direction.Meanwhile collimater 10 is in the control of electro-motor 20
Lower rotation, make outgoing optical transport to the center of convex lens I 11, and convex lens I 11 are vertical with optical transmission direction.System is realized with this
Wide area imaging pattern.Then, region of interest is marked out with mouse, into high resolution mode, then the rotate counterclockwise of swivel mount 18,
Make scanning optical transport to the center of amplifying lens 17, and amplifying lens 17 is vertical with optical transmission direction.Meanwhile electro-motor
20 control collimaters 10 rotate, and emergent light is all transferred to the center of convex lens II 13, and convex lens II 13 and optical transmission direction
Vertically.Scanning range is that mouse marks scope, and the high resolution mode of system is realized with this.Under wide area mode, system is laterally differentiated
Rate is 24.8 μm；And under high resolution mode, the lateral resolution of system is up to 6 μm.
Embodiment three：As shown in figure 4, the different light paths of adjustable reference arm 5 are realized using electronic sliding support 21.Can
Adjusting reference arm 5 includes collimater 10, convex lens I 11, plane mirror I 12 corresponding with convex lens I 11, electric sliding support 21
And fixed small rack 22.Adjustable sample arm 6 includes：Focal length be 75mm long-focus lens 16, the amplification of multiplication factor × 10
Lens 17.Adjustable sample arm 6 and adjustable reference arm 5 are connected with the electro-motor controlled by computer 9 respectively, same profit
Regulation is controlled with computer 9.
First, into wide area mode, then it can adjust swivel mount 18 in sample arm 6 and turn clockwise, arrive scanning optical transport
The center of long-focus lens 16, and long-focus lens 16 is vertical with optical transmission direction.Meanwhile fixed small rack 22 fixes standard
Straight device 10 is motionless, and electro-motor controls electric sliding support 21 to drive convex lens 11 and plane mirror 12 to reach relevant position, makes
The light that adjustable sample arm 6 and adjustable reference arm 5 return is interfered, and the wide area mode of system is realized with this.Then, use
Mouse marks out region of interest, and into high resolution mode, then the rotate counterclockwise of swivel mount 18, makes scanning optical transport to amplifying lens
17 center, and amplifying lens 17 is vertical with optical transmission direction.Meanwhile to control electric sliding support 21 to drive convex for electro-motor
Lens 11 and plane mirror 12 move in parallel to collimater direction, reach correct position.Then scanning mouse tab area, with
This realizes the high resolution mode of system.
The light path flexible adjustment of adjustable reference arm 5 is various, and the focal length of different focal can be used in adjustable sample arm 6
Amplifying lens away from lens and different amplification, make areas imaging and imaging resolution more flexible and changeable.
Example IV：As shown in figure 5, realize the difference of adjustable reference arm 5 using electronic adjustable light delay device 23
Light path.Adjustable reference arm 5 includes collimater 10, convex lens I 11, plane mirror I 12 corresponding with convex lens I 11 and electronic
Adjustable light delay device 23.Adjustable sample arm 6 includes：Focal length is 75mm long-focus lens 16, and multiplication factor × 10 are put
Big lens 17.Computer 9 controls the adjustable lens of sample arm 6 to switch by electro-motor.In electronic adjustable light delay device 23
It is middle to input different values to control the light path of adjustable reference arm 5.
First, into wide area mode, then it can adjust swivel mount 18 in sample arm 6 and turn clockwise, arrive scanning optical transport
The center of long-focus lens 16, and long-focus lens 16 is vertical with optical transmission direction.Meanwhile in electronic adjustable light delay
A fixed value A is inputted in device 23, changes the adjustable light path of reference arm 5, the wide area mode of system is realized with this.Then, mouse is used
Region of interest is marked out, into high resolution mode, then the rotate counterclockwise of swivel mount 18, makes scanning optical transport to amplifying lens 17
Center, and amplifying lens 17 is vertical with optical transmission direction.Meanwhile inputted in electronic adjustable light delay device 23 another
Individual fixed value B, change the adjustable light path of reference arm 5.Then scanning mouse tab area, the high-resolution mould of system is realized with this
Formula.
The value inputted in electronic adjustable light delay device 23 is different, then the light path that can adjust reference arm 5 changes, can
, using the long-focus lens of different focal and the amplifying lens of different amplification, to make system reachable in adjustable sample arm 6
The areas imaging and imaging resolution arrived is more changeable.
Claims (10)
- A kind of 1. micro- angiographic imaging system of double mode optics based on OCT, it is characterised in that：It includes light source, instruction light, annular Device, coupler, adjustable reference arm, adjustable sample arm, spectrometer, capture card and computer；What the light source was sent sweeps The optical signal for retouching laser respectively enters adjustable reference arm and adjustable sample arm after circulator and coupler, from adjustable The light that reference arm and adjustable sample arm return interferes in coupler, forms coherent light；The coherent light of return passes through ring Shape device is by spectrometer collection；The spectrometer collection optical signal, and optical signal is converted to analog signal；The capture card collection Analog signal, and it is transferred to computer；The computer carries out signal transacting, system imaging and system control；It is described adjustable Sample arm includes realizing the long-focus lens of wide area mode and realizes the amplifying lens of high resolution mode；The adjustable reference arm Including respectively from the wide area mode and high resolution mode of the adjustable sample arm corresponding to different light path patterns；It is described adjustable Reference arm and adjustable sample arm control row mode of going forward side by side to change by computer；The instruction light respectively enters by coupler Adjustable reference arm and adjustable sample arm.
- A kind of 2. micro- angiographic imaging system of double mode optics based on OCT according to claim 1, it is characterised in that：It is described The long-focus lens and amplifying lens of adjustable sample arm are arranged on electronic rotation frame；The electronic rotation frame is arranged on electronic On support；The electronic rotation frame passes through the electrical motor driven that is controlled by computer；During wide area mode, swivel mount rotation, make Optical transport is scanned to the center of long-focus lens, and lens are vertical with optical transmission direction；During high resolution mode, swivel mount rotation Turn, make scanning optical transport to the center of amplifying lens, and lens are vertical with optical transmission direction.
- A kind of 3. micro- angiographic imaging system of double mode optics based on OCT according to claim 1, it is characterised in that：It is described Adjustable reference arm includes collimater, convex lens I, plane mirror I corresponding with convex lens I, convex lens II and convex lens II Corresponding plane mirror II and electric reflector mirror baffle plate；The electric reflector mirror baffle plate passes through the electronic horse that is controlled by computer Change reflection angle up to driving, the light of different angle respectively enters the center of convex lens I or convex lens II, and lens pass with light Defeated direction is vertical.
- A kind of 4. micro- angiographic imaging system of double mode optics based on OCT according to claim 3, it is characterised in that：It is described When adjustable sample arm be in wide area mode, electric reflector mirror baffle plate level and is not hidden by computer under electro-motor control The optical transport of reference arm is kept off, the light of collimater is all transferred to the center of convex lens I, and convex lens I hang down with optical transmission direction Directly, the wide area imaging pattern of system is realized with this；When adjustable sample arm is in high resolution mode, electric reflector mirror baffle plate passes through Computer speculum baffle plate and optical transmission direction under motor control are in 45 ° of angles, the light that collimater is emitted is passed through speculum Baffle plate all reflexes to the center of convex lens II, and convex lens II are vertical with optical transmission direction, scans tab area, is realized with this and be The high resolution mode of system.
- A kind of 5. micro- angiographic imaging system of double mode optics based on OCT according to claim 1, it is characterised in that：It is described Adjustable reference arm includes collimater, convex lens I, plane mirror I corresponding with convex lens I, convex lens II and convex lens II Corresponding plane mirror II and electro-motor；The collimater changes outgoing by the electrical motor driven controlled by computer The direction of light, the light of different directions respectively enter the center of convex lens I or convex lens II, and lens hang down with optical transmission direction Directly.
- A kind of 6. micro- angiographic imaging system of double mode optics based on OCT according to claim 5, it is characterised in that：It is described When adjustable sample arm is in wide area mode, collimater rotates under electric motor control, makes outgoing optical transport to convex lens I Center, and convex lens I are vertical with optical transmission direction, and the wide area imaging pattern of system is realized with this；Adjustable sample arm is in During high resolution mode, collimater rotates under electric motor control, emergent light is all transferred to the center of convex lens II, and convex Lens II are vertical with optical transmission direction, scan tab area, and the high resolution mode of system is realized with this.
- A kind of 7. micro- angiographic imaging system of double mode optics based on OCT according to claim 1, it is characterised in that：It is described It is small that adjustable reference arm includes collimater, convex lens I, plane mirror I corresponding with convex lens I, electric sliding support and fixation Support；The convex lens I and plane mirror I are fixedly mounted on electric sliding support；The collimater is consolidated with fixed small rack Dingan County fills；The electric sliding support by the electrical motor driven that is controlled by computer change convex lens I and plane mirror I with The distance between collimater；The emergent light of the collimater enters the center of convex lens I, convex lens I and optical transmission direction Vertically.
- A kind of 8. micro- angiographic imaging system of double mode optics based on OCT according to claim 7, it is characterised in that：It is described When adjustable sample arm is in wide area mode, electric sliding support moves to away from collimater direction under electric motor control, Drive convex lens I and plane mirror I to reach relevant position, outgoing optical transport is arrived the center of convex lens I, and convex lens I and Optical transmission direction is vertical, interferes sample arm and the light of reference arm return, the wide area mode of system is realized with this；It is adjustable When sample arm is in high resolution mode, electric sliding support moves to collimater direction under electric motor control, drives convex lens Mirror I and plane mirror I reach relevant position, outgoing optical transport is arrived the center of convex lens I, and convex lens I and optical transport side To vertical, tab area is scanned, the high resolution mode of system is realized with this.
- A kind of 9. micro- angiographic imaging system of double mode optics based on OCT according to claim 1, it is characterised in that：It is described Adjustable reference arm includes collimater, convex lens I, plane mirror I corresponding with convex lens I and electronic adjustable light delay Device；The collimater is connected with electronic adjustable light delay device, and different values is inputted to control in electronic adjustable light delay device The light path of reference arm；The emergent light of the collimater enters the center of convex lens I, and convex lens I are vertical with optical transmission direction.
- A kind of 10. micro- angiographic imaging system of double mode optics based on OCT according to claim 9, it is characterised in that：It is described When adjustable sample arm is in wide area mode, a fixed value is inputted in electronic adjustable light delay device, changes reference arm light Journey, the wide area mode of system is realized with this；When adjustable sample arm is in high resolution mode, in electronic adjustable light delay device Another fixed value is inputted, changes reference arm light path, scans tab area, the high resolution mode of system is realized with this.
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