CN110013212A - Multi-parameter, multi-functional eyes measuring instrument based on optical coherence tomography - Google Patents
Multi-parameter, multi-functional eyes measuring instrument based on optical coherence tomography Download PDFInfo
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- 210000001508 eye Anatomy 0.000 title claims abstract description 43
- 238000012014 optical coherence tomography Methods 0.000 title claims abstract description 31
- 230000003287 optical effect Effects 0.000 claims abstract description 21
- 239000000835 fiber Substances 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 2
- 238000003384 imaging method Methods 0.000 abstract description 22
- 238000005259 measurement Methods 0.000 abstract description 8
- 238000012423 maintenance Methods 0.000 abstract description 4
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- 238000006243 chemical reaction Methods 0.000 abstract description 3
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- 238000001514 detection method Methods 0.000 description 6
- 210000005252 bulbus oculi Anatomy 0.000 description 5
- 238000007689 inspection Methods 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 3
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- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000008859 change Effects 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000001525 retina Anatomy 0.000 description 2
- 238000010408 sweeping Methods 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000002159 anterior chamber Anatomy 0.000 description 1
- 230000004323 axial length Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
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- 235000008434 ginseng Nutrition 0.000 description 1
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- 230000007246 mechanism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011158 quantitative evaluation Methods 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000011896 sensitive detection Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/0016—Operational features thereof
- A61B3/0025—Operational features thereof characterised by electronic signal processing, e.g. eye models
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/102—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/117—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
- A61B3/1225—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes using coherent radiation
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Abstract
The present invention provides a kind of multi-parameters based on optical coherence tomography, multi-functional eyes measuring instrument；Measuring instrument measuring instrument structure of the invention is simple, design is reasonable, convenient for light path regulation, it realizes the conversion between the time domain and frequency domain of OCT reference arm optical path, so that single equipment has a variety of imaging functions, greatly improves the performance of equipment, meet common ophthalmic measurement demand, the parameter at measurement each position of eyes is obtained convenient for doctor, has saved the purchase cost, maintenance cost and the training on operation cost for corresponding to equipment of equipment, the management cost of equipment.
Description
The invention belongs to ophthalmology checking Instrument technical fields, and in particular to a kind of more ginsengs based on optical coherence tomography
Several, multi-functional eyes measuring instrument.
Background technique
Optical coherence tomography (OCT) is a kind of emerging imaging technique, is occurred from 1991 till now, with research
Go deep into, this technology has many advantages, such as in the noninvasive lossless, high-resolution of living body, quantitative evaluation, its working principle is that utilizing low phase
Dry principle of interference combination confocal scanning carries out the microstructure inside biological tissue or other scattering mediums high-resolution
Computed tomography scanning passes through the image of computer reconstruction sample.With the exploitation of corresponding software algorithm, widely answer
It uses in the clinical applications such as blood flow imaging, eye detection.Wherein, in terms of eye detection, due to the superior resolution ratio of OCT, make
It obtains " goldstandard " that OCT has become eye detection.
OCT points are two major classes: time domain TD-OCT and frequency domain SD-OCT at present.The working principle of TD-OCT is low-coherence light source
The light of sending is divided into two-beam at fiber coupler, and a branch of reference light directive reference arm reaches plane mirror and reflects, separately
Outer a branch of measurement light emission is scattered back to come backward to sample, by sample, and reference beam is reflected with measuring beam on sample
The rear orientation light of generation is interfered in fiber coupler.Subsequent photoelectric sensor receives this interference signal and handles, finally
The faultage image of sample is obtained by computer disposal.By the scanning of longitudinal reference arm, realize that sample interior longitudinal direction information is (deep
Spend direction) point-by-point acquisition.Due to the limitation of the scan mechanism, the axial line scanning speed (A-line) of TD-OCT is generally limited
System significantly limits the image taking speed of TD-OCT in 2-4kHz.
With unlike TD-OCT System Working Principle, SD-OCT is in optical receiving end by photoelectric sensor with spectrometer generation
It replaces, it is no longer necessary to longitudinal scanning reference arm, to improve scanning speed, increase stability.Specifically, being connect to spectrometer
The interference spectrum data received, are analyzed by inverse Fourier transform, and the final longitudinal information for obtaining measured matter passes through meter
The acquisition and analysis of calculation machine completion image data.The design of this system changes device by time domain and frequency domain light path, realizes two kinds
Effective conversion of light path reaches and detects to each position multi-parameter of eyes, realizes the multi-functional of measuring instrument.
Currently, ophthalmology checking Instrument in the market is such as surveyed for axis oculi length both for a certain eye parameters target
Amount, the retina such as is imaged using single TD-OCT or SD-OCT, they, can on single target imaging
The needs of meeting clinically.But imaging inspection if desired is carried out to multiple targets, it is necessary to a variety of inspection apparatus are equipped with, and
As deeply, some diseases can be related with the multiple positions of eyes to ophthalmology disease research, that is, ophthalmology disease occurs, to multi-section
Position carry out morphosis imaging, which has, centainly to be needed.
Therefore traditional ophthalmology checking Instrument for simple target, it is difficult to which practical need is applicable in by an inspection item
It asks, multiple detection devices is needed to detect patient.Not only increase the purchase cost of detecting instrument in this way, but also also increases
The maintenance cost of machine, training cost of related personnel etc..
Summary of the invention
The object of the present invention is to be directed to the deficiency of existing ophthalmology checking Instrument, a kind of multi-parameter is provided, multi-functional eyes are surveyed
Instrument is measured, it can be with parameters such as one-shot measurement multiple parameters, including more anterior ocular segments, retina, axis oculi length.
In order to reach above-mentioned technical purpose, technical scheme is as follows: a kind of based on optical coherence tomography
Multi-parameter, multi-functional eyes measuring instrument, including light source, light coupling device, reference arm, sample arm, detector and processor；
The light source is for providing incipient beam of light；
The fiber coupler is used to the incipient beam of light being divided into two parts, respectively enters the reference arm and sample
Arm, and receive the light beam of the reference arm and sample arm return；
The reference arm includes parallel arrangement of frequency domain module and time domain module, and the frequency domain module includes collimating mirror and frequency
Zero light path position changing device of domain, the time domain module include collimating mirror and Time Domain Optical delay line device；
The sample arm is for being scanned eyes to be measured；
The detector is used to receive the light beam that reference arm and sample arm return and interferes the interference-type to be formed, and by its
It is converted into electric signal；It includes parallel arrangement of spectrometer and photoelectric sensor；
The processor is imaged for receiving the electric signal.
Eyes measuring instrument of the invention is changed by the way that parallel zero light path position of frequency domain is respectively set in sample arm and detector
Become device and Time Domain Optical delay line device and spectrometer and photoelectric sensor；So that the light beam that light source issues, Ke Yixuan
It selects using frequency domain light path, also can choose using frequency domain light path, specific frequency domain light path are as follows: the light that light source issues, through optical fiber coupling
Clutch is divided into two parts, a branch of to enter reference arm, into reference arm light beam can through zero light path position changing device of frequency domain, into
Enter frequency domain module, the interference of light that the light most returned afterwards through reflecting mirror and sample arm return, to be imaged by spectrometer detection；Time domain
Light path are as follows: the light that light source issues is divided into two parts through fiber coupler, and a branch of to enter reference arm, the light beam into reference arm can
To enter time domain module, the most interference of light of the light afterwards through reflecting mirror return and sample arm return through optical delay line device, thus
Photodetector and processor detection imaging.
Time domain OCT module can be utilized respectively in this way to measure axis oculi length, and frequency domain OCT module then carries out eyes
Imaging, to realize the inspection to eyes multiple location.
Further, the zero light path position changing device of frequency domain includes: collimation lens and movable plane mirror, structure letter
It is single, it is corresponded to convenient for light path adjustment.
Preferably, the movable plane mirror includes motor driven guide rail and the plane mirror on guide rail.
Time Domain Optical delay line device is primarily to quickly change the light path of reference arm, it is preferable that the Time Domain Optical
Delay line device includes round turntable, and several reflecting mirrors being fixed on the turntable at an angle, and structure is simple, is convenient for
Light path adjustment corresponds to.
Further, it is 840nm that the light source, which is center wavelength, and bandwidth range is the laser light source of 49nm, mean power
For 20mW.Tissue scatter can be reduced using near-infrared light waves to reach bigger imaging depth；Bandwidth range is narrow to can ensure that figure
It is influenced as not moved inevitably by eyeballs itself such as the micro- pans of eyeball.
Further, the sample arm includes collimating mirror, quick scanning galvanometer, slow scanning galvanometer and the first lens group
With the second lens group, after light enters, successively pass through collimating mirror, quick scanning galvanometer, slow scanning galvanometer, subsequently into first
Lens group or the second lens group, first lens group are divergent lens group, and second lens group is collector lens group, institute
Stating can be switched between the first lens group and the second lens group.First lens group is divergent lens group, so that scanning ray enters eye
It is a directional light before eyeball, then can be focused on eyeground after the light system of eyes, so as to which eyeground is imaged；
Second lens group is collector lens group, and the directional light entered in this way can be focused by the first lens group room before eyes,
To which camera oculi anterior be imaged.Pass through the switching of the first lens group and the second lens group in this way, then whole device both can be right
Fundus imaging can also be imaged camera oculi anterior, so as to obtain more information.
Preferably, first lens group includes two condenser lenses compositions parallel to each other, and two condenser lenses
4f system is formed, structure is simple, regulates and controls convenient for light path.
Preferably, second lens group is made of a condenser lens, convenient for focusing, is also convenient for the regulation of system light path.
Preferably, the spectrometer includes collimation lens, grating, condenser lens and CMOS line-scan digital camera.
Measuring instrument structure of the invention is simple, and design rationally, regulates and controls convenient for light path, realizes the time domain of OCT reference arm optical path
Conversion between frequency domain greatly improves the performance of equipment, for common so that single equipment has a variety of imaging functions
Ophthalmic measurement demand, such as anterior chamber's imaging, eye ground imaging, the long measurement of axis oculi, blood flow imaging etc. can meet, thus
The parameter at measurement each position of eyes is obtained convenient for doctor, has saved the purchase cost of equipment, maintenance cost and corresponding equipment
Training on operation cost, the management cost of equipment.
Detailed description of the invention
Fig. 1 is the multi-parameter provided in an embodiment of the present invention based on optical coherence tomography, multi-functional eyes measuring instrument
Structural schematic diagram；
Fig. 2 is the zero light path position changing device structural schematic diagram of frequency domain of the embodiment of the present invention；
Fig. 3 is the Time Domain Optical delay line device structural schematic diagram of the embodiment of the present invention.
Specific embodiment
The technical solution that the present invention will be described in detail in the following with reference to the drawings and specific embodiments.
Show referring to Fig.1, multi-parameter, multi-functional eyes measuring instrument based on optical coherence tomography, including light source 1, light
Fine coupler 2, reference arm, sample arm, detector and processor.
Wherein reference arm includes parallel arrangement of frequency domain module and time domain module, and frequency domain module includes collimating mirror 3 and frequency domain
Zero light path position changing device 5, as shown in Fig. 2, zero light path position changing device 5 of frequency domain is a movable plane mirror, including electricity
Machine drives guide rail 51 and the plane mirror 52 on guide rail, by the movement of motor driven guide rail 51, so that plane mirror 52 is mobile,
Reach change with reference to arm lengths, so that consistent with sample arm lengths to be measured with reference to arm lengths.Time domain module includes collimation
Mirror 3 and Time Domain Optical delay line device 4, wherein the structure of Time Domain Optical delay line device 4 is as shown in Figure 3；Including round turntable
41, and several reflecting mirrors 42 being fixed on turntable 41 at an angle；Reflecting mirror 42 rotates the time with the rotation of turntable 41
The position beaten on reflecting mirror 42 is changed, so that changing with reference to arm lengths.
Sample arm includes collimating mirror 3, quick scanning galvanometer 6, slow scanning galvanometer 7, and the first changeable lens group and
Second lens group, the first lens group are divergent lens group, and the second lens group is collector lens group, wherein the first lens group is by two
Condenser lens 8 parallel to each other forms, and two condenser lenses 8 form 4f system；Second lens group is by 8 groups of a condenser lens
At；Detector includes parallel arrangement of spectrometer and photoelectric sensor 9, and wherein spectrometer includes collimating mirror 3, grating 10, focuses
Lens 8 and CMOS line-scan digital camera 11；Processor is a computer 12.
Prolonged by the way that parallel zero light path position changing device 5 of frequency domain and Time Domain Optical is respectively set in sample arm and detector
Slow line apparatus 4 and spectrometer and photoelectric sensor 9；So that the light beam that light source issues, can choose using frequency domain light path,
Also it can choose using frequency domain light path.
The optical path of the frequency domain OCT of the measuring instrument of the embodiment of the present invention is that light source 1 issues light beam and enters fiber coupler 2
On be divided into two, a branch of reference arm that enters into zero light path position changing device of frequency domain specifically, passes through a fiber optic collimator
Device 3 becomes a branch of directional light, and then directional light is beaten on a moveable plane mirror 52, due to moving for plane mirror 52
Property, system is adjusted according to the difference (such as be imaged or eyeground is imaged to camera oculi anterior) of imageable target
The position of plane mirror, and then the brachium of reference arm is adjusted, it is matched on light path with the target to be imaged.Into reference arm
After light reflects on reflecting mirror 52, in backtracking to fiber coupler 2.Another light beam then enters sample arm, by sweeping at a slow speed
Retouch galvanometer 6, then by quick scanning galvanometer 7, then the lens group by matching with target --- the first lens group or the
Two lens groups focus scanning, through backtracking after the reflection of scanning light in the tissue, in fiber coupler in the target of imaging
The light returned in 2 with reference arm interferes, and subsequently into explorer portion, that is, includes collimation lens 3, grating 10, focuses thoroughly
The spectrometer that mirror 8 and CMOS line-scan digital camera 11 form, optical signal are converted into electric signal, and final signal is transferred to electronics calculating
It is imaged on machine 12.
The time domain OCT optical path optical path of the measuring instrument of the embodiment of the present invention is that light source 1 issues light beam and enters fiber coupler
It is divided into two on 2, a branch of to enter reference arm, into Time Domain Optical delay line device 4, specifically, collimator 3 is laggard to remove optics
Delay line device 4, then backtracking, enters in fiber coupler 2.Another light beam then enters sample arm, by sweeping at a slow speed
Retouch galvanometer 6, then by quick scanning galvanometer 7, then the lens group by matching with target --- the first lens group or the
Two lens groups focus scanning, through backtracking after the reflection of scanning light in the tissue, in fiber coupler in the target of imaging
The light returned in 2 with reference arm interferes, and subsequently into photosensor part, optical signal is converted by photoelectric sensor 9
Electric signal, final signal are transferred on electronic computer 12 and are imaged.
The light source of OCT system determines the attainable performance level of institute, the determined longitudinal resolution of central wavelength, and is
The attainable investigation depth of system institute.Therefore, the light source 1 of the measuring instrument of the present embodiment preferably, is voluntarily determined using by computer MSR Information system
The central wavelength of system is 840nm, and bandwidth range is the laser light source of 49nm, mean power 20mW, such axial resolution < 12
μm, to realize that highly sensitive detection and rapid image acquisition provide possibility in human eye.It can be reduced using near-infrared light waves simultaneously
Tissue scatter is to reach bigger imaging depth；Bandwidth range is narrow to can ensure that image can not by eyeballs itself such as the micro- pans of eyeball
The influence of the movement avoided.
Meanwhile in the present embodiment, changeable the first lens group and the second lens group are set, the first lens group is that diverging is saturating
Then microscope group can focus so that scanning ray enters before eyes for a directional light after the light system of eyes on eyeground,
So as to which eyeground is imaged；Second lens group is collector lens group, and the directional light entered in this way can pass through first
Lens group room before eyes is focused, so that camera oculi anterior be imaged.Pass through the first lens group and the second lens group in this way
Switching, then whole device camera oculi anterior can also both be imaged fundus imaging, so as to obtain more information.
In this way, the eyes measuring instrument of the embodiment of the present invention, while it being provided with time domain OCT and frequency domain OCT module, and having can
The first lens group and the second lens group of choosing, can use in this way frequency domain mould respectively to eyeground and anterior ocular segment focal imaging
Block obtains the structural information of eyes, such as camera oculi anterior structural information, retinal structure information, and can pass through corresponding imaging
Algorithm introduces, and then can be to blood flow imaging.And to camera oculi anterior and fundus imaging, it is the length by changing reference arm in frequency domain
Degree and corresponding condenser lens, come what target was imaged.And axiallength is measured by time domain system etc., this
Sample covers the important parameter in eye examination substantially.
And measuring instrument of the invention, designed by the element of preferred each structure so that structure is simple, be conveniently adjusted it is different at
As position optical focus, reference arm light path correspondence problem, the measuring instrument scanning of the embodiment of the present invention is quickly, time-consuming short, convenient for doctor
The raw parameter for obtaining measurement each position of eyes has saved the operation training of the purchase cost, maintenance cost and corresponding equipment of equipment
Instruct cost, the management cost of equipment.
According to the disclosure and teachings of the above specification, those skilled in the art in the invention can also be to above-mentioned embodiment party
Formula is changed and is modified.Therefore, the invention is not limited to the specific embodiments disclosed and described above, to of the invention
Some modifications and changes should also be as falling into the scope of the claims of the present invention.In addition, although being used in this specification
Some specific terms, these terms are merely for convenience of description, does not limit the present invention in any way.
Claims (10)
1. multi-parameter, multi-functional eyes measuring instrument based on optical coherence tomography, which is characterized in that including light source, light
Coupler, reference arm, sample arm, detector and processor；
The light source is for providing incipient beam of light；
The fiber coupler is used to the incipient beam of light being divided into two parts, respectively enters the reference arm and sample arm, and
Receive the light beam of the reference arm and sample arm return；
The reference arm includes parallel arrangement of frequency domain module and time domain module, and the frequency domain module includes collimating mirror and frequency domain zero
Light path position changing device, the time domain module include collimating mirror and Time Domain Optical delay line device；
The sample arm is for being scanned eyes to be measured；
The detector is used to receive reference arm and the light beam of sample arm return interferes the interference-type to be formed, and is converted
For electric signal；It includes parallel arrangement of spectrometer and photoelectric sensor；
The processor is imaged for receiving the electric signal.
2. eyes measuring instrument according to claim 1, which is characterized in that the zero light path position changing device packet of frequency domain
It includes: collimation lens and movable plane mirror.
3. eyes measuring instrument according to claim 2, which is characterized in that the movable plane mirror includes that motor driven is led
Rail and the plane mirror on guide rail.
4. eyes measuring instrument according to claim 1, which is characterized in that the Time Domain Optical delay line device includes circle
Turntable, and several reflecting mirrors being fixed on the turntable at an angle.
5. eyes measuring instrument according to claim 1, which is characterized in that the light source is that center wavelength is 840nm, bandwidth
Range is the laser light source of 49nm, mean power 20mW.
6. eyes measuring instrument according to claim 1, which is characterized in that the sample arm includes collimating mirror, is quickly scanned
Galvanometer, slow scanning galvanometer and the first lens group and the second lens group, after light enters, successively by collimating mirror, quickly scanning
Galvanometer, slow scanning galvanometer, subsequently into the first lens group or the second lens group, first lens group is collector lens
Group, second lens group are divergent lens group, be can be switched between first lens group and the second lens group.
7. eyes measuring instrument according to claim 6, which is characterized in that first lens group includes two parallel to each other
Condenser lens composition, and two condenser lenses form 4f systems.
8. eyes measuring instrument according to claim 6, which is characterized in that second lens group is by a focus lens group
At.
9. eyes measuring instrument according to claim 1, which is characterized in that, the spectrometer include collimation lens, grating,
First condenser lens and CMOS line-scan digital camera.
10. eyes measuring instrument according to claim 1, which is characterized in that the processor is one with store function
Terminal device.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111110183A (en) * | 2019-12-17 | 2020-05-08 | 温州医科大学 | Binocular optical coherence automatic focusing imaging device and working method |
| CN111643051A (en) * | 2020-06-11 | 2020-09-11 | 苏州比格威医疗科技有限公司 | Reference arm, ophthalmic OCT imaging system and imaging method thereof |
| CN116223374A (en) * | 2023-02-03 | 2023-06-06 | 电子科技大学 | Optical coherence tomography multi-point distributed imaging method |
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