CN107648660A - A kind of antiphlogistic antibacterial type tapon and preparation method thereof - Google Patents
A kind of antiphlogistic antibacterial type tapon and preparation method thereof Download PDFInfo
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- CN107648660A CN107648660A CN201711034172.0A CN201711034172A CN107648660A CN 107648660 A CN107648660 A CN 107648660A CN 201711034172 A CN201711034172 A CN 201711034172A CN 107648660 A CN107648660 A CN 107648660A
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- lactic acid
- acid bacteria
- lamella
- motherwort
- bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/20—Tampons, e.g. catamenial tampons; Accessories therefor
- A61F13/2002—Tampons, e.g. catamenial tampons; Accessories therefor characterised by the use
- A61F13/202—Catamenial tampons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/20—Tampons, e.g. catamenial tampons; Accessories therefor
- A61F13/2071—Tampons, e.g. catamenial tampons; Accessories therefor characterised by the material or the structure of the outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
Abstract
The invention discloses a kind of antiphlogistic antibacterial type tapon, including tampon body and cotton thread, tampon body includes sliver and lactic acid bacteria lamella；Lactic acid bacteria lamella is arranged at the inside or surface of sliver；Lactic acid bacteria lamella includes lactic bacteria composition and motherwort chip.Wherein, lactic bacteria composition includes lactic acid sclerote and coated layer.The invention also discloses the preparation method of this antiphlogistic antibacterial type tapon.The present invention has the characteristics of adjustment acid vagina environment, eliminate colpitis and suppress other bacteria breeds by introducing lactic acid bacteria and motherwort simultaneously in tapon.
Description
Technical field
The present invention relates to hygiene article sector, more particularly to a kind of antiphlogistic antibacterial type tapon and preparation method thereof.
Background technology
Tapon is a kind of catamenial devices, is contacted by woman's vaginal cavity and absorbs menstruation stream to prevent menstruation outflow cloudy
Road junction.Built-in tapon because use when do not influence to wear clothes and move, absorb fully will not side leakage, by increasing people
Accreditation and use.
But because tapon contacts with vaginal epithelial cell the resistance of body may closely declined, between replacing
Every overlong time endometrium can be caused dry and cracked, intravaginal staphylococcus aureus can enter blood circulation system, produce poisoning
Shock-syndrome.Female menstrual period can not be sterilized effectively, remove toxic shock syndromes, and women is also easy to pruritus of vagina, palace occur
Neck is scorching, the irregular menstruation caused by the pelvic infecton blood stasis deficiency of blood, dysmenorrhoea, through gynecological diseases such as cold and palace colds；Women was obtaining gynaecological disease
Hospital is needed after disease by having an injection, the mode such as take medicine is treated, and easily cross-infection repeatedly.
Therefore tapon needs have higher standard and effect in antibacterial sterilizing；Simultaneously as tapon is built in the moon
Road and spread all over intensive miniature wound in menstrual period endometrium, this also provides the field of dispenser for the prevention and treatment of gynecological disease
Institute.
There are many reasons in female vagina, but main cause is caused by flora imbalance.And normally parasitize
In healthy women vaginal flora, lactic acid bacteria is dominant, and action breaks of the glycogen through lactic acid bacteria of vagina epithelium are lactic acid, make vagina
Local is in weakly acidic condition.At present, for gynaecological imflammation caused by vaginal dysbacteriosis, having occurred some has anti-inflammation
The tapon of effect, use doctor trained in Western medicine antibiosis extract for treating more, but effect is not felt quite pleased, and easily recurrence, brings very big to patient
Pain, while produce certain drug resistance.
Also there is nano-antibacterial tapon, nano-antibacterial technology is one kind in physical antibacterial technology, can utilize nanometer
The dimensional effect of yardstick brings higher level strong osmotic and physical antibacterial performance, but cost is higher therefore, and exploitation is a kind of
Good effect, treatment uneasy to recur and low toxic side effect.
The content of the invention
In order to solve the problems, such as antiphlogistic antibacterial type tapon cost height, effect difference in the prior art, the embodiment of the present invention
Provide a kind of antiphlogistic antibacterial type tapon and preparation method thereof.The technical scheme is as follows：
On the one hand, it is described the embodiments of the invention provide a kind of antiphlogistic antibacterial type tapon, including tampon body and cotton thread
Tampon body includes sliver and lactic acid bacteria lamella；The lactic acid bacteria lamella is arranged at the inside or surface of the sliver；The lactic acid
Bacterium lamella includes lactic bacteria composition and motherwort chip.
Further, the lactic bacteria composition includes lactic acid sclerote and coated layer.
Specifically, the coated layer includes oligoisomaltose, protein material and nitrocellulose.
Preferably, the lactic acid bacteria lamella also includes freeze drying protectant.
Specifically, the freeze drying protectant is in trehalose, sucrose, sodium glutamate, sorbierite, mannitol or glucan
The composition of any one or more.
Further, the embedded center being arranged at the center of the sliver or along the sliver of the lactic acid bacteria lamella
Axis is arranged at the outer surface of the sliver around setting or lactic acid bacteria lamella cladding.
Specifically, the lactic acid bacteria lamella is the fixed porous cotton piece for being attached with lactic bacteria composition and motherwort chip
Layer or the preparation tabletting including lactic bacteria composition and motherwort chip.
Alternatively, the motherwort chip is motherwort powder or the preparation tabletting of Herba Leonuri granule or the leaching of motherwort decoction
The cotton lamella that stain is crossed.
On the other hand, the embodiment of the invention also discloses a kind of preparation method of antiphlogistic antibacterial type tapon, the side
Method includes：
S1：From absorbency fiber, fully dry；
S2：Fixed weight absorbency fiber is weighed, absorbency fiber is pressed into fibre strip layer；
S3：Cotton thread is fixed in fibre strip layer centre, the exposed 10- outside fibre strip layer of cotton thread tail end
20cm；
S4：Fibre strip layer is curled into strip cylindrical absorbent body；
S5：Lactic acid bacteria lamella is attached and is arranged at fibre strip layer surface, or the embedded fibre strip layer that is arranged at crimps
Inside the absorber of formation；
S6：It is with non-woven fabrics that absorber tight is exposed outside tampon body into tampon body, cotton thread tail end；
S7：Tampon body is packed, got product.
Further, methods described also includes preparing lactic bacteria composition and motherwort chip in the lactic acid bacteria lamella.
It should be noted that the term " comprising " used in the present invention is pardon or open, however not excluded that extra
, the element not being quoted or method and step.
Unless otherwise indicated, for the meaning and this hair of all terms (including technology and scientific terminology) for disclosing the present invention
Bright one skilled in the art are generally understood that identical, and by further instructing, subsequent definition is used for more preferable
Understand the teachings of the present invention.
Involved " lactic acid bacteria (lactic acid bacterium) " this term, typically refers to be selected from the present invention
Lactococcus (lactoucoccus) species, lactobacillus (Lactobacilus) species, streptococcus
(Streptococcus) species, Pediococcus (Pediococcus) species, Bifidobacterium (Bifidobacterium) thing
The bacterium of kind and Leuconostoc (Leuconostoc) species, and including being classified as above-mentioned any monoid in the art (such as
Species, subspecies, strain).
The beneficial effect that technical scheme provided in an embodiment of the present invention is brought is：
1st, the embodiment of the present invention has adjustment vagina acid by introducing lactic acid bacteria and motherwort composition in tapon
Property environment, have eliminate colpitis, suppress the characteristics of other bacteria breeds；Meanwhile also utilizing motherwort, there is diuresis to disappear
Swollen, to shrink uterus effect Chinese medicine treatment irregular menstruation, dysmenorrhoea, through gynecological diseases such as cold and palace colds and health care uterus
The effect of cause the embodiment of the present invention to make full use of tapon as dispenser carrier, it is synchronous to carry out anti-inflammatory and the dual work(of health care
Effect；
2nd, the lactic acid bacteria being related in the embodiment of the present invention can produce the metabolites such as lactic acid, can by reduce pH value with
Strengthen the activity of other acid such as acetic acid, suppress saccharomycete, fungi, bacterium and some other harmful microbe and grow and breed,
With good antibacterial characteristics；
3rd, the lactic acid bacteria lamella and tapon being related in the embodiment of the present invention are combined, and have good biology with human body
Compatibility, lactic acid bacteria is introduced into tapon and played for the gentle non-stimulated antiphlogistic antibacterial characteristic of vagina；
4th, the metabolite for the lactic acid bacteria being related in the embodiment of the present invention has good heat endurance and preferable antioxygen
Change hydrogen enzyme and antiprotease activity, and as pH value reduces, its bacteriostasis enhancing, so that the tapon tool prepared
There is the effect of longer anti-inflammatory, antibacterial；
5th, the embodiment of the present invention adds cryoprotector in lactic acid bacteria lamella, and is subsequently freeze-dried so that breast
Sour bacterium can keep activity, be advantageous to store for a long time；
6th, the biological antibiotic technology for the lactic acid bacteria that the embodiment of the present invention uses resists relative to the medicine in existing hygienic articles
Bacterium, chemical antibacterial etc., have no drug resistance this potential safety hazard, also without chemicals change vagina acid-base degree the drawbacks of, this sterilizing side
Formula is safe, nonirritant；
7th, the disclosed lactic acid bacteria lamella that introduced in the tampon body of tapon of the embodiment of the present invention prepares antiphlogistic antibacterial type
The processing step of tapon is simple, simple operation, cost are cheap.
Embodiment
To make the object, technical solutions and advantages of the present invention clearer, below by the technology in the embodiment of the present invention
Scheme is clearly and completely described, it is clear that and described embodiment is only part of the embodiment of the present invention, rather than entirely
The embodiment in portion.Based on the embodiment in the present invention, those of ordinary skill in the art are not under the premise of creative work is made
The every other embodiment obtained, belongs to the scope of protection of the invention.
Embodiment 1
The embodiments of the invention provide a kind of antiphlogistic antibacterial type tapon, including tampon body and cotton thread, tampon body to include
Sliver and lactic acid bacteria lamella；Lactic acid bacteria lamella is arranged at the surface of sliver.The embodiment of the present invention in tapon by introducing
Lactic Acid Bacteria Metabolites, there is adjustment acid vagina environment, have and eliminate colpitis, suppress the characteristics of other bacteria breeds.
Wherein, lactic acid bacteria lamella includes lactic bacteria composition and motherwort chip.
Further, lactic bacteria composition includes lactic acid sclerote and coated layer.
Specifically, coated layer includes oligoisomaltose, protein material and nitrocellulose；And oligoisomaltose,
The component of protein material and nitrocellulose ratio is 40：45：15.
Preferably, the freeze drying protectant that lactic acid bacteria lamella also includes sucrose, prepared by sodium glutamate combination.Specifically, sucrose
Addition concentration with sodium glutamate is respectively 10% and 7.5% w/v (W/V).
In specific implementation, freeze drying protectant can also be trehalose, sucrose, sodium glutamate, sorbierite, mannitol or Portugal
The composition of any one or more in glycan.
Further, lactic acid bacteria lamella cladding is arranged at the outer surface of the sliver；In specific implementation, lactic acid bacteria lamella
Set location and mode include but is not limited to it is embedded be arranged at the center of sliver or along sliver central axis around setting
Put.
Specifically, lactic acid bacteria lamella is the preparation tabletting for including lactic bacteria composition and motherwort chip.
Alternatively, the motherwort chip is motherwort powder formulation tabletting.The dosage for adding motherwort is 0.5g.
In a particular embodiment, it is possibility to have motherwort or the combination of other Chinese medicines are in the form of powdered, Formulation
It is added to jointly in tampon body with lactic acid bacteria lamella.
Further, tampon body also includes composite web top layer；Composite web top layer is coated on the outer surface of sliver.
Specifically, composite web top layer is disposed with pro-skin top layer and antibacterial layer from outside to inside.
Wherein, pro-skin top layer is fat-soluble pro-skin top layer or water-soluble pro-skin top layer.
Further, water-soluble pro-skin top layer also includes motherwort decoction.The dosage for adding motherwort decoction is 2.0g.
In specific implementation, antibacterial layer can be nano antibacterial layer；The present invention can use lactic acid antibacterial and nano-antibacterial
The means that technology is combined, higher level strong osmotic effect can be brought using the dimensional effect of nanoscale, with reference to breast
Acid for adjusting pH environment so that this sterilization method is safer, long-acting.
The embodiment of the present invention makes using the suppleness and biocompatibility on the pro-skin top layer coated in the outer surface of sliver
Tapon is more soft and adhere well to skin, tapon can do certain reversible with the stretching of skin when people moves
Deformation, it is ensured that the close of tapon is filled in while the comfort level of user significantly improves, the discomfort that basic foreign is filled in
Sense.
Moreover, pro-skin top layer can be fat-soluble pro-skin top layer or water-soluble pro-skin top layer.Used in the embodiment of the present invention
Water-soluble pro-skin top layer can enhance medical dispenser function as the solvent and carrier of water soluble drug.In the present invention, water
Dissolubility pro-skin top layer includes motherwort decoction, can more fully play motherwort it is this have inducing diuresis to remove edema, shrink uterus make
Chinese medicine treatment irregular menstruation, dysmenorrhoea, through gynecological diseases such as cold and palace colds and health care uterus.
Preferably, lactic acid bacteria lamella also includes freeze drying protectant.The freeze drying protectant that the embodiment of the present invention uses is paddy ammonia
The composition of sour sodium, mannitol and glucan.Freeze drying protectant causes lactic acid being maintained to live after frozen dried
Property, be advantageous to store for a long time.
Freeze-drying is considered as being best suitable for one of active component dehydration process, and its purpose is intended to acquisition solid and stable
Final preparation, it is that the suitable cryoprotector of selection is the pass for increasing survival rate of the lactic acid bacteria during lyophilized and subsequent storage
Key factor.
Specifically, the anti-microbial property of lactic acid bacteria mostlys come from its metabolin, and the major metabolite of lactic acid bacteria includes lactic acid
With the composition of acetic acid.
In a particular embodiment, lactic acid bacteria metabolite includes lactic acid bacteria and carries out homofermentation and different to carbon sources such as glucose
Type ferments, and can produce substantial amounts of lactic acid, acetic acid, in addition to other acidic end products such as a small amount of formic acid, propionic acid.
Wherein, for lactic acid by reducing pH value to strengthen other sour activity, acetic acid has stronger bacteriostatic activity and wider
Scope of restraining fungi, saccharomycete, fungi can be suppressed, bacterium and some other harmful microbe grow and propagation.
In addition, there is lactic acid bacteria metabolite good heat endurance and preferably anti-oxidant hydrogen enzyme and antiprotease to live
Property, and as pH value reduces, the enhancing of its bacteriostasis.
In order to verify that the fungistatic effect of lactic acid has carried out bacteriostatic test, specific experiment comprises the following steps：
S1, with rubbing method staphylococcus aureus, EHEC are seeded in nutrient agar flat board respectively, in vain
Color candida albicans is inoculated with Sabouraud agar medium flat board, Bacillus acidi lactici inoculation MSR agar medium flat boards.With beating for 5mm apertures
After hole device punches on the above medium, the μ l of sample 20 are added with liquid-transfering gun；
S2, the culture of staphylococcus aureus, EHEC, Candida albicans put into common incubator 37 DEG C of trainings
Result is observed after supporting 24 hours, and the culture of Bacillus acidi lactici is observed after putting in common incubator 30 DEG C of cultures 48 hours；With inhibition zone
Diameter be fungistatic effect characterization parameter, concrete outcome is as shown in table 1.
Inhibition zone data result in the lactic acid bacteria metabolite bacteriostatic test of table 1
| Strain | Staphylococcus aureus | EHEC | Candida albicans | Bacillus acidi lactici |
| Antibacterial circle diameter/mm | 6.7 | 9.2 | 9 | 0 |
The as shown by data of table 1, lactic acid bacteria metabolite have for staphylococcus aureus, EHEC and Candida albicans
There is obvious inhibitory action, inhibitory action is had no for Bacillus acidi lactici.So lactic acid metabolism product is added in tampon body,
By the use of tampon body as dispenser carrier, both there is obvious inhibiting effect to harmful bacteria, and do not influence to maintain acyclic acidic for vagina
The growth of the flora of the favourable lactic acid bacteria in border.
In addition, there is lactic acid bacteria metabolite good heat endurance and preferably anti-oxidant hydrogen enzyme and antiprotease to live
Property, and as pH value reduces, the enhancing of its bacteriostasis.
In order to further prove the antiphlogistic antibacterial effect of the embodiment of the present invention, clinical test has also been carried out.
1st, clinical observation
Using the present embodiments relate to antiphlogistic antibacterial type tapon be supplied to the women of use demand totally 200
People, different degrees of gynaecological imflammation is made a definite diagnosis through gynecologial examination, its age distribution was at 20~48 years old, average out to 35 years old.At random
It is divided into two groups, the people of control group 100, the people for the treatment of group 100.
2nd, treatment means
Control group uses the tapon added without lactic acid bacteria metabolite, and 3 menstrual periods are used continuously；
Treatment group choosing the present embodiments relate to have lactic acid metabolism product add antiphlogistic antibacterial type tapon, continuously
Use 3 menstrual periods.
3rd, diagnostic criteria
In order to verify the present embodiments relate to have the antiphlogistic antibacterial type tapon of lactic acid bacteria lamella cloudy for improving
The effect of road environment, inhibiting bacteria and diminishing inflammation, employ the amount of vaginal fluid, whether have pruritus vulvue, cusalgia, whether with frequent micturition,
Odynuria and intercourse pain, vagina mucosa it is whether congested or it is visible be dispersed in bleeding spot, posterior fornix of vagina whether have volume leukorrhea and its
Character, smell are as clinical judgment symptom；
The gemma of trichomonad or candidiasis judged using vaginal fluid laboratory examination simultaneously and mycelia whether there is and
Amount number.
4th, efficacy assessment standard
Cure：After treatment end, clinical symptoms are wholly absent；
Effectively：After treatment end, clinical symptoms partial disappearance, the state of an illness is alleviated substantially；
It is invalid：After treatment end, clinical symptoms are not taken on a new look substantially, disease amelioration unobvious.
Specific treatment results are shown in Table 2：
The antiphlogistic antibacterial type tapon clinical efficacy that the embodiment 1 of table 2 is related to
As shown by data in table 2, used the present embodiments relate to have lactic acid bacteria lamella add antiphlogistic antibacterial type defend
Raw sliver, the clinical symptoms of the colpitis of the women for the treatment of group are eased, and have 53% can be cured, 42% women
Inflammation can be controlled effectively, the effective percentage of overall therapeutic is up to 97%.Meanwhile the women of all treatment groups is treating
The health care in uterus and the nursing of gentle diuresis have been enjoyed while gynaecological imflammation.
Term " comprising " used in the present invention is pardon or open, however not excluded that extra, be not quoted
Element or method and step；
Unless otherwise indicated, for the meaning and this hair of all terms (including technology and scientific terminology) for disclosing the present invention
Bright one skilled in the art are generally understood that identical, and by further instructing, subsequent definition is used for more preferable
Understand the teachings of the present invention.
Involved " lactic acid bacteria (lactic acid bacterium) " this term, typically refers to be selected from the present invention
Lactococcus (lactoucoccus) species, genus lactubacillus (Lactobacilus) species, streptococcus
(Streptococcus) species, Pediococcus (Pediococcus) species, Bifidobacterium (Bifidobacterium) thing
The bacterium of kind and Leuconostoc (Leuconostoc) species, and including being classified as above-mentioned any monoid in the art (such as
Species, subspecies, strain).
The beneficial effect that technical scheme provided in an embodiment of the present invention is brought is：
1st, the embodiment of the present invention has adjustment vagina acid by introducing lactic acid bacteria and motherwort composition in tapon
Property environment, have eliminate colpitis, suppress the characteristics of other bacteria breeds；Meanwhile also utilizing motherwort, there is diuresis to disappear
Swollen, to shrink uterus effect Chinese medicine treatment irregular menstruation, dysmenorrhoea, through gynecological diseases such as cold and palace colds and health care uterus
The effect of cause the embodiment of the present invention to make full use of tapon as dispenser carrier, it is synchronous to carry out anti-inflammatory and the dual work(of health care
Effect；
2nd, the lactic acid bacteria being related in the embodiment of the present invention can produce the metabolites such as main metabolites lactic acid, have anti-
Bacterium acts on, and can strengthen the activity of other acid such as acetic acid by reducing pH value, suppress saccharomycete, fungi, bacterium and other one
A little harmful microbes grow and propagation, have good antibacterial characteristics；
3rd, the lactic acid bacteria lamella and tapon being related in the embodiment of the present invention are combined, and are had well with human body
Biocompatibility, lactic acid bacteria is introduced into tapon and played for the gentle non-stimulated antiphlogistic antibacterial characteristic of vagina；
4th, the lactic acid bacteria metabolite for the lactic acid bacteria being related in the embodiment of the present invention because with good heat endurance and
Preferable anti-oxidant hydrogen enzyme and antiprotease activity, and as pH value reduces, the enhancing of its bacteriostasis, so that prepare
Tapon has the effect of longer anti-inflammatory, antibacterial；
5th, the embodiment of the present invention adds cryoprotector in Lactic Acid Bacteria Metabolites lactic acid bacteria lamella, and is subsequently freezed
Dry so that lactic acid bacteria can keep activity, be advantageous to store for a long time；
6th, the biological antibiotic technology for the Lactic Acid Bacteria Metabolites that the embodiment of the present invention uses is relative in existing hygienic articles
Medicine antibacterial, chemistry of micro-organisms antibacterial etc., have no drug resistance this potential safety hazard, also changes the disadvantage of vagina acid-base degree without chemicals
End, this sterilization method are safe, nonirritant；
7th, the disclosed lactic acid bacteria lamella that introduced in the tampon body of tapon of the embodiment of the present invention prepares antiphlogistic antibacterial type
The processing step of tapon is simple, simple operation, cost are cheap.
Embodiment 2
The embodiments of the invention provide a kind of antiphlogistic antibacterial type tapon, including tampon body and cotton thread, tampon body to include
Sliver and lactic acid bacteria lamella；Lactic acid bacteria lamella is arranged at the inside of sliver, and specifically, the above-mentioned embedded setting of lactic acid bacteria lamella
At the center of sliver.
Further, lactic acid bacteria lamella is the preparation tabletting for including Lactic Acid Bacteria Metabolites.
In a particular embodiment, it is possibility to have motherwort or the combination of other Chinese medicines are in the form of powdered, Formulation
It is added to jointly in above-mentioned Lactic Acid Bacteria Metabolites preparation tabletting with lactic acid bacteria lamella.Wherein, effectively contain in motherwort Formulation
Measure as 0.5g.
Further, tampon body also includes composite web top layer；Composite web top layer is coated on the outer surface of sliver.
Specifically, composite web top layer is disposed with pro-skin top layer and antibacterial layer from outside to inside.
Wherein, pro-skin top layer is fat-soluble pro-skin top layer or water-soluble pro-skin top layer.
Further, water-soluble pro-skin top layer also includes motherwort decoction.The dosage of motherwort decoction is 1.0g.
Wherein, antibacterial layer is nano antibacterial layer；The embodiment of the present invention is combined using lactic acid antibacterial and nano-antibacterial technology
Means, higher level strong osmotic effect can be brought using the dimensional effect of nanoscale, with reference to newborn acid for adjusting pH ring
Border so that this sterilization method is safer, long-acting.
The embodiment of the present invention makes using the suppleness and biocompatibility on the pro-skin top layer coated in the outer surface of sliver
Tapon is more soft and adhere well to skin, tapon can do certain reversible with the stretching of skin when people moves
Deformation, it is ensured that the close of tapon is filled in while the comfort level of user significantly improves, the discomfort that basic foreign is filled in
Sense.
Preferably, the lactic acid bacteria lamella also includes freeze drying protectant.
Specifically, the freeze drying protectant used in the embodiment of the present invention for sucrose, sorbierite and mannitol composition.Tool
Body, the addition concentration of sucrose, sorbierite and mannitol is respectively 10%, 4% and 7.5% w/v (W/V).It is lyophilized to protect
Shield agent causes lactic acid being maintained to activity after frozen dried, is advantageous to store for a long time.
Freeze-drying is considered as being best suitable for one of active component dehydration process, and its purpose is intended to acquisition solid and stable
Final preparation, it is that the suitable cryoprotector of selection is the pass for increasing survival rate of the lactic acid bacteria during lyophilized and subsequent storage
Key factor.
Specifically, the Lactic Acid Bacteria Metabolites include the composition of lactic acid and acetic acid, in addition to a small amount of formic acid and propionic acid
Composition.
In a particular embodiment, lactic acid bacteria metabolite includes lactic acid bacteria and carries out homofermentation and different to carbon sources such as glucose
Type ferments, and can produce other acidic end products such as substantial amounts of lactic acid, acetic acid and a small amount of formic acid, propionic acid.
Wherein, for lactic acid by reducing pH value to strengthen other sour activity, acetic acid has stronger bacteriostatic activity and wider
Scope of restraining fungi, saccharomycete, fungi can be suppressed, bacterium and some other harmful microbe grow and propagation；Propionic acid is to ferment
Female bacterium and fungi have very strong bacteriostasis.
Lactic acid bacteria metabolite has good heat endurance and preferably anti-oxidant hydrogen enzyme and antiprotease activity, and
As pH value reduces, the enhancing of its bacteriostasis.
In order to verify that the fungistatic effect of lactic acid has carried out bacteriostatic test, test data shows, lactic acid bacteria metabolite for
Staphylococcus aureus, EHEC and Candida albicans have obvious inhibitory action, for Bacillus acidi lactici and unrestraint
Effect.So lactic acid metabolism product is added in tampon body, by the use of tampon body as dispenser carrier, both had to harmful bacteria
Obvious inhibiting effect, and do not influence to maintain the growth of the flora of the favourable lactic acid bacteria of sour environment for vagina.
In addition, there is lactic acid bacteria metabolite good heat endurance and preferably anti-oxidant hydrogen enzyme and antiprotease to live
Property, and as pH value reduces, the enhancing of its bacteriostasis.
In order to further prove the antiphlogistic antibacterial effect of the embodiment of the present invention, clinical test has also been carried out.
1st, clinical observation
Using the present embodiments relate to antiphlogistic antibacterial type tapon be supplied to the women of use demand totally 200
People, different degrees of gynaecological imflammation is made a definite diagnosis through gynecologial examination, its age distribution was at 20~48 years old, average out to 35 years old.At random
It is divided into two groups, the people of control group 100, the people for the treatment of group 100.
2nd, treatment means
Control group uses the tapon added without lactic acid bacteria metabolite, and 3 menstrual periods are used continuously；
Treatment group choosing the present embodiments relate to have lactic acid metabolism product add antiphlogistic antibacterial type tapon, continuously
Use 3 menstrual periods.
3rd, diagnostic criteria
In order to verify the present embodiments relate to have lactic acid metabolism product add antiphlogistic antibacterial type tapon for
Improve vaginal environment, the effect of inhibiting bacteria and diminishing inflammation, employ the amount of vaginal fluid, whether have pruritus vulvue, cusalgia, whether with
Frequent micturition, odynuria and intercourse pain, vagina mucosa it is whether congested or it is visible be dispersed in bleeding spot, whether posterior fornix of vagina has volume leukorrhea
And its character, smell are as clinical judgment symptom；
The gemma of trichomonad or candidiasis judged using vaginal fluid laboratory examination simultaneously and mycelia whether there is and
Amount number.
4th, efficacy assessment standard
Cure：After treatment end, clinical symptoms are wholly absent；
Effectively：After treatment end, clinical symptoms partial disappearance, the state of an illness is alleviated substantially；
It is invalid：After treatment end, clinical symptoms are not taken on a new look substantially, disease amelioration unobvious.
Specific treatment results are shown in Table 3：
The antiphlogistic antibacterial type tapon clinical efficacy that the embodiment 2 of table 3 is related to
As shown by data in table 3, used the present embodiments relate to have lactic acid bacteria lamella add antiphlogistic antibacterial type defend
Raw sliver, the clinical symptoms of the colpitis of the women for the treatment of group are eased, and have 38% can be cured, 50% women
Inflammation can be controlled effectively, the effective percentage of overall therapeutic is up to 88%.
Term " comprising " used in the present invention is pardon or open, however not excluded that extra, be not quoted
Element or method and step；
Unless otherwise indicated, for the meaning and this hair of all terms (including technology and scientific terminology) for disclosing the present invention
Bright one skilled in the art are generally understood that identical, and by further instructing, subsequent definition is used for more preferable
Understand the teachings of the present invention.
Involved " lactic acid bacteria (lactic acid bacterium) " this term, typically refers to be selected from the present invention
Lactococcus (lactoucoccus) species, genus lactubacillus (Lactobacilus) species, streptococcus
(Streptococcus) species, Pediococcus (Pediococcus) species, Bifidobacterium (Bifidobacterium) species
With the bacterium of Leuconostoc (Leuconostoc) species, and including being classified as above-mentioned any monoid (such as thing in the art
Kind, subspecies, strain).
The beneficial effect that technical scheme provided in an embodiment of the present invention is brought is：
1st, the embodiment of the present invention has adjustment vagina acid by introducing lactic acid bacteria and motherwort composition in tapon
Property environment, have eliminate colpitis, suppress the characteristics of other bacteria breeds；Meanwhile also utilizing motherwort, there is diuresis to disappear
Swollen, to shrink uterus effect Chinese medicine treatment irregular menstruation, dysmenorrhoea, through gynecological diseases such as cold and palace colds and health care uterus
The effect of cause the embodiment of the present invention to make full use of tapon as dispenser carrier, it is synchronous to carry out anti-inflammatory and the dual work(of health care
Effect；
2nd, the lactic acid bacteria being related in the embodiment of the present invention can produce the metabolites such as lactic acid, can be by reducing pH value
To strengthen the activity of other acid such as acetic acid, suppress saccharomycete, fungi, bacterium and some other harmful microbe and grow and increase
Grow, there are good antibacterial characteristics；
3rd, the lactic acid bacteria lamella and tapon being related in the embodiment of the present invention are combined, and have good biology with human body
Compatibility, lactic acid bacteria is introduced into tapon and played for the gentle non-stimulated antiphlogistic antibacterial characteristic of vagina；
4th, the metabolite for the lactic acid bacteria being related in the embodiment of the present invention has good heat endurance and preferable antioxygen
Change hydrogen enzyme and antiprotease activity, and as pH value reduces, its bacteriostasis enhancing, so that the tapon tool prepared
There is the effect of longer anti-inflammatory, antibacterial；
5th, the embodiment of the present invention adds cryoprotector in lactic acid bacteria lamella, and is subsequently freeze-dried so that breast
Sour bacterium can keep activity, be advantageous to store for a long time；
6th, the biological antibiotic technology for the lactic acid bacteria that the embodiment of the present invention uses resists relative to the medicine in existing hygienic articles
Bacterium, chemical antibacterial etc., have no drug resistance this potential safety hazard, also without chemicals change vagina acid-base degree the drawbacks of, this sterilizing side
Formula is safe, nonirritant；
7th, the disclosed lactic acid bacteria lamella that introduced in the tampon body of tapon of the embodiment of the present invention prepares antiphlogistic antibacterial type
The processing step of tapon is simple, simple operation, cost are cheap.
Embodiment 3
The embodiments of the invention provide a kind of antiphlogistic antibacterial type tapon, including tampon body and cotton thread, tampon body to include
Sliver and lactic acid bacteria lamella；Lactic acid bacteria lamella is arranged at the inside of sliver.
Specifically, the embedded inside for being arranged at sliver of lactic acid bacteria lamella and along sliver central axis around set.
Further, lactic acid bacteria lamella is the fixed porous cotton lamella for being attached with Lactic Acid Bacteria Metabolites.
In a particular embodiment, it is possibility to have motherwort or the combination of other Chinese medicines are in the form of powdered, Formulation
It is added to jointly in tampon body with lactic acid bacteria lamella.Or impregnate motherwort in the porous cotton lamella of above-mentioned lactic acid bacteria lamella
Decoction.Motherwort decoction, it can more fully play this Chinese medicine for having inducing diuresis to remove edema, shrinking uterus effect of motherwort and control
Treat irregular menstruation, dysmenorrhoea, through gynecological diseases such as cold and palace colds and health care uterus.
Further, tampon body also includes composite web top layer；Composite web top layer is coated on the outer surface of sliver.
Specifically, composite web top layer is disposed with pro-skin top layer and antibacterial layer from outside to inside.
Wherein, pro-skin top layer is fat-soluble pro-skin top layer or water-soluble pro-skin top layer.
Further, water-soluble pro-skin top layer also includes motherwort decoction.Specifically, the additive capacity of motherwort decoction is
3.0g。
Wherein, antibacterial layer is nano antibacterial layer；The embodiment of the present invention is combined using lactic acid antibacterial and nano-antibacterial technology
Means, higher level strong osmotic effect can be brought using the dimensional effect of nanoscale, with reference to newborn acid for adjusting pH ring
Border so that this sterilization method is safer, long-acting.
The embodiment of the present invention makes using the suppleness and biocompatibility on the pro-skin top layer coated in the outer surface of sliver
Tapon is more soft and adhere well to skin, tapon can do certain reversible with the stretching of skin when people moves
Deformation, it is ensured that the close of tapon is filled in while the comfort level of user significantly improves, the discomfort that basic foreign is filled in
Sense.
Moreover, pro-skin top layer can be fat-soluble pro-skin top layer or water-soluble pro-skin top layer.Used in the embodiment of the present invention
Fat-soluble pro-skin top layer, it can cause the outer surface of tapon more lubricates to be easy to fill in vivo, be advantageous to tapon more
Give full play to medical dispenser function.
A variety of combinations of lactic acid and tapon can cause the bioactivity point of lactic acid in the embodiment of the present invention
Son diffusive migration uniform when in use can make full use of menstrual period endometrium to spread all over close to positions such as vagina top layer, uterus inwalls
The miniature wound dispenser of collection, has preferable therapeutic effect；In this specific implementation, lactic acid can be with motherwort or other Chinese medicines as worked as
Return, radix glycyrrhizae, rhizoma zingiberis, perilla leaf, folium artemisiae argyi and Ge Gong etc. carry out certain proportion mixing, play acidic pH environment antibacterial and herbal pharmacology
Antiinflammation is cooperateed with, more preferable therapeutic effect is played for gynecological disease.
Preferably, lactic acid bacteria lamella also includes freeze drying protectant.Freeze drying protectant is used in embodiments of the present invention to be sweet
Reveal the composition of alcohol and glucan.Specifically, the addition concentration of mannitol and glucan is respectively 7.5% and 5% bulking value
Than (W/V).
Freeze-drying is considered as being best suitable for one of active component dehydration process, and its purpose is intended to acquisition solid and stable
Final preparation, it is that the suitable cryoprotector of selection is the pass for increasing survival rate of the lactic acid bacteria during lyophilized and subsequent storage
Key factor.
Specifically, Lactic Acid Bacteria Metabolites include lactic acid.
In a particular embodiment, lactic acid bacteria metabolite includes lactic acid bacteria and carries out homofermentation and different to carbon sources such as glucose
Type ferments, and can produce other acidic end products such as substantial amounts of lactic acid, acetic acid and a small amount of formic acid, propionic acid.The embodiment of the present invention
Separated for the lactic acid in lactic acid bacteria metabolite this metabolite, purify to obtain.
Lactic acid suppresses saccharomycete, fungi, bacterium and the growth of some other harmful microbe and propagation by reducing pH value；
And lactic acid has good heat endurance and preferably anti-oxidant hydrogen enzyme and antiprotease activity, and as pH value reduces,
Its bacteriostasis strengthens.
In order to verify that the fungistatic effect of lactic acid has carried out bacteriostatic test, test data shows, lactic acid bacteria metabolite for
Staphylococcus aureus, EHEC and Candida albicans have obvious inhibitory action, for Bacillus acidi lactici and unrestraint
Effect.So lactic acid metabolism product is added in tampon body, by the use of tampon body as dispenser carrier, both had to harmful bacteria
Obvious inhibiting effect, and do not influence to maintain the growth of the flora of the favourable lactic acid bacteria of sour environment for vagina.
In addition, there is lactic acid bacteria metabolite good heat endurance and preferably anti-oxidant hydrogen enzyme and antiprotease to live
Property, and as pH value reduces, the enhancing of its bacteriostasis.
In order to further prove the antiphlogistic antibacterial effect of the embodiment of the present invention, clinical test has also been carried out.
1st, clinical observation
Using the present embodiments relate to antiphlogistic antibacterial type tapon be supplied to the women of use demand totally 200
People, different degrees of gynaecological imflammation is made a definite diagnosis through gynecologial examination, its age distribution was at 20~48 years old, average out to 35 years old.At random
It is divided into two groups, the people of control group 100, the people for the treatment of group 100.
2nd, treatment means
Control group uses the tapon added without lactic acid bacteria metabolite, and 3 menstrual periods are used continuously；
Treatment group choosing the present embodiments relate to have lactic acid metabolism product add antiphlogistic antibacterial type tapon, continuously
Use 3 menstrual periods.
3rd, diagnostic criteria
In order to verify the present embodiments relate to have lactic acid metabolism product add antiphlogistic antibacterial type tapon for
Improve vaginal environment, the effect of inhibiting bacteria and diminishing inflammation, employ the amount of vaginal fluid, whether have pruritus vulvue, cusalgia, whether with
Frequent micturition, odynuria and intercourse pain, vagina mucosa it is whether congested or it is visible be dispersed in bleeding spot, whether posterior fornix of vagina has volume leukorrhea
And its character, smell are as clinical judgment symptom；
The gemma of trichomonad or candidiasis judged using vaginal fluid laboratory examination simultaneously and mycelia whether there is and
Amount number.
4th, efficacy assessment standard
Cure：After treatment end, clinical symptoms are wholly absent；
Effectively：After treatment end, clinical symptoms partial disappearance, the state of an illness is alleviated substantially；
It is invalid：After treatment end, clinical symptoms are not taken on a new look substantially, disease amelioration unobvious.
Specific treatment results are shown in Table 3：
The antiphlogistic antibacterial type tapon clinical efficacy that the embodiment 3 of table 4 is related to
As shown by data in table 3, used the present embodiments relate to have lactic acid bacteria lamella add antiphlogistic antibacterial type defend
Raw sliver, the clinical symptoms of the colpitis of the women for the treatment of group are eased, and have 30% can be cured, 60% women
Inflammation can be controlled effectively, the effective percentage of overall therapeutic is up to 90%.
Term " comprising " used in the present invention is pardon or open, however not excluded that extra, be not quoted
Element or method and step；
Unless otherwise indicated, for the meaning and this hair of all terms (including technology and scientific terminology) for disclosing the present invention
Bright one skilled in the art are generally understood that identical, and by further instructing, subsequent definition is used for more preferable
Understand the teachings of the present invention.
Involved " lactic acid bacteria (lactic acid bacterium) " this term, typically refers to be selected from the present invention
Lactococcus (lactoucoccus) species, genus lactubacillus (Lactobacilus) species, streptococcus
(Streptococcus) species, Pediococcus (Pediococcus) species, Bifidobacterium (Bifidobacterium) thing
The bacterium of kind and Leuconostoc (Leuconostoc) species, and including being classified as above-mentioned any monoid in the art (such as
Species, subspecies, strain).
The beneficial effect that technical scheme provided in an embodiment of the present invention is brought is：
1st, the embodiment of the present invention has adjustment vagina acid by introducing lactic acid bacteria and motherwort composition in tapon
Property environment, have eliminate colpitis, suppress the characteristics of other bacteria breeds；Meanwhile also utilizing motherwort, there is diuresis to disappear
Swollen, to shrink uterus effect Chinese medicine treatment irregular menstruation, dysmenorrhoea, through gynecological diseases such as cold and palace colds and health care uterus
The effect of cause the embodiment of the present invention to make full use of tapon as dispenser carrier, it is synchronous to carry out anti-inflammatory and the dual work(of health care
Effect；
2nd, the lactic acid bacteria being related in the embodiment of the present invention can produce the metabolites such as lactic acid, can be by reducing pH value
To strengthen the activity of other acid such as acetic acid, suppress saccharomycete, fungi, bacterium and some other harmful microbe and grow and increase
Grow, there are good antibacterial characteristics；
3rd, the lactic acid bacteria lamella and tapon being related in the embodiment of the present invention are combined, and have good biology with human body
Compatibility, lactic acid bacteria is introduced into tapon and played for the gentle non-stimulated antiphlogistic antibacterial characteristic of vagina；
4th, the metabolite for the lactic acid bacteria being related in the embodiment of the present invention has good heat endurance and preferable antioxygen
Change hydrogen enzyme and antiprotease activity, and as pH value reduces, its bacteriostasis enhancing, so that the tapon tool prepared
There is the effect of longer anti-inflammatory, antibacterial；
5th, the embodiment of the present invention adds cryoprotector in lactic acid bacteria lamella, and is subsequently freeze-dried so that breast
Sour bacterium can keep activity, be advantageous to store for a long time；
6th, the biological antibiotic technology for the lactic acid bacteria that the embodiment of the present invention uses resists relative to the medicine in existing hygienic articles
Bacterium, chemical antibacterial etc., have no drug resistance this potential safety hazard, also without chemicals change vagina acid-base degree the drawbacks of, this sterilizing side
Formula is safe, nonirritant；
7th, the disclosed lactic acid bacteria lamella that introduced in the tampon body of tapon of the embodiment of the present invention prepares antiphlogistic antibacterial type
The processing step of tapon is simple, simple operation, cost are cheap.
Embodiment 4
The embodiment of the invention also discloses the preparation method for preparing above-mentioned antiphlogistic antibacterial type tapon, method includes：
S1：From absorbency fiber, fully dry；
S2：Fixed weight absorbency fiber is weighed, absorbency fiber is pressed into fibre strip layer；
S3：Cotton thread is fixed in fibre strip layer centre, the exposed 10- outside fibre strip layer of cotton thread tail end
20cm, preferably 12cm；
S5：Fibre strip layer is curled into strip cylindrical absorbent body；
S6：Lactic acid bacteria lamella is attached and is arranged at fibre strip layer surface, or the embedded fibre strip layer that is arranged at crimps
Inside the absorber of formation；
S6：It is with non-woven fabrics that absorber tight is exposed outside tampon body into tampon body, cotton thread tail end；
S7：Tampon body is packed, got product.
Wherein, lactic acid bacteria lamella is arranged to the mode of the fibre strip layer also to be included attaching lactic acid bacteria lamella setting
Composite fibre layer is made in fibre strip layer surface.
Specifically, absorbency fiber is natural fiber or synthetic fibers in step S1；
The specific weight that fixed weight absorbency fiber is weighed in step S2 is 1.5g-4.0g, preferably 3.5g.
Above-mentioned lactic acid bacteria lamella is arranged at sliver outer surface.In specific implementation, lactic acid bacteria lamella can also be arranged at cotton
The inside of bar, can be with the embedded circular setting of central axis being arranged at the center of sliver or along sliver.
Further, Lactic Acid Bacteria Metabolites lamella is Lactic Acid Bacteria Metabolites preparation tabletting.In specific implementation, lactic acid bacteria tablet
Layer can also be the fixed porous cotton lamella for being attached with lactic acid bacteria.Wherein, the effective content of lactic acid bacteria is 0.5-2.0g, preferably
For 1.0g.
In specific implementation, lactic acid can with motherwort or other Chinese medicines for example Radix Angelicae Sinensis, radix glycyrrhizae, rhizoma zingiberis, perilla leaf, folium artemisiae argyi and
Ge Gong etc. carries out certain proportion mixing, plays acidic pH environment antibacterial and cooperates with antiinflammation with herbal pharmacology, for gynecological disease
Play more preferable therapeutic effect.
In step s 6, Chinese herbal medicine is added to tampon body jointly in the form of powdered, Formulation with lactic acid bacteria lamella
In.Or impregnate herbal liquid medicine in the porous cotton lamella of above-mentioned lactic acid bacteria lamella.Wherein, the dosage of herbal liquid medicine is
0.5-5.0g, preferably 2.0g.
The disclosed introducing lactic acid bacteria lamella in the tampon body of tapon of the embodiment of the present invention prepares antiphlogistic antibacterial type and defended
The processing step of raw sliver is simple, simple operation, cost are cheap, and obtained tapon product has with adjusting acid vagina
Environment, have and eliminate colpitis, suppress the characteristics of other bacteria breeds；And have good biocompatibility with human body, will
Lactic acid introduces tapon and plays non-stimulated antiphlogistic antibacterial characteristic.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent substitution and improvements made etc., it should be included in the scope of the protection.
Claims (10)
1. a kind of antiphlogistic antibacterial type tapon, including tampon body and cotton thread, it is characterised in that the tampon body include sliver and
Lactic acid bacteria lamella；The lactic acid bacteria lamella is arranged at the inside or surface of the sliver；The lactic acid bacteria lamella includes lactic acid bacteria
Composition and motherwort chip.
2. antiphlogistic antibacterial type tapon according to claim 1, it is characterised in that the lactic bacteria composition includes breast
Sour sclerote and coated layer.
3. antiphlogistic antibacterial type tapon according to claim 2, it is characterised in that the coated layer includes oligomeric different wheat
Bud sugar, protein material and nitrocellulose.
4. antiphlogistic antibacterial type tapon according to claim 1, it is characterised in that the lactic acid bacteria lamella also wraps
Include freeze drying protectant.
5. antiphlogistic antibacterial type tapon according to claim 4, it is characterised in that the freeze drying protectant is marine alga
The composition of any one or more in sugar, sucrose, sodium glutamate, sorbierite, mannitol or glucan.
6. antiphlogistic antibacterial type tapon according to claim 1, it is characterised in that the lactic acid bacteria lamella is embedded to be set
It is placed at the center of the sliver or is set along the central axis of the sliver around setting or lactic acid bacteria lamella cladding
In the outer surface of the sliver.
7. the antiphlogistic antibacterial type tapon according to claim 1 or 6, it is characterised in that the lactic acid bacteria lamella is solid
Surely it is attached with the porous cotton lamella of lactic bacteria composition and motherwort chip or including lactic bacteria composition and motherwort chip
Preparation tabletting.
8. antiphlogistic antibacterial type tapon according to claim 7, it is characterised in that the motherwort chip is motherwort
The preparation tabletting of powder or Herba Leonuri granule or the impregnated cotton lamella of motherwort decoction.
9. a kind of preparation method of antiphlogistic antibacterial type tapon, it is characterised in that methods described includes：
S1：From absorbency fiber, fully dry；
S2：Fixed weight absorbency fiber is weighed, absorbency fiber is pressed into fibre strip layer；
S3：Cotton thread is fixed in fibre strip layer centre, the exposed 10-20cm outside fibre strip layer of cotton thread tail end；
S4：Fibre strip layer is curled into strip cylindrical absorbent body；
S5：Lactic acid bacteria lamella is attached and is arranged at fibre strip layer surface, or the embedded fibre strip layer that is arranged at curls into
Absorber inside；
S6：It is with non-woven fabrics that absorber tight is exposed outside tampon body into tampon body, cotton thread tail end；
S7：Tampon body is packed, got product.
10. the preparation method of antiphlogistic antibacterial type tapon according to claim 9, it is characterised in that methods described is also
Including preparing lactic bacteria composition and motherwort chip in the lactic acid bacteria lamella.
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| CN109620547A (en) * | 2018-12-13 | 2019-04-16 | 湖南千金卫生用品股份有限公司 | It is a kind of to have effects that alleviate the tapon and preparation method thereof of gynecological disease |
| CN113456351A (en) * | 2021-08-11 | 2021-10-01 | 浙江天晴制造科技集团有限公司 | Novel degradable tampon and preparation method thereof |
| CN113456350A (en) * | 2021-08-11 | 2021-10-01 | 浙江天晴制造科技集团有限公司 | Colored tampon and manufacturing method thereof |
| CN114870033A (en) * | 2022-05-31 | 2022-08-09 | 成都中医药大学 | Traditional Chinese medicine type tampon and manufacturing method thereof |
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| CN109620547A (en) * | 2018-12-13 | 2019-04-16 | 湖南千金卫生用品股份有限公司 | It is a kind of to have effects that alleviate the tapon and preparation method thereof of gynecological disease |
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| CN113456350A (en) * | 2021-08-11 | 2021-10-01 | 浙江天晴制造科技集团有限公司 | Colored tampon and manufacturing method thereof |
| CN114870033A (en) * | 2022-05-31 | 2022-08-09 | 成都中医药大学 | Traditional Chinese medicine type tampon and manufacturing method thereof |
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