CN114870033A - Traditional Chinese medicine type tampon and manufacturing method thereof - Google Patents
Traditional Chinese medicine type tampon and manufacturing method thereof Download PDFInfo
- Publication number
- CN114870033A CN114870033A CN202210613643.8A CN202210613643A CN114870033A CN 114870033 A CN114870033 A CN 114870033A CN 202210613643 A CN202210613643 A CN 202210613643A CN 114870033 A CN114870033 A CN 114870033A
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- China
- Prior art keywords
- cyclodextrin
- beta
- cotton
- fructus cnidii
- cotton fabric
- Prior art date
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- 239000003814 drug Substances 0.000 title claims abstract description 119
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 17
- 229920000742 Cotton Polymers 0.000 claims abstract description 255
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 165
- 239000001116 FEMA 4028 Substances 0.000 claims abstract description 165
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims abstract description 165
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims abstract description 165
- 229960004853 betadex Drugs 0.000 claims abstract description 165
- 238000001035 drying Methods 0.000 claims abstract description 52
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 36
- 239000006096 absorbing agent Substances 0.000 claims abstract description 22
- 238000011282 treatment Methods 0.000 claims abstract description 20
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 252
- 239000004744 fabric Substances 0.000 claims description 149
- 239000000243 solution Substances 0.000 claims description 104
- 239000000284 extract Substances 0.000 claims description 70
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 64
- 238000006243 chemical reaction Methods 0.000 claims description 59
- 150000001875 compounds Chemical class 0.000 claims description 57
- 239000000463 material Substances 0.000 claims description 47
- 239000012153 distilled water Substances 0.000 claims description 46
- 239000010410 layer Substances 0.000 claims description 45
- 238000002360 preparation method Methods 0.000 claims description 45
- 238000004140 cleaning Methods 0.000 claims description 42
- 239000011259 mixed solution Substances 0.000 claims description 42
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 claims description 18
- 230000010355 oscillation Effects 0.000 claims description 18
- 206010042674 Swelling Diseases 0.000 claims description 15
- 230000008961 swelling Effects 0.000 claims description 15
- 239000000706 filtrate Substances 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 14
- 238000009210 therapy by ultrasound Methods 0.000 claims description 14
- 229940079593 drug Drugs 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 10
- 238000002791 soaking Methods 0.000 claims description 10
- 238000006735 epoxidation reaction Methods 0.000 claims description 9
- 239000000047 product Substances 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 7
- 238000010025 steaming Methods 0.000 claims description 7
- 239000002131 composite material Substances 0.000 claims description 6
- 238000003825 pressing Methods 0.000 claims description 6
- 239000000022 bacteriostatic agent Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 230000003385 bacteriostatic effect Effects 0.000 claims description 4
- 238000002386 leaching Methods 0.000 claims description 4
- 238000010298 pulverizing process Methods 0.000 claims description 4
- 238000009960 carding Methods 0.000 claims description 3
- 239000004745 nonwoven fabric Substances 0.000 claims description 3
- 238000012216 screening Methods 0.000 claims description 3
- 239000002344 surface layer Substances 0.000 claims description 3
- 241000356446 Cnidium monnieri Species 0.000 claims description 2
- 235000019084 Selinum monnieri Nutrition 0.000 claims description 2
- 206010046914 Vaginal infection Diseases 0.000 abstract description 12
- 201000008100 Vaginitis Diseases 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 10
- 241000283973 Oryctolagus cuniculus Species 0.000 description 8
- 238000011156 evaluation Methods 0.000 description 8
- 238000010438 heat treatment Methods 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- LRWZZZWJMFNZIK-UHFFFAOYSA-N 2-chloro-3-methyloxirane Chemical compound CC1OC1Cl LRWZZZWJMFNZIK-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 210000001215 vagina Anatomy 0.000 description 3
- 208000004926 Bacterial Vaginosis Diseases 0.000 description 2
- 241000212948 Cnidium Species 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 229960000282 metronidazole Drugs 0.000 description 2
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical group CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 239000006041 probiotic Substances 0.000 description 2
- 235000018291 probiotics Nutrition 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000007984 Female Infertility Diseases 0.000 description 1
- 206010021928 Infertility female Diseases 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 208000006399 Premature Obstetric Labor Diseases 0.000 description 1
- 206010036600 Premature labour Diseases 0.000 description 1
- 208000007074 Trichomonas Vaginitis Diseases 0.000 description 1
- 208000025206 Trichomonas vaginitis urogenital infection Diseases 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000007140 dysbiosis Effects 0.000 description 1
- 210000004696 endometrium Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000003821 menstrual periods Effects 0.000 description 1
- 208000015994 miscarriage Diseases 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 208000026440 premature labor Diseases 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M11/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
- D06M13/11—Compounds containing epoxy groups or precursors thereof
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
- D06M15/01—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment with natural macromolecular compounds or derivatives thereof
- D06M15/03—Polysaccharides or derivatives thereof
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/14—Female reproductive, genital organs
- A61M2210/1475—Vagina
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M2101/00—Chemical constitution of the fibres, threads, yarns, fabrics or fibrous goods made from such materials, to be treated
- D06M2101/02—Natural fibres, other than mineral fibres
- D06M2101/04—Vegetal fibres
- D06M2101/06—Vegetal fibres cellulosic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Textile Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
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- Medical Informatics (AREA)
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- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a traditional Chinese medicine type tampon and a manufacturing method thereof, and solves the technical problems that the tampon added with traditional Chinese medicine components in the prior art has low medicine attachment rate, and the treatment effect is influenced because the medicine falls off before use. The tampon comprises a tampon absorber and a pull wire, and is characterized in that: the cotton strip absorber is sequentially provided with a skin-friendly layer, an antibacterial layer and an absorber from outside to inside; the absorber is internally provided with a beta-cyclodextrin traditional Chinese medicine inclusion chip. The traditional Chinese medicine type tampon and the manufacturing method thereof provided by the invention can treat vaginitis, can play a role in bacteriostasis in daily care, and can play a role in preventing vaginitis; the problem of difficult drying is avoided, and the possibility of mildew is avoided as much as possible, so that the tampon is safer and safer to use; and the medicine has high adhesion rate, can avoid the falling of the medicine before use, and has good use effect.
Description
Technical Field
The invention relates to the field of manufacturing of hygienic products, in particular to a traditional Chinese medicine type tampon and a manufacturing method thereof.
Background
Vaginitis is a common gynecological disease mainly caused by vaginal microbial flora imbalance or exogenous invasive pathogenic microbial infection, and is mainly divided into 3 types: bacterial vaginitis, trichomonas vaginitis, and candidal vaginitis, all three of which have been shown to interact and may occur simultaneously. Vaginitis can lead to female infertility, premature labor, miscarriage and other complications such as infectious diseases, which have adverse effects on female health, and vaginal infections have become a major public health problem worldwide. The main drug for treating vaginitis at present is metronidazole, but the metronidazole has no effect on vaginal microbial imbalance, and has high recurrence rate and incidence rate of adverse developmental reaction. In addition, invasive treatments are also common. Under normal conditions, a large amount of probiotics such as lactobacillus exist in the female vagina, when the amount of the probiotics is reduced due to the change of external environment (such as the use of antibiotics), a large amount of harmful bacteria can propagate, and when the harmful bacteria propagate in a large amount, the vaginal microbiology balance is broken, so that vaginitis often attacks. For example: the recurrence rate of bacterial vaginitis in vaginitis is high, 40% after 3 months of traditional antibiotic treatment and increased to 60% after 6 months. Such high recurrence rates lead to repeated use of antibiotics, rendering the bacteria resistant.
The sanitary cotton strip, also called sanitary tampon, is a cotton cylinder, mainly made of cotton, artificial fiber or the mixture of the two materials, and has the size of 1cm to 1.9 cm in diameter, and the tail end is attached with cotton thread (pull rope). Some tampons added with traditional Chinese medicine components are also available in the market at present, but the production process of the tampons added with the traditional Chinese medicine components usually comprises the following steps: the shaped tampon is entirely soaked in the drug solution or the drug solution is sprayed on the outer surface of the tampon. However, in the above process, when a drug is added into the formed tampon, the formed tampon is soaked in a drug solution, and the drying at the later stage is difficult, and it is difficult to judge whether the inside of the tampon meets the drying standard, and the damp inside of the tampon is easy to cause mildew, which affects the use. The spraying of the medicinal solution on the outer surface of the tampon may cause low drug attachment rate after drying and drop of the drug before use, which may affect the therapeutic effect.
The applicant has found that the prior art has at least the following technical problems:
1. in the prior art, the problem that the tampon added with traditional Chinese medicine components is difficult to dry and possibly mildews;
2. the tampon added with traditional Chinese medicine components in the prior art also has the problems of low drug attachment rate, drug falling off before use and influence on treatment effect.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine type tampon and a manufacturing method thereof, and aims to solve the technical problems that the tampon added with traditional Chinese medicine components in the prior art is low in medicine attachment rate, and medicines fall off before use to influence the treatment effect.
In order to achieve the purpose, the invention provides the following technical scheme:
the invention provides a traditional Chinese medicine type tampon, which comprises a tampon absorber and a pull string, and is characterized in that: the cotton strip absorber is sequentially provided with a skin-friendly layer, an antibacterial layer and an absorber from outside to inside; a beta-cyclodextrin traditional Chinese medicine inclusion chip is arranged in the absorber; the preparation method of the beta-cyclodextrin traditional Chinese medicine inclusion chip material comprises the following steps:
s1, preparing fructus Cnidii extract
Pulverizing fructus Cnidii, and extracting by leaching to obtain fructus Cnidii extract;
s2, preparing a beta-cyclodextrin traditional Chinese medicine inclusion compound chip material;
s21 epoxidation of cotton fabric
S211, placing the cotton fabric into a reaction container, and adding NaOH solution to perform swelling treatment on the cotton fabric;
s212, adding a mixture of the following components in a volume ratio of 0.5-1.5: 0.5-1.5: 0.5-1.5 of distilled water, an epichlorohydrin solution and a NaOH solution, and placing the swelled cotton fabric into the container; reacting at 45-55 deg.C for 0.8-1.5 h;
s213, taking out the cotton fabric treated in the step S212, and cleaning and drying the cotton fabric to obtain an epoxidized cotton fabric;
s22 reaction of epoxidized cotton fabric with beta-cyclodextrin
S221, placing the epoxidized cotton fabric obtained in the step S21 into a mixed solution of NaOH solution and beta-cyclodextrin, and carrying out oscillation reaction for 2-3h at the temperature of 40-50 ℃;
s222, taking out the epoxidized cotton fabric treated in the step S221, cleaning and drying to obtain a cotton fabric grafted with beta-cyclodextrin;
s23 preparation of beta-cyclodextrin traditional Chinese medicine inclusion compound chip material
S231, placing the cotton fabric grafted with the beta-cyclodextrin obtained in the step S22 into another reaction container, adding a fructus cnidii extracting solution prepared from the fructus cnidii extract prepared in the step S1 into the reaction container, and carrying out oscillation reaction at the temperature of 45-55 ℃ for 3.5-4.5 hours;
the mass ratio of the cotton fabric and the fructus cnidii extract to the beta-cyclodextrin is 90-100: 1-2: 1-2;
s232, taking out the cotton fabric grafted with the beta-cyclodextrin and treated in the step S231, cleaning and drying to obtain the beta-cyclodextrin traditional Chinese medicine inclusion chip material.
Further, in the step S211, the NaOH solution is 0.05 to 0.2 mol/L;
in the step S212, the epichlorohydrin solution is 8-12mol/L and NaOH solution, and the NaOH solution is 0.05-0.2 mol/L; the volume ratio of the distilled water to the epichlorohydrin solution to the NaOH solution is 0.5-1.5: 0.5-1.5: 0.5-1.5;
in step S221, the preparation method of the mixed solution of NaOH and β -cyclodextrin is: according to the mass ratio, NaOH: beta-cyclodextrin: water 45-55: 1: 100, uniformly mixing NaOH, beta-cyclodextrin and water to obtain a mixed solution of the NaOH and the beta-cyclodextrin; the mass ratio of the cotton fabric to the beta-cyclodextrin is 90-100: 1-2;
in step S231, the preparation method of the fructus cnidii extract solution includes: dissolving the fructus cnidii extract prepared in the step S1 in distilled water, wherein the mass ratio of the fructus cnidii extract to the distilled water is 10-20:100, and obtaining fructus cnidii extract; the mass ratio of the cotton fabric to the fructus cnidii extract is 90-100: 1-2.
Further, the skin-friendly layer is a surface layer of a spunlace non-woven fabric material; the skin-friendly layer is wrapped on the outer side of the antibacterial layer in a surrounding manner; the antibacterial layer is closely wrapped on the outer side of the absorber in a surrounding manner; the antibacterial layer is prepared from a non-woven fabric layer containing a bacteriostatic agent; the absorber and the skin-friendly layer are both made of natural cotton fibers.
Furthermore, the beta-cyclodextrin traditional Chinese medicine inclusion compound chips are multiple, and the multiple beta-cyclodextrin traditional Chinese medicine inclusion compound chips are arranged around the central shaft of the absorber.
Furthermore, 2-6 beta-cyclodextrin traditional Chinese medicine inclusion compound chips are provided.
The invention provides a method for manufacturing a traditional Chinese medicine type tampon, which comprises the following steps:
(1) preparing a beta-cyclodextrin traditional Chinese medicine inclusion compound chip;
(2) screening high-quality natural cotton fibers, and carding the cotton fiber raw material;
(3) paving and overlapping the cotton fiber raw materials carded in the step (2) into a composite cotton fiber net, and pressing the composite cotton fiber net into a plurality of strip-shaped cotton fiber blocks, wherein the cotton fiber blocks comprise cotton fiber blocks serving as cotton strip bodies, cotton fiber blocks serving as antibacterial layers and cotton fiber blocks serving as skin-friendly layers;
(4) soaking the cotton fiber block serving as the antibacterial layer obtained in the step (3) with a bacteriostatic agent, and drying to obtain a bacteriostatic cotton fiber block;
(5) placing the beta-cyclodextrin traditional Chinese medicine inclusion compound chip obtained in the step (1) on a cotton fiber block serving as a cotton sliver body;
(6) sequentially laying an antibacterial cotton fiber block serving as an antibacterial layer and a cotton fiber block serving as a skin-friendly layer on a cotton fiber block serving as a cotton strip body and pressing the cotton fiber blocks into a whole, wherein a beta-cyclodextrin traditional Chinese medicine inclusion compound chip is positioned between the cotton fiber block serving as the cotton strip body and the antibacterial cotton fiber block serving as the antibacterial layer; fixing a pull rope in the middle of a cotton fiber block serving as a cotton strip body, wherein the tail end of the pull rope is exposed out of the strip-shaped cotton fiber layer;
(7) and (3) curling the cotton fiber as the cotton strip body, the antibacterial cotton fiber as the antibacterial layer and the cotton fiber as the skin-friendly layer which are pressed into a whole together to form a cylindrical cotton strip absorber, thus obtaining the finished product of the traditional Chinese medicine type sanitary cotton strip.
Further, in the step 2, the preparation of the beta-cyclodextrin traditional Chinese medicine inclusion compound chip comprises the following steps:
s1, preparing fructus Cnidii extract
Pulverizing fructus Cnidii, and extracting by leaching to obtain fructus Cnidii extract;
s2, preparing a beta-cyclodextrin traditional Chinese medicine inclusion compound chip material;
s21 epoxidation of cotton fabric
S211, placing the cotton fabric into a reaction container, and adding NaOH solution to perform swelling treatment on the cotton fabric;
s212, adding a mixture of the components with the volume ratio of 0.5-1.5: 0.5-1.5: 0.5-1.5 of distilled water, an epichlorohydrin solution and a NaOH solution, and placing the swelled cotton fabric into the container; reacting at 45-55 deg.C for 0.8-1.5 h;
s213, taking out the cotton fabric treated in the step S212, and cleaning and drying the cotton fabric to obtain an epoxidized cotton fabric;
s22 reaction of epoxidized cotton fabric with beta-cyclodextrin
S221, placing the epoxidized cotton fabric obtained in the step S21 into a mixed solution of NaOH solution and beta-cyclodextrin, and carrying out oscillation reaction for 2-3h at the temperature of 40-50 ℃;
s222, taking out the epoxidized cotton fabric treated in the step S221, cleaning and drying to obtain a cotton fabric grafted with beta-cyclodextrin;
s23 preparation of beta-cyclodextrin traditional Chinese medicine inclusion compound chip material
S231, placing the cotton fabric grafted with the beta-cyclodextrin obtained in the step S22 into another reaction container, adding a fructus cnidii extracting solution prepared from the fructus cnidii extract prepared in the step S1 into the reaction container, and carrying out oscillation reaction at the temperature of 45-55 ℃ for 3.5-4.5 hours;
the mass ratio of the cotton fabric and the fructus cnidii extract to the beta-cyclodextrin is 90-100: 1-2: 1-2;
s232, taking out the cotton fabric grafted with the beta-cyclodextrin and treated in the step S231, cleaning and drying to obtain the beta-cyclodextrin traditional Chinese medicine inclusion chip material.
Further, in the step S211, the NaOH solution is 0.05 to 0.2 mol/L;
in the step S212, the epichlorohydrin solution is 8-12mol/L and NaOH solution, and the NaOH solution is 0.05-0.2 mol/L; the volume ratio of the distilled water to the epichlorohydrin solution to the NaOH solution is 0.5-1.5: 0.5-1.5: 0.5-1.5;
in step S221, the preparation method of the mixed solution of NaOH and β -cyclodextrin is: according to the mass ratio, NaOH: beta-cyclodextrin: water 45-55: 1: 100, uniformly mixing NaOH, beta-cyclodextrin and water to obtain a mixed solution of the NaOH and the beta-cyclodextrin; the mass ratio of the cotton fabric to the beta-cyclodextrin is 90-100: 1-2;
in step S231, the preparation method of the fructus cnidii extract solution includes: dissolving the fructus cnidii extract prepared in the step S1 in distilled water, wherein the mass ratio of the fructus cnidii extract to the distilled water is 10-20:100, and obtaining fructus cnidii extract; the mass ratio of the cotton fabric to the fructus cnidii extract is 90-100: 1-2.
Further, in step S1, the step of preparing the cnidium monnieri fruit extract includes:
s11, crushing a fructus cnidii medicinal material to obtain fructus cnidii powder;
s12, soaking the fructus cnidii powder in ethanol for 20-30 h;
s13, carrying out ultrasonic treatment on the soaked fructus cnidii and ethanol at 35-45 ℃ for 0.8-1.5 h;
s14, filtering after ultrasonic treatment to obtain filtrate;
s15, putting the filtrate into a rotary steaming machine for spin-drying to obtain the fructus cnidii extract. .
Based on the technical scheme, the embodiment of the invention can at least produce the following technical effects:
(1) the traditional Chinese medicine type tampon and the manufacturing method thereof provided by the invention can treat vaginitis, can play a role in bacteriostasis in daily care, and can play a role in preventing vaginitis; the cnidium fruit is used as a pharmacodynamic raw material, the cnidium fruit is prepared into a beta-cyclodextrin traditional Chinese medicine inclusion compound chip, and then the beta-cyclodextrin traditional Chinese medicine inclusion compound chip is embedded into a tampon, so that bioactive molecules of the medicine can be uniformly diffused and transferred to the positions of the vaginal surface layer, the uterine inner wall and the like in use, the dense micro wound of endometrium in menstrual period can be fully utilized for medicine application, and a better treatment effect is achieved; thereby treating or preventing vaginitis well.
(2) The traditional Chinese medicine type tampon and the manufacturing method thereof provided by the invention have the advantages that as the beta-cyclodextrin traditional Chinese medicine inclusion compound chip is manufactured firstly and then is embedded into the tampon, the beta-cyclodextrin traditional Chinese medicine inclusion compound chip is dried thoroughly in the manufacturing process, the problem of difficult drying is avoided, the possibility of mildew is avoided as much as possible, and the tampon is safer and more reassuring to use
(3) According to the traditional Chinese medicine type tampon and the manufacturing method thereof provided by the invention, as the beta-cyclodextrin traditional Chinese medicine inclusion compound chip is manufactured firstly and then is embedded in the tampon, the medicine attachment rate is high, the medicine can be prevented from falling off before use, and the using effect is good.
Detailed Description
Preparation of one, beta-cyclodextrin Chinese medicine inclusion compound chip
Example 1:
the preparation of the beta-cyclodextrin traditional Chinese medicine inclusion compound chip comprises the following steps:
s1, preparing fructus Cnidii extract
S11, crushing the fructus cnidii medicinal material to obtain fructus cnidii powder;
s12, soaking the fructus cnidii powder in ethanol for 25 hours;
s13, carrying out ultrasonic treatment on the soaked fructus cnidii and ethanol at 40 ℃ for 1.2 h;
s14, filtering after ultrasonic treatment to obtain filtrate;
s15, putting the filtrate into a rotary steaming machine for spin-drying to obtain the fructus cnidii extract;
s2 preparation of beta-cyclodextrin traditional Chinese medicine inclusion compound chip material
S21 epoxidation of cotton fabric
S211, placing the cotton fabric into a reaction container, and adding 0.1mol/L NaOH solution to perform swelling treatment on the cotton fabric, wherein the cotton fabric needs to be completely immersed in the NaOH solution during the swelling treatment;
s212, adding a mixture of the two materials into another reaction container according to the volume ratio of 1: 1: 1, uniformly mixing distilled water, 10mol/L epichlorohydrin solution and 0.1mol/L NaOH solution to obtain a mixed solution; heating the mixed solution to 50 ℃, immersing the swelled cotton fabric in the mixed solution, and reacting for 0.8-1.5h at the temperature of 50 ℃;
s213, taking out the cotton fabric treated in the step S212, cleaning the cotton fabric by using distilled water (detecting the cleaning solution by using an indicator until the cleaning solution does not contain epichlorohydrin), and cleaning the cotton fabric by using acetone; drying to obtain an epoxidized cotton fabric; the drying is to dry for 45min at the temperature of 85 ℃;
s22 reaction of epoxidized cotton fabric with beta-cyclodextrin
S221, placing the epoxidized cotton fabric obtained in the step S21 into a mixed solution of NaOH solution and beta-cyclodextrin, and carrying out oscillation reaction for 2.5 hours at the temperature of 45 ℃;
the preparation method of the mixed solution of NaOH and beta-cyclodextrin comprises the following steps: according to the mass ratio, NaOH: beta-cyclodextrin: 50 parts of water: 1: 100, uniformly mixing NaOH, beta-cyclodextrin and water to obtain a mixed solution of the NaOH and the beta-cyclodextrin; the mass ratio of the cotton fabric to the beta-cyclodextrin is 95: 1.5;
s222, taking out the epoxidized cotton fabric treated in the step S221, cleaning with distilled water, and drying to obtain a cotton fabric grafted with beta-cyclodextrin; the drying is carried out at 85 ℃ for 40-50 min;
s23 preparation of beta-cyclodextrin traditional Chinese medicine inclusion compound chip material
S231, placing the cotton fabric grafted with the beta-cyclodextrin obtained in the step S22 into another reaction container, adding a fructus cnidii extracting solution prepared from the fructus cnidii extract prepared in the step S1 into the reaction container, and carrying out oscillation reaction for 4 hours at the temperature of 50 ℃;
the preparation method of the fructus cnidii extracting solution comprises the following steps: dissolving the fructus cnidii extract prepared in the step S1 in distilled water, wherein the mass ratio of the fructus cnidii extract to the distilled water is 15:100, and thus obtaining a fructus cnidii extracting solution; the mass ratio of the cotton fabric to the fructus cnidii extract is 95: 1.5;
s232, taking the cotton fabric grafted with the beta-cyclodextrin and treated in the step S231 out, cleaning with distilled water, and drying to obtain the beta-cyclodextrin traditional Chinese medicine inclusion compound chip material.
Example 2:
the preparation of the beta-cyclodextrin traditional Chinese medicine inclusion compound chip comprises the following steps:
s1, preparing fructus Cnidii extract
S11, crushing the fructus cnidii medicinal material to obtain fructus cnidii powder;
s12, soaking the fructus cnidii powder in ethanol for 30 hours;
s13, carrying out ultrasonic treatment on the soaked fructus cnidii and ethanol at 45 ℃ for 0.8 h;
s14, filtering after ultrasonic treatment to obtain filtrate;
s15, putting the filtrate into a rotary steaming machine for spin-drying to obtain the fructus cnidii extract;
s2 preparation of beta-cyclodextrin traditional Chinese medicine inclusion compound chip material
S21 epoxidation of cotton fabric
S211, placing the cotton fabric into a reaction container, and adding 0.2mol/L NaOH solution to perform swelling treatment on the cotton fabric, wherein the cotton fabric needs to be completely immersed in the NaOH solution during the swelling treatment;
s212, adding a mixture of the organic solvent and the organic solvent in a volume ratio of 1.5: 0.5: uniformly mixing 1.5 mol/L of distilled water, 8mol/L of epoxy chloropropane solution and 0.2mol/L of NaOH solution to obtain a mixed solution; heating the mixed solution to 45 ℃, then immersing the swelled cotton fabric in the mixed solution, and reacting for 0.8h at the temperature of 45 ℃;
s213, taking out the cotton fabric processed in the step S212, cleaning the cotton fabric with distilled water (detecting the cleaning solution by using an indicator until the cleaning solution does not contain epichlorohydrin), and cleaning the cotton fabric with acetone; drying to obtain an epoxidized cotton fabric; the drying is carried out for 40min at the temperature of 90 ℃;
s22 reaction of epoxidized cotton fabric with beta-cyclodextrin
S221, placing the epoxidized cotton fabric obtained in the step S21 into a mixed solution of NaOH solution and beta-cyclodextrin, and carrying out oscillation reaction for 2 hours at the temperature of 50 ℃;
the preparation method of the mixed solution of NaOH and beta-cyclodextrin comprises the following steps: according to the mass ratio, NaOH: beta-cyclodextrin: water 45: 1: 100, uniformly mixing NaOH, beta-cyclodextrin and water to obtain a mixed solution of the NaOH and the beta-cyclodextrin; the mass ratio of the cotton fabric to the beta-cyclodextrin is 90: 1;
s222, taking out the epoxidized cotton fabric treated in the step S221, cleaning with distilled water, and drying to obtain a cotton fabric grafted with beta-cyclodextrin; the drying is carried out at the temperature of 80 ℃ for 50 min;
s23 preparation of beta-cyclodextrin traditional Chinese medicine inclusion compound chip material
S231, placing the cotton fabric grafted with the beta-cyclodextrin obtained in the step S22 into another reaction container, adding a fructus cnidii extracting solution prepared from the fructus cnidii extract prepared in the step S1 into the reaction container, and carrying out oscillation reaction for 3.5 hours at the temperature of 55 ℃;
the preparation method of the fructus cnidii extracting solution comprises the following steps: dissolving the fructus cnidii extract prepared in the step S1 in distilled water, wherein the mass ratio of the fructus cnidii extract to the distilled water is 10:100, and thus obtaining a fructus cnidii extracting solution; the mass ratio of the cotton fabric to the fructus cnidii extract is 90: 1;
s232, taking out the cotton fabric grafted with the beta-cyclodextrin and treated in the step S231, cleaning with distilled water, and drying to obtain the beta-cyclodextrin traditional Chinese medicine inclusion compound chip material.
Example 3:
the preparation of the beta-cyclodextrin traditional Chinese medicine inclusion compound chip comprises the following steps:
s1, preparing fructus Cnidii extract
S11, crushing the fructus cnidii medicinal material to obtain fructus cnidii powder;
s12, soaking the fructus cnidii powder in ethanol for 20 hours;
s13, carrying out ultrasonic treatment on the soaked fructus cnidii and ethanol at 35 ℃ for 1.5 h;
s14, filtering after ultrasonic treatment to obtain filtrate;
s15, putting the filtrate into a rotary steaming machine for spin-drying to obtain the fructus cnidii extract;
s2 preparation of beta-cyclodextrin traditional Chinese medicine inclusion compound chip material
S21 epoxidation of cotton fabric
S211, placing cotton fabrics in a reaction container, and adding 0.05mol/L NaOH solution to carry out swelling treatment on the cotton fabrics, wherein the cotton fabrics need to be completely immersed in the NaOH solution during the swelling treatment;
s212, adding a mixture of the two materials into another reaction container in a volume ratio of 0.5: 1.5: uniformly mixing 0.5 mol/L of distilled water, 12mol/L of epoxy chloropropane solution and 0.05mol/L of NaOH solution to obtain a mixed solution; heating the mixed solution to 45 ℃, then immersing the swelled cotton fabric in the mixed solution, and reacting for 1.5h at the temperature of 45 ℃;
s213, taking out the cotton fabric processed in the step S212, cleaning the cotton fabric with distilled water (detecting the cleaning solution by using an indicator until the cleaning solution does not contain epichlorohydrin), and cleaning the cotton fabric with acetone; drying to obtain epoxidized cotton fabric; the drying is carried out at the temperature of 80 ℃ for 50 min;
s22 reaction of epoxidized cotton fabric with beta-cyclodextrin
S221, placing the epoxidized cotton fabric obtained in the step S21 into a mixed solution of NaOH solution and beta-cyclodextrin, and carrying out oscillation reaction for 3 hours at the temperature of 40 ℃;
the preparation method of the mixed solution of NaOH and beta-cyclodextrin comprises the following steps: according to the mass ratio, NaOH: beta-cyclodextrin: water 55: 1: 100, uniformly mixing NaOH, beta-cyclodextrin and water to obtain a mixed solution of the NaOH and the beta-cyclodextrin; the mass ratio of the cotton fabric to the beta-cyclodextrin is 100: 2;
s222, taking out the epoxidized cotton fabric treated in the step S221, cleaning with distilled water, and drying to obtain a cotton fabric grafted with beta-cyclodextrin; the drying is carried out for 40min at the temperature of 90 ℃;
s23 preparation of beta-cyclodextrin traditional Chinese medicine inclusion compound chip material
S231, placing the cotton fabric grafted with the beta-cyclodextrin obtained in the step S22 into another reaction container, adding a fructus cnidii extracting solution prepared from the fructus cnidii extract prepared in the step S1 into the reaction container, and carrying out oscillation reaction for 4.5 hours at the temperature of 45 ℃;
the preparation method of the fructus cnidii extracting solution comprises the following steps: dissolving the fructus cnidii extract prepared in the step S1 in distilled water, wherein the mass ratio of the fructus cnidii extract to the distilled water is 20:100, and thus obtaining a fructus cnidii extracting solution; the mass ratio of the cotton fabric to the fructus cnidii extract is 100: 2;
s232, taking out the cotton fabric grafted with the beta-cyclodextrin and treated in the step S231, cleaning with distilled water, and drying to obtain the beta-cyclodextrin traditional Chinese medicine inclusion compound chip material.
Example 4:
the preparation of the beta-cyclodextrin traditional Chinese medicine inclusion compound chip comprises the following steps:
s1, preparing fructus Cnidii extract
S11, crushing the fructus cnidii medicinal material to obtain fructus cnidii powder;
s12, soaking the fructus cnidii powder in ethanol for 28 hours;
s13, carrying out ultrasonic treatment on the soaked fructus cnidii and ethanol at 42 ℃ for 1 h;
s14, filtering after ultrasonic treatment to obtain filtrate;
s15, putting the filtrate into a rotary steaming machine for spin-drying to obtain the fructus cnidii extract;
s2 preparation of beta-cyclodextrin traditional Chinese medicine inclusion compound chip material
S21 epoxidation of cotton fabric
S211, placing the cotton fabric into a reaction container, and adding 0.08mol/L NaOH solution to perform swelling treatment on the cotton fabric, wherein the cotton fabric needs to be completely immersed in the NaOH solution during the swelling treatment;
s212, adding a mixture of the two materials into another reaction container according to the volume ratio of 1: 1.5: uniformly mixing 0.5 mol/L of distilled water, 12mol/L of epoxy chloropropane solution and 0.2mol/L of NaOH solution to obtain a mixed solution; heating the mixed solution to 52 ℃, then immersing the swelled cotton fabric in the mixed solution, and reacting for 1h while keeping the temperature at 52 ℃;
s213, taking out the cotton fabric processed in the step S212, cleaning the cotton fabric with distilled water (detecting the cleaning solution by using an indicator until the cleaning solution does not contain epichlorohydrin), and cleaning the cotton fabric with acetone; drying to obtain an epoxidized cotton fabric; the drying is carried out for 48min at the temperature of 82 ℃;
s22 reaction of epoxidized cotton fabric with beta-cyclodextrin
S221, placing the epoxidized cotton fabric obtained in the step S21 into a mixed solution of NaOH solution and beta-cyclodextrin, and carrying out oscillation reaction for 2.2h at the temperature of 48 ℃;
the preparation method of the mixed solution of NaOH and beta-cyclodextrin comprises the following steps: according to the mass ratio, NaOH: beta-cyclodextrin: water 42: 1: 100, uniformly mixing NaOH, beta-cyclodextrin and water to obtain a mixed solution of the NaOH and the beta-cyclodextrin; the mass ratio of the cotton fabric to the beta-cyclodextrin is 98: 1-2;
s222, taking out the epoxidized cotton fabric treated in the step S221, cleaning with distilled water, and drying to obtain a cotton fabric grafted with beta-cyclodextrin; the drying is carried out for 42min at the temperature of 88 ℃;
s23 preparation of beta-cyclodextrin traditional Chinese medicine inclusion compound chip material
S231, placing the cotton fabric grafted with the beta-cyclodextrin obtained in the step S22 into another reaction container, adding a fructus cnidii extracting solution prepared from the fructus cnidii extract prepared in the step S1 into the reaction container, and carrying out oscillation reaction for 4.2 hours at the temperature of 50 ℃;
the preparation method of the fructus cnidii extracting solution comprises the following steps: dissolving the fructus cnidii extract prepared in the step S1 in distilled water, wherein the mass ratio of the fructus cnidii extract to the distilled water is 18:100, and thus obtaining a fructus cnidii extracting solution; the mass ratio of the cotton fabric to the fructus cnidii extract is 92: 2;
s232, taking out the cotton fabric grafted with the beta-cyclodextrin and treated in the step S231, cleaning with distilled water, and drying to obtain the beta-cyclodextrin traditional Chinese medicine inclusion compound chip material.
Example 5:
the preparation of the beta-cyclodextrin traditional Chinese medicine inclusion compound chip comprises the following steps:
s1, preparing fructus Cnidii extract
S11, crushing the fructus cnidii medicinal material to obtain fructus cnidii powder;
s12, soaking the fructus cnidii powder in ethanol for 22 hours;
s13, carrying out ultrasonic treatment on the soaked fructus cnidii and ethanol at 45 ℃ for 1.5 h;
s14, filtering after ultrasonic treatment to obtain filtrate;
s15, putting the filtrate into a rotary steaming machine for spin-drying to obtain the fructus cnidii extract;
s2 preparation of beta-cyclodextrin traditional Chinese medicine inclusion compound chip material
S21 epoxidation of cotton fabric
S211, placing the cotton fabric into a reaction container, and adding 0.2mol/L NaOH solution to perform swelling treatment on the cotton fabric, wherein the cotton fabric needs to be completely immersed in the NaOH solution during the swelling treatment;
s212, adding a mixture of the two materials into another reaction container in a volume ratio of 0.5: 1: uniformly mixing 1.5 mol/L of distilled water, 9mol/L of epoxy chloropropane solution and 0.12mol/L of NaOH solution to obtain a mixed solution; heating the mixed solution to 52 ℃, then immersing the swelled cotton fabric in the mixed solution, and reacting for 1.5h at the temperature of 52 ℃;
s213, taking out the cotton fabric processed in the step S212, cleaning the cotton fabric with distilled water (detecting the cleaning solution by using an indicator until the cleaning solution does not contain epichlorohydrin), and cleaning the cotton fabric with acetone; drying to obtain an epoxidized cotton fabric; the drying is to dry for 50min at the temperature of 90 ℃;
s22 reaction of epoxidized cotton fabric with beta-cyclodextrin
S221, placing the epoxidized cotton fabric obtained in the step S21 into a mixed solution of NaOH solution and beta-cyclodextrin, and carrying out oscillation reaction for 3 hours at the temperature of 45 ℃;
the preparation method of the mixed solution of NaOH and beta-cyclodextrin comprises the following steps: according to the mass ratio, NaOH: beta-cyclodextrin: water 48: 1: 100, uniformly mixing NaOH, beta-cyclodextrin and water to obtain a mixed solution of the NaOH and the beta-cyclodextrin; the mass ratio of the cotton fabric to the beta-cyclodextrin is 95: 2;
s222, taking out the epoxidized cotton fabric treated in the step S221, cleaning with distilled water, and drying to obtain a cotton fabric grafted with beta-cyclodextrin; the drying is carried out for 42min at the temperature of 88 ℃;
s23 preparation of beta-cyclodextrin traditional Chinese medicine inclusion compound chip material
S231, placing the cotton fabric grafted with the beta-cyclodextrin obtained in the step S22 into another reaction container, adding a fructus cnidii extracting solution prepared from the fructus cnidii extract prepared in the step S1 into the reaction container, and carrying out oscillation reaction for 4 hours at the temperature of 50 ℃;
the preparation method of the fructus cnidii extracting solution comprises the following steps: dissolving the fructus cnidii extract prepared in the step S1 in distilled water, wherein the mass ratio of the fructus cnidii extract to the distilled water is 12:100, and thus obtaining a fructus cnidii extracting solution; the mass ratio of the cotton fabric to the fructus cnidii extract is 95: 2;
s232, taking out the cotton fabric grafted with the beta-cyclodextrin and treated in the step S231, cleaning with distilled water, and drying to obtain the beta-cyclodextrin traditional Chinese medicine inclusion compound chip material.
Secondly, preparing the traditional Chinese medicine type tampon
Example 6:
(1) cutting the beta-cyclodextrin traditional Chinese medicine inclusion chip material prepared in the example 1 into a sheet with the size of 0.8-2cm in length and 0.5-1cm in width, namely obtaining the beta-cyclodextrin traditional Chinese medicine inclusion chip;
(2) screening high-quality natural cotton fibers, and carding the cotton fiber raw material;
(3) paving and overlapping the cotton fiber raw materials carded in the step (2) into a composite cotton fiber net, and pressing the composite cotton fiber net into a plurality of strip-shaped cotton fiber blocks, wherein the cotton fiber blocks comprise cotton fiber blocks serving as cotton strip bodies, cotton fiber blocks serving as antibacterial layers and cotton fiber blocks serving as skin-friendly layers;
(4) soaking the cotton fiber block serving as the antibacterial layer obtained in the step (3) with a bacteriostatic agent, and drying to obtain a bacteriostatic cotton fiber block;
(5) placing the beta-cyclodextrin traditional Chinese medicine inclusion compound chip obtained in the step (1) on a cotton fiber block serving as a cotton sliver body;
in this embodiment, there are two beta-cyclodextrin Chinese medicinal inclusion chips, and the two beta-cyclodextrin Chinese medicinal inclusion chips are symmetrically disposed on two sides of the absorber.
(6) Sequentially laying an antibacterial cotton fiber block serving as an antibacterial layer and a cotton fiber block serving as a skin-friendly layer on a cotton fiber block serving as a cotton strip body and pressing the cotton fiber blocks into a whole, wherein a beta-cyclodextrin traditional Chinese medicine inclusion compound chip is positioned between the cotton fiber block serving as the cotton strip body and the antibacterial cotton fiber block serving as the antibacterial layer; fixing a pull rope in the middle of a cotton fiber block serving as a cotton strip body, wherein the tail end of the pull rope is exposed out of the strip-shaped cotton fiber layer;
(7) and (3) curling the cotton fiber as the cotton strip body, the antibacterial cotton fiber as the antibacterial layer and the cotton fiber as the skin-friendly layer which are pressed into a whole together to form a cylindrical cotton strip absorber, thus obtaining the finished product of the traditional Chinese medicine type sanitary cotton strip.
Example 7:
the beta-cyclodextrin traditional Chinese medicine inclusion compound chip prepared by the beta-cyclodextrin traditional Chinese medicine inclusion compound chip preparation material prepared in the embodiment 2 is applied; otherwise, the same as example 6; obtaining the finished product of the traditional Chinese medicine type tampon.
Example 8:
the beta-cyclodextrin traditional Chinese medicine inclusion compound chip prepared by the beta-cyclodextrin traditional Chinese medicine inclusion compound chip preparation material prepared in the embodiment 3 is applied; otherwise, the same as example 6; obtaining the finished product of the traditional Chinese medicine type tampon.
Example 9:
the beta-cyclodextrin traditional Chinese medicine inclusion compound chip prepared by the beta-cyclodextrin traditional Chinese medicine inclusion compound chip preparation material prepared in the embodiment 4 is applied; otherwise the same as example 6; obtaining the finished product of the traditional Chinese medicine type tampon.
Example 10:
the beta-cyclodextrin traditional Chinese medicine inclusion compound chip prepared by the beta-cyclodextrin traditional Chinese medicine inclusion compound chip preparation material prepared in the example 5 is applied; otherwise, the same as example 6; obtaining the finished product of the traditional Chinese medicine type tampon.
Third, Experimental example
1. Evaluation of safety
Safety evaluation by vaginal mucosa experiment
(1) Experimental methods
The traditional Chinese medicine type tampons prepared in examples 6-10 were soaked in sterile normal saline, respectively, at a ratio of 1g/10ml, and then left to stand at 37 ℃ for 24 hours, and then stirred sufficiently with a glass rod for 5 minutes, left to stand and cooled. After cooling, the sanitary cotton strip in the normal saline soak solution is taken out, 2ml of the normal saline soak solution is taken out by the injector and injected into the internal vagina of a healthy female big-ear white rabbit which is prepared in advance and has the weight of about 2.5kg-3.5kg, and three big-ear white rabbits are adopted for experiment in each embodiment; meanwhile, 2ml of sterile normal saline is injected into the internal vagina of three healthy female big-ear white rabbits with the body weight of about 2.5kg-3.5kg as a control example. After 24 hours, the white big-ear rabbits are killed, the abdomens of the rabbits are dissected to observe whether the abdomens of the rabbits have congestion, swelling and the like, and if the abdomens of the rabbits are abnormal, the pathogeny of the abnormal parts is checked.
(2) Results of experimental evaluation are shown in table 1 below:
TABLE 1 vaginal mucosa test results
As can be seen from table 1, the β -cyclodextrin inclusion compound chips in the tampon of traditional Chinese medicine type prepared in examples 6 to 10 did not have a safety problem for big ear white rabbits.
2. Evaluation of stability
(1) The stability evaluation was carried out by the following three evaluation methods:
naturally reserving a sample: packaging and sealing the traditional Chinese medicine type tampons prepared in examples 6-10, and then placing the original packaged sample at room temperature for 1 year for bacteriostasis or sterilization performance test;
and (5) accelerating the test: the tampons of the chinese medicine type prepared in examples 6-10 were packaged and sealed, and then placed under different storage conditions and storage days (shown in table 2 below) for bacteriostatic or bactericidal performance tests.
TABLE 2 storage conditions and days of storage
| Processing sequence number | Storage conditions | Retention time |
| 1 | 52℃-56℃ | 14d |
| 2 | 35℃-39℃ | 90d |
| 3 | 40℃-45℃ | 180d |
| 4 | 35℃-40℃ | 270d |
③ Strong light irradiation test: the tampon of the present invention is prepared by packaging and sealing the tampon of the present invention prepared in examples 6 to 10, placing the tampon in an open petri dish with a thickness of 5mm or less, placing a liquid sample to be tested in a 250ml colorless transparent ground bottle with a loading capacity of 80% of the ground bottle, covering the cap tightly, placing the tampon in a high-light test box, storing the tampon for 10 days under conditions of an illumination of 4500 lx 500lx, a temperature of 25 ℃ 2 ℃ and a relative humidity of (60 shi 10)% for testing antibacterial or bactericidal properties.
(2) The evaluation results are shown in table 3:
TABLE 3 stability evaluation results
The stability of the sample is good, and the quality problem does not exist after the detection.
Claims (9)
1. A traditional Chinese medicine type tampon is characterized by comprising a tampon absorber and a pull wire, and is characterized in that: the cotton strip absorber is sequentially provided with a skin-friendly layer, an antibacterial layer and an absorber from outside to inside; a beta-cyclodextrin traditional Chinese medicine inclusion chip is arranged in the absorber; the preparation method of the beta-cyclodextrin traditional Chinese medicine inclusion chip material comprises the following steps:
s1, preparing fructus Cnidii extract
Pulverizing fructus Cnidii, and extracting by leaching to obtain fructus Cnidii extract;
s2, preparing a beta-cyclodextrin traditional Chinese medicine inclusion compound chip material;
s21 epoxidation of cotton fabric
S211, placing the cotton fabric into a reaction container, and adding NaOH solution to perform swelling treatment on the cotton fabric;
s212, adding a mixture of the following components in a volume ratio of 0.5-1.5: 0.5-1.5: 0.5-1.5 of distilled water, an epichlorohydrin solution and a NaOH solution, and placing the swelled cotton fabric into the container; reacting at 45-55 deg.C for 0.8-1.5 h;
s213, taking out the cotton fabric treated in the step S212, and cleaning and drying the cotton fabric to obtain an epoxidized cotton fabric;
s22 reaction of epoxidized cotton fabric with beta-cyclodextrin
S221, placing the epoxidized cotton fabric obtained in the step S21 into a mixed solution of NaOH solution and beta-cyclodextrin, and carrying out oscillation reaction for 2-3h at the temperature of 40-50 ℃;
s222, taking out the epoxidized cotton fabric treated in the step S221, cleaning and drying to obtain a cotton fabric grafted with beta-cyclodextrin;
s23 preparation of beta-cyclodextrin traditional Chinese medicine inclusion compound chip material
S231, placing the cotton fabric grafted with the beta-cyclodextrin obtained in the step S22 into another reaction container, adding a fructus cnidii extracting solution prepared from the fructus cnidii extract prepared in the step S1 into the reaction container, and carrying out oscillation reaction at the temperature of 45-55 ℃ for 3.5-4.5 hours;
the mass ratio of the cotton fabric and the fructus cnidii extract to the beta-cyclodextrin is 90-100: 1-2: 1-2;
s232, taking out the cotton fabric grafted with the beta-cyclodextrin and treated in the step S231, cleaning and drying to obtain the beta-cyclodextrin traditional Chinese medicine inclusion chip material.
2. The traditional Chinese medicine type tampon according to claim 1, wherein in the step S211, the NaOH solution is 0.05-0.2 mol/L;
in the step S212, the epichlorohydrin solution is 8-12mol/L and NaOH solution, and the NaOH solution is 0.05-0.2 mol/L; the volume ratio of the distilled water to the epichlorohydrin solution to the NaOH solution is 0.5-1.5: 0.5-1.5: 0.5-1.5;
in step S221, the preparation method of the mixed solution of NaOH and β -cyclodextrin is: according to the mass ratio, NaOH: beta-cyclodextrin: water = 45-55: 1: 100, uniformly mixing NaOH, beta-cyclodextrin and water to obtain a mixed solution of the NaOH and the beta-cyclodextrin; the mass ratio of the cotton fabric to the beta-cyclodextrin is 90-100: 1-2;
in step S231, the preparation method of the fructus cnidii extract solution includes: dissolving the fructus cnidii extract prepared in the step S1 in distilled water, wherein the mass ratio of the fructus cnidii extract to the distilled water is 10-20:100, and obtaining fructus cnidii extract; the mass ratio of the cotton fabric to the fructus cnidii extract is 90-100: 1-2.
3. The traditional Chinese medicine type tampon according to claim 1, wherein the skin-friendly layer is a surface layer of a spunlace nonwoven material; the skin-friendly layer is wrapped on the outer side of the antibacterial layer in a surrounding manner; the antibacterial layer is closely wrapped on the outer side of the absorber in a surrounding manner; the antibacterial layer is prepared from a non-woven fabric layer containing a bacteriostatic agent; the absorber and the skin-friendly layer are both made of natural cotton fibers.
4. The tampon of claim 1, wherein the plurality of beta-cyclodextrin drug clathrate chips are disposed about a central axis of the absorber.
5. The traditional Chinese medicine type tampon of claim 4, wherein the number of beta-cyclodextrin traditional Chinese medicine inclusion compound chips is 2-6.
6. The manufacturing method of the tampon of any of claims 1 to 5, wherein the manufacturing method comprises the steps of:
(1) preparing a beta-cyclodextrin traditional Chinese medicine inclusion compound chip;
(2) screening high-quality natural cotton fibers, and carding the cotton fiber raw material;
(3) paving and overlapping the cotton fiber raw materials carded in the step (2) into a composite cotton fiber net, and pressing the composite cotton fiber net into a plurality of strip-shaped cotton fiber blocks, wherein the cotton fiber blocks comprise cotton fiber blocks serving as cotton strip bodies, cotton fiber blocks serving as antibacterial layers and cotton fiber blocks serving as skin-friendly layers;
(4) soaking the cotton fiber block serving as the antibacterial layer obtained in the step (3) with a bacteriostatic agent, and drying to obtain a bacteriostatic cotton fiber block;
(5) placing the beta-cyclodextrin traditional Chinese medicine inclusion compound chip obtained in the step (1) on a cotton fiber block serving as a cotton sliver body;
(6) sequentially laying an antibacterial cotton fiber block serving as an antibacterial layer and a cotton fiber block serving as a skin-friendly layer on a cotton fiber block serving as a cotton strip body and pressing the cotton fiber blocks into a whole, wherein a beta-cyclodextrin traditional Chinese medicine inclusion compound chip is positioned between the cotton fiber block serving as the cotton strip body and the antibacterial cotton fiber block serving as the antibacterial layer; fixing a pull rope in the middle of a cotton fiber block serving as a cotton strip body, wherein the tail end of the pull rope is exposed out of the strip-shaped cotton fiber layer;
(7) and (3) curling the cotton fiber as the cotton strip body, the antibacterial cotton fiber as the antibacterial layer and the cotton fiber as the skin-friendly layer which are pressed into a whole together to form a cylindrical cotton strip absorber, thus obtaining the finished product of the traditional Chinese medicine type sanitary cotton strip.
7. The method of claim 6, wherein the step 2 of preparing the beta-cyclodextrin inclusion compound chip comprises the steps of:
s1, preparing fructus Cnidii extract
Pulverizing fructus Cnidii, and extracting by leaching method to obtain fructus Cnidii extract;
s2, preparing a beta-cyclodextrin traditional Chinese medicine inclusion compound chip material;
s21 epoxidation of cotton fabric
S211, placing the cotton fabric into a reaction container, and adding NaOH solution to perform swelling treatment on the cotton fabric;
s212, adding a mixture of the following components in a volume ratio of 0.5-1.5: 0.5-1.5: 0.5-1.5 of distilled water, an epichlorohydrin solution and a NaOH solution, and placing the swelled cotton fabric into the container; reacting at 45-55 deg.C for 0.8-1.5 h;
s213, taking out the cotton fabric treated in the step S212, and cleaning and drying the cotton fabric to obtain an epoxidized cotton fabric;
s22 reaction of epoxidized cotton fabric with beta-cyclodextrin
S221, placing the epoxidized cotton fabric obtained in the step S21 into a mixed solution of NaOH solution and beta-cyclodextrin, and carrying out oscillation reaction for 2-3h at the temperature of 40-50 ℃;
s222, taking out the epoxidized cotton fabric treated in the step S221, cleaning and drying to obtain a cotton fabric grafted with beta-cyclodextrin;
s23 preparation of beta-cyclodextrin traditional Chinese medicine inclusion compound chip material
S231, placing the cotton fabric grafted with the beta-cyclodextrin obtained in the step S22 into another reaction container, adding a fructus cnidii extracting solution prepared from the fructus cnidii extract prepared in the step S1 into the reaction container, and carrying out oscillation reaction at the temperature of 45-55 ℃ for 3.5-4.5 hours;
the mass ratio of the cotton fabric and the fructus cnidii extract to the beta-cyclodextrin is 90-100: 1-2: 1-2;
s232, taking out the cotton fabric grafted with the beta-cyclodextrin and treated in the step S231, cleaning and drying to obtain the beta-cyclodextrin traditional Chinese medicine inclusion chip material.
8. The method of manufacturing a tampon according to claim 6, wherein in step S211, the NaOH solution is 0.05-0.2 mol/L;
in the step S212, the epichlorohydrin solution is 8-12mol/L and NaOH solution, and the NaOH solution is 0.05-0.2 mol/L; the volume ratio of the distilled water to the epichlorohydrin solution to the NaOH solution is 0.5-1.5: 0.5-1.5: 0.5-1.5;
in step S221, the preparation method of the mixed solution of NaOH and β -cyclodextrin is: according to the mass ratio, NaOH: beta-cyclodextrin: water = 45-55: 1: 100, uniformly mixing NaOH, beta-cyclodextrin and water to obtain a mixed solution of the NaOH and the beta-cyclodextrin; the mass ratio of the cotton fabric to the beta-cyclodextrin is 90-100: 1-2;
in step S231, the preparation method of the fructus cnidii extract solution includes: dissolving the fructus cnidii extract prepared in the step S1 in distilled water, wherein the mass ratio of the fructus cnidii extract to the distilled water is 10-20:100, and obtaining fructus cnidii extract; the mass ratio of the cotton fabric to the fructus cnidii extract is 90-100: 1-2.
9. The method for manufacturing a tampon of claim 6, wherein in step S1, the step of preparing the cnidium monnieri extract comprises the following steps:
s11, crushing the fructus cnidii to obtain fructus cnidii powder;
s12, soaking the fructus cnidii powder in ethanol for 20-30 h;
s13, carrying out ultrasonic treatment on the soaked fructus cnidii and ethanol at 35-45 ℃ for 0.8-1.5 h;
s14, filtering after ultrasonic treatment to obtain filtrate;
s15, putting the filtrate into a rotary steaming machine for spin-drying to obtain the fructus cnidii extract.
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| CN107648660A (en) * | 2017-10-30 | 2018-02-02 | 苏州宝丽洁医疗科技有限公司 | A kind of antiphlogistic antibacterial type tapon and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107648660A (en) * | 2017-10-30 | 2018-02-02 | 苏州宝丽洁医疗科技有限公司 | A kind of antiphlogistic antibacterial type tapon and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 孙盛梅；等: "蛇床子提取物对小鼠阴道菌群影响的研究", 黑龙江医药科学, vol. 43, no. 1, pages 188 - 189 * |
| 朱平;等: "β-环糊精接枝棉织物包合药物的研究", 《纺织学报》, vol. 31, no. 7, pages 5 - 7 * |
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