CN106361294A - Device and method for endovascular optical coherence tomography - opto-acoustic - ultrasonic multimode imaging - Google Patents
Device and method for endovascular optical coherence tomography - opto-acoustic - ultrasonic multimode imaging Download PDFInfo
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- CN106361294A CN106361294A CN201611004118.7A CN201611004118A CN106361294A CN 106361294 A CN106361294 A CN 106361294A CN 201611004118 A CN201611004118 A CN 201611004118A CN 106361294 A CN106361294 A CN 106361294A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
Abstract
The invention belongs to the field of blood vessel endoscopic imaging and discloses a device and method for endovascular optical coherence tomography - opto-acoustic - ultrasonic multimode imaging. The device comprises a computer, an optical coherence tomography (OCT) excitation and collection system, an opto-acoustic signal excitation and collection system, an ultrasonic signal excitation and collection system and an integrated probe. The OCT excitation and collection system comprises a field programmable logic array (PFGA) panel, a superluminescent diode, an isolator, a first optical fiber coupler, a reference arm, a linear array charge coupled device (CCD) and a first collecting card. The opto-acoustic signal excitation and collection system comprises a pulsed laser, a diaphragm, a second optical fiber coupler and a doubly clad optical fiber. The ultrasonic signal excitation and collection system comprises a pulse ultrasonic emitter/receiver, a signal amplifier, a signal filter and a second collecting card. The OCT, opto-acoustic and ultrasonic tri-modal blood vessel endoscopic imaging system integrates three imaging modes and respective advantages thereof, and multi-parameter physiological function information and multiscale structural information of a blood vessel can be obtained.
Description
Technical field
The present invention relates to the research field of blood vessel endoscope, particularly to a kind of intravascular optical coherence tomography-optoacoustic-
Ultrasonic multi-modality imaging apparatus and method.
Background technology
Cardiovascular and cerebrovascular disease is the higher disease of present mortality rate, and the accuracy of blood vessel detection there has also been higher requirement.
Modern medicine detects that the means of blood vessel have, including magnetic resonance (mri) blood vessel imaging and angiographic imaging (ivus) and Ink vessel transfusing
Optical coherence tomography images (oct), above several detection meanss can preferably present formalness or the inner wheel of blood vessel
Exterior feature, but the local detail information of blood vessel wall and lumen of vessels cannot be provided.Intravascular photoacoustic imaging technique is a kind of new doctor
Learn imaging technique, cardinal principle is to organize by pulsed laser irradiation, tissue resorption light produces thermoelastic ripple, by surpassing to generation
Sound wave carries out being imaged the relevant information that can obtain tissue.And intravascular photoacoustic imaging technique is endoscopic technique and optics, electricity
The product that the technology such as sub-, Digital Image Processing constantly develop and merge.From a kind of unique visual angle, that is, from internal blood vessel to blood
Pipe section is imaged. it is able to observe that the fine structure of blood vessel wall that other imaging methods cannot observe and tube chamber, very
To component of organization.Traditional optical vessel based endoscopic imaging principle is all to obtain detection figure using optical scattering or reflected signal
Picture, because light is affected greatly, there is penetration depth shallow (mm level) by medium scatters.
Optical coherence tomography (oct): be an emerging Tomography technology, Ink vessel transfusing oct can
Accurate measurement arteria coronaria inner membrance and fibrous cap thickness, provide tissue in situ and real-time imaging, greatly strengthen image resolution and
Contrast. but oct is affected larger, the relatively low deep layer signal that can not identify blood vessel of imaging depth by blood scattering.
Intravascular ultrasound imaging (ivus) is to be imaged based on detection echo in blood vessel wall for the ultrasonic signal, reflects blood
The diversity of tubing acoustic impedance；Intravascular photoacoustic imaging is to absorb the optoacoustic letter producing after pulse laser based on detection blood vessel wall
Number it is imaged, the optical absorption difference of reflection vascular tissue.Both technology are respectively from acoustic impedance and two parameters of light absorbs
The upper information providing blood vessel, the imaging depth of two kinds of imaging methods can reach more than 10cm, and therefore both technology are very suitable
Close and based endoscopic imaging is carried out to blood vessel.
Three kinds of imaging methods are combined by Ink vessel transfusing oct- optoacoustic-ultrasonic multi-modality imaging technology, effectively overcome list
The deficiency of one mode imaging, using the teaching of the invention it is possible to provide Ink vessel transfusing many reference amounts, the information of various dimensions, contribute to diagnosing endovascular speckle feelings
Condition.
Application No. 201210510661.x, patent entitled " non-contact photoacoustic and optical coherence tomographic imaging apparatus and
Detection method ", disclose a kind of imaging device and the method that oct and photoacoustic imaging combine, this technology realizes plane using galvanometer
Two-dimensional scan, but Ink vessel transfusing cannot be applied to.
Application No. 201010187650.3, patent name is a kind of " intravascular photoacoustic ultrasonic double-mode imaging endoscope dress
Put and its imaging method " document disclose a kind of technology.This technology adopts hollow circular ring array ultrasonic sensors and the conical surface anti-
Penetrate mirror, during photoacoustic imaging, pulse laser transmits through optical fiber and going out the transmitting of light end, scatters simultaneously on the face of conical reflector
Irradiate whole blood vessel wall, excite photoacoustic signal, receive, using circle ring array ultrasonic detector, the photoacoustic signal producing；Ultra sonic imaging
When circle ring array ultrasonic detector transmitting ultrasonic signal, then receive the ultrasonic signal of vasoreflex, probe have photoacoustic imaging and
The performance of ultra sonic imaging.
Its deficiency is that the pulse laser of this technology expands in conical reflector, excites whole internal blood vessel simultaneously, required
Laser energy is big；And because pulse laser does not converge, so the resolution of photoacoustic image is not good, the probe of this device in addition
Using 64 acoustic sensors, the receiving efficiency of single acoustic sensor is not good and complex structure.
Application No. 201210220399.5, patent name is " focusing rotation sweep photoacoustic ultrasound blood vessel endoscope imaging
Device and its imaging method " document disclose a kind of imaging device, can be utilized this device carry out photoacoustic ultrasound integration blood vessel
Interior imaging method research.Direct 90 ° of the optical fiber connector of this device goes out light, laser be divergent irradiation on object under test, laser does not have
There is convergence, equally exist the poor problem of the resolution of photoacoustic image, and the coupling of device disclosed in this technology, laser and optical fiber
Direct-coupled mode is taken in conjunction, easily deviation so during fiber spinning, thus leading to laser to the biography of optical fiber
Defeated efficiency reduces, and directly affects the generation of photoacoustic signal.
Content of the invention
Present invention is primarily targeted at overcoming shortcoming and the deficiency of prior art, a kind of intravascular optical is provided to be concerned with disconnected
Layer imaging-optoacoustic-ultrasonic multi-modality imaging device, can realize the imaging of oct- optoacoustic-ultrasonic Three models, energy using this device
Enough Ink vessel transfusing many reference amounts of acquisition simultaneously, multiple dimensioned information, improve the accuracy of detection of plaque within blood vessels.
Another object of the present invention is to providing a kind of method being imaged using above-mentioned imaging device, using this imaging
Method, can obtain endovascular oct image, photoacoustic image and ultrasonoscopy.
In order to reach above-mentioned first purpose, the present invention employs the following technical solutions:
The device of a kind of endovascular optical coherence tomography-optoacoustic-ultrasonic multi-modality imaging of the present invention, including meter
Calculation machine, oct are excited to be excited with acquisition system, photoacoustic signal and are excited and acquisition system and one with acquisition system, ultrasonic signal
Change probe, endovascular optical coherence tomography oct exciting light and photo-acoustic excitation light are using different light sources, and pass through double clad
Optical fiber carries out Laser Transmission and collection；
Wherein, described oct is excited and is included with acquisition system: fpga plate, superluminescent diode, isolator, the first optical fiber coupling
Clutch, reference arm, linear array ccd and the first capture card；Described fpga plate produces signal excitation superluminescent diode and produces oct
Exciting light, is partly into doubly clad optical fiber fibre core for oct signal by the first fiber coupler after isolator
Excite, a part carries out signal as reference arm laser signal, the laser entering doubly clad optical fiber fibre core by integrated probe
Excite and gather oct signal to return along doubly clad optical fiber fibre core again, gathered by linear array ccd after reference arm and be converted into electricity
Signal, then send computer acquisition by the first capture card, finally rebuilds and obtains Ink vessel transfusing oct image；
Described photoacoustic signal is excited and is included with acquisition system: pulse laser, diaphragm, the second fiber coupler, Yi Jishuan
Cladded-fiber, described pulse laser is excited after producing pulse laser to enter by the second fiber coupler after diaphragm
Enter the covering of doubly clad optical fiber, then excited by integrated probe and by the integrated ultrasonic transducer collection optoacoustic of integrated probe
Signal, then changes into the signal of telecommunication by connecting the coaxial cable of transducer after light electric slip ring by ultrasonic by ultrasonic transducer
Receptor receives, and amplifies through signal and gathered by the second capture card after filtering, and then send computer disposal weight by signal
Build photoacoustic image；
Described ultrasonic signal is excited and is included with acquisition system: impulse ultrasound emitting/receiving, signal amplifier, signal filter
Ripple device and the second capture card, described impulse ultrasound emitting/receiving launches ultrasonic pulse after receiving trigger, passes through
Coaxial cable is transferred to the ultrasonic transducer of the probe of integration, makes ultrasonic transducer produce ultrasound wave, blood vessel is detected
And receiving the ultrasound wave reflecting, reflected ultrasonic is converted into the signal of telecommunication again through coaxial cable, light by ultrasonic transducer
Electric slip ring, ultrasound emission receptor, through signal amplifier, then are transferred to calculating through traffic filter by the second capture card
Machine, obtains Vascular Ultrasonography image through image reconstruction.
As preferred technical scheme, transmit oct light source and photo-acoustic excitation light source employs a doubly clad optical fiber simultaneously
Transmission, the fibre core of doubly clad optical fiber is single mode transport, for transmitting oct exciting light；Outer layer is multimode transmissions, for transmitting optoacoustic
Exciting light, this double clad is divided into two sections to connect by light electric slip ring, and light electric slip ring and rotating stepper motor are fixed, thus realizing revolving
Turn.
As preferred technical scheme, the optical maser wavelength that described superluminescent diode is launched is 1310nm；
Described pulse laser is semiconductor laser, solid state laser, dye laser or gas laser, output
The wave-length coverage of pulse laser is 400nm～2500nm, and pulse width is 5ns～50ns.
As preferred technical scheme, the frequency range that ultrasonic signal launched by described ultrasound pulse transmission/receptor is
20mhz～50mhz, the frequency range receiving ultrasonic signal is 1khz～75mhz, and described signal amplifier can amplification frequency be
5-75mhz, gain amplifier is 10-60db, and signaling rate wave filter is band filter, a width of 5-50mhz of passband.
As preferred technical scheme, described integrated probe be internally integrated high-frequency transducer, high frequency ultrasound
The dominant frequency of transducer is 50mhz, carries a width of 80%, the frequency range of transmitting ultrasonic signal is 20mhz～50mhz, receives ultrasonic
The frequency range of signal or photoacoustic signal is 1khz～75mhz.
As preferred technical scheme, described doubly clad optical fiber end focuses on it through after grin lens and metallic-membrane plating reflector
Rear side goes out light to 110 °, carries out oct to blood vessel wall and photoacoustic signal excites, described doubly clad optical fiber, grin lens and plated film
It is in the circular titanium tube that 1.0mm internal diameter is 0.5mm that reflecting mirror and high-frequency transducer are together placed on external diameter；
Described doubly clad optical fiber, ultrasonic transducer holding wire both pass through medical guiding wire, medical guiding wire one end and light electric slip ring
It is mechanically connected, the other end is mechanically connected with circular titanium tube, and electric rotating machine passes through the rotation that light electric slip ring drives fixing seal wire, from
And drive the oct- optoacoustic-ultrasonic Three models rotation in circular titanium tube and circular titanium tube to excite collection signal.
As preferred technical scheme, described medical guiding wire and the titanium tube being connected with medical guiding wire are placed in medical leading
Guan Zhong, medical catheter is fixing device, and seal wire drives titanium tube to rotate in the catheter, constitutes rotary apparatuss, and the effect of conduit is to protect
Card seal wire rotation when not eccentric, described rotary apparatuss be placed on advance/recession platform realize integrated probe in intravascular before
After move, described rotary apparatuss with advance/recession platform collectively form rotation/advance/recession platform.
As preferred technical scheme, described rotation/advance/recession platform is by horizontal direction motor and axial direction
Motor forms, and horizontal direction motor band moving platform completes advance/recession function, the synchronization of axial direction motor
Gear is mechanically connected with light electric slip ring, and the lead of ultrasonic transducer is electrically connected with light electric slip ring, and light electric slip ring outlet connects ultrasonic
Signal emitting/receiving, signal inputs the second capture card after amplifier, traffic filter, above-mentioned smooth electric slip ring, ultrasonic
Signal emitting/receiving, signal amplifier, traffic filter, the second capture card are electrical connection, when motor is by tooth
When wheel drives the rotation of photoelectricity slip ring, realize driving 360 ° of rotations of probe of photoacoustic ultrasound integration by seal wire.
As preferred technical scheme, whole system sequencing contro is as follows, and computer controls fpga produce signal excitation and surpass
Light emitting diode produces oct exciting light, and after collecting oct signal, triggering ultrasound emission/receptor generation is ultrasonic, this ultrasonic
Emitter produces synchronous triggering signal simultaneously, and this synchronous triggering signal excitation pulse laser instrument after chronotron produces optoacoustic and swashs
Luminous.
In order to reach above-mentioned second purpose, the present invention employs the following technical solutions:
A kind of method being imaged using multi-modality imaging device of the present invention, is comprised the steps:
(1) excite: this device is positioned over Ink vessel transfusing, computer controls fpga plate produces signal excitation superluminescent diode
Produce oct exciting light, this exciting light excites oct to believe by integrated probe with the fibre core of doubly clad optical fiber through the light electric slip ring when
Number；After collecting oct signal, triggering ultrasound emission/receptor produces ultrasonic, the ultrasound emission/receptor transmitting signal of telecommunication, warp
Cross light electric slip ring and ultrasonic signal is converted electrical signals into by the integrated ultrasonic transducer of integrated probe, ultrasonic signal is to blood
Pipe detects；This emitting/receiving produces synchronous triggering signal simultaneously, the excitation pulse after chronotron of this synchronous triggering signal
Laser instrument produce photo-acoustic excitation light, this exciting light after diaphragm by doubly clad optical fiber inner cladding after light electric slip ring
By the lateral 110 ° of directive blood vessels of integrated probe, excite photoacoustic signal；
(2) data acquisition: the oct signal of generation is passed back through after light electric slip ring by the fibre core of above-mentioned doubly clad optical fiber, and
Gathered by linear array ccd, collect oct signal and computer is sent into by the first capture card；The ultrasonic signal returning is by ultrasonic transducer
Receive, and ultrasonic signal be converted into the signal of telecommunication, by the coaxial wire being connected with ultrasonic transducer through light electric slip ring it
Received by ultrasound emission/receptor afterwards, after being then passed through signal amplifier and traffic filter, meter is sent into by the second capture card
Calculation machine；Photoacoustic signal is received by ultrasonic transducer, and photoacoustic waves signal is converted into the signal of telecommunication, by be connected with ultrasonic transducer
Coaxial wire is received by ultrasound emission/receptor after light electric slip ring, is then passed through signal amplifier and signal filtering
After device, computer is sent into by the second capture card；
(3) after completing the oct- optoacoustic-ultrasonic signal data acquisition of blood vessel a certain position, operating computer makes rotation walk
Stepper motor works, and rotating stepper motor drives runner assembly, and runner assembly drives the rotor of light electric slip ring to rotate, and light electric slip ring turns
The rotational band movement and motor-driven integrative probe of son rotates, thus carrying out data acquisition to blood vessel next one position, until integrated probe is complete
Become 360 ° of rotations, thus completing the data acquisition in a certain section of blood vessel；After completing the data acquisition in a certain section of blood vessel, manipulate meter
Calculation machine makes translation stepper motor work, and translation stepper motor drives translation platform, and translation platform drives integrated probe translation, from
And data acquisition is carried out to next section of blood vessel；
(4) image reconstruction: the data collecting is used for the reconstruction of oct image, photoacoustic image, ultrasonoscopy by computer.
The present invention compared with prior art, has the advantage that and beneficial effect:
1. present invention achieves oct is imaged, the integration of photoacoustic imaging and three kinds of intravascular imaging method of ultra sonic imaging, letter
Change detection program, reduce detection difficulty, it is possible to achieve three kinds of imaging methods work simultaneously.
2. the present invention can obtain the acoustic impedance of vascular tissue, optical absorption, optical scattering, the thickness of plaque within blood vessels simultaneously
The information such as degree and mechanical property, can more accurately diagnose vascular plaque.
3. the rotation sweep pattern of the present invention can obtain 360 ° of information of blood vessel, and sensitivity is high, and good resolution can
Realize the comparison of three kinds of imaging patterns.
4. present configuration is simple, compact, it is easy to accomplish, integrated probe size is little, fully meets for tiny blood vessels
Or pathological changes block the detection of blood vessel.
Brief description
Fig. 1 is Ink vessel transfusing oct- optoacoustic-ultrasonic multi-modality imaging schematic device；
Fig. 2 is the schematic diagram of the integrated probe that Ink vessel transfusing oct- optoacoustic-ultrasonic multi-modality imaging device is used.
Drawing reference numeral illustrates: 1, computer；2nd, fpga plate；3rd, superluminescent diode；4th, isolator；5th, the first optical fiber coupling
Device；6th, reference arm；7th, linear array ccd；8th, the first capture card；9th, doubly clad optical fiber bundling device；10th, impulse ultrasound emitting/receiving；
11st, signal amplifier；12nd, traffic filter；13rd, the second capture card；14th, chronotron；15th, pulse laser；16th, diaphragm；17、
Second fiber coupler；18th, light electric slip ring；19th, rotation/translation platform；20 integrated probes；21st, coaxial wire；22nd, double
Cladded-fiber；23rd, titanium tube；24th, grin lens；25th, metallic-membrane plating reflector；26th, ultrasonic transducer；27th, blood vessel sample.
Specific embodiment
With reference to embodiment and accompanying drawing, the present invention is described in further detail, but embodiments of the present invention do not limit
In this.
Embodiment
As shown in figure 1, present embodiment discloses a kind of endovascular optical coherence tomography-optoacoustic-ultrasonic multi-modal
The device of imaging, is excited to be excited with acquisition system, photoacoustic signal and is excited with acquisition system, ultrasonic signal including computer 1, oct
With acquisition system and integrated probe 20, described integrated probe is fixed on rotation/translation platform 19 by light electric slip ring 18
On；Endovascular optical coherence tomography oct exciting light and photo-acoustic excitation light are using different light sources, and pass through doubly clad optical fiber
Carry out Laser Transmission and collection；
Wherein, described oct is excited and is included with acquisition system: fpga plate 2, superluminescent diode 3, isolator 4, the first optical fiber
Bonder 5, reference arm 6, linear array ccd 7 and the first capture card 8；Described fpga plate produces signal excitation superluminescent diode
Produce oct exciting light, after isolator, doubly clad optical fiber fibre core is partly into for oct by the first fiber coupler
The exciting of signal, a part carries out letter as reference arm laser signal, the laser entering doubly clad optical fiber by integrated probe
Number excite and gather oct signal to return along doubly clad optical fiber fibre core again, gathered by linear array ccd after reference arm and be converted into
The signal of telecommunication, then send computer acquisition by the first capture card, finally rebuilds and obtains Ink vessel transfusing oct image；
Described photoacoustic signal is excited and is included with acquisition system: pulse laser 15, diaphragm 16, the second fiber coupler 17,
And doubly clad optical fiber, described pulse laser be excited generation pulse laser after after diaphragm pass through the second optical fiber coupling
Clutch enters the covering of doubly clad optical fiber, then is excited by integrated probe and adopted by the integrated ultrasonic transducer of integrated probe
Collection photoacoustic signal, then by ultrasonic transducer change into the signal of telecommunication by connect the coaxial cable of transducer after electric slip ring by
Ultrasonic receiver receives, and amplifies through signal and gathered by the second capture card after filtering, and then send signal at computer
Reason rebuilds photoacoustic image；
Described ultrasonic signal is excited and is included with acquisition system: impulse ultrasound emitting/receiving 10, signal amplifier 11, letter
Number wave filter 12 and the second capture card 13, are additionally provided with chronotron 15 between described traffic filter and pulse laser, described
First fiber coupler and the second fiber coupler carry out the conjunction bundle of optical fiber by doubly clad optical fiber bundling device 9, and signal is passed
Pass integrated probe；Described impulse ultrasound emitting/receiving launches ultrasonic pulse, through coaxial electrical after receiving trigger
Cable is transferred to the ultrasonic transducer of the probe of integration, makes ultrasonic transducer produce ultrasound wave, blood vessel is detected and receives
The ultrasound wave reflecting, ultrasonic transducer by reflected ultrasonic be converted into the signal of telecommunication again through coaxial cable, light electric slip ring,
Ultrasound emission receptor, through signal amplifier, then is transferred to computer, Jing Guotu through traffic filter by the second capture card
Obtain Vascular Ultrasonography image as rebuilding.
As shown in Fig. 2 described integrated probe 20 to include coaxial wire 21, doubly clad optical fiber 22, titanium tube 23, grin saturating
Mirror 24 and metallic-membrane plating reflector 25, ultrasonic transducer 26, described integrated probe 20 is arranged on blood vessel sample 27 when using；
Described doubly clad optical fiber end goes out light through lateral 110 ° after focusing on after grin lens and metallic-membrane plating reflector, and blood vessel wall is carried out
Oct and photoacoustic signal excite, and described doubly clad optical fiber, grin lens and metallic-membrane plating reflector and high-frequency transducer are together
It is placed on external diameter to be in the circular titanium tube that 1.0mm internal diameter is 0.5mm；Described doubly clad optical fiber, ultrasonic transducer holding wire both pass through
Medical guiding wire, medical guiding wire one end is mechanically connected with light electric slip ring, and the other end is mechanically connected with circular titanium tube, and electric rotating machine passes through
Light electric slip ring drives the rotation of fixing seal wire, thus driving the oct- optoacoustic-ultrasonic three in circular titanium tube and circular titanium tube
The pattern rotation of kind excites collection signal.
In addition, described integrated probe be internally integrated high-frequency transducer, the dominant frequency of high-frequency transducer is
50mhz, carries a width of 80%, the frequency range of transmitting ultrasonic signal is 20mhz～50mhz, receives ultrasonic signal or photoacoustic signal
Frequency range be 1khz～75mhz.
In the present embodiment, transmission oct light source and photo-acoustic excitation light source employ a doubly clad optical fiber simultaneous transmission, double-contracting
The fibre core of layer optical fiber is single mode transport, for transmitting oct exciting light；Outer layer is multimode transmissions, excites and returns for transmitting oct
Light, this double clad is divided into two sections to connect by light electric slip ring, and light electric slip ring and rotating stepper motor are fixed, thus realizing rotating.
In the present embodiment, the optical maser wavelength that described superluminescent diode is launched is 1310nm；
Described pulse laser is semiconductor laser, solid state laser, dye laser or gas laser, output
The wave-length coverage of pulse laser is 400nm～2500nm, and pulse width is 5ns～50ns；
The frequency range that ultrasonic signal launched by described ultrasound pulse transmission/receptor is 20mhz～50mhz, receives ultrasonic
The frequency range of signal is 1khz～75mhz, and described signal amplifier can amplification frequency be 5-75mhz, and gain amplifier is 10-
60db, signaling rate wave filter is band filter, a width of 5-50mhz of passband.
Described medical guiding wire and the titanium tube being connected with medical guiding wire are placed in medical catheter, and medical catheter is to fix
Device, seal wire drives titanium tube to rotate in the catheter, constitutes rotary apparatuss, and the effect of conduit is to ensure that seal wire is not eccentric when rotating,
Described rotary apparatuss are placed in movable, the described rotary apparatuss realizing integrated probe on advance/recession platform in intravascular
Platform collectively forms rotation/advance/recession platform with advancing/dropping back.
Described rotation/advance/recession platform is made up of horizontal direction motor and axial direction motor, level side
Complete advance/recession function, the synchromesh gear of axial direction motor and light electric slip ring machinery to motor band moving platform
Connect, the lead of ultrasonic transducer is electrically connected with light electric slip ring, light electric slip ring outlet connects ultrasonic signal emission/receptor, letter
Number input the second capture card, above-mentioned smooth electric slip ring, ultrasonic signal emission/receptor, letter after amplifier, traffic filter
Number amplifier, traffic filter, the second capture card are electrical connection, rotate when motor passes through gear driven light electric slip ring
When, realize driving 360 ° of rotations of probe of photoacoustic ultrasound integration by seal wire.
According to the description above, whole system sequencing contro is as follows, and computer controls fpga produce signal excitation and surpass
Light emitting diode produces oct exciting light, and after collecting oct signal, triggering ultrasound emission/receptor generation is ultrasonic, this ultrasonic
Emitter produces synchronous triggering signal simultaneously, and this synchronous triggering signal excitation pulse laser instrument after chronotron produces optoacoustic and swashs
Luminous.
A kind of method being imaged using described multi-modality imaging device of the present embodiment, is comprised the steps:
(1) excite: this device is positioned over Ink vessel transfusing, computer controls fpga plate produces signal excitation superluminescent diode
Produce oct exciting light, this exciting light excites oct to believe by integrated probe with the fibre core of doubly clad optical fiber through the light electric slip ring when
Number；After collecting oct signal, triggering ultrasound emission/receptor produces ultrasonic, the ultrasound emission/receptor transmitting signal of telecommunication, warp
Cross light electric slip ring and ultrasonic signal is converted electrical signals into by the integrated ultrasonic transducer of integrated probe, ultrasonic signal is to blood
Pipe detects；This emitting/receiving produces synchronous triggering signal simultaneously, the excitation pulse after chronotron of this synchronous triggering signal
Laser instrument produce photo-acoustic excitation light, this exciting light after diaphragm by doubly clad optical fiber inner cladding after light electric slip ring
By the lateral 110 ° of directive blood vessels of integrated probe, excite photoacoustic signal；
(2) data acquisition: the oct signal of generation is passed back through after light electric slip ring by the fibre core of above-mentioned doubly clad optical fiber, and
Gathered by linear array ccd, collect oct signal and computer is sent into by the first capture card；The ultrasonic signal returning is by ultrasonic transducer
Receive, and ultrasonic signal be converted into the signal of telecommunication, by the coaxial wire being connected with ultrasonic transducer through light electric slip ring it
Received by ultrasound emission/receptor afterwards, after being then passed through signal amplifier and traffic filter, meter is sent into by the second capture card
Calculation machine；Photoacoustic signal is received by ultrasonic transducer, and photoacoustic waves signal is converted into the signal of telecommunication, by be connected with ultrasonic transducer
Coaxial wire is received by ultrasound emission/receptor after light electric slip ring, is then passed through signal amplifier and signal filtering
After device, computer is sent into by the second capture card；
(3) after completing the oct- optoacoustic-ultrasonic signal data acquisition of blood vessel a certain position, operating computer makes rotation walk
Stepper motor works, and rotating stepper motor drives runner assembly, and runner assembly drives the rotor of light electric slip ring to rotate, and light electric slip ring turns
The rotational band movement and motor-driven integrative probe of son rotates, thus carrying out data acquisition to blood vessel next one position, until integrated probe is complete
Become 360 ° of rotations, thus completing the data acquisition in a certain section of blood vessel；After completing the data acquisition in a certain section of blood vessel, manipulate meter
Calculation machine makes translation stepper motor work, and translation stepper motor drives translation platform, and translation platform drives integrated probe translation, from
And data acquisition is carried out to next section of blood vessel；
(4) image reconstruction: the data collecting is used for the reconstruction of oct image, photoacoustic image, ultrasonoscopy by computer.
Above-described embodiment is the present invention preferably embodiment, but embodiments of the present invention are not subject to above-described embodiment
Limit, other any spirit without departing from the present invention and the change made under principle, modification, replacement, combine, simplify,
All should be equivalent substitute mode, be included within protection scope of the present invention.
Claims (10)
1. a kind of device of endovascular optical coherence tomography-optoacoustic-ultrasonic multi-modality imaging is it is characterised in that include
Computer, oct are excited to be excited with acquisition system, photoacoustic signal and are excited and acquisition system, Yi Jiyi with acquisition system, ultrasonic signal
Bodyization is popped one's head in, and endovascular optical coherence tomography oct exciting light and photo-acoustic excitation light are using different light sources, and pass through double-contracting
Layer optical fiber carries out Laser Transmission and collection；
Wherein, described oct is excited and is included with acquisition system: fpga plate, superluminescent diode, isolator, the first fiber coupler,
Reference arm, linear array ccd and the first capture card；Described fpga plate produces signal excitation superluminescent diode generation oct and excites
Light, is partly into doubly clad optical fiber fibre core exciting for oct signal by the first fiber coupler after isolator,
A part carries out signal excitation simultaneously as reference arm laser signal, the laser entering doubly clad optical fiber fibre core by integrated probe
Collection oct signal returns along doubly clad optical fiber fibre core again, is gathered by linear array ccd and be converted into the signal of telecommunication after reference arm,
Then send computer acquisition by the first capture card, finally rebuild and obtain Ink vessel transfusing oct image；
Described photoacoustic signal is excited and is included with acquisition system: pulse laser, diaphragm, the second fiber coupler and double clad
Optical fiber, described pulse laser is excited after producing pulse laser and passes through the second fiber coupler entrance pair after diaphragm
The covering of cladded-fiber, then excited by integrated probe and by the integrated ultrasonic transducer collection optoacoustic letter of integrated probe
Number, then the signal of telecommunication is changed into by ultrasonic transducer and connect by ultrasonic after light electric slip ring by the coaxial cable connecting transducer
Receive device to receive, and amplify through signal and gathered by the second capture card after filtering, then send computer disposal to rebuild signal
Photoacoustic image；
Described ultrasonic signal is excited and is included with acquisition system: impulse ultrasound emitting/receiving, signal amplifier, traffic filter,
And second capture card, described impulse ultrasound emitting/receiving launches ultrasonic pulse, through coaxial electrical after receiving trigger
Cable is transferred to the ultrasonic transducer of the probe of integration, makes ultrasonic transducer produce ultrasound wave, blood vessel is detected and receives
The ultrasound wave reflecting, ultrasonic transducer by reflected ultrasonic be converted into the signal of telecommunication again through coaxial cable, light electric slip ring,
Ultrasound emission receptor, through signal amplifier, then is transferred to computer, Jing Guotu through traffic filter by the second capture card
Obtain Vascular Ultrasonography image as rebuilding.
2. the device of endovascular optical coherence tomography-optoacoustic-ultrasonic multi-modality imaging according to claim 1, its
It is characterised by, transmission oct light source and photo-acoustic excitation light source employ a doubly clad optical fiber simultaneous transmission, the fibre of doubly clad optical fiber
Core is single mode transport, for transmitting oct exciting light；Outer layer is multimode transmissions, and for transmitting optoacoustic exciting light, this double clad is divided into
Two sections are connected by light electric slip ring, and light electric slip ring and rotating stepper motor are fixed, thus realizing rotating.
3. the device of endovascular optical coherence tomography-optoacoustic-ultrasonic multi-modality imaging according to claim 1, its
It is characterised by, the optical maser wavelength that described superluminescent diode is launched is 1310nm, band is wider than 100nm；
Described pulse laser is semiconductor laser, solid state laser, dye laser or gas laser, the pulse of output
The wave-length coverage of laser is 400nm～2500nm, and pulse width is 5ns～50ns.
4. the device of endovascular optical coherence tomography-optoacoustic-ultrasonic multi-modality imaging according to claim 1, its
It is characterised by, the frequency range that ultrasonic signal launched by described ultrasound pulse transmission/receptor is 20mhz～50mhz, receives ultrasonic
The frequency range of signal is 1khz～75mhz, and described signal amplifier can amplification frequency be 5-75mhz, and gain amplifier is 10-
60db, signaling rate wave filter is band filter, a width of 5-50mhz of passband.
5. the device of endovascular optical coherence tomography-optoacoustic-ultrasonic multi-modality imaging according to claim 1, its
Be characterised by, described integrated probe be internally integrated high-frequency transducer, the dominant frequency of high-frequency transducer is
50mhz, carries a width of 80%, the frequency range of transmitting ultrasonic signal is 20mhz～50mhz, receives ultrasonic signal or photoacoustic signal
Frequency range be 1khz～75mhz.
6. the device of endovascular optical coherence tomography-optoacoustic-ultrasonic multi-modality imaging according to claim 1, its
It is characterised by, described doubly clad optical fiber end goes out light through lateral 110 ° after focusing on after grin lens and metallic-membrane plating reflector, right
Blood vessel wall carries out oct and photoacoustic signal excites, described doubly clad optical fiber, grin lens and metallic-membrane plating reflector and high frequency ultrasound
It is in the circular titanium tube that 1.0mm internal diameter is 0.5mm that transducer is together placed on external diameter；
Described doubly clad optical fiber, ultrasonic transducer holding wire both pass through medical guiding wire, medical guiding wire one end and light electric slip ring machinery
Connect, the other end is mechanically connected with circular titanium tube, and electric rotating machine passes through the rotation that light electric slip ring drives fixing seal wire, thus carrying
Move the oct- optoacoustic in circular titanium tube and circular titanium tube-ultrasonic Three models rotation and excite collection signal.
7. the device of endovascular optical coherence tomography-optoacoustic-ultrasonic multi-modality imaging according to claim 6, its
It is characterised by, described medical guiding wire and the titanium tube being connected with medical guiding wire are placed in medical catheter, and medical catheter is solid
Determine device, seal wire drives titanium tube to rotate in the catheter, constitute rotary apparatuss, the effect of conduit is to ensure that seal wire is not inclined when rotating
The heart, described rotary apparatuss are placed in movable, the described rotating dress realizing integrated probe on advance/recession platform in intravascular
Put and collectively form rotation/advance/recession platform with the platform that advances/drop back.
8. the device of endovascular optical coherence tomography-optoacoustic-ultrasonic multi-modality imaging according to claim 7, its
It is characterised by, described rotation/advance/recession platform is made up of horizontal direction motor and axial direction motor, level
Direction motor band moving platform completes advance/recession function, the synchromesh gear of axial direction motor and light electric slip ring machine
Tool connects, and the lead of ultrasonic transducer is electrically connected with light electric slip ring, and light electric slip ring outlet connects ultrasonic signal emission/receptor,
Signal inputs the second capture card after amplifier, traffic filter, above-mentioned smooth electric slip ring, ultrasonic signal emission/receptor,
Signal amplifier, traffic filter, the second capture card are electrical connection, revolve when motor passes through gear driven light electric slip ring
When turning, realize driving 360 ° of rotations of probe of photoacoustic ultrasound integration by seal wire.
9. the device of endovascular optical coherence tomography-optoacoustic-ultrasonic multi-modality imaging according to claim 1, its
It is characterised by, whole system sequencing contro is as follows, computer controls fpga produce signal excitation superluminescent diode generation oct and swash
Luminous, after collecting oct signal, triggering ultrasound emission/receptor generation is ultrasonic, and this ultrasonic transmitter produces synchronous touching simultaneously
Signal, this synchronous triggering signal excitation pulse laser instrument after chronotron produces photo-acoustic excitation light.
10. a kind of method being imaged using the multi-modality imaging device any one of claim 1-9, its feature exists
In comprising the steps:
(1) excite: this device is positioned over Ink vessel transfusing, computer controls fpga plate produces signal excitation superluminescent diode and produces
Oct exciting light, this exciting light excites oct signal by integrated probe with the fibre core of doubly clad optical fiber through the light electric slip ring when；
After collecting oct signal, triggering ultrasound emission/receptor produces ultrasonic, the ultrasound emission/receptor transmitting signal of telecommunication, Jing Guoguang
Electric slip ring converts electrical signals into ultrasonic signal by the integrated ultrasonic transducer of integrated probe, and ultrasonic signal is examined to blood vessel
Survey；This emitting/receiving produces synchronous triggering signal simultaneously, this synchronous triggering signal excitation pulse laser after chronotron
Device produce photo-acoustic excitation light, this exciting light after diaphragm by doubly clad optical fiber inner cladding after light electric slip ring by one
The bodyization lateral 110 ° of directive blood vessels of probe, excite photoacoustic signal；
(2) data acquisition: the oct signal of generation is passed back through after light electric slip ring by the fibre core of above-mentioned doubly clad optical fiber, and by line
Battle array ccd collection, collects oct signal and sends into computer by the first capture card；The ultrasonic signal returning is received by ultrasonic transducer,
And ultrasonic signal is converted into the signal of telecommunication, surpassed after light electric slip ring by the coaxial wire being connected with ultrasonic transducer
Acoustic emission/receptor receives, and sends into computer by the second capture card after being then passed through signal amplifier and traffic filter；Light
Acoustical signal is received by ultrasonic transducer, and photoacoustic waves signal is converted into the signal of telecommunication, by the coaxial electrical being connected with ultrasonic transducer
Cable is received by ultrasound emission/receptor after light electric slip ring, after being then passed through signal amplifier and traffic filter
Computer is sent into by the second capture card；
(3) after completing the oct- optoacoustic-ultrasonic signal data acquisition of blood vessel a certain position, operating computer makes rotation stepping electricity
Machine works, and rotating stepper motor drives runner assembly, and runner assembly drives the rotor of light electric slip ring to rotate, photoelectricity slip-ring rotor
Rotational band movement and motor-driven integrative probe rotates, thus carrying out data acquisition to blood vessel next one position, until integrated probe completes
360 ° of rotations, thus complete the data acquisition in a certain section of blood vessel；After completing the data acquisition in a certain section of blood vessel, maneuvering calculation
Machine makes translation stepper motor work, and translation stepper motor drives translation platform, and translation platform drives integrated probe translation, thus
Data acquisition is carried out to next section of blood vessel；
(4) image reconstruction: the data collecting is used for the reconstruction of oct image, photoacoustic image, ultrasonoscopy by computer.
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