CN103446206B - Improve composition and its application of toxicity caused by Chemotherapy in Malignant Carcinoma Patients - Google Patents
Improve composition and its application of toxicity caused by Chemotherapy in Malignant Carcinoma Patients Download PDFInfo
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- CN103446206B CN103446206B CN201210184710.5A CN201210184710A CN103446206B CN 103446206 B CN103446206 B CN 103446206B CN 201210184710 A CN201210184710 A CN 201210184710A CN 103446206 B CN103446206 B CN 103446206B
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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Abstract
The purpose of the present invention is to provide a kind of compositions of toxicity caused by improvement Chemotherapy in Malignant Carcinoma Patients, 5~200 parts of raw material ganoderma lucidum, American Ginseng or 5~150 parts of ginseng, 1~90 part of fermentation cordyceps and/or 1~120 part of cordyceps sinensis containing following weight parts, or by above-mentioned raw materials water and/or alcohol extracting thing as the composition that active ingredient forms preparation improve Chemotherapy in Malignant Carcinoma Patients caused by toxicity health care product or drug or product in application.
Description
Technical field
The present invention relates to the composition for improving toxicity caused by Chemotherapy in Malignant Carcinoma Patients and its applications.
Background technique
Chemotherapy is one of the means in Multimodality Therapy of Malignant Tumors, and for the treatment of kinds of tumors, but chemotherapy is anti-in performance
A series of brought toxicities also can not be ignored while cancer, cancer suppressing action, and chemotherapeutics can cause gastrointestinal reaction (to be disliked
The heart, vomiting, diarrhea), Local toxic reaction (phlebitis, chemotherapeutics extravasation), stomatitis, bone marrow suppression, alopecia etc., this is greatly
Ground increases the pain of patient, and most of patients is caused to be reluctant that receiving chemotherapy or refusal continues medication.Publication No.
The patent application document of CN101292742A discloses a kind of pharmaceutical composition including ganoderma lucidum, American Ginseng, fermentation cordyceps,
With strengthen immunity effect；The patent application document of Publication No. CN102228252A disclose it is a kind of containing American Ginseng and/
Or ginseng, ganoderma lucidum, fermentation cordyceps Chinese medicine composition, have alleviate physical fatigue effect；Publication No.
CN102000129A includes Cordyceps sinensis polysaccharide or fermentation cordyceps, ganoderma lucidum, the medicine group of American Ginseng the invention discloses one kind
Object is closed, there is strengthen immunity effect；Currently without by ganoderma lucidum, American Ginseng or ginseng, fermentation cordyceps and/or cordyceps sinensis
Manufactured composition has the document or report of toxicity caused by improving Chemotherapy in Malignant Carcinoma Patients.
Summary of the invention
The purpose of the present invention is to provide the composition for improving toxicity caused by Chemotherapy in Malignant Carcinoma Patients and its applications.
The present invention selects raw material ganoderma lucidum, American Ginseng or ginseng, fermentation cordyceps and/or cordyceps sinensis to be combined, and anticipates
Other places discovery the composition can improve the effect of toxicity caused by Chemotherapy in Malignant Carcinoma Patients.
The present invention provides a kind of composition for improving toxicity caused by Chemotherapy in Malignant Carcinoma Patients, is by containing following
Made of the raw material of parts by weight: 5~150 parts of 5~200 parts of ganoderma lucidum, American Ginseng or ginseng, 1~90 part of fermentation cordyceps and/or
1~120 part of cordyceps sinensis.Its raw material for containing parts by weight described above is made by the water and/or alcohol extracting thing of above-mentioned raw materials
Active ingredient composition.Perhaps after the raw material mixing water mention and/or alcohol extracting obtain one of composition or the raw material or
It is several to be mentioned through water and/or alcohol extracting extract makees active ingredient and forms the composition.
It is preferred that 10~90 parts of 20~120 parts of ganoderma lucidum, American Ginseng or ginseng, 3~60 parts of fermentation cordyceps and/or worm summer in winter
3~90 parts of grass.
More preferable 40 parts of ganoderma lucidum, American Ginseng or 30 parts of ginseng, 20 parts of fermentation cordyceps and/or 6.7 parts of cordyceps sinensis.
Addition can also be further included in the present composition, and other do not weaken the following weight parts of effect of the present invention
The water and/or alcohol extract of raw material or following raw materials according: 5~90 parts of rose, 5~150 parts of lucidum spore powder, ganoderma lucidum spore oil 1
~90 parts, 10~400 parts of radix pseudostellariae, 1~120 part of folium panacis japonici cum caule, 3~400 parts of Radix Codonopsis, one or more of 3~400 parts of Radix Astragali
Any combination.
It is preferred that 10~60 parts of rose, 10~120 parts of lucidum spore powder, 10~60 parts of ganoderma lucidum spore oil, radix pseudostellariae 20~
200 parts, 20~90 parts of folium panacis japonici cum caule, 20~200 parts of Radix Codonopsis, one or more of 20~200 parts of Radix Astragali any combination.
More preferable 30 parts of rose, ganoderma lucidum, 30 parts of conidia powder, 20 parts of ganoderma lucidum spore oil, 40 parts of radix pseudostellariae, folium panacis japonici cum caule 30
Any combination of one or more of part, 40 parts of Radix Codonopsis, 40 parts of Radix Astragali.
The present composition most preferably 5~200 parts of ganoderma lucidum, American Ginseng or 5~150 parts of ginseng, fermentation cordyceps 1~90
Part and/or 1~120 part of cordyceps sinensis, 5~90 parts of rose.
Preferably, the present composition is by 20~120 parts of ganoderma lucidum, American Ginseng or 10~90 parts of ginseng, fermentation cordyceps 3
~60 parts and/or 3~90 parts of cordyceps sinensis, 10~60 parts of rose be made.
Most preferably, the present composition by 30 parts of 40 parts of ganoderma lucidum, American Ginseng or ginseng, 20 parts of fermentation cordyceps and/
Or 6.7 parts of cordyceps sinensis, 30 parts of rose be made.
The present invention can also select folium panacis japonici cum caule, radix pseudostellariae, Radix Codonopsis, Radix Astragali substitution American Ginseng or ginseng, dosage and in this hair
The additive amount further included in bright composition is identical.
Ganoderma lucidum of the invention is bracket fungus Kolding fungi red sesame Ganoderma lucidum (Leyss.ex Fr.)
Karst. or the drying fructification of purple sesame Ganoderma sinense Zhao, Xu et Zhang, nature and flavor are sweet, flat, return heart, lung,
Liver and kidney channel has the function of strengthening by means of tonics, antitoxic heart-soothing and sedative；Heretofore described ginseng is Araliaceae ginseng Panax
GinsengC.A.Mey. dry root and rhizome, can be various ginsengs, as garden ginsent, wild ginseng, sun-dried ginseng, dried wild ginseng,
White sugar ginseng, red ginseng；The folium panacis japonici cum caule is the dried leaf of Araliaceae ginseng Panax ginseng C.A.Mey.；The present invention
Described in American Ginseng also known as U.S.'s ginseng, American ginseng, American ginseng, Guangdong ginseng, be the western skill American ginseng Panax of Araliaceae
The dry root of quinquefolium L., nature and flavor are sweet, slight bitter, cool, return heart, lung, kidney channel, have boosting qi and nourishing yin, clearing heat and promoting fluid
Function；Heretofore described cordyceps sinensis is section ergot fungus cordyceps sinensis bacterium Cordyceps sinensis (Berk.)
Sace. the drying complex of parasitic stroma and larva corpse on the larvae of batrachidae insects.
Heretofore described fermentation cordyceps are from natural cordyceps Cordyceps sinensis (Berk.)
Sace. the product of the fermented culture of the strain separated in can be such as following strain: Paecilomyces hepiali chen
Paecilomyces hepialliChen et Dai, sp.nov；Chinese coat spore Hirsutella sinensis Liu,
Guo, Yu-et Zeng, sp.nov；Section ergot fungus cordyceps sinensis cephalo Cephalosporium sinensis Chen
sp.nov；Bat moth is by spore enzyme Mortiscrslla hepialid C.T.& B.liu；Paecilomyces sinensis Paecilomyces
Sinensis Chen, Xiao et Shi, sp.nov；Soil taxonomy Tolypocladium sinensis C.lan Li；In
The mould Cephalosporium sinens Chen sp.nov of state's cephalo；Scytalidium hepiali Scytal idium hepialii
C.L.Li；The mould Chrysosporium sinens Z.Q.liang of Chinese gold spore；China wheel branch spore Verticillium sinens
Wamg sp.nov；Cephalosporium acremonium Cephalosporium acremonium Corda, Icones Fungorum；Chinese beam
Silk spore Synnematium sinensis Yin& Shen；Worm flower Isaria Isaria farinose (Holmsk.)
Fr.Systema Mycologicum；Metarhizium anisopliae Metarhizium anisopliae (Metsch) Sorokin；Bat
Moth coat spore Hirsutella hepialid Chen et Shen；Cordyceps sinensis cluster spore Sporothrix insectorum de
Hong & H.C.Evans；Gliocladiumroseum Gliocladium roseum (link) Thom；The mould category fungi Mortierella of spore
One of SP or any combination.
The preferred Paecilomyces hepiali chen of strain belonging to fermentation cordyceps of the present invention or Hirsutella hepiali Chen et Shen or Chinese synnema
One of spore or the mould category fungi of Gliocladiumroseum or spore or section ergot fungus cordyceps sinensis cephalo or Chinese coat spore are any
Combination.
Heretofore described rose is the dry flower of rosaceous plant rose (Rosa rugosa Thumb),
It can be polyphyll red rose Rose rugosacv.Plena；Acrid flavour, sweet, slight bitter, warm-natured, most obvious effect is exactly promoting the circulation of qi solution
Strongly fragrant and blood, analgesic, pharmacological property are mild.
Radix Codonopsis is Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., codonopsis pilosula var. modesta
Codonopsis pilosula Nannf.var.modesta (Nannf.) L.T.Shen or radix codonpsis tangshen Codonopsis
The dry root of tangshen Oliv..
Radix pseudostellariae of the present invention is pinkwort caryophyllaceous ginseng Pseudostellaria heterophylla
(Miq.) dried root of Pax ex Pax et Hoffm..
Folium panacis japonici cum caule is the dried leaf of Araliaceae ginseng Panar ginseng C.A.Mey..
Radix Astragali is leguminous mongolian scutellaria Astragalus membranaceus (Fisch)
Bge.var.mongholicus (Bge) Hsiao or Astragalus membranacus Astragalus membranaceus (Fisch) Bge.'s is dry
Dry.
The preferred ganoderma spove powder of lucidum spore powder of the present invention.
Lucidum spore powder of the invention is the sexual reproductive cell of ganoderma lucidum --- basidiospore powder.
Ganoderma lucidum spore oil of the invention is the grease lipid matter extracted from lucidum spore powder.
Alcohol of the present invention is methanol or ethyl alcohol；Methanol concentration 5-95%, concentration of alcohol 5-95%.
The present composition can be added acceptable additives or excipient in health care product or drug or product and be prepared into
Any dosage form.
The dosage form can be tablet, oral solution, granule, capsule, soft extract, pill, pill, powder, pastille, stream
Extract, extract, injection, any one in syrup.
The present invention provides the composition containing ganoderma lucidum, American Ginseng or ginseng, fermentation cordyceps and/or cordyceps sinensis or
Person's composition made of the raw material containing ganoderma lucidum, American Ginseng or ginseng, fermentation cordyceps and/or cordyceps sinensis or by spirit
Composition made of sesame, American Ginseng or ginseng, fermentation cordyceps and/or cordyceps sinensis improves malignant tumor patient in preparation
The composition of toxicity caused by treating or the purposes in product.
The present invention also provides contain ganoderma lucidum, American Ginseng or ginseng, fermentation cordyceps and/or cordyceps sinensis, rose
Composition or by the raw material system containing ganoderma lucidum, American Ginseng or ginseng, fermentation cordyceps and/or cordyceps sinensis, rose
At composition or made of ganoderma lucidum, American Ginseng or ginseng, fermentation cordyceps and/or cordyceps sinensis, rose combine
Purposes of the object in the composition or product that preparation improves toxicity caused by Chemotherapy in Malignant Carcinoma Patients.
Provide the composition containing ganoderma lucidum, American Ginseng or ginseng, fermentation cordyceps and/or cordyceps sinensis or by containing
There is composition made of the raw material of ganoderma lucidum, American Ginseng or ginseng, fermentation cordyceps and/or cordyceps sinensis or by ganoderma lucidum, west
Rose, lucidum spore powder, ganoderma lucidum spore is added in composition made of American ginseng or ginseng, fermentation cordyceps and/or cordyceps sinensis
The composition of any composition composition of one or more of seed oil, radix pseudostellariae, folium panacis japonici cum caule, Radix Codonopsis, Radix Astragali improves pernicious in preparation
The composition of toxicity caused by Chemotherapy of Tumor Patients or the purposes in product.
Provide the composition containing ganoderma lucidum, American Ginseng or ginseng, fermentation cordyceps and/or cordyceps sinensis, rose
Or it is combined made of the raw material containing ganoderma lucidum, American Ginseng or ginseng, fermentation cordyceps and/or cordyceps sinensis, rose
Spirit is added in object or the composition made of ganoderma lucidum, American Ginseng or ginseng, fermentation cordyceps and/or cordyceps sinensis, rose
The composition of any composition composition of one or more of Ganoderma lucidum spore powder, ganoderma lucidum spore oil, radix pseudostellariae, folium panacis japonici cum caule, Radix Codonopsis, Radix Astragali
Purposes in the composition or product that preparation improves toxicity caused by Chemotherapy in Malignant Carcinoma Patients.
The water of the raw material of Chinese medicine composition of the present invention and/or the preparation process of alcohol extracting thing, comprising the following steps:
1) traditional Chinese medicinal material raw materials are weighed by recipe quantity；
2) is obtained by extracting solution and does active ingredient, additives or excipient is added for above-mentioned medicinal material refluxing extraction with alcohol or water,
Various dosage forms are made.
The water of the raw material of Chinese medicine composition of the present invention and/or the preparation process of alcohol extracting thing also may include following
Step:
1) traditional Chinese medicinal material raw materials are weighed by recipe quantity, raw medicinal material plus methanol or ethyl alcohol is extracted, extracting solution recycles first
Alcohol or ethyl alcohol, obtain extract I；
2) after the above-mentioned dregs of a decoction being volatilized alcohol, water is added to extract, obtains extract II；
3) merge extract I and extract II, filtering, filtrate is concentrated into right amount, is added and pharmaceutically commonly uses auxiliary material, using medicine
Required preparation is made in the upper common process of agent.
The water of the raw material of Chinese medicine composition of the present invention and/or the preparation process of alcohol extracting thing can also include following
Step:
1) traditional Chinese medicinal material raw materials raw material preparation: are weighed by recipe quantity；
2) extract concentration: after the raw material weighed up is soaked in water, heating is decocted repeatedly, combined extract filtering, and filtrate is dense
It is reduced in right amount, lets cool rear high speed centrifugation removal of impurities, it is spare；
3) preparation is prepared: by the auxiliary material that concentrate obtained in step 2 is independent or addition is medically acceptable, using medicament
Required preparation is made in common process on；
Above-mentioned steps 2) in soaking time be 20 minutes~60 minutes, rear heating decocts 1~3 time, 1~2 hour every time, adds
6~13 times of water.
Use of the present invention in the composition or product that preparation improves toxicity caused by Chemotherapy in Malignant Carcinoma Patients
The composition includes health care product and drug on the way, wherein " product " includes its being not included in health care product or drug
Its product, such as smoked oil, pillow etc..
It for a better understanding of the present invention, below will be with by ganoderma lucidum, ginseng or American Ginseng, fermentation cordyceps and/or winter
Composition and with by ganoderma lucidum, rose, ginseng or American Ginseng, fermentation cordyceps and/or cordyceps sinensis made of worm summer grass
The clinical test of manufactured composition and result improve Chemotherapy in Malignant Carcinoma Patients institute intoxicating to illustrate that the present composition has
The effect of side reaction.
Similarly be added lucidum spore powder, ganoderma lucidum spore oil, ginseng, radix pseudostellariae, Radix Codonopsis, Radix Astragali etc. it is any one or several its
Any combination, which can reach, same pharmacological action；American Ginseng or ginseng are substituted with folium panacis japonici cum caule, radix pseudostellariae, Radix Codonopsis, Radix Astragali,
Can reach has same pharmacological action.
Clinical test confirms that the present composition can significantly improve malignant tumor patient diarrhea, skin symptom and nausea and vomit
3 kinds of toxicities are spat, the immune function of patient is enhanced, are improved its quality of life.Specific clinical test is as follows:
One, case selection
1, diagnostic criteria
Pathological diagnosis: pathological examination is diagnosed as malignant tumour.
2, it is included in standard
(1) through pathology/cytolgical examination turn out to be malignant tumour through patients undergoing chemotherapy；
(2) age 18-75 years old, male or female；
(3) estimated life cycle > 6 months；
(4) this research is participated in informed consent, signs informed consent form.
3, exclusion criteria
(1) with severe cardiac, Liver and kidney function obstacle person；
(2) second of malignant tumour person is suffered from simultaneously；
(3) disease in the blood system or severe infections person
(4) breast feeding women；
(5) suffer from mental disorder and be unable to partner；
(6) allergic constitution and to a variety of drug allergy persons.
Two, therapeutic scheme
1, test specimen: composition 2, composition 3, composition 4, the prescription of composition 6 and preparation method are shown in following implementation
In example 2, embodiment 3, embodiment 4 and embodiment 6.
2, it is grouped: a group case will be entered and be assigned randomly to test group and control group, different sexes between test group and control group,
All ages and classes, the distribution of the different course of disease are through statistical test there are no significant meaning (P > 0.05), and clinical data has between showing two groups
There is comparativity.
3, instructions of taking: each test group takes corresponding test specimen, i.e. composition 2 respectively on basis of conventional therapy
Group takes composition 2, and following each group is analogized, and daily 1 time, 1 bottle every time (200ml/ bottles).Control group only carries out conventional control
It treats.
4, the course for the treatment of: 2 periods, each cycle 21-28 days.
Three, observation item
1, the performance and indexing standard (WHO) of clinical chemotherapy toxicity:
2, European cancer research and treatment tissue (EORTC) aim at the quality of life scale QLQ-C30 of cancer patient's development
(v3.0) Chinese edition please beats " O " on every corresponding Arabic numerals in the following table
It is required that: check every observation index and chemotherapy adverse effect variation after treating preceding and treatment.
Four, clinical effectiveness
Table 1: toxicity degree compares
Each composition group of table 2 is compared with control group quality of life
Note: P value be each composition group compared with the control group
The above clinical research shows that the present composition 2,3,4 and 6 can significantly improve malignant tumor patient diarrhea, skin
Skin symptom and the toxicity of nausea and vomiting, each composition group have significant difference compared with the control group；To pernicious swollen after chemotherapy
The Analysis of life quality of 30 observation items of tumor patient, wherein 13 observation item each groups such as sleep quality, tired out sense and appetite
Close object group has significant difference compared with the control group, shows that the present composition can improve Chemotherapy in Malignant Carcinoma Patients institute intoxicating pair
Reaction, effectively promotion Quality of Life in Patients with Malignancy.
Specific embodiment
Embodiment 1
American Ginseng 300g, ganoderma lucidum 400g, cordyceps sinensis 67g, fermentation cordyceps 200g, rose 300g are weighed, the West
Ginseng, ganoderma lucidum slice, fermentation cordyceps are placed in cloth bag, and cordyceps sinensis is beaten powder and is placed in cloth bag, and the above five tastes soak in water 1
Hour, heating decocts 3 times, 2 hours for the first time, every time 1 hour later, every time plus 10 times of water amounts, merge No. 3 extracting solutions filterings,
Filtrate is concentrated into right amount, lets cool rear high speed centrifugation removal of impurities, oral solution is added and often uses auxiliary material, is uniformly mixed, by oral solution routine work
20000ml oral solution is made in skill.
Embodiment 2
American Ginseng 300g, ganoderma lucidum 400g, fermentation cordyceps 200g, rose 300g are weighed, American Ginseng, ganoderma lucidum are sliced,
Fermentation cordyceps are placed in cloth bag, and above four taste soaks in water 20min, and heating decocts 3 times, 1 hour every time, add water 9 every time
It measures again, merges No. 3 extracting solutions filterings, filtrate is concentrated into right amount, and rear high speed centrifugation removal of impurities is let cool, oral solution is added and often uses auxiliary material,
It is uniformly mixed, 20000ml oral solution is made by oral solution common process.Obtained composition is composition 2, is faced for above
Bed test.
Embodiment 3
Weigh ganoderma lucidum 380g, American Ginseng 320g, fermentation cordyceps 210g, American Ginseng, ganoderma lucidum slice, fermentation cordyceps
It is placed in cloth bag, above 3 taste soaks in water 30min, and heating decocts 3 times, and for the first time plus 13 times of amount water, decoction 2 hours are later every
Secondary plus 10 times of water amounts, decoct and extract 1 hour, merge No. 3 extracting solution filterings, and filtrate is concentrated into right amount, lets cool rear high speed centrifugation and remove
It is miscellaneous, oral solution is added and often uses auxiliary material, is uniformly mixed, 20000ml oral solution is made by oral solution common process.Obtained composition
It is composition 3, for clinical test above.
Embodiment 4
Ganoderma lucidum 350g, American Ginseng 310g, cordyceps sinensis 70g, American Ginseng, ganoderma lucidum slice are weighed, cordyceps sinensis beats powder postposition
In cloth sack, above 3 taste soaks in water 30min, and heating decocts 2 times, adds 12 times of amount water for the first time, decocts 2 hours, second
Add 8 times of water amounts, decoct and extract 1.5 hours, merge No. 2 extracting solution filterings, filtrate is concentrated into right amount, lets cool rear high speed centrifugation and remove
It is miscellaneous, oral solution is added and often uses auxiliary material, is uniformly mixed, 20000ml oral solution is made by oral solution common process.Obtained composition
It is composition 4, for clinical test above.
Embodiment 5
Ganoderma lucidum 400g, American Ginseng 300g, cordyceps sinensis 67g, fermentation cordyceps 200g are weighed, American Ginseng, ganoderma lucidum are sliced,
Cordyceps sinensis is beaten powder and is placed in cloth sack, and fermentation cordyceps are placed in cloth sack, and above 4 taste soaks in water 40min, heating
It decocts 3 times, first time plus 14 times of amount water decoct 2 hours, add 12 times of water amounts every time later, decoct and extract 1 hour, merge 3 times and mention
Liquid is taken to filter, filtrate is concentrated into right amount, lets cool rear high speed centrifugation removal of impurities, oral solution is added and often uses auxiliary material, is uniformly mixed, by oral
20000ml oral solution is made in liquid common process.
Embodiment 6
Weigh American Ginseng 290g, ganoderma lucidum 370g, cordyceps sinensis 53g, rose 250g, American Ginseng, ganoderma lucidum slice, worm summer in winter
Grass is beaten powder and is placed in cloth bag, and above four taste soaks in water 30min, and heating decocts 3 times, adds 13 times of amount water for the first time, and it is small to decoct 2
When, add 10 times of water amounts every time later, decoct and extract 1 hour, merge No. 3 extracting solution filterings, filtrate is concentrated into right amount, lets cool rear height
Speed centrifugation removal of impurities, is added oral solution and often uses auxiliary material, be uniformly mixed, 20000ml oral solution is made by oral solution common process.It obtains
Composition be composition 6, for clinical test above.
Embodiment 7
Weigh American Ginseng 1.5kg, ganoderma lucidum 2.0kg, fermentation cordyceps (Chinese coat spore Hirsutella sinensis
Liu, Guo, Yu-et Zeng, sp.nov) 1.0kg, rose 1.5kg, American Ginseng, ganoderma lucidum slice, fermentation cordyceps are placed in
In cloth bag, above four taste soaks in water 30min, and heating decocts 3 times, adds 13 times of amount water for the first time, decocts 2 hours, later every time
Add 10 times of water amounts, decoct and extract 1 hour, merge No. 3 extracting solution filterings, filtrate is condensed into clear cream, and composite powder is made in spray drying.
Embodiment 8
Weigh ganoderma lucidum 2.0kg, American Ginseng 1.5kg, cordyceps sinensis 0.33kg, fermentation cordyceps (Paecilomyces hepiali chen
Paecilomyces hepialli Chen et Dai, sp.nov) 1.0kg, rose 1.5kg, American Ginseng, ganoderma lucidum slice, the winter
Worm summer grass is beaten after powder and is placed in cloth bag with fermentation cordyceps, and the above medicinal material soaks in water 30min, and heating decocts 3 times, for the first time
Add 12 times of amount water, decoct 2 hours, add 10 times of water amounts every time later, decoct and extract 1 hour, merges No. 3 extracting solution filterings, filtrate
It is condensed into clear cream, composite powder is made in spray drying.
Embodiment 9
Weigh American Ginseng 150g, fermentation cordyceps (Hirsutella hepiali Chen et Shen Hirsutella hepialid Chen et
Shen) 90g, cordyceps sinensis 120g, ganoderma lucidum 200g, rose 90g, American Ginseng, ganoderma lucidum slice, cordyceps sinensis are beaten after powder and ferment
Cordyceps are placed in cloth bag, and the above medicinal material is soaked in water 1 hour, and heating decocts 3 times, 2 hours for the first time, later 1 small every time
When, every time plus 10 times of water are measured, and merge No. 3 extracting solutions filterings, and filtrate is concentrated into right amount, let cool rear high speed centrifugation removal of impurities, mouth is added
It takes liquid and often uses auxiliary material, be uniformly mixed, 20000ml oral solution is made by oral solution common process.
Embodiment 10
Weigh ginseng 500g, fermentation cordyceps (Chinese synnema spore Synnematium sinensis Yin & Shen)
100g, ganoderma lucidum 500g, rose 500g, ginseng, ganoderma lucidum slice, fermentation cordyceps are placed in cloth bag, and above four taste adds water logging
30min is steeped, heating decocts 3 times, and for the first time plus 12 times of amount water decoct 2 hours, and every time 1 hour later, every time plus 10 times of water amounts, conjunction
And No. 3 extracting solution filterings, filtrate are concentrated into right amount, let cool rear high speed centrifugation removal of impurities, and oral solution is added and often uses auxiliary material, mixing is equal
It is even, 20000ml oral solution is made by oral solution common process.
Embodiment 11
Weigh American Ginseng 500g, fermentation cordyceps (Chinese coat spore Hirsutella sinensis Liu, Guo, Yu-
Et Zeng, sp.nov) 100g, ganoderma lucidum 500g, rose 500g, American Ginseng, ganoderma lucidum slice, fermentation cordyceps are placed in cloth bag
In, above four taste soaks in water 20min, and heating decocts 3 times, and 2 hours for the first time, every time 1 hour later, every time plus 10 times of water
Amount merges No. 3 extracting solution filterings, and filtrate is concentrated into right amount, lets cool rear high speed centrifugation removal of impurities, oral solution is added and often uses auxiliary material, mixes
It closes uniformly, 20000ml oral solution is made by oral solution common process.
Embodiment 12
Weigh American Ginseng 150g, cordyceps sinensis 120g, ganoderma lucidum 200g, rose 90g, American Ginseng, ganoderma lucidum slice, worm summer in winter
Grass is beaten powder and is placed in cloth bag, and above four taste soaks in water 40min, and heating decocts 3 times, 2 hours first times, later 1 small every time
When, every time plus 10 times of water are measured, and merge No. 3 extracting solutions filterings, and filtrate is concentrated into right amount, let cool rear high speed centrifugation removal of impurities, mouth is added
It takes liquid and often uses auxiliary material, be uniformly mixed, 20000ml oral solution is made by oral solution common process.
Embodiment 13
Weigh ginseng 150g, fermentation cordyceps (Gliocladiumroseum Gliocladium roseum (link) Thom) 90g, spirit
Sesame 200g, rose 90g, ginseng, ganoderma lucidum slice, fermentation cordyceps are placed in cloth bag, and above four taste is soaked in water 1 hour,
Heating decocts 2 times, and 12 times of amount water extract 2 hours for the first time, and for the second time plus 8 times of amounts of water are extracted 1.5 hours, merges No. 2 extracting solutions
Filtering, filtrate are concentrated into right amount, let cool rear high speed centrifugation removal of impurities, oral solution is added and often uses auxiliary material, is uniformly mixed, normal by oral solution
20000ml oral solution is made in rule technique.
Embodiment 14
Weigh American Ginseng 150g, fermentation cordyceps (Hirsutella hepiali Chen et Shen Hirsutella hepialid Chen et
Shen) 90g, cordyceps sinensis 120g, ganoderma lucidum 200g, rose 90g, American Ginseng, ganoderma lucidum slice, cordyceps sinensis are beaten after powder and ferment
Cordyceps are placed in cloth bag, and the above medicinal material is soaked in water 1 hour, and heating decocts 3 times, 2 hours for the first time, later 1 small every time
When, every time plus 10 times of water are measured, and merge No. 3 extracting solutions filterings, and filtrate is concentrated into right amount, let cool rear high speed centrifugation removal of impurities, mouth is added
It takes liquid and often uses auxiliary material, be uniformly mixed, 20000ml oral solution is made by oral solution common process.
Embodiment 15
Weigh American Ginseng 100g, cordyceps sinensis 30g, ganoderma lucidum 200g, rose 100g, American Ginseng, ganoderma lucidum slice, worm summer in winter
Grass is beaten powder and is placed in cloth bag, and above four taste soaks in water 30min, and heating decocts 3 times, 2 hours first times, later 1 small every time
When, every time plus 10 times of water are measured, and merge No. 3 extracting solutions filterings, and filtrate is concentrated into right amount, let cool rear high speed centrifugation removal of impurities, mouth is added
It takes liquid and often uses auxiliary material, be uniformly mixed, 20000ml oral solution is made by oral solution common process.
Embodiment 16
Weigh American Ginseng 150g, fermentation cordyceps (Chinese coat spore Hirsutella sinensis Liu, Guo, Yu-
Et Zeng, sp.nov) 30g, ganoderma lucidum 200g, rose 100g, American Ginseng, ganoderma lucidum slice, fermentation cordyceps are placed in cloth bag
In, above four taste is soaked in water 1 hour, and heating decocts 3 times, and 2 hours for the first time, every time 1 hour later, every time plus 10 times of water
Amount merges No. 3 extracting solution filterings, and filtrate is concentrated into right amount, lets cool rear high speed centrifugation removal of impurities, oral solution is added and often uses auxiliary material, mixes
It closes uniformly, 20000ml oral solution is made by oral solution common process.
Embodiment 17
Weigh American Ginseng 90g, cordyceps sinensis 90g, ganoderma lucidum 120g, rose 60g, American Ginseng, ganoderma lucidum slice, cordyceps sinensis
Powder to be beaten to be placed in cloth bag, above four taste soaks in water 20min, and heating decocts 3 times, 1 hour every time, add 10 times of water amounts every time,
Merge No. 3 extracting solution filterings, filtrate is concentrated into right amount, lets cool rear high speed centrifugation removal of impurities, and oral solution is added and often uses auxiliary material, mixing is equal
It is even, 20000ml oral solution is made by oral solution common process.
Embodiment 18
Ginseng 90g, cordyceps sinensis 90g, ganoderma lucidum 120g, rose 60g, ginseng, ganoderma lucidum slice are weighed, cordyceps sinensis beats powder
It is placed in cloth bag, above four taste soaks in water 30min, and heating decocts 3 times, and 1 hour every time, every time plus 10 times of water were measured, and merged 3
Secondary extracting solution filtering, filtrate are concentrated into right amount, let cool rear high speed centrifugation removal of impurities, oral solution is added and often uses auxiliary material, is uniformly mixed, presses
20000ml oral solution is made in oral solution common process.
Embodiment 19
Weigh American Ginseng 90g, fermentation cordyceps (section ergot fungus cordyceps sinensis cephalo Cephalosporium
Sinensis Chen sp.nov) 60g, ganoderma lucidum 120g, rose 60g, American Ginseng, ganoderma lucidum slice, fermentation cordyceps are placed in
In cloth bag, above four taste soaks in water 20min, and heating decocts 3 times, and 1 hour every time, every time plus 10 times of water were measured, and merged 3 extractions
Liquid filtering, filtrate are concentrated into right amount, let cool rear high speed centrifugation removal of impurities, oral solution is added and often uses auxiliary material, is uniformly mixed, by oral solution
20000ml oral solution is made in common process.
Embodiment 20
Weigh American Ginseng 300g, ganoderma lucidum 400g, cordyceps sinensis 67g, rose 300g, American Ginseng, ganoderma lucidum slice, worm summer in winter
Grass is beaten powder and is placed in cloth bag, and above four taste is soaked in water 1 hour, and heating decocts 3 times, 2 hours first times, later 1 small every time
When, every time plus 10 times of water are measured, and merge No. 3 extracting solutions filterings, and filtrate is concentrated into right amount, are let cool rear high speed centrifugation removal of impurities, are depressurized dense
It shortens cream or spraying drying powder-forming into, tablet is added and often uses auxiliary material, is uniformly mixed, various tablets is made by tablet common process.
Embodiment 21
Weigh American Ginseng 300g, ganoderma lucidum 400g, fermentation cordyceps (Paecilomyces hepiali chen Paecilomyces
Hepialli Chen et Dai, sp.nov) 200g, rose 300g, American Ginseng, ganoderma lucidum slice, fermentation cordyceps are placed in
In cloth bag, above four taste soaks in water 20min, and heating decocts 3 times, and 1 hour every time, every time plus 10 times of water were measured, and merged 3 extractions
Liquid filtering, filtrate are concentrated into right amount, let cool rear high speed centrifugation removal of impurities, oral solution is added and often uses auxiliary material, is uniformly mixed, by oral solution
20000ml oral solution is made in common process.
Embodiment 22
American Ginseng 500g, cordyceps sinensis 100g, ganoderma lucidum 500g, rose 500g, ganoderma spove powder 500g are weighed, west
American ginseng, ganoderma lucidum slice, cordyceps sinensis beats powder and is placed in cloth bag, and above four taste soaks in water 20min, heating decoction 3 times, and first
Secondary plus 12 times of amount water extract 2 hours, every time 1 hour later, every time plus 10 times of water amounts, merge No. 3 extracting solutions filterings, filtrate is concentrated
To appropriate, rear high speed centrifugation removal of impurities is let cool, is concentrated under reduced pressure into cream or spraying drying powder-forming, ganoderma spove powder and tablet is added
Common auxiliary material, is uniformly mixed, various tablets is made by tablet common process.
Embodiment 23
Weigh ginseng 500g, fermentation cordyceps (Paecilomyces sinensis Paecilomyces sinensis Chen, Xiao
Et Shi, sp.nov) 100g, ganoderma lucidum 500g, rose 500g, ganoderma spove powder 500g, ginseng, ganoderma lucidum slice, fermentation
Cordyceps and ganoderma spove powder are placed in cloth bag, and above 5 taste soaks in water 20min, and heating decocts 3 times, are added for the first time
12 times of amount water extract 2 hours, every time 1 hour later, every time plus 10 times of water amounts, merge No. 3 extracting solutions filterings, filtrate is concentrated into suitable
Amount lets cool rear high speed centrifugation removal of impurities, is concentrated under reduced pressure into cream or spraying drying powder-forming, granule is added and often uses auxiliary material, is uniformly mixed,
Granule is made by granule common process.
Embodiment 24
Weigh American Ginseng 150g, fermentation cordyceps (Soil taxonomy Tolypocladium sinensis C.lan
Li) 90g, ganoderma lucidum 200g, rose 90g, ganoderma spove powder 150g, American Ginseng, ganoderma lucidum slice, fermentation cordyceps are placed in
In cloth bag, above four taste soaks in water 20min, and heating decocts 3 times, for the first time plus 12 times the extractions of amount water 2 hours, later every time 1
Hour, every time plus 10 times of water are measured, and merge No. 3 extracting solutions filterings, and filtrate is concentrated into right amount, let cool rear high speed centrifugation removal of impurities, decompression
It is condensed into cream or spraying drying powder-forming, lucidum spore powder is added and tablet often uses auxiliary material, is uniformly mixed, by tablet common process system
At various tablets.
Embodiment 25
Weigh American Ginseng 150g, fermentation cordyceps (Hirsutella hepiali Chen et Shen Hirsutella hepialid Chen et
Shen) 90g, ganoderma lucidum 200g, rose 90g, Radix Codonopsis 400g, American Ginseng, ganoderma lucidum, Radix Codonopsis slice, fermentation cordyceps are placed in cloth
In bag, above 5 taste soaks in water 40min, and heating decocts 3 times, and 2 hours for the first time, every time 1 hour later, every time plus 10 times of water
Amount merges No. 3 extracting solution filterings, and filtrate is concentrated into right amount, lets cool rear high speed centrifugation removal of impurities, is concentrated under reduced pressure into cream or spray drying
Cheng Fen is added tablet and often uses auxiliary material, is uniformly mixed, various tablets are made by tablet common process.
Embodiment 26
Weigh American Ginseng 150g, cordyceps sinensis 120g, ganoderma lucidum 200g, rose 90g, Radix Astragali 400g, American Ginseng, ganoderma lucidum,
Radix Astragali slice, cordyceps sinensis are beaten powder and are placed in cloth bag, and above 5 taste soaks in water 20min, and heating decocts 3 times, and 2 is small for the first time
When, every time 1 hour later, every time plus 10 times of water amounts, merge No. 3 extracting solutions filterings, filtrate is concentrated into right amount, after letting cool at a high speed from
Heart removal of impurities is added pastille and often uses auxiliary material, is uniformly mixed, pastille is made by pastille common process.
Embodiment 27
Weigh American Ginseng 500g, fermentation cordyceps (Paecilomyces hepiali chen Paecilomyces hepialli Chen et
Dai, sp.nov) 50g；Fermentation cordyceps (Chinese coat spore Hirsutella sinensis Liu, Guo, Yu-et Zeng,
Sp.nov) 50g, ganoderma lucidum 500g, rose 500g, Radix Codonopsis 300g, American Ginseng, ganoderma lucidum, Radix Codonopsis slice, fermentation cordyceps are placed in
In cloth bag, above 5 taste is soaked in water 1 hour, and heating decocts 3 times, and 2 hours for the first time, every time 1 hour later, every time plus water 10
It measures again, merges No. 3 extracting solutions filterings, filtrate is concentrated into right amount, lets cool rear high speed centrifugation removal of impurities, is concentrated under reduced pressure at cream or dry by spraying
It is dry that powder is added and often uses auxiliary material at powder, it is uniformly mixed, powder is made by powder common process.
Embodiment 28
Weigh American Ginseng 500g, cordyceps sinensis 100g, ganoderma lucidum 500g, rose 500g, Radix Astragali 300g, American Ginseng, ganoderma lucidum,
Radix Astragali slice, cordyceps sinensis are beaten powder and are placed in cloth bag, and above 5 taste soaks in water 20min, and heating decocts 3 times, and 2 is small for the first time
When, every time 1 hour later, every time plus 10 times of water amounts, merge No. 3 extracting solutions filterings, filtrate is concentrated into right amount, after letting cool at a high speed from
Heart removal of impurities is added oral solution and often uses auxiliary material, is uniformly mixed, 20000ml oral solution is made by oral solution common process.
Embodiment 29
Weigh American Ginseng 100g, ganoderma lucidum 200g, cordyceps sinensis 30g, fermentation cordyceps (Cs-C-Q80Hirsutella
Sinensis Liu, Guo, Yu-et Zeng, sp.nov) 3g, rose 100g, lucidum spore powder 100g, American Ginseng, ganoderma lucidum cut
Piece, cordyceps sinensis are placed in cloth bag after beating powder with lucidum spore powder, and the above five tastes soak in water 20min, and heating decocts 3 times, the
Primary plus 12 times of amount water extract 2 hours, every time 1 hour later, every time plus 10 times of water amounts, merge No. 3 extracting solutions and filter, filtrate is dense
It is reduced in right amount, lets cool rear high speed centrifugation removal of impurities, be concentrated under reduced pressure into cream or spraying drying powder-forming, tablet is added and often uses auxiliary material, mixes
Uniformly, various tablets are made by tablet common process.
Embodiment 30
Weighing American Ginseng 100g, ganoderma lucidum 200g, fermentation cordyceps, (bat moth is by spore enzyme Mortiscrslla
Hepialid C.T.& B.liu) 30g, rose 100g, lucidum spore powder 100g, American Ginseng, ganoderma lucidum slice, ferment cordyceps sinensis bacterium
Powder and lucidum spore powder are placed in cloth bag, and above 5 taste soaks in water 20min, and heating decocts 3 times, and for the first time plus 12 times of amount water mention
It takes 2 hours, every time 1 hour later, every time plus 10 times of water amounts, merges No. 3 extracting solutions filterings, filtrate is concentrated into right amount, and filtrate is dense
It is reduced in right amount, lets cool rear high speed centrifugation removal of impurities, be concentrated under reduced pressure into cream or spraying drying powder-forming, pill is added and often uses auxiliary material, mixes
Uniformly, various pills are made by pill common process.
Embodiment 31
Weigh American Ginseng 100g, ganoderma lucidum 200g, cordyceps sinensis 30g, rose 100g, radix pseudostellariae 200g, American Ginseng, ganoderma lucidum
Slice, cordyceps sinensis are beaten powder and are placed in cloth bag, and above 5 taste soaks in water 40min, and heating decocts 3 times, add 12 times of water for the first time
Amount is extracted 2 hours, adds 10 times of amounts of water to extract every time 1 hour later, merges No. 3 extracting solution filterings, and filtrate is concentrated into right amount, is added
Cream grows common auxiliary material, is uniformly mixed, and grows common process by cream and cream taste is made.
Embodiment 32
Weigh American Ginseng 100g, ganoderma lucidum 200g, cordyceps sinensis 30g, rose 100g, radix pseudostellariae 200g, American Ginseng, ganoderma lucidum
Slice, cordyceps sinensis are beaten powder and are placed in cloth bag, and above 5 taste soaks in water 40min, and heating decocts 3 times, add 13 times of water for the first time
Amount is extracted 2 hours, adds 10 times of amounts of water to extract every time 1 hour later, merges No. 3 extracting solution filterings, and filtrate is concentrated into right amount, lets cool
High speed centrifugation cleans afterwards, and syrup is added and often uses auxiliary material, is uniformly mixed, syrup is made by syrup common process.
Embodiment 33
Weigh American Ginseng 100g, ganoderma lucidum 200g, fermentation cordyceps (the mould category fungi Mortierella SP of spore) 30g, rose
Rare colored 100g, Radix Codonopsis 200g, American Ginseng, ganoderma lucidum, Radix Codonopsis slice, fermentation cordyceps are placed in cloth bag, and above 5 taste is soaked in water
40min, heating decoct 3 times, 2 hours for the first time, every time 1 hour later, every time plus 10 times of water amounts, merge No. 3 extracting solutions filterings,
Filtrate is concentrated into right amount, lets cool rear high speed centrifugation removal of impurities, is concentrated under reduced pressure into cream or spraying drying powder-forming, addition tablet is commonly used auxiliary
Material is uniformly mixed, various tablets is made by tablet common process.
Embodiment 34
Weigh American Ginseng 100g, ganoderma lucidum 200g, fermentation cordyceps (China wheel branch spore Verticillium sinens
Wamg sp.nov) 30g, rose 100g, Radix Astragali 200g, American Ginseng, ganoderma lucidum, Radix Astragali slice, fermentation cordyceps are placed in cloth bag
In, above 5 taste soaks in water 40min, and heating decocts 3 times, and 2 hours for the first time, every time 1 hour later, every time plus 10 times of water amounts,
Merge No. 3 extracting solution filterings, filtrate is concentrated into right amount, lets cool rear high speed centrifugation removal of impurities, is concentrated under reduced pressure into cream or is spray dried to
Powder is added capsule and often uses auxiliary material, is uniformly mixed, capsule is made by capsule common process.
Embodiment 35
Weigh American Ginseng 90g, ganoderma lucidum 120g, fermentation cordyceps (section ergot fungus cordyceps sinensis cephalo
Cephalosporium sinensis Chen sp.nov) 30g, fermentation cordyceps (Chinese synnema spore Synnematium
Sinensis Yin & Shen) 30g, rose 60g, American Ginseng, ganoderma lucidum slice, fermentation cordyceps are placed in cloth bag, above
Four tastes are soaked in water 1 hour, and heating decocts 3 times, 2 hours for the first time, every time 1 hour later, every time plus 13 times of water amounts, merge 3
Secondary extracting solution filtering, filtrate are concentrated into right amount, let cool rear high speed centrifugation removal of impurities, are concentrated under reduced pressure into cream or spraying drying powder-forming, add
Enter pill and often use auxiliary material, is uniformly mixed, various pills are made by pill common process.
Embodiment 36
Weigh American Ginseng 90g, ganoderma lucidum 120g, cordyceps sinensis 90g, rose 60g, Radix Astragali 200g, American Ginseng, ganoderma lucidum, Huang
Stilbene slice, cordyceps sinensis are beaten powder and are placed in cloth bag, and above 5 taste soaks in water 40min, and heating decocts 3 times, add water 12 for the first time
Amount is extracted 2 hours again, adds 10 times of amounts of water to extract every time 1 hour later, merges No. 3 extracting solutions filterings, and filtrate is concentrated into right amount, puts
High speed centrifugation removal of impurities after cold is added syrup and often uses auxiliary material, is uniformly mixed, syrup is made by syrup common process.
Embodiment 37
Weigh American Ginseng 300g, ganoderma lucidum 400g, fermentation cordyceps (Scytalidium hepiali Scytalidium hepialii
C.L.Li) 200g, rose 300g, lucidum spore powder 400g, American Ginseng, ganoderma lucidum slice, cordyceps sinensis beat powder and are placed on cloth bag
In, above four taste soaks in water 20min, and heating decocts 3 times, for the first time plus 15 times the extractions of amount water 2 hours, every time 1 hour later,
Every time plus 10 times of water amounts, merge the filtering of No. 3 extracting solutions, filtrate is concentrated into right amount, let cool rear high speed centrifugation removal of impurities, reduced pressure at
Cream or spraying drying powder-forming, are added lucidum spore powder and tablet often uses auxiliary material, are uniformly mixed, are made by tablet common process various
Tablet.
Embodiment 38
Weigh American Ginseng 300g, ganoderma lucidum 400g, fermentation cordyceps (the Chinese mould Cephalosporium s inens of cephalo
Chen sp.nov) 200g, rose 300g, radix pseudostellariae 400g, American Ginseng, ganoderma lucidum slice, fermentation cordyceps are placed in cloth bag
In, above 5 taste soaks in water 40min, and heating decocts 3 times, and 2 hours for the first time, every time 1 hour later, every time plus 10 times of water amounts,
Merge No. 3 extracting solution filterings, filtrate is concentrated into right amount, lets cool rear high speed centrifugation removal of impurities, is concentrated under reduced pressure into cream or is spray dried to
Powder is added tablet and often uses auxiliary material, is uniformly mixed, various tablets are made by tablet common process.
Embodiment 39
Weigh American Ginseng 300g, ganoderma lucidum 400g, cordyceps sinensis 67g, rose 300g, radix pseudostellariae 400g, American Ginseng, ganoderma lucidum
Slice, cordyceps sinensis are beaten powder and are placed in cloth bag, and above 5 taste soaks in water 40min, and heating decocts 3 times, add 15 times of water for the first time
Amount is extracted 2 hours, adds 10 times of amounts of water to extract every time 1 hour later, merges No. 3 extracting solution filterings, and filtrate is concentrated into right amount, lets cool
High speed centrifugation cleans afterwards, and syrup is added and often uses auxiliary material, is uniformly mixed, syrup is made by syrup common process.
Embodiment 40
Weigh American Ginseng 300g, ganoderma lucidum 400g, fermentation cordyceps (the China mould Chrysosporium sinens of gold spore
Z.Q.liang)100g；Fermentation cordyceps (Chinese coat spore Hirsutella sinensis Liu, Guo, Yu-et Zeng,
Sp.nov) 100g, rose 300g, American Ginseng, ganoderma lucidum slice, cordyceps are placed in cloth bag, 55% methanol eddy are added and mentions
It takes 2 times, 1 hour every time, is then combined with extracting solution, obtains alcohol extract after recycling methanol；The dregs of a decoction add water heating and decoct 2 times,
2 hours for the first time, every time 1 hour later, every time plus 10 times of water amounts, merge alcohol extract and aqueous extract, filtering, filtrate concentration
To appropriate, rear high speed centrifugation removal of impurities is let cool, is concentrated under reduced pressure into cream or spraying drying powder-forming, granule is added and often uses auxiliary material, mixes
Uniformly, granule is made by granule common process.
Embodiment 41
Weigh American Ginseng 300g, ganoderma lucidum 400g, cordyceps sinensis 67g, fermentation cordyceps (Chinese coat spore Hirsutella
Sinensis Liu, Guo, Yu-et Zeng, sp.nov) 20g, rose 300g, American Ginseng, ganoderma lucidum slice, cordyceps sinensis powder
It is broken to be placed in cloth bag, 75% alcohol reflux is added and extracts 2 hours, obtains alcohol extract after recycling ethyl alcohol；The dregs of a decoction, which add water, to be added
Heat decocts 3 times, 2 hours every time, merges alcohol extract and aqueous extract, filtering, and filtrate is concentrated into right amount, lets cool rear high speed centrifugation
Removal filtration is added oral solution and often uses auxiliary material, is uniformly mixed, 20000ml oral solution is made by oral solution common process.
Embodiment 42
Take ginseng 300g, ganoderma lucidum 400g, fermentation cordyceps (cephalosporium acremonium Cephalosporium acremonium
Corda, Icones Fungorum) 200g, rose 300g, Radix Codonopsis 400g, American Ginseng, ganoderma lucidum, Radix Codonopsis slice, cordyceps
It is placed in cloth bag, 15% alcohol reflux is added and extracts 2 times, 1 hour every time, is then combined with extracting solution, obtains alcohol after recycling ethyl alcohol
Extracting solution；The dregs of a decoction add water heating and decoct 3 times, 2 hours for the first time, every time 1 hour later, every time plus 10 times of water amounts, merge alcohol
Extracting solution and aqueous extract, filtering, filtrate are concentrated into right amount, let cool rear high speed centrifugation removal of impurities, are concentrated under reduced pressure at cream or dry by spraying
It is dry that granule is added and often uses auxiliary material at powder, it is uniformly mixed, granule is made by granule common process.
Embodiment 43
Take ginseng 300g, ganoderma lucidum 400g, fermentation cordyceps (cordyceps sinensis cluster spore Sporothrix insectorum de
Hong & H.C.Evans) 200g, rose 300g, Radix Codonopsis 400g, ginseng, ganoderma lucidum slice, cordyceps sinensis crushing be placed on cloth
In bag, 95% alcohol reflux is added and extracts 2 hours, obtains alcohol extract after recycling ethyl alcohol；The dregs of a decoction add water heating and decoct 3 times,
2 hours every time, merge alcohol extract and aqueous extract, filtering, filtrate is concentrated into right amount, and concentrate lets cool rear high speed centrifugation removal of impurities
Filtering is added oral solution and often uses auxiliary material, is uniformly mixed, 20000ml oral solution is made by oral solution common process.
Embodiment 44
Take ginseng 300g, ganoderma lucidum 400g, cordyceps sinensis 67g, rose 300g, lucidum spore powder 300g, Radix Astragali 400g, people
Ginseng, ganoderma lucidum slice, cordyceps sinensis crushing are placed in cloth bag, and 5% alcohol reflux is added and extracts 2 hours, obtains after recycling ethyl alcohol
Alcohol extract；The dregs of a decoction add water heating and decoct 2 times, 2 hours every time, merge alcohol extract and aqueous extract, filtering, filtrate concentration
To appropriate, concentrate lets cool rear high speed centrifugation removal filtration, and oral solution is added and often uses auxiliary material, is uniformly mixed, conventional by oral solution
20000ml oral solution is made in technique.
Embodiment 45
Take American Ginseng 300g, ganoderma lucidum 400g, fermentation cordyceps (worm flower Isaria Isaria farinose (Holmsk.)
Fr.Systema Mycologicum) 200g, rose 300g, Radix Astragali 400g, American Ginseng, ganoderma lucidum slice, cordyceps are placed in
In cloth bag, 60% alcohol reflux is added and extracts 2 times, 1 hour every time, is then combined with extracting solution, obtains alcohol extracting after recycling ethyl alcohol
Liquid；The dregs of a decoction add water heating and decoct 3 times, 2 hours for the first time, every time 1 hour later, every time plus 10 times of water amounts, merge alcohol extracting
Liquid and aqueous extract, filtering, filtrate are concentrated into right amount, and concentrate lets cool rear high speed centrifugation removal of impurities, and reduced pressure is at cream or by spraying
It is dried to powder, granule is added and often uses auxiliary material, is uniformly mixed, granule is made by granule common process.
Claims (18)
1. the composition made of the raw material containing following composition improves toxicity caused by Chemotherapy in Malignant Carcinoma Patients in preparation
Product in purposes: the raw material contain 20~120 parts of ganoderma lucidum, American Ginseng or 10~90 parts of ginseng, fermentation cordyceps 3~
60 parts and/or 3 ~ 90 parts of cordyceps sinensis, 10~60 parts of rose；Wherein, toxicity caused by chemotherapy refers to nausea and vomiting or abdomen
It rushes down.
2. purposes according to claim 1, it is characterised in that contain 30 parts of 40 parts of ganoderma lucidum, American Ginseng or ginseng, fermentation worm
20 parts of grass volvatus powder and/or 6.7 parts of cordyceps sinensis, 30 parts of rose.
3. purposes according to claim 1, which is characterized in that wherein the raw material is: 20~120 parts of ganoderma lucidum, American Ginseng
Or 3 ~ 90 parts of 10~90 parts of ginseng, 3~60 parts of fermentation cordyceps and/or cordyceps sinensis, 10~60 parts of rose.
4. purposes according to claim 3, it is characterised in that: 40 parts of ganoderma lucidum, American Ginseng or 30 parts of ginseng, ferment cordyceps sinensis bacterium
20 parts of powder and/or 6.7 parts of cordyceps sinensis, 30 parts of rose.
5. purposes according to claim 1, it is characterised in that: the raw material further includes lucidum spore powder 5~150
Part, 1~90 part of ganoderma lucidum spore oil, 10~400 parts of radix pseudostellariae, 1~120 part of folium panacis japonici cum caule, 3~400 parts of Radix Codonopsis, 3~400 parts of Radix Astragali
One or more of any combination.
6. purposes according to claim 5, it is characterised in that: wherein include 10~120 parts of lucidum spore powder, Reishi sporule
One of 10~60 parts of oil, 20~200 parts of radix pseudostellariae, 20~90 parts of folium panacis japonici cum caule, 20~200 parts of Radix Codonopsis, 20~200 parts of Radix Astragali
Or several any combination.
7. purposes according to claim 6, it is characterised in that: wherein include 30 parts of lucidum spore powder, ganoderma lucidum spore oil 20
One of part, 40 parts of radix pseudostellariae, 30 parts of folium panacis japonici cum caule, 40 parts of Radix Codonopsis, 40 parts of Radix Astragali or any combination thereof.
8. purposes according to any one of claims 1 to 4, it is characterised in that: wherein bacterium belonging to the fermentation cordyceps
Kind is that Paecilomyces hepiali chen or Hirsutella hepiali Chen et Shen or Chinese synnema spore or Gliocladiumroseum or the mould category fungi of spore or Clavicipitaceae are true
Any combination of one or more of bacterium aweto-cephalosporin or Chinese coat spore.
9. wherein lucidum spore powder is ganoderma spove powder according to any purposes of claim 6-7.
10. -7 any purposes according to claim 1, it is characterised in that: composition is added pharmaceutically acceptable additional
Agent or excipient are prepared into any dosage form.
11. purposes according to claim 10, it is characterised in that: the dosage form is tablet, oral solution, granule, capsule
Agent, soft extract, pill, powder, pastille, liquid extract, extract, injection, any one in syrup.
12. purposes as claimed in claim 1 to 7, which is characterized in that wherein the composition made of the raw material is to pass through
Made of following method: by the raw material mix or the raw material mix after water mention and/or alcohol extracting obtains composition, or
One or more of raw material described in person is mentioned through water and/or alcohol extracting extract makees active ingredient and prepares the composition.
13. purposes according to claim 12, it is characterised in that: the composition made of the raw material be by with
Made of lower step:
1) traditional Chinese medicinal material raw materials are weighed；
2) is obtained by extracting solution and does active ingredient, additives are added, are made various doses for above-mentioned medicinal material refluxing extraction with alcohol or water
Type.
14. purposes according to claim 13, it is characterised in that: the composition made of the raw material be by with
Made of lower step:
1) traditional Chinese medicinal material raw materials are weighed, raw medicinal material plus methanol or ethyl alcohol are extracted, extracting solution recycles methanol or ethyl alcohol, obtains
Extract I；
2) after the dregs of a decoction in upper step being volatilized alcohol, water is added to extract, obtains extract II；
3) merge extract I and extract II, filtering, filtrate is concentrated into right amount, is added and pharmaceutically commonly uses auxiliary material, using pharmacy
Required preparation is made in upper common process.
15. purposes according to claim 12, it is characterised in that: the composition made of the raw material be by with
Made of lower step:
1) traditional Chinese medicinal material raw materials raw material preparation: are weighed；
2) extract concentration: after the raw material handled well in step 1 is soaked in water, heating is decocted repeatedly, combined extract filtering, filter
Liquid is concentrated into right amount, and concentrate lets cool rear high speed centrifugation removal of impurities, spare；
3) preparation is prepared: by the auxiliary material that concentrate obtained in step 2 is independent or addition is medically acceptable, using in pharmacy
Required preparation is made in common process.
16. purposes according to claim 15, it is characterised in that:
Soaking time is -60 minutes 20 minutes in step 2, latter heating decoction 1~3 time, 1~2 hour every time, and amount of water 6
~13 times.
17. purposes according to claim 13, it is characterised in that: wherein the alcohol is methanol or ethyl alcohol.
18. purposes according to claim 17, it is characterised in that: methanol concentration 5-95%, concentration of alcohol are 5-95%.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210184710.5A CN103446206B (en) | 2012-05-29 | 2012-05-29 | Improve composition and its application of toxicity caused by Chemotherapy in Malignant Carcinoma Patients |
| PCT/CN2013/000624 WO2013177949A1 (en) | 2012-05-29 | 2013-05-27 | Composition for alleviating toxic and side effect of chemotherapy on malignant tumor patients and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210184710.5A CN103446206B (en) | 2012-05-29 | 2012-05-29 | Improve composition and its application of toxicity caused by Chemotherapy in Malignant Carcinoma Patients |
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| CN103446206B true CN103446206B (en) | 2019-07-19 |
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| CN106993801A (en) * | 2016-01-22 | 2017-08-01 | 许昌世纪香生物科技有限公司 | The preparation method of broken wall Hericium erinaceus conidia powder |
| CN107184912A (en) * | 2017-06-22 | 2017-09-22 | 孙沈平 | The positive disperse accumulations compound preparation of one breeding and its application |
| CN113198613B (en) * | 2021-05-08 | 2022-04-22 | 江西仙客来生物科技有限公司 | Process for quickly removing shriveled shell and impurities of ganoderma lucidum spore powder |
| CN116474061A (en) * | 2022-01-13 | 2023-07-25 | 罗登 | Medicine for treating side effects of tumor radiotherapy and chemotherapy and preparation method thereof |
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| CN102274258A (en) * | 2011-07-25 | 2011-12-14 | 江中药业股份有限公司 | Traditional Chinese medicine composition for enhancing immune function of human bodies |
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| CN102406163B (en) * | 2010-09-17 | 2014-11-05 | 江中药业股份有限公司 | Application of traditional Chinese medicine composition in preparation of health food or medicament for preventing and relieving physical fatigue |
| CN102048959B (en) * | 2011-01-14 | 2012-01-25 | 湖南龙石山铁皮石斛基地有限公司 | Dendrobium candidum compound preparation capable of regulating function of human body in two-way manner and preparation method thereof |
| CN102274259A (en) * | 2011-07-25 | 2011-12-14 | 江中药业股份有限公司 | Traditional Chinese medicine composition for enhancing immune function of human bodies |
| CN102247487B (en) * | 2011-08-18 | 2012-07-04 | 湖南省普天春生物科技有限公司 | Chinese medicinal preparation and use thereof |
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