CN102274259A - Traditional Chinese medicine composition for enhancing immune function of human bodies - Google Patents
Traditional Chinese medicine composition for enhancing immune function of human bodies Download PDFInfo
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Abstract
The invention aims to provide a traditional Chinese medicine composition for relieving physical fatigue. The composition comprises 5-150 parts of American ginseng and/or ginseng, 5-160 parts of lucid ganoderma and 1-90 parts of ferment cordyceps sinensis by weight, wherein the raw materials root in the traditional Chinese medicines or comprise water and/or alcohol extracts of the raw materials and pharmaceutically acceptable additives; and the water and/or alcohol extracts of the raw materials are taken as the active ingredients. The composition is characterized in that 5-90 parts by weight of rose can be added. The composition can be prepared into any conventional dosage form by adopting the conventional method of the traditional Chinese medicine preparation and any one pharmaceutically acceptable auxiliary material which includes but is not limited to tablets, granules, capsules, oral liquid, syrup and pills is added.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to the Chinese medicine composition that strengthens immune function of human body, the component of said composition can be Chinese crude drug that directly is used as medicine or the Chinese medicine extract that obtains through extraction.
Background technology
At present Chinese patent literature discloses many a kind of Chinese medicine compositions that strengthen immune function of human body, and wherein to have selected Radix Panacis Quinquefolii, Ganoderma and extract thereof, Cordyceps and extract or fermented Cordyceps powder etc. for use be raw material to portioned product, as
Application number is that to disclose a kind of be the Chinese patent medicine of raw material with Cordyceps extract, Ganoderma extract, Radix Panacis Quinquefolii Saponin for 03111771.6 Chinese patent application file; Application number is that 200910033212.9 Chinese patent application file discloses and a kind ofly had human body immunity improving power, strengthened the health product of vitality, anti-senescence function by what Radix Panacis Quinquefolii, Cordyceps king, Radix Notoginseng were formed; Application number is that 200810106904.7 Chinese patent application file discloses a kind of health product of being made up of Radix Panacis Quinquefolii, Ganoderma, three kinds of raw materials of fermented Cordyceps powder CS-4 and these four kinds of raw material prescriptions of Radix Panacis Quinquefolii, Ganoderma, fermented Cordyceps powder CS-4 and Flos Rosae Rugosae with enhancing immunity, foregoing invention, the fermented Cordyceps powder strain is single, the defective that curative effect is very not outstanding.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition of more efficiently enhancing immune function of human body, or Chinese crude drug that can directly be used as medicine or the Chinese medicine extract that obtains through extraction; Another object of the present invention has provided the application of compositions in the low medicine of preparation control immune function of human body that contains this Chinese medicine.
The present invention selects medicine Radix Panacis Quinquefolii and/or Radix Ginseng, Ganoderma, fermented Cordyceps powder to make up, and makes each efficacy of drugs produce synergism these drug regimens, thereby can more effectively strengthen immune function of human body; From returning through as can be seen of Radix Panacis Quinquefolii and/or Radix Ginseng, fermented Cordyceps powder, Ganoderma three flavor medicines, conscience spleen lung kidney has, and reaches the five internal organs and transfers; Radix Panacis Quinquefolii, acrid in the mouth, sweet, little hardship, warm in nature, the most tangible effect is exactly promoting QI circulation for relieving depression, and blood, pain relieving; Radix Ginseng, sweet, little hardship, tepor; Ganoderma, strengthening by means of tonics, strengthening the body resistance; Fermented Cordyceps powder, sweet, flat, return lung, kidney channel, the kidney tonifying tonifying the lung helps the Ganoderma strengthening the body resistance together with Radix Panacis Quinquefolii or Radix Ginseng.
In order to obtain optimum curative effect, medicine of the present invention can add Flos Rosae Rugosae on the basis of said medicine, reaches the effect of Synergistic; Because Flos Rosae Rugosae pattern energy and blood, the circulation of qi promoting of fragrant energy, dispersing the stagnated live-QI to relieve the stagnation of QI and the effect of invigorating blood circulation are arranged, play coordination, promotion and equilibrated effect, be adjuvant, four medicines share, the five internal organs and accent, warm cool complementation, qi and blood tonifying, benefit be not and dry, and taste is and oiliness, and flat benefit is finely tuned, effect is gentle, it is stronger to strengthen the immune function of human body effect, and curative effect is better.
The various combinations of medicine of the present invention and the consumption of each component have the effect that strengthens immune function of human body preferably in the following weight parts scope:
Form or by the water of following raw materials according and/or ethanol extract is made active ingredient and pharmaceutically acceptable additives are formed: 5～150 parts of Radix Panacis Quinquefolii and/or Radix Ginsengs, 5～160 parts of Ganodermas, 1～90 part of fermented Cordyceps powder by the raw material of following weight parts;
Preferred Radix Panacis Quinquefolii and/or 10～90 parts of Radix Ginsengs, 20～90 parts of Ganodermas, 3.3～60 parts of fermented Cordyceps powder;
Most preferably 30 parts of Radix Panacis Quinquefolii and/or Radix Ginsengs, 40 parts of Ganodermas, 20 parts of fermented Cordyceps powder.
Compositions of the present invention can also add 5～90 parts of Flos Rosae Rugosaes;
Preferred Radix Panacis Quinquefolii and/or 10～90 parts of Radix Ginsengs, 20～90 parts of Ganodermas, 3.3～60 parts of fermented Cordyceps powder, 10～60 parts of Flos Rosae Rugosaes;
Most preferably 30 parts of Radix Panacis Quinquefolii and/or Radix Ginsengs, 40 parts of Ganodermas, 20 parts of fermented Cordyceps powder, 30 parts of Flos Rosae Rugosaes.
The middle liquid medicine and/or the ethanol extract that can also add the raw material of other following weight parts that do not weaken effect of the present invention in the present composition or be equivalent to following Chinese crude drug crude drug amount are made active ingredient, as a kind of or combination in any in 3～300 parts of Radix Pseudostellariaes, 1～120 part of Folium Ginseng, 3～160 parts of Radix Codonopsis, 3～200 parts of the Radixs Astragali, 5～150 parts of Semen Cuscutae etc. any or its combination.
The present invention relates to contain the application of above-mentioned composition in the medicine low as preparation control immune function of human body.
Ganoderma of the present invention is basidiomycetes Polyporaceae Ganoderma plant Ganoderma lucidum (Leyss. Ex Fr.) Karst.
Ganoderma lucidum(Leyss.ex Fr.) or Ganoderma
Ganoderma sinenseZhao, the dry sporophore of Xu et Zhang, nature and flavor are sweet, flat, and GUIXIN, lung, liver, kidney channel have the function of strengthening by means of tonics, mind tranquilizing and the heart calming.
Radix Ginseng described in the present invention is dry root and the rhizome of Araliaceae Radix Ginseng Panax ginseng C. A. Mey., can be the ginseng of various kinds, as Park Ginseng, SHANSHEN, Radix Ginseng, sun-dried SHANSHEN, white sugar ginseng, Radix Ginseng Rubra; Can also select for use Folium Ginseng to substitute Radix Panacis Quinquefolii or Radix Ginseng, described Folium Ginseng is Araliaceae Radix Ginseng Panax ginseng C. A. Mey.
Dried leaves
Radix Panacis Quinquefolii described in the present invention has another name called U.S.'s ginseng, Radix Panacis Quinquefolii, Radix Panacis Quinquefolii, Guangdong ginseng, is Araliaceae west skill Radix Panacis Quinquefolii
Panax quinquefoliumL. dry root, sweet, the little hardship of nature and flavor, cold, GUIXIN, lung, kidney channel have boosting qi and nourishing yin, the function of clearing away heat and promoting production of body fluid.
Fermented Cordyceps powder described in the present invention is to remove peacilomyce hepiahi Paecilongces hepialli Chen et Dai, sp.nov; With the product of the Hirsutella hepiali Chen et Shen Hirsutella hepialid Chen et Shen mycelia of from following natural cordyceps, separating in addition through fermentation culture, as Hirsutlla sinensis Hirsutsua sinensis Liu, Guo, Yu et Zeng, sp.nov; Aweto-cephalosporin Cephalosporium sinensis Chen sp.nov; Hepialus armorieanus Oberthur is by spore enzyme Mortiscrslla hepialid C.T.﹠amp; B.liu; China Paecilomyces varioti Paecilomyces sinensis Chen, Xiao et Shi, sp.nov; The curved mould Tolypocladium sinensis of the neck C.lan Li of China; The mould Cephalosporium sinens of China's cephalo Chen sp.nov; The mould Scytalidium hepialii of Hepialus armorieanus Oberthur post C.L.Li; The mould Chrysosporium sinens of the golden spore of China Z.Q.liang; China wheel branch spore Verticillium sinens Wamg sp.nov; Cephalosporium acremonium Cephalosporium acremonium Corda, Icones Fungorum; China synnema spore Synnematium sinensis Yin ﹠amp; Shen sp.nov; Worm flower Isaria Isaria farinose (Holmsk.) Fr.Systema Mycologicum; Metarhizium anisopliae Metarhizium anisopliae (Metsch) Sorokin; Cordyceps bunch spore Sporothrix insectorum de Hong ﹠amp; H.C.Evans; Gliocladium roseum Bain Gliocladium roseum (link) Thom; The mould genus of spore fungus Mortierella SP.
Flos Rosae Rugosae described in the present invention be the rosaceous plant Flos Rosae Rugosae (
Rosa rugosaThumb) dry flower, acrid in the mouth, sweet, little hardship, warm in nature.
Radix Codonopsis is the dry root of campanulaceae plant Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., plain flower Radix Codonopsis Codonopsis pilosula Nannf.var.modesta (Nannf.) L.T.Shen or radix codonpsis tangshen Codonopsis tangshen 01iv..Semen Cuscutae is the dry mature seed of convolvulaceous plant south Semen Cuscutae Cuscuta australis. or Semen Cuscutae Cuscuta chinensis Lam.; The Radix Astragali described in the present invention is the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch) Bge.var.mongholicus (Bge) Hsiao or Radix Astragali Astragalus membranaceus (Fisch) Bge..
The preparation technology of Chinese medicine composition of the present invention may further comprise the steps:
Take by weighing following weight portion Chinese crude drug and make raw material:
1) 5～150 parts of Radix Ginseng and/or Radix Panacis Quinquefoliis, 5～160 parts of Ganodermas, 1～90 part of fermented Cordyceps powder or Flos Rosae Rugosae are 5～90 parts;
2) use alcohol or water to above-mentioned medical material reflux, extract,, obtain extracting solution and do active ingredient, add additives, make various dosage forms.
The preparation technology of Chinese medicine composition of the present invention also can may further comprise the steps:
1) Radix Panacis Quinquefolii, Ganoderma, fermented Cordyceps powder, Flos Rosae Rugosae are added methanol or ethanol extracts, extracting solution reclaims methanol or ethanol, obtains the extract I;
2) above-mentioned medicinal residues are volatilized alcohol after, add water and extract, obtain the extract II;
3) united extraction thing I and extract II are filtered, and filtrate is concentrated in right amount, add adjuvant pharmaceutically commonly used, and common process is made required preparation on the employing pharmaceutics.
Pharmaceutical composition of the present invention can adopt the Chinese medicine preparation conventional method to be prepared into any regular dosage form, adds and is used as medicine
Acceptable any one adjuvant includes but not limited to tablet, granule, capsule, oral liquid, syrup, pill etc. on; The active constituent of medicine of the present invention also can add preparation various dosage forms required various conventional adjuvant, is prepared into any peroral dosage form commonly used as disintegrating agent, lubricated, binding agent etc. with the method for Chinese medicinal of routine.
Pharmaceutical composition of the present invention is surprised to find that the effect with good enhancing immune function of human body.
In order to understand essence of the present invention better, below will be with fermented Cordyceps powder China synnema spore Synnematium sinensis Yin ﹠amp; The test of pesticide effectiveness of Shen sp.nov Cs-C-Q80 and fermented Cordyceps (CS-4) or Hirsutella hepiali Chen et Shen comes the described fermented Cordyceps curative effect of furthermore bright pharmaceutical composition of the present invention to be better than compositions Radix Panacis Quinquefolii, Ganoderma, fermented Cordyceps (CS-4) or Hirsutella hepiali Chen et Shen, the Flos Rosae Rugosae of existing enhancing immune function of human body.Similarly, other strain of the described fermented Cordyceps of pharmaceutical composition of the present invention all can reach same effect.
Similarly add any or its combination in any such as Radix Ginseng, Radix Pseudostellariae, Radix Codonopsis, the Radix Astragali, Semen Cuscutae and all can reach same pharmacological action is arranged, difference is the use amount difference.
1. materials and methods
1.1 sample source and processing: being subjected to reagent is that Chinese medicine composition I oral liquid (is got Radix Panacis Quinquefolii 300g, Ganoderma 400g, fermented Cordyceps powder China synnema spore Synnematium sinensis Yin ﹠amp; Shen sp.nov Cs-C-Q80 200g, Flos Rosae Rugosae 300g) provide by Jiangzhong Pharmaceutical Co., Ltd., get Radix Panacis Quinquefolii, Ganoderma section, fermented Cordyceps powder places cloth bag, more than four the flavor soaked 1 hour, heating decocts 3 times, and 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrated solution is put the high speed centrifugation remove impurity of cold back, add oral liquid adjuvant commonly used and be deployed into 20000ml, the fill sterilization gets product.It is 0.2g crude drug/kg BW for 200ml/60kg BW(that the crowd recommends daily intaking amount).
The contrast medicine is Chinese medicine composition II oral liquid (Radix Panacis Quinquefolii 300g, Ganoderma 400g, fermented Cordyceps powder Paecilongces hepialli Chen et Dai, sp.nov CS-4 200g, Flos Rosae Rugosae 300g) provide by Jiangzhong Pharmaceutical Co., Ltd., method for making is with being subjected to reagent, add oral liquid adjuvant commonly used and be deployed into 20000ml, the fill sterilization gets product.It is 0.2g crude drug/kg BW for 200ml/60kg BW(that the crowd recommends daily intaking amount).
Consider the preparation of animal experiment medicine, above-mentioned oral liquid is concentrated 10 times, 1200g crude drug/2000ml, i.e. 0.6 g crude drug/ml.The contrast medicine is also handled with method.
1.2 laboratory animal: cleaning level Healthy female Kunming mouse, body weight 18-22g, the Jiangxi College of Traditional Chinese Medicine Experimental Animal Center provides, credit number: SCXK (Jiangxi) 2006-0001.Animal feeding is in Jiangxi College of Traditional Chinese Medicine animal housing, environmental permit: SYXK (Jiangxi) 2004-0001,21～23 ℃ of feeding environment temperature, relative humidity 50～60%.
1.3 experimental technique
1.3.1 animal grouping:
Be divided into four big groups of experiment, big group of every experiment comprises blank group, Chinese medicine composition II oral liquid matched group, is subjected to the basic, normal, high dosage group of reagent Chinese medicine composition I oral liquid, and each dosage group laboratory animal number is 10.
1.3.2 the dosage design: it is 200ml/60kg BW that the crowd recommends daily intaking amount, converting and obtaining everyone recommended intake every day is that 12g crude drug/60kg BW is 0.2g crude drug/kg BW).Recommend daily intaking amount 0.2g crude drug/kg BW to enlarge 10,20,30 times by the crowd basic, normal, high three dosage groups are set, extrapolate mice intake every day thus and be: low dose group, 2.0g crude drug/kg body weight; Middle dosage group, 4.0g crude drug/kg body weight; High dose group, 6g crude drug/kg body weight is with spissated sample (0.6 g crude drug/ml) be mixed with respective concentration with distilled water.High dose: get 100ml 0.6 g crude drug/ml concentrated solution adding distil water to 200ml; Middle dosage: get 66.7ml 0.6 g crude drug/ml concentrated solution adding distil water to 200ml; Low dosage: get 33.3ml 0.6 g crude drug/ml concentrated solution adding distil water to 200ml; The mouse stomach amount is pressed the 0.2ml/10g body weight and is calculated.Chinese medicine composition II group gives middle dosage 4.0g crude drug/kg body weight (be equivalent to people's intake every day 20 times), and sample is got the 66.7ml adding distil water to 200ml, irritates the stomach amount and press the calculating of 0.2ml/10g body weight.The blank group gives the equal-volume distilled water and irritates stomach.Irritate stomach every day 1 time, continuous 30 days.Each is organized mice and all raises with normal diet, ad lib, drinking-water.
1.3.3 test rating: one group of immunization experiment carries out delayed allergy and Turnover of Mouse Peritoneal Macrophages is engulfed the chicken red blood cell experiment; Two groups of immunization experiments carry out lymphatic organ/weight ratio pH-value determination pH and carbon is cleaned up experiment; Immunization experiment carries out inductive mouse lymphocyte transformation experiment of ConA and NK cytoactive mensuration for three groups; Four groups of mensuration and antibody-producting cells that carry out serum hemolysin of immunization experiment detect.
1.3.4 statistical method: experimental data with
One factor analysis of variance is adopted in expression, is relatively tried the difference between each dosage group detection index of thing and the blank group; And relatively tried each dosage group of thing and detect difference between index and the Chinese medicine composition II group, P＜0.05 is judged as difference and has significance.
2 results
2.1 the weight of animals growth pattern: compare with the blank group, each dosage group of Chinese medicine composition I oral liquid and Chinese medicine composition II group mice body weight there was no significant difference (
P0.05), compare with Chinese medicine composition II group, each dosage group mice body weight there was no significant difference of Chinese medicine composition I oral liquid (
P0.05), the results are shown in Table 1.
Table 1 Chinese medicine composition I oral liquid to the influence of weight of mice (g,
)
2.2 influence to mouse thymus coefficient and index and spleen index: with the blank group relatively, each dosage group of Chinese medicine composition I oral liquid and Chinese medicine composition II group mouse thymus system, index and spleen index there was no significant difference (
P0.05), with Chinese medicine composition II group relatively, each dosage group thymus system of Chinese medicine composition I oral liquid, index and spleen index mice body weight there was no significant difference (
P0.05), the results are shown in Table 2.
Table 2 Chinese medicine composition I oral liquid to the influence of mouse thymus coefficient and index and spleen index (
)
2.3 influence: compare with the blank group to mice spleen lymphocytes proliferation ability and mice delayed allergy, the dosage group all has the DTH reaction (P＜0.05, P＜0.01) that significance enhancing inductive spleen lymphocyte proliferation ability of ConA and mice are brought out DNFB in middle and high dosage group of Chinese medicine composition I oral liquid and the Chinese medicine composition II.Compare with the contrast of Chinese medicine composition II, the middle and high dosage group of Chinese medicine composition I oral liquid all has significance to strengthen the inductive spleen lymphocyte proliferation ability of ConA and mice reacts (P＜0.05) to the DTH that DNFB brings out.Experimental result sees Table 3.
Table 3 Chinese medicine composition I oral liquid to the mouse cell Immune Effects (
)
Compare * with the blank group
P＜0.05, * *
P＜0.05; Compare with Chinese medicine composition II group,
▲ P＜0.05,
▲ ▲ P＜0.05.
2.4 influence to the mice serum hemolysin level: with the blank group relatively, the dosage group effect (P＜0.05) of mice serum hemolysin level that all is significantly increased in middle and high dosage group of Chinese medicine composition I oral liquid and the Chinese medicine composition II.Compare with the contrast of Chinese medicine composition II, the middle and high dosage group of Chinese medicine composition I oral liquid all has significance to significantly improve the effect (P＜0.05) of mice serum hemolysin level.Experimental result sees Table 4.
Table 4 Chinese medicine composition I oral liquid to the influence of mice serum hemolysin level (
)
Compare * with the blank group
P＜0.05, * *
P＜0.05; Compare with Chinese medicine composition II group,
▲ P＜0.05,
▲ ▲ P＜0.05.
2.5 influence to the Turnover of Mouse Peritoneal Macrophages phagocytic function: with the blank group relatively, the dosage group effect (P＜0.01) of Turnover of Mouse Peritoneal Macrophages phagocytic percentage that all is significantly increased in middle and high dosage group of Chinese medicine composition I oral liquid and the Chinese medicine composition II.Compare with the contrast of Chinese medicine composition II, Chinese medicine composition I oral liquid high dose group has to show all has significance to significantly improve the effect (P＜0.05) of peritoneal macrophage phagocytic percentage, and the dosage group has the trend (P=0.087) that improves the Turnover of Mouse Peritoneal Macrophages phagocytic percentage in the Chinese medicine composition I oral liquid.Experimental result sees Table 5.
Table 5 Chinese medicine composition I oral liquid to the influence of peritoneal macrophage phagocytic function (
)
Compare * with the blank group
P＜0.05, * *
P＜0.05; Compare with Chinese medicine composition II group,
▲ P＜0.05,
▲ ▲ P＜0.05.
2.6 influence to mice carbon clearance function: with the blank group relatively, the dosage group effect (P＜0.05, P＜0.01) of phagocytic index that all is significantly increased in middle and high dosage group of Chinese medicine composition I oral liquid and the Chinese medicine composition II.Compare with the contrast of Chinese medicine composition II, the middle and high dosage group of Chinese medicine composition I oral liquid has significance to improve the effect (P＜0.05, P＜0.01) of phagocytic index.Experimental result sees Table 6.
Table 6 Chinese medicine composition I oral liquid to the influence of mice carbon clearance function (
)
Compare * with the blank group
P＜0.05, * *
P＜0.05; Compare with Chinese medicine composition II group,
▲ P＜0.05,
▲ ▲ P＜0.05.
2.7 influence to mouse antibodies cellulation function: with the blank group relatively, the dosage group effect (P＜0.05, P＜0.01) of hemolysis plaque number that all is significantly increased in middle and high dosage group of Chinese medicine composition I oral liquid and the Chinese medicine composition II.Compare with the contrast of Chinese medicine composition II, the middle and high dosage group of Chinese medicine composition I oral liquid has significance to improve the effect (P＜0.05) of hemolysis plaque number.Experimental result sees Table 7.
Table 7 Chinese medicine composition I oral liquid to the influence of mouse antibodies cellulation function (
)
Compare * with the blank group
P＜0.05, * *
P＜0.05; Compare with Chinese medicine composition II group,
▲ P＜0.05,
▲ ▲ P＜0.05.
2.8 to the active influence of NK cells in mice: with the blank group relatively, the active there was no significant difference of each dosage group of Chinese medicine composition I oral liquid and Chinese medicine composition II group NK cells in mice (
P0.05), compare with Chinese medicine composition II group, the active there was no significant difference of each dosage group NK cells in mice of Chinese medicine composition I oral liquid (
P0.05), the results are shown in Table 8.
Table 8 Chinese medicine composition I oral liquid to the active influence of NK cells in mice (
)
Compare * with the blank group
P＜0.05, * *
P＜0.05; Compare with Chinese medicine composition II group,
▲ P＜0.05,
▲ ▲ P＜0.05.
3. conclusion:
Recommend daily intaking amount 12.0g crude drug/60kg body weight to enlarge 10,20 and 30 times according to Chinese medicine composition I oral liquid crowd basic, normal, high three dosage groups are set, be 2.0g crude drug, 4.0g crude drug, 6.0g crude drug/kg body weight, other establishes blank group, model control group and Chinese medicine composition II group (4.0g crude drug/kg body weight).Adopt cleaning level Healthy female Kunming mouse continuous irrigation stomach to be tried thing, detect index of correlation after 30 days.Experimental result is with P＜0.05, and P＜0.01 is judged as difference and has significance and utmost point significance.Show through animal experiment study: the middle and high dosage group of Chinese medicine composition I oral liquid all can improve the inductive spleen lymphocyte proliferation ability of mice ConA and mice reacts the DTH that DNFB brings out, the effect of mice serum hemolysin level is significantly increased, all the be significantly increased effect of hemolysis plaque number of the effect of the Turnover of Mouse Peritoneal Macrophages that is significantly increased phagocytic percentage and mice carbon clearance function, the middle and high dosage group of Chinese medicine composition I oral liquid.And the middle and high dosage group of Chinese medicine composition I oral liquid all is better than Chinese medicine composition II matched group to the influence through last index, think that Chinese medicine composition I oral liquid has raise immunity, and the enhance immunity effect is better than Chinese medicine composition II group.
The specific embodiment
Embodiment 1
Get Radix Panacis Quinquefolii and/or Radix Ginseng 300g, Ganoderma 400g, fermented Cordyceps powder Cs-C-Q80 200g, Flos Rosae Rugosae 300 g, Radix Panacis Quinquefolii, Ganoderma section, the packing of fermented Cordyceps powder cloth bag, all medical materials were soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of water gagings at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrated solution is put the high speed centrifugation remove impurity of cold back, adds oral liquid adjuvant commonly used, mix homogeneously is made the 20000ml oral liquid by the oral liquid common process.
Embodiment 2
Get Radix Ginseng 50g, Ganoderma 50g, fermented Cordyceps powder Gliocladium roseum Bain Gliocladium roseum (link) Thom 10g, Flos Rosae Rugosae 50 g, Radix Ginseng, Ganoderma section, the packing of fermented Cordyceps powder cloth bag, all medical materials were soaked 1.5 hours, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 8 times of water gagings at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrated solution is put the high speed centrifugation remove impurity of cold back, adds oral liquid adjuvant commonly used, mix homogeneously is made the 20000ml oral liquid by the oral liquid common process.
Embodiment 3
Get Radix Panacis Quinquefolii 150g, Ganoderma 160g, the mould genus of fermented Cordyceps powder spore fungus Mortierella SP 90g, Radix Panacis Quinquefolii, Ganoderma section, the packing of fermented Cordyceps powder cloth bag, all medical materials were soaked 1 hour, and heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 9 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrated solution is put the high speed centrifugation remove impurity of cold back, adds oral liquid adjuvant commonly used, mix homogeneously is made the 20000ml oral liquid by the oral liquid common process.
Embodiment 4
Get Radix Ginseng and/or Radix Panacis Quinquefolii 900g, Ganoderma 900g, fermented Cordyceps powder Cordyceps cephalo Cephalosporium sinensis Chen sp.nov 900g, Radix Ginseng, Ganoderma section, the packing of fermented Cordyceps powder cloth bag, all medical materials were soaked 1.2 hours, heating decocts 2 times, 2.5 hours for the first time, each 1 hour later on, add 9 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrated solution is put the high speed centrifugation remove impurity of cold back, adds oral liquid adjuvant commonly used, mix homogeneously is made the 20000ml oral liquid by the oral liquid common process.
RealExecute example 5
Get Radix Ginseng 1500g, Ganoderma 1600g, fermented Cordyceps powder China synnema spore Synnematium sinensis Yin ﹠amp; Shen 500g, the section of Radix Panacis Quinquefolii, Ganoderma, Cordyceps is played cloth bag packing behind the powder, all medical materials were soaked 1 hour, and heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrated solution is put the high speed centrifugation remove impurity of cold back, add oral liquid adjuvant commonly used, mix homogeneously is made the 20000ml oral liquid by the oral liquid common process.
Embodiment 6
Get Radix Panacis Quinquefolii 200g, Ganoderma 200g, the fermented Cordyceps powder Hepialus armorieanus Oberthur is by spore enzyme Mortiscrslla hepialid C.T.﹠amp; B.liu 90g, Radix Panacis Quinquefolii, Ganoderma section, the packing of fermented Cordyceps powder cloth bag, all medical materials were soaked 1 hour, and heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 5 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrated solution is put the high speed centrifugation remove impurity of cold back, add oral liquid adjuvant commonly used, mix homogeneously is made the 20000ml oral liquid by the oral liquid common process.
Embodiment 7
Get Radix Ginseng Rubra 5g, Ganoderma 5g, fermented Cordyceps powder China Paecilomyces varioti Paecilomyces sinensis Chen, Xiao et Shi, sp.nov1g, Radix Panacis Quinquefolii, Ganoderma section, the packing of fermented Cordyceps powder cloth bag, all medical materials were soaked 1.2 hours, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 5 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrated solution is put the high speed centrifugation remove impurity of cold back, adds oral liquid adjuvant commonly used, mix homogeneously is made the 20000ml oral liquid by the oral liquid common process.
Embodiment 8
Get Radix Panacis Quinquefolii 300g and/or Radix Pseudostellariae 300g, Ganoderma 400g, the curved mould Tolypocladium sinensis of the neck C. lan Li 67g of fermented Cordyceps powder China, Flos Rosae Rugosae 300g, Radix Panacis Quinquefolii and/or Radix Pseudostellariae, the Ganoderma section, the packing of fermented Cordyceps powder cloth bag, all medical materials were soaked 1.4 hours, and heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 6 times of water gagings at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrated solution is put the high speed centrifugation remove impurity of cold back, add oral liquid adjuvant commonly used, mix homogeneously is made the 20000ml oral liquid by the oral liquid common process.
Embodiment 9
Get Radix Panacis Quinquefolii 500g and/or Radix Codonopsis 160g, Ganoderma 200g, the mould Scytalidium hepialii of fermented Cordyceps powder Hepialus armorieanus Oberthur post C.L.Li90g, Flos Rosae Rugosae 500g, Radix Panacis Quinquefolii and/or Radix Codonopsis, the Ganoderma section, the packing of fermented Cordyceps powder cloth bag, all medical materials were soaked 1 hour, and heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of water gagings at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrated solution is put the high speed centrifugation remove impurity of cold back, add oral liquid adjuvant commonly used, mix homogeneously is made the 20000ml oral liquid by the oral liquid common process.
Embodiment 10
Get Radix Ginseng 100g and/or Radix Astragali 200g, Ganoderma 900g, fermented Cordyceps powder 30g, Flos Rosae Rugosae 100g, Radix Panacis Quinquefolii, Ganoderma section, the packing of fermented Cordyceps powder cloth bag, all medical materials were soaked 1 hour, heating decocts 3 times, and 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrated solution is put the high speed centrifugation remove impurity of cold back, add oral liquid adjuvant commonly used, mix homogeneously is made the 20000ml oral liquid by the oral liquid common process.
RealExecute example 11
Get Radix Panacis Quinquefolii 1000g and/or Radix Astragali 500g, Ganoderma 1600g, fermented Cordyceps powder 70g, Flos Rosae Rugosae 900g, the Radix Panacis Quinquefolii and/or the Radix Astragali, Ganoderma section, the packing of fermented Cordyceps powder cloth bag, all medical materials were soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrated solution is put the high speed centrifugation remove impurity of cold back, adds oral liquid adjuvant commonly used, mix homogeneously is made the 20000ml oral liquid by the oral liquid common process.
Embodiment 12
Get Radix Panacis Quinquefolii 450g, Ganoderma 200g, Cordyceps powder (Hirsutlla sinensis Hirsutsua sinensis Liu, Guo, Yu et Zeng, sp.nov) 600g, Radix Panacis Quinquefolii, Ganoderma section, the packing of Cordyceps powder cloth bag, all medical materials were soaked 1 hour, and heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of water gagings at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrated solution is put the high speed centrifugation remove impurity of cold back, add oral liquid adjuvant commonly used, mix homogeneously is made the 20000ml oral liquid by the oral liquid common process.
Embodiment 13
Get Radix Ginseng 100g, Ganoderma 800g, Cordyceps powder (Gliocladium roseum Bain Gliocladium roseum (link) Thom) 300g, Radix Panacis Quinquefolii, Ganoderma section, the packing of Cordyceps powder cloth bag, all medical materials were soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1.5 hours later on, add 9 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrated solution is put the high speed centrifugation remove impurity of cold back, adds oral liquid adjuvant commonly used, mix homogeneously is made the 20000ml oral liquid by the oral liquid common process.
Embodiment 14
Get Radix Panacis Quinquefolii 250g, Ganoderma 600g and/or Semen Cuscutae 120g, Cordyceps powder (the mould genus of spore fungus Mortierella SP) 100g, Radix Panacis Quinquefolii, Ganoderma section, the packing of Cordyceps powder cloth bag, all medical materials were soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 7 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrated solution is put the high speed centrifugation remove impurity of cold back, adds oral liquid adjuvant commonly used, mix homogeneously is made the 20000ml oral liquid by the oral liquid common process.
RealExecute example 15
Get Radix Panacis Quinquefolii 50g, Ganoderma 1600g, Cordyceps powder (Chinese synnema spore Synnematium sinensis Yin ﹠amp; Shen) 100g, Radix Panacis Quinquefolii, Ganoderma section, the packing of Cordyceps powder cloth bag, all medical materials were soaked 1 hour, and heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 8 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrated solution is put the high speed centrifugation remove impurity of cold back, add oral liquid adjuvant commonly used, mix homogeneously is made the 20000ml oral liquid by the oral liquid common process.
Embodiment 16
Get Radix Ginseng 1500g and/or Radix Codonopsis 300g, Ganoderma 200g, Cordyceps powder (aweto-cephalosporin Cephalosporium sinensis Chen sp.nov) 33g, Radix Panacis Quinquefolii and/or Radix Codonopsis, Ganoderma section, the packing of Cordyceps powder cloth bag, all medical materials were soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrated solution is put the high speed centrifugation remove impurity of cold back, adds oral liquid adjuvant commonly used, mix homogeneously is made the 20000ml oral liquid by the oral liquid common process.
Embodiment 17
Get Radix Panacis Quinquefolii 450g, Ganoderma 200g, Cordyceps powder Cordyceps powder (the mould genus of spore fungus Mortierella SP) 50g, Flos Rosae Rugosae 100g, Radix Panacis Quinquefolii, Ganoderma section, Cordyceps is beaten behind the powder and the packing of Cordyceps powder cloth bag, all medical materials were soaked 1 hour, and heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of water gagings at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrated solution is put the high speed centrifugation remove impurity of cold back, add oral liquid adjuvant commonly used, mix homogeneously is made the 20000ml oral liquid by the oral liquid common process.
Embodiment 18
Get Radix Ginseng 250g, Ganoderma 300g, Cordyceps powder (Hirsutlla sinensis Hirsutsua sinensis Liu, Guo, Yu et Zeng, sp.nov) 200g, Flos Rosae Rugosae 300g, Radix Panacis Quinquefolii, Ganoderma section, the packing of Cordyceps powder cloth bag, all medical materials were soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrated solution is put the high speed centrifugation remove impurity of cold back, adds oral liquid adjuvant commonly used, mix homogeneously is made the 20000ml oral liquid by the oral liquid common process.
Embodiment 19
Get Radix Panacis Quinquefolii 300g, Ganoderma 400g, Cordyceps powder (the mould Cephalosporium sinens of Chinese cephalo Chen sp.nov) 200g, Flos Rosae Rugosae 300g, Radix Panacis Quinquefolii, Ganoderma section, Cordyceps powder places cloth bag, above medical material was soaked 1 hour, heating decocts 3 times, 2.2 hours for the first time, each 1 hour later on, add 7 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrated solution is put the high speed centrifugation remove impurity of cold back, and concentrating under reduced pressure becomes clear paste, spraying drying powder-forming is made composite powder.
Embodiment 20
Get Radix Panacis Quinquefolii 300g, Ganoderma 300g, Cordyceps powder (Chinese synnema spore Synnematium sinensis Yin ﹠amp; Shen sp.nov) 200g, Flos Rosae Rugosae 300g, Radix Panacis Quinquefolii, Ganoderma section, Cordyceps powder places cloth bag, above medical material was soaked 1.5 hours, and heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 5 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrated solution is put the high speed centrifugation remove impurity of cold back, and concentrating under reduced pressure becomes cream or spraying drying powder-forming, adds granule adjuvant commonly used, mix homogeneously is made granule by the granule common process.
Embodiment 21
Get Radix Panacis Quinquefolii 300g, Ganoderma 400g, Cordyceps powder 200g, Flos Rosae Rugosae 200g, Radix Panacis Quinquefolii, Ganoderma section, Cordyceps powder places cloth bag, and above medical material was soaked 1 hour, and heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 9 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrated solution is put the high speed centrifugation remove impurity of cold back, concentrating under reduced pressure becomes cream or spraying drying powder-forming, add capsule adjuvant commonly used, mix homogeneously is made capsule by the capsule common process.
Embodiment 22
Get Radix Panacis Quinquefolii 300g, Ganoderma 400g, Cordyceps powder 200g/ or Semen Cuscutae 150g, Flos Rosae Rugosae 200g, Radix Panacis Quinquefolii, Ganoderma section, Cordyceps powder places cloth bag, adds alcohol reflux 1-2 time, each 1-2 hour, merge extractive liquid, obtains alcohol extract behind the recovery ethanol then; Medicinal residues add the water heating again and decoct 1～3 time, and each 1～2 hour, merge alcohol extract and aqueous extract, to filter, filtrate is concentrated in right amount, and concentrated solution is put the high speed centrifugation remove impurity of cold back, and is standby.Above medical material was soaked 1 hour, heating decocts 3 times, and 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge alcohol extract and aqueous extract and filter, filtrate is concentrated in right amount, and concentrated solution is put the high speed centrifugation remove impurity of cold back, concentrating under reduced pressure becomes cream or spraying drying powder-forming, add capsule adjuvant commonly used, mix homogeneously is made capsule by the capsule common process.
Claims (10)
1. one kind has a kind of Chinese medicine composition that strengthens immune function of human body, and the raw material that it is characterized in that containing following weight parts is formed or by the water of following raw materials according and/or ethanol extract is made active ingredient and pharmaceutically acceptable additives are formed: 5～150 parts of Radix Panacis Quinquefolii and/or Radix Ginsengs, 5～160 parts of Ganodermas, 1～90 part of fermented Cordyceps powder.
2. ask 1 described Chinese medicine composition according to right, it is characterized in that: 10～90 parts of Radix Panacis Quinquefolii and/or Radix Ginsengs, 20～90 parts of Ganodermas, 3.3～60 parts of fermented Cordyceps powder.
3. ask 2 described Chinese medicine compositions according to right, it is characterized in that: 30 parts of Radix Panacis Quinquefolii and/or Radix Ginsengs, 40 parts of Ganodermas, 20 parts of fermented Cordyceps powder.
4. ask 3 described Chinese medicine compositions according to right, it is characterized in that: wherein raw material also has 5～90 parts of Flos Rosae Rugosaes.
5. ask 4 described Chinese medicine compositions according to right, it is characterized in that: 10～90 parts of Radix Panacis Quinquefolii and/or Radix Ginsengs, 20～90 parts of Ganodermas, 3.3～60 parts of fermented Cordyceps powder, 10～60 parts of Flos Rosae Rugosaes.
6. ask 5 described Chinese medicine compositions according to right, it is characterized in that: 30 parts of Radix Panacis Quinquefolii and/or Radix Ginsengs, 40 parts of Ganodermas, 20 parts of fermented Cordyceps powder, 30 parts of Flos Rosae Rugosaes.
7. according to the arbitrary described Chinese medicine composition of claim 1-6, it is characterized in that: also can add any or combination in any in 5～150 parts of 3～300 parts of the Radix Pseudostellariaes, 1～120 part of Folium Ginseng, 3～160 parts of Radix Codonopsis, 3～200 parts of the Radixs Astragali, Semen Cuscutae.
8. pharmaceutical composition according to claim 1, wherein said alcohol are ethanol or methanol.
9. according to the preparation method of the arbitrary described Chinese medicine composition of claim 1-6, it is characterized in that comprising the following steps:
(1), take by weighing following weight portion Chinese crude drug and make raw material:
5～90 parts of 5～150 parts of Radix Ginseng and/or Radix Panacis Quinquefoliis, 5～160 parts of Ganodermas, 1～90 part of fermented Cordyceps powder or Flos Rosae Rugosaes;
(2), with alcohol or water to above-mentioned medical material reflux, extract,, obtain extracting solution and do active ingredient, add additives, make various dosage forms.
10. the application of the arbitrary described compositions of claim 1-7 in the medicine low as preparation control immune function of human body.
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| CN102895276A (en) * | 2012-10-23 | 2013-01-30 | 贵州百花医药股份有限公司 | Method for preparing ginseng ganoderma preparation |
| WO2013155720A1 (en) * | 2012-04-21 | 2013-10-24 | 江苏安惠生物科技有限公司 | Fatigue relief and health care capsule |
| WO2013177945A1 (en) * | 2012-05-29 | 2013-12-05 | 江中药业股份有限公司 | Composition for preventing and treating aids and preparation method thereof |
| WO2013177948A1 (en) * | 2012-05-29 | 2013-12-05 | 江中药业股份有限公司 | Application of composition in preparing health care product or medicine for preventing and treating leukopenia caused by radiotherapy and chemotherapy |
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| WO2013155720A1 (en) * | 2012-04-21 | 2013-10-24 | 江苏安惠生物科技有限公司 | Fatigue relief and health care capsule |
| US9744203B2 (en) | 2012-05-29 | 2017-08-29 | Jiangzhong Pharmaceutical Co., Ltd. | Application of composition in preparing health care product or medicine for preventing and treating leukopenia caused by radiotherapy and chemotherapy |
| WO2013177948A1 (en) * | 2012-05-29 | 2013-12-05 | 江中药业股份有限公司 | Application of composition in preparing health care product or medicine for preventing and treating leukopenia caused by radiotherapy and chemotherapy |
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| CN103479693A (en) * | 2012-06-14 | 2014-01-01 | 江中药业股份有限公司 | Drug composition, uses and preparation method thereof |
| EP2949334A4 (en) * | 2012-09-13 | 2016-06-01 | Jiangzhong Pharmaceutical Co Ltd | Traditional chinese medicine combination for regulating immune function and preparation method therefor |
| WO2014040396A1 (en) * | 2012-09-13 | 2014-03-20 | 江中药业股份有限公司 | Traditional chinese medicine combination for regulating immune function and preparation method therefor |
| US9775868B2 (en) | 2012-09-13 | 2017-10-03 | Jiangzhong Pharmaceutical Co., Ltd. | Traditional Chinese medicine combination for regulating immune function and preparation method therefor |
| CN109512926A (en) * | 2012-09-13 | 2019-03-26 | 江中药业股份有限公司 | Slow down composition and its application of toxicity caused by chemicotherapy |
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| US10537600B2 (en) | 2012-09-13 | 2020-01-21 | Jiangzhong Pharmaceuticals Co., Ltd. | Traditional Chinese medicine combination for regulating immune function and preparation method therefor |
| CN102895276A (en) * | 2012-10-23 | 2013-01-30 | 贵州百花医药股份有限公司 | Method for preparing ginseng ganoderma preparation |
| US11090330B2 (en) | 2014-05-26 | 2021-08-17 | Songyuan Chen | Pharmaceutical solution having a toxicity-reducing effect for antitumor drugs, and pharmaceutical composition comprising same |
| CN110279737A (en) * | 2019-07-08 | 2019-09-27 | 湖北圣峰药业有限公司 | Careless preparation of a kind of selenium-rich ginseng spirit and preparation method thereof |
| CN111012867A (en) * | 2019-12-23 | 2020-04-17 | 刘海波 | Cordyceps sinensis mycelium tablet and preparation method thereof |
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