CN102228252A - Application of Chinese medicinal composition in preparation of healthcare foods and medicines for improving hypoxia tolerance - Google Patents
Application of Chinese medicinal composition in preparation of healthcare foods and medicines for improving hypoxia tolerance Download PDFInfo
- Publication number
- CN102228252A CN102228252A CN2011102088672A CN201110208867A CN102228252A CN 102228252 A CN102228252 A CN 102228252A CN 2011102088672 A CN2011102088672 A CN 2011102088672A CN 201110208867 A CN201110208867 A CN 201110208867A CN 102228252 A CN102228252 A CN 102228252A
- Authority
- CN
- China
- Prior art keywords
- parts
- oral liquid
- cordyceps
- american ginseng
- glossy ganoderma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention aims to provide an application of a Chinese medicinal composition in preparation of healthcare foods and medicines for improving hypoxia tolerance. The Chinese medicinal composition is prepared from the following components in parts by weight: 5-90 parts of American ginseng, 5-160 parts of glossy ganoderma, 1-90 parts of fermentative cordycep fungal powder and/or 1-120 parts of cordyceps, and the raw materials are Chinese herbal medicines or Chinese medicine extracts with equal dose of the Chinese herbal medicines, wherein 5-90 parts by weight of rose further can be added to the Chinese medicinal composition. The Chinese medicinal composition disclosed by the invention can be prepared into any conventional formulations by adopting a Chinese medicinal preparation conventional method, including but not limited to tablets, granules, capsules, oral liquids, syrups and pills, and any one of pharmaceutically accepted auxiliary materials can be added to the Chinese medicinal composition.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and purposes in health food and medicine field that improves anoxia endurance health food and medicine.
Background technology
American Ginseng has another name called U.S.'s ginseng, American ginseng, American ginseng, Guangdong ginseng, is Araliaceae Panax herbaceos perennial.The effect of American Ginseng aspect the enhancing body's immunity is remarkable; its chemical composition is numerous; the major physiological active material is an American ginseng saponin; polysaccharide; flavonoids; volatile oil; trace element; wherein American ginseng saponin is the most significant material of physiologically active; these people have been carried out a large amount of research to it; successively isolate many kinds of monomer saponins of 2O; except strengthening the body's immunity effect, also have many pharmacological actions: relieving convulsion as calmness; the short intelligence of calming the nerves; anti-arrhythmia; anti-shock; the protection cardiac muscle; anti-blood vessel is filled in firmly; blood falls; reducing blood lipid; resisting stress; antitumor; protect the liver etc.
Glossy ganoderma is the dry fructification of basidiomycetes Polyporaceae Ganoderma plant glossy ganoderma or purple sesame, and nature and flavor are sweet, flat, have the function of strengthening by means of tonics, antitoxic heart-soothing and sedative.The chemical composition of glossy ganoderma is abundanter, contains polysaccharide, triterpenoid, organic acid, fungal lysozyme, protease, soluble protein, amino acid, alkaloid, polypeptide, adenine, adenosine, uracil, uridine and D-mannose, trace element etc.Modern medicine has been made appropriate evaluation to the pharmacological action of glossy ganoderma, it is reported that it has three big advantages: 1. have no side effect; 2. the disease to all organs of human body all has health care and medical effect; 3. can regulate the inharmonic part of body, impel the function normalization of whole internal organ or organ, fundamentally treat disease.Particularly, glossy ganoderma has the effect of regulating nervous system, cardiovascular system, respiratory system; Protein, the synthetic synergistic effect of nucleic acid; Physiological function such as toxin expelling and immunoregulation effect.
Fermentation cordyceps has similar composition to natural cordyceps: 1. nucleoside compound and adenosine etc.; 2. phytosterin compound; 3. sugar and glycitols compound such as sweet mellow wine etc.; 4. amino acids: hydrolysis amino acid l8 kind, free amino acid l5 kind; 5. other compounds such as zinc, potassium, manganese, phosphorus, selenium and other trace elements and vitamin B1, B2, vitamin E etc.Zoopery shows that also both have similar biologically active.Cordyceps sinensis is cell immunomodulator, the humoral immunity regulating action is also arranged simultaneously, playing multiple link in the immunity of organism pathologic process regulates or inhibitory action, can alleviate or prevent the cellular immune function disturbance state by regulating, from multi-angle, too many levels, the autoimmune pathological change of multi-faceted reverse.
The property of medicine of rose as mild as a dove, the conscience blood vessels of can temperature supporting the people, strongly fragrant gas in the Shu Fati plays calmness, pacifies, antidepressant effect.Along with the transformation of medical model and the enhancing of people's health care consciousness, rose has received increasing concern in the effect aspect cardiovascular and cerebrovascular diseases, tumor prevention, the anti-ageing and beauty and health care.
At present Chinese patent literature discloses the health food of many anti-oxidant, antifatigues, hypolipemic function, and wherein to have selected American Ginseng, glossy ganoderma and extract thereof, Cordyceps sinensis and extract or fermentation cordyceps etc. for use be raw material to portioned product.As application number is that to disclose a kind of be the anti-anoxic of having of major ingredient, antifatigue, anti-ageing, the health protection tea of improving the beneficial gas body-building of sleep by glossy ganoderma, rhodiola root for 02115148.2 Chinese patent; Application number is that to disclose a kind of be the health protection tea that has antifatigue, anti-ageing, reducing blood lipid blood sugar, strengthens the blood circulation effect that primary raw material is formed by Cordyceps sinensis, glossy ganoderma, genseng, matrimony vine for 99117565.4 Chinese patent; Application number is that 02146103.1 Chinese patent discloses a kind of Flos Rosae Rugosae extract and is used for anti-oxidantly, improves immunity of organisms, as the health products of promoting longevity; Foregoing invention, contain plurality of Chinese, be unfavorable for that the patient takes for a long time, still do not adopt at present American Ginseng, glossy ganoderma, fermentation cordyceps or three kinds of raw materials of Cordyceps sinensis and, the health food and the medicine of the raising anoxia endurance of American Ginseng, glossy ganoderma, fermentation cordyceps or three kinds of raw materials of Cordyceps sinensis and these four kinds of raw material prescriptions preparations of rose.
Summary of the invention
The object of the present invention is to provide a kind of more efficiently raising anoxia endurance health food and medicine Chinese medicine composition, another object of the present invention has provided the new application of composition in health food and medicine field that contains this Chinese medicine.
The present invention selects medicine American Ginseng and/or genseng, glossy ganoderma, Cordyceps sinensis to make up, and makes each efficacy of drugs produce synergy these drug regimens, thereby can more effectively strengthen immune function of human body; From returning through as can be seen of American Ginseng and/or genseng, Cordyceps sinensis, glossy ganoderma three flavor medicines, conscience spleen lung kidney has, and reaches the five internal organs and transfers; American Ginseng, hot, sweet, the little hardship, warm in nature of distinguishing the flavor of, the most tangible effect is exactly promoting qi circulation and removing obstruction in the collateral, and blood, pain relieving; Genseng, sweet, little hardship, tepor; Glossy ganoderma, strengthening by means of tonics is strengthened the body resistance to consolidate the constitution; Cordyceps sinensis, sweet, flat, return lung, kidney channel, the kidney-nourishing tonifying lung helps glossy ganoderma to strengthen the body resistance to consolidate the constitution with American Ginseng or genseng together.
In order to obtain better curative effect, medicine of the present invention can add rose on the basis of said medicine, reach the effect of Synergistic; Because rose pattern energy and blood, the promoting the circulation of qi of fragrant energy has soothing liver-qi stagnation and the effect of invigorating blood circulation, play the effect of coordination, promotion and balance, be adjuvant, four medicines share, the five internal organs and transfer, temperature cool complementary, qi-blood tonifying, mend and not dry, grow and oiliness, flat mend finely tune, effect is gentle, it is stronger to improve the human body anoxia tolerance effect, curative effect is better, in order to reach better therapeutic, can also add fermentation cordyceps and make up, it is the strongest to improve the human body anoxia tolerance effect, curative effect the best.
The various combinations of medicine of the present invention and the consumption of each component have the effect that improves human body anoxia tolerance preferably in the following weight parts scope:
The present composition contains following raw material or by the water of following raw materials according and/or alcohol extract is made active ingredient and pharmaceutically acceptable additives are formed: 5～150 parts of American Ginseng and/or gensengs, 1～120 part of Cordyceps sinensis and/or 1～90 part of fermentation cordyceps, 5～160 parts of glossy ganodermas;
3.3～60 parts of preferred American Ginseng and/or 10～90 parts of gensengs, 20～90 parts of glossy ganodermas, 3～90 parts of Cordyceps sinensis and/or fermentation cordyceps; More preferably 30 parts of American Ginseng and/or gensengs, 40 parts of glossy ganodermas, 6.7 parts of Cordyceps sinensis and/or fermentation cordyceps are 20 parts.
Medicine of the present invention is all right:
Contain following raw material or by the water of following raw materials according and/or alcohol extract is made active ingredient and pharmaceutically acceptable additives are formed: 5～150 parts of American Ginseng and/or gensengs, 1 ~ 120 part of Cordyceps sinensis and/or 1～90 part of fermentation cordyceps, 5～160 parts of glossy ganodermas, 5～90 parts of roses;
Preferred American Ginseng and/or 10～90 parts of gensengs, 20～90 parts of glossy ganodermas, 3～90 parts of Cordyceps sinensis and/or 3～60 parts of fermentation cordyceps, 10～60 parts of roses; More preferably 30 parts of American Ginseng and/or gensengs, 40 parts of glossy ganodermas, 6.7 parts of Cordyceps sinensis and/or 20 parts of fermentation cordyceps, 30 parts of roses.
Can also add the raw material of other following weight parts that do not weaken effect of the present invention in the present composition or contain following raw material or by the water of following raw materials according and/or alcohol extract is made active ingredient and pharmaceutically acceptable additives are formed: as a kind of or its any combination in 5～150 parts of 3～300 parts of the radix pseudostellariaes, 1～120 part of folium panacis japonici cum caule, 3～160 parts of Radix Codonopsis, 3～200 parts of the Radixs Astragali, the seed of Chinese dodder.
The present invention relates to also to reach and contains above-mentioned composition in the application that improves as preparation in human body anoxia tolerance health food and the medicine.
Relate to the application of pharmaceutical composition in preparation raising anoxia endurance health food and medicine of forming by American Ginseng 10～50 weight portions, glossy ganoderma 10～50 weight portions, fermentation cordyceps 10～50 weight portions.
Relate to the application of pharmaceutical composition in preparation raising anoxia endurance health food and medicine of forming by American Ginseng 10～50 weight portions, glossy ganoderma 10～50 weight portions, fermentation cordyceps 10～50 weight portions, rose 10～40 weight portions.
Glossy ganoderma of the present invention is the red sesame of basidiomycetes Polyporaceae Ganoderma plant
Ganoderma lucidum(Leyss.ex Fr.) or purple sesame
Ganoderma sinenseZhao, the dry fructification of Xu et Zhang, nature and flavor are sweet, flat, and the thoughts of returning home, lung, liver, kidney channel have the function of strengthening by means of tonics, antitoxic heart-soothing and sedative.
Genseng described in the present invention is dry root and the rhizome of Araliaceae genseng Panax ginseng C. A. Mey., can be the ginseng of various kinds, as garden ginsent, mountain ginseng, sun-dried ginseng, sun-dried mountain ginseng, white sugar ginseng, red ginseng; Can also select for use the folium panacis japonici cum caule to substitute American Ginseng or genseng, described folium panacis japonici cum caule is the dried leaves of Araliaceae genseng Panax ginseng C. A. Mey.
American Ginseng described in the present invention has another name called U.S.'s ginseng, American ginseng, American ginseng, Guangdong ginseng, is Araliaceae west skill American ginseng
Panax quinquefoliumL. dry root, sweet, the little hardship of nature and flavor, cold, the thoughts of returning home, lung, kidney channel have boosting qi and nourishing yin, the function of clearing heat and promoting fluid.
Fermentation cordyceps described in the present invention can be the mycelia of separating from the following natural cordyceps product through fermented and cultured, as Paecilomyces hepiali chen Paecilongces hepialli Chen et Dai, sp.nov; China is by hair spore Hirsutsua sinensis Liu, Guo, Yu et Zeng, sp.nov; Aweto-cephalosporin Cephalosporium sinensis Chen sp.nov; The bat moth is by spore enzyme Mortiscrslla hepialid C.T.﹠amp; B.liu; China Paecilomyces varioti Paecilomyces sinensis Chen, Xiao et Shi, sp.nov; The curved mould Tolypocladium sinensis of the neck C.lan Li of China; The mould Cephalosporium sinens of China's cephalo Chen sp.nov; The mould Scytalidium hepialii of bat moth post C.L.Li; The mould Chrysosporium sinens of the golden spore of China Z.Q.liang; China wheel branch spore Verticillium sinens Wamg sp.nov; Cephalosporium acremonium Cephalosporium acremonium Corda, Icones Fungorum; China synnema spore Synnematium sinensis Yin ﹠amp; Shen; Worm flower Isaria Isaria farinose (Holmsk.) Fr.Systema Mycologicum; Metarhizium anisopliae Metarhizium anisopliae (Metsch) Sorokin; Hirsutella hepiali Chen et Shen Hirsutella hepialid Chen et Shen; Chinese caterpillar fungus bunch spore Sporothrix insectorum de Hong ﹠amp; H.C.Evans; Gliocladiumroseum Gliocladium roseum (link) Thom; The mould genus of spore fungi Mortierella SP.
Rose described in the present invention be the rosaceous plant rose (
Rosa rugosaThumb) dry flower, hot, sweet, the little hardship, warm in nature of distinguishing the flavor of, the most tangible effect is exactly promoting qi circulation and removing obstruction in the collateral, and blood, pain relieving, property of medicine gentleness, the conscience blood vessels of can temperature supporting the people, strongly fragrant gas in the Shu Fati plays calmness, pacifies, antidepressant effect.
Radix Codonopsis is the dry root of Campanulaceae plant Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., plain flower Radix Codonopsis Codonopsis pilosula Nannf.var.modesta (Nannf.) L.T.Shen or radix codonpsis tangshen Codonopsis tangshen 01iv..
The seed of Chinese dodder is the dry mature seed of convolvulaceous plant south seed of Chinese dodder Cuscuta australis. or seed of Chinese dodder Cuscuta chinensis Lam.; The Radix Astragali described in the present invention is the dry root of legume astragalus mongolicus Astragalus membranaceus (Fisch) Bge.var.mongholicus (Bge) Hsiao or Astragalus membranacus Astragalus membranaceus (Fisch) Bge..
The preparation technology of Chinese medicine composition of the present invention may further comprise the steps:
Take by weighing the following traditional Chinese medicines material and make raw material:
1) 5～150 parts of genseng and/or American Ginsengs, 5～160 parts of glossy ganodermas, 1 ~ 120 part of Cordyceps sinensis and/or 1～90 part of fermentation cordyceps or rose 5～90;
2) use alcohol or water to above-mentioned medicinal material refluxing extraction, obtain extract and do active ingredient, add additives, make various formulations.
The preparation technology of Chinese medicine composition of the present invention also can may further comprise the steps:
1) American Ginseng, glossy ganoderma, Cordyceps sinensis and/or fermentation cordyceps, rose are added methyl alcohol or ethanol extracts, extract reclaims methyl alcohol or ethanol, obtains the extract I;
2) the above-mentioned dregs of a decoction are volatilized alcohol after, add water and extract, obtain the extract II;
3) merge extract I and extract II, filter, filtrate is concentrated in right amount, adds auxiliary material pharmaceutically commonly used, and common process is made required preparation on the employing pharmacy.
Pharmaceutical composition of the present invention can adopt the Chinese medicine preparation conventional method to be prepared into any regular dosage form, adds and is used as medicine
Acceptable any one auxiliary material includes but not limited to tablet, granule, capsule, oral liquid, syrup, pill etc. on; The active constituent of medicine of the present invention also can add preparation various formulations required various conventional auxiliary material, is prepared into any peroral dosage form commonly used as disintegrant, lubricated, adhesive etc. with the method for Chinese medicinal of routine.
The composition that the pharmaceutical composition that American Ginseng of the present invention and/or genseng, glossy ganoderma, Cordyceps sinensis are formed is formed than American Ginseng, glossy ganoderma, ferment cordyceps sinensis bacterium improves the human body anoxia tolerance better efficacy.
The composition that the pharmaceutical composition that American Ginseng of the present invention and/or genseng, glossy ganoderma, Cordyceps sinensis, rose are formed is formed than American Ginseng, glossy ganoderma, ferment cordyceps sinensis bacterium, rose improves the human body anoxia tolerance better efficacy.
The composition that the pharmaceutical composition that American Ginseng of the present invention and/or genseng, glossy ganoderma, Cordyceps sinensis, fermentation cordyceps are formed is formed than American Ginseng, glossy ganoderma, ferment cordyceps sinensis bacterium improves the human body anoxia tolerance better efficacy.
The composition that the pharmaceutical composition that American Ginseng of the present invention and/or genseng, glossy ganoderma, Cordyceps sinensis, fermentation cordyceps, rose are formed is formed than American Ginseng, glossy ganoderma, ferment cordyceps sinensis bacterium, rose improves the human body anoxia tolerance more remarkable treatment effect.
In order to understand essence of the present invention better, to use the zoopery and the result of the pharmaceutical composition of forming by genseng or American Ginseng, glossy ganoderma, fermentation cordyceps that its new purposes in improving human body anoxia tolerance health food and pharmaceutical field is described below, add Cordyceps sinensis or substitute fermentation cordyceps with Cordyceps sinensis, can increase curative effect, as adding the effect that rose can reach Synergistic in each composition.
Similarly add any or its any combinations such as genseng, radix pseudostellariae, Radix Codonopsis, the Radix Astragali, the seed of Chinese dodder and all can reach same pharmacological action is arranged, difference is the use amount difference.
Chinese medicine composition I of the present invention (American Ginseng, glossy ganoderma, fermentation cordyceps) proves to have the anoxia in mice of raising tolerance function, and have no side effect through animal experiment, the zoopery report is described as follows:
1 material and method
1.1 sample:
Chinese medicine composition I of the present invention (American Ginseng, glossy ganoderma, fermentation cordyceps) oral liquid by Jiangzhong Pharmaceutical Co., Ltd. provides is pale brown look or chocolate brown powder.Long-term normal temperature is preserved, and uses for experiment.Company provides Chinese medicine composition I oral liquid prescription of the present invention to be: American Ginseng 15g, glossy ganoderma 20g, fermentation cordyceps 10g and auxiliary material 75g, 120g altogether.The RD of Chinese medicine composition I oral liquid of the present invention is equivalent to the 0.4g/d/kg body weight for adult (pressing the 60kg batheroom scale) 24g every day.Wherein, American Ginseng accounts for 12.5%, and glossy ganoderma accounts for 16.7%, and Chinese caterpillar fungus accounts for 8.3%.
1.2 animal used as test:
The Balb/c healthy male mice that provides by Chinese Academy of Medical Sciences's Experimental Animal Center (quality certification number: 6 ~ 8 ages in week SCXK (capital) 2005-0013), 18 ~ 22g, totally 120, be divided into three batches and experimentize, every batch is divided into 4 groups at random, 10 every group.Test a collection of anti-anoxic experiment of normal pressure of carrying out; Test two batches and carry out natrium nitrosum moderate survival experiment; Test three batches and carry out the experiment of acute cerebral ischemia anoxic.Experimental animal feeding is in Department Of Medicine, Peking University Experimental Animal Center secondary animal housing.
1.3 grouping:
Basic, normal, high dosage group of Chinese medicine composition I oral liquid of the present invention and blank group are established in experiment, are respectively 3.3 times, 10 times, 30 times of Chinese medicine composition I oral liquid human body recommended amounts of the present invention, i.e. 4.5g/kg/d, 1.5g/kg/d, 0.5g/kg/d.Tried thing water (sterilizing) preparation, per os gives once a day, weighs in weekly to adjust and irritates the stomach amount, and the continuous irrigation stomach is surveyed every immune indexes after 45 days.The mouse stomach volume is heavy for the 0.1mL/10g mouse.Establish a blank group (0g/kg/d) simultaneously, water (sterilizing) replaces being tried thing, and it is long-pending with respectively to be tried the thing group identical to irritate body of stomach every day.Experimental session animal ad lib, drinking-water.
1.4 key instrument and reagent:
250mL port grinding bottle, stopwatch, 1mL syringe, scissors.
Vaseline, soda lime, natrium nitrosum.
1.5 experimental technique:
1.5.1 the anti-anoxic experiment of normal pressure
Irritate stomach after 45 days, after last is irritated stomach 1 hour, each group mouse is put into the 250mL port grinding bottle (1 every bottle) that fills the 5g soda lime respectively, seal bottleneck with vaseline, cover completely, make it air tight, timing immediately is an index with the breath stopped, observes mouse because of the dead time of anoxic.Given the test agent group and control group compare, prolonged survival period, and have statistical significance, then judge this experimental result positive.
1.5.2 natrium nitrosum moderate survival experiment
After last is irritated stomach 1 hour, each organized mouse by 200-240mg/kgBW dosage lumbar injection natrium nitrosum (injection volume is 0.1mL/10g), timing immediately, record animals survived time.Given the test agent group and control group compare, prolonged survival period, and have statistical significance, then judge this experimental result positive.
1.5.3 acute cerebral ischemia anoxic experiment
After last is irritated stomach 1 hour, each treated animal (under the ether light anaesthesia) from neck by broken end only, immediately by behind the stopwatch record mouse broken end to the dwell time of breathing of dehiscing.Given the test agent group and control group compare, the time lengthening of breathing, and have statistical significance, then judge this experimental result positive.
1.6 statistical method
All results are with mean
Standard deviation is represented, adopts SPSS16.0 software to carry out one-way analysis of variance, relatively the difference of each experimental group and control group.But need to carry out homogeneity test of variance earlier by the program of variance analysis, variance is neat, calculates the F value, F value＜F
0.05, conclusion: each organizes the mean differences does not have conspicuousness; F value 〉=F
0.05, P≤0.05 is added up with the comparative approach in twos of mean between a plurality of experimental group and control group; The data of abnormal or heterogeneity of variance are carried out the conversion of suitable variable, wait to satisfy normal state or variance are neat require after, add up with the data after changing; If do not reach normal state or the neat purpose of variance yet after the variable conversion, use rank test instead and add up.
1.7 judgment basis as a result
" health food check and assessment technique standard " (2003 editions) regulation: appoint the binomial experimental result positive in the anti-anoxic experiment of normal pressure, natrium nitrosum poisoning survival experiment, three experiments of acute cerebral ischemia anoxic experiment, this given the test agent of decidable has the effect of raising anoxia tolerant function.
2 results
2.1 the influence of high, medium and low dosage group of Chinese medicine composition I oral liquid of the present invention and control group mice normal pressure hypoxia endurance time
Table 1 Chinese medicine composition I of the present invention oral liquid is to the influence of mouse normal pressure hypoxia endurance time (x ± SD)
*: with control group significant difference is arranged relatively, P＜0.05
By table 1 as seen, per os gives mouse and is tried thing after 45 days, and Chinese medicine composition I oral liquid dosage group of the present invention and blank group compare, and low, high dose group can significant prolongation mouse normal pressure hypoxia endurance time (P＜0.05).
2.2 high, medium and low dosage group of Chinese medicine composition I oral liquid of the present invention and the influence of control group mice natrium nitrosum moderate time-to-live
Table 2 is tried thing to the mouse natrium nitrosum influence of moderate time-to-live (x ± SD)
*: with control group significant difference is arranged relatively, P＜0.05;
By table 2 as seen, per os gives mouse and is tried thing after 45 days, Chinese medicine composition I oral liquid dosage group group of the present invention and blank group are relatively, high dose group to mouse natrium nitrosum moderate after the time-to-live have conspicuousness to improve (P＜0.05), Chinese medicine composition I oral liquid promptly of the present invention is survival ability after dosage 4.5g/kg/d group can strengthen mouse natrium nitrosum moderate.
2.3 high, medium and low dosage group of Chinese medicine composition I oral liquid of the present invention and the influence of control group mice acute cerebral ischemia anoxic time-to-live
Table 3 Chinese medicine composition I of the present invention oral liquid is to the influence of mouse brain ischemic anoxia time-to-live (x ± SD)
| Group | Number of animals (only) | The mouse brain ischemic anoxia time-to-live |
| Contrast | 10 | 19.42±3.33 |
| Low | 10 | 21.19±1.63 |
| In | 10 | 22.10±3.07 |
| High | 10 | 22.31±1.98* |
*: with 0 group significant difference is relatively arranged, P＜0.05
By table 3 as seen, per os gave the Chinese medicine composition I oral liquid of mouse various dose after 45 days, three dosage groups and control group are relatively, but the time-to-live (P＜0.05) of high dose group significant prolongation chmice acute cerebral ischemia anoxic, Chinese medicine composition I oral liquid promptly of the present invention can improve the chmice acute hypoxia endurance time at 4.5g/kg/d.
3. brief summary
Per os gave the Chinese medicine composition I oral liquid of the present invention of mouse various dose after 45 days, compare with the blank group, this is tried thing 4.5g/kg/d group mouse normal pressure hypoxia endurance time, natrium nitrosum moderate time-to-live and cerebral ischemia anoxic time-to-live all is significantly increased; 0.5g/kgBW group is significantly increased to mouse normal pressure hypoxia endurance time.
According to above-mentioned efficacy test, Chinese medicine composition I oral liquid of the present invention has the health care that improves anoxia endurance.
Chinese medicine composition II composite powder of the present invention (American Ginseng, glossy ganoderma, fermentation cordyceps, rose) proves to have the anoxia in mice of raising tolerance function, and have no side effect through animal experiment, the zoopery report is described as follows:
1 material and method
1.1 sample:
Being subjected to reagent is that Chinese medicine composition II composite powder (American Ginseng, glossy ganoderma, fermentation cordyceps, rose) is provided by Jiangzhong Pharmaceutical Co., Ltd., sample is that brown solid is Powdered, 1g composite powder dry powder is equivalent to total raw medicinal herbs 12.56g, faces with preceding to be mixed with desired concn with distilled water.Chinese medicine composition I composite powder (American Ginseng, glossy ganoderma, fermentation cordyceps) is provided by Jiangzhong Pharmaceutical Co., Ltd., and sample is that brown solid is Powdered, and 1g composite powder dry powder is equivalent to total raw medicinal herbs 11.41g, faces with preceding to be mixed with desired concn with distilled water.
1.2 animal used as test:
The healthy male mice in kunming of cleaning level, body weight 18-22g, the Jiangxi College of Traditional Chinese Medicine Experimental Animal Center provides, credit number: SCXK (Jiangxi) 2006-0001.Animal feeding is in Jiangxi College of Traditional Chinese Medicine animal housing, environmental permit: SYXK (Jiangxi) 2004-0001,21～23 ℃ of feeding environment temperature, relative humidity 50～60%.
1.3 experimental technique
1.3.1 animal grouping: totally 150 of mouse, be divided into three batches and experimentize, every batch is divided into 5 groups at random, 10 every group.Test a collection of anti-anoxic experiment of normal pressure of carrying out; Test two batches and carry out natrium nitrosum moderate survival experiment; Test three batches and carry out the experiment of acute cerebral ischemia anoxic.
1.3.2 the dosage design: everyone recommended intake every day of Chinese medicine composition II composite powder (American Ginseng, glossy ganoderma, fermentation cordyceps, rose) is: the 200ml/60kg body weight, the total raw medicinal herbs of 120g is mixed with 1000ml Chinese medicine composition II oral liquid, 1g composite powder dry powder is equivalent to total raw medicinal herbs 12.56g, and conversion obtains everyone recommended intake every day of Chinese medicine composition II composite powder (American Ginseng, glossy ganoderma, fermentation cordyceps, rose) and is: 24g crude drug/60kg body weight.Extrapolating mouse intake every day thus is: low dose group, 2.0g crude drug/kg body weight; Middle dosage group, 4.0g crude drug/kg body weight; High dose group, 12g crude drug/kg body weight is equivalent to 5,10 and 30 times of people's intake every day respectively.Sample is mixed with respective concentration with distilled water, and (the filling gastric juice of 0.0159g dry powder/ml, 0.0318g dry powder/ml, 0.0995g dry powder/ml) experimentizes, and the mouse stomach amount is pressed the 0.1ml/10g body weight and calculated.Everyone recommended intake every day of Chinese medicine composition I composite powder composite powder is: the 200ml/60kg body weight, the total raw medicinal herbs of 120g is mixed with 1000ml Chinese medicine composition I oral liquid, 1g Chinese medicine composition I composite powder dry powder is equivalent to total raw medicinal herbs 11.41g, Chinese medicine composition I composite powder gives middle dosage 4.0g crude drug/kg body weight (be equivalent to people's intake every day 10 times), sample is mixed with 0.0350g dry powder/ml filling gastric juice with distilled water experimentizes, irritate the stomach amount and press the calculating of 0.1ml/10g body weight.Per os gives once a day, weighs in weekly and adjust to irritate the stomach amount, and the continuous irrigation stomach is surveyed every index after 45 days, establish a blank group simultaneously, irritates body of stomach every day and amasss and respectively tried the identical distilled water of thing group.Experimental session animal ad lib, drinking-water.
1.3.3 the anti-anoxic experiment of normal pressure
Irritate stomach after 45 days, after last is irritated stomach 1 hour, each group mouse is put into the 250mL port grinding bottle (1 every bottle) that fills the 5g soda lime respectively, seal bottleneck with vaseline, cover completely, make it air tight, timing immediately is an index with the breath stopped, observes mouse because of the dead time of anoxic.
1.3.4 natrium nitrosum moderate survival experiment
After last is irritated stomach 1 hour, each organized mouse by 240mg/kgBW lumbar injection natrium nitrosum (injection volume is 0.1mL/10g), timing immediately, record animals survived time.
1.3.5 acute cerebral ischemia anoxic experiment
After last is irritated stomach 1 hour, each treated animal (under the ether light anaesthesia) from neck by broken end only, immediately by behind the stopwatch record mouse broken end to the dwell time of breathing of dehiscing.
1.4 key instrument and reagent: 250mL port grinding bottle, stopwatch, 1mL syringe, scissors.Vaseline, soda lime, natrium nitrosum.
1.5 statistical method
All results are with mean
Standard deviation is represented, adopts SPSS15.0 software to carry out one-way analysis of variance, relatively the difference of each experimental group and control group.But need to carry out homogeneity test of variance earlier by the program of variance analysis, variance is neat, calculates the F value, F value＜F
0.05, conclusion: each organizes the mean differences does not have conspicuousness; F value 〉=F
0.05, P≤0.05 is added up with the comparative approach in twos of mean between a plurality of experimental group and control group; The data of abnormal or heterogeneity of variance are carried out the conversion of suitable variable, wait to satisfy normal state or variance are neat require after, add up with the data after changing; If do not reach normal state or the neat purpose of variance yet after the variable conversion, use rank test instead and add up.
1.6 judgment basis as a result
The anti-anoxic experiment of normal pressure, natrium nitrosum are poisoned, and survival is tested, the acute cerebral ischemia anoxic is tested and appointed the binomial experimental result positive in three experiments, and this given the test agent of decidable has the effect of the anoxia tolerant function of raising.
2 results
2.1 Chinese medicine composition II (American Ginseng, glossy ganoderma, fermentation cordyceps, rose) oral liquid is to the influence of mouse normal pressure hypoxia endurance time
Chinese medicine composition II oral liquid basic, normal, high dosage group mouse and Chinese medicine composition I mouse normal pressure hypoxia endurance time all obviously are longer than blank group (P＜0.05, P＜0.01), the middle and high dosage group of Chinese medicine composition II oral liquid mouse normal pressure hypoxia endurance time all obviously is longer than Chinese medicine composition I control group (P＜0.05).The results are shown in Table 1.
Table 1 Chinese medicine composition II oral liquid to the influence of mouse normal pressure hypoxia endurance time (
)
Compare * P＜0.05, * * P＜0.01 with the blank group; Compare with Chinese medicine composition I group,
▲P＜0.05.
2.2 Chinese medicine composition II oral liquid is to the influence of moderate time-to-live of mouse natrium nitrosum
The middle and high dosage group of the Chinese medicine composition II oral liquid mouse natrium nitrosum moderate time-to-live all obviously is longer than blank group (P＜0.01), and the middle and high dosage group of the Chinese medicine composition II oral liquid mouse natrium nitrosum moderate time-to-live all obviously is longer than Chinese medicine composition I control group (P＜0.05).The results are shown in Table 2.
Table 2 Chinese medicine composition II oral liquid to the influence of moderate time-to-live of mouse natrium nitrosum (
)
Compare * * P＜0.01 with the blank group; Compare with the Chinese medicine composition I,
▲P＜0.05.
2.3 Chinese medicine composition II oral liquid is to the influence of anoxic time-to-live of chmice acute cerebral ischemia
Middle and high dosage group of Chinese medicine composition II oral liquid and Chinese medicine composition I group mouse brain ischemic anoxia time-to-live all obviously are longer than blank group (P＜0.05, P＜0.01), the middle and high dosage group of the Chinese medicine composition II oral liquid mouse brain ischemic anoxia time-to-live all obviously is longer than Chinese medicine composition I control group (P＜0.05).The results are shown in Table 3.
Table 3 Chinese medicine composition II oral liquid to the influence of mouse brain ischemic anoxia time-to-live (
)
Compare * P＜0.05, * * P＜0.01 with the blank group; Compare with Chinese medicine composition I group,
▲P＜0.05.
3. brief summary
Recommend daily intaking amount 24g crude drug/60kg body weight to enlarge 5,10 and 30 times according to Chinese medicine composition II oral liquid composite powder crowd basic, normal, high three dosage groups are set, be 2.0g crude drug, 4.0g crude drug, 12.0g crude drug/kg body weight, other establishes blank group, Chinese medicine composition I control group.Adopt cleaning level healthy male mice continuous irrigation stomach to be tried thing, detect index of correlation after 45 days.Experimental result is judged as difference with P＜0.05 and has conspicuousness.Show through animal experiment study: the basic, normal, high dosage group of Chinese medicine composition II oral liquid composite powder mouse normal pressure hypoxia endurance time obviously is longer than the blank group.The middle and high dosage group of Chinese medicine composition II oral liquid composite powder mouse natrium nitrosum moderate time-to-live, cerebral ischemia anoxic time-to-live obviously are longer than the blank group.The middle and high dosage group of Chinese medicine composition II oral liquid composite powder mouse, normal pressure hypoxia endurance time, natrium nitrosum moderate time-to-live, cerebral ischemia anoxic time-to-live obviously are longer than Chinese medicine composition I control group, think that Chinese medicine composition II oral liquid composite powder has the health care that improves anoxia endurance, and its raising anoxic tolerance function is better than the Chinese medicine composition I.
The specific embodiment
Embodiment 1
1 material and method
1.1 sample: being tried thing is that Chinese medicine composition I oral liquid composite powder (American Ginseng, glossy ganoderma, Cordyceps sinensis) is provided by Jiangzhong Pharmaceutical Co., Ltd., 1g composite powder dry powder is equivalent to total raw medicinal herbs 11.41g, and everyone is at recommended intake every day: 24g crude drug/60kg body weight.Tester is that Chinese medicine composition II composite powder (American Ginseng, glossy ganoderma, fermentation cordyceps) is provided by Jiangzhong Pharmaceutical Co., Ltd., and 1g composite powder dry powder is equivalent to total raw medicinal herbs 10.97g, and everyone is at recommended intake every day: 24g crude drug/60kg body weight.
1.2 animal used as test: the healthy male mice in kunming of cleaning level, body weight 18-22g, the Jiangxi College of Traditional Chinese Medicine Experimental Animal Center provides, credit number: SCXK (Jiangxi) 2006-0001.Animal feeding is in Jiangxi College of Traditional Chinese Medicine animal housing, environmental permit: SYXK (Jiangxi) 2004-0001,21～23 ℃ of feeding environment temperature, relative humidity 50～60%.
1.3 experimental technique
1.3.1 animal grouping: totally 150 of mouse, be divided into three batches and experimentize, every batch is divided into 5 groups at random, 10 every group.Test a collection of anti-anoxic experiment of normal pressure of carrying out; Test two batches and carry out natrium nitrosum moderate survival experiment; Test three batches and carry out the experiment of acute cerebral ischemia anoxic.
1.3.2 dosage design: be subjected to everyone recommended intake every day of reagent Chinese medicine composition I oral liquid to be: the 200mL/60kg body weight, the total raw medicinal herbs of 120g is mixed with 1000mL Chinese medicine composition I oral liquid, everyone is at recommended intake every day: 24g crude drug/60kg body weight, extrapolating mouse intake every day thus is: low dose group, 2.0g crude drug/kg body weight; Middle dosage group, 4.0g crude drug/kg body weight; High dose group, 12g crude drug/kg body weight is equivalent to 5,10 and 30 times of people's intake every day respectively.Sample is mixed with respective concentration with distilled water, and (the filling gastric juice of 0.0175g dry powder/mL, 0.0350g dry powder/mL, 0.1050g dry powder/mL) experimentizes, and the mouse stomach amount is pressed the 0.1mL/10g body weight and calculated.Everyone recommended intake every day of Chinese medicine composition II is: 24g crude drug/60kg body weight, the dosage that is scaled mouse is 4.0g crude drug/kg body weight (be equivalent to people's intake every day 10 times), sample is mixed with 0.0365g dry powder/mL filling gastric juice with distilled water experimentizes, irritate the stomach amount and press the calculating of 0.1mL/10g body weight.Irritate stomach once a day and give, weigh in weekly and adjust to irritate the stomach amount, the continuous irrigation stomach is surveyed every index after 45 days, establish a blank group simultaneously, irritates body of stomach every day and amasss and respectively tried the identical distilled water of thing group.Experimental session animal ad lib, drinking-water.
1.3.3 the anti-anoxic experiment of normal pressure: irritate stomach after 45 days, after last is irritated stomach 1 hour, each group mouse is put into the 250mL port grinding bottle (1 every bottle) that fills the 5g soda lime respectively, seal bottleneck with vaseline, cover completely, make it air tight, immediately timing, with the breath stopped is index, observes mouse because of the dead time of anoxic.
1.3.4 natrium nitrosum moderate survival experiment: after last is irritated stomach 1 hour, each organized mouse by 240mg/kg lumbar injection natrium nitrosum (injection volume is 0.1mL/10g), timing immediately, record animals survived time.
1.3.5 acute cerebral ischemia anoxic experiment: after last is irritated stomach 1 hour, each treated animal (under the ether light anaesthesia) from neck by broken end only, immediately by behind the stopwatch record mouse broken end to the dwell time of breathing of dehiscing.
1.4 key instrument and reagent: 250mL port grinding bottle, stopwatch, 1mL syringe, scissors.Vaseline, soda lime, natrium nitrosum.
1.5 statistical method: all results are with mean
Standard deviation is represented, adopts SPSS15.0 software to carry out one-way analysis of variance, relatively the difference of each experimental group and control group.
1.6 judgment basis as a result: " health food check and assessment technique standard " (2003 editions) regulation: the anti-anoxic experiment of normal pressure, natrium nitrosum are poisoned and are appointed the binomial experimental result positive in survival experiment, three experiments of acute cerebral ischemia anoxic experiment, and this given the test agent of decidable has the effect of the anoxia tolerant function of raising.
2 results
2.1 Chinese medicine composition I oral liquid is to the influence of mouse normal pressure hypoxia endurance time
Experimental result sees Table 1.Chinese medicine composition I oral liquid basic, normal, high dosage group mouse and Chinese medicine composition II group mouse normal pressure hypoxia endurance time all obviously are longer than the blank group, and the middle and high dosage group of Chinese medicine composition I oral liquid mouse normal pressure hypoxia endurance time all obviously is longer than Chinese medicine composition II control group.
Table 1 Chinese medicine composition I oral liquid to the influence of mouse normal pressure hypoxia endurance time (
)
Compare * P＜0.05, * * P＜0.01 with the blank group; Compare with Chinese medicine composition II group,
▲P＜0.05,
▲ ▲P＜0.01.
2.2 Chinese medicine composition I oral liquid is to the influence of moderate time-to-live of mouse natrium nitrosum
Experimental result sees Table 2.The middle and high dosage group of Chinese medicine composition I oral liquid, the Chinese medicine composition II control group mice natrium nitrosum moderate time-to-live all obviously is longer than the blank group, and the middle and high dosage group of the Chinese medicine composition I oral liquid mouse natrium nitrosum moderate time-to-live all obviously is longer than Chinese medicine composition II control group.
Table 2 Chinese medicine composition I oral liquid to the influence of moderate time-to-live of mouse natrium nitrosum (
)
Compare * P＜0.05, * * P＜0.01 with the blank group; Compare with Chinese medicine composition II group,
▲P＜0.05,
▲ ▲P＜0.01.
2.3 Chinese medicine composition I oral liquid is to the influence of anoxic time-to-live of chmice acute cerebral ischemia
Experimental result sees Table 3.Middle and high dosage group of Chinese medicine composition I oral liquid and Chinese medicine composition II group mouse brain ischemic anoxia time-to-live all obviously are longer than the blank group, and the middle and high dosage group of the Chinese medicine composition I oral liquid mouse brain ischemic anoxia time-to-live all obviously is longer than Chinese medicine composition II control group.
Table 3 Chinese medicine composition I oral liquid to the influence of mouse brain ischemic anoxia time-to-live (
)
Compare * P＜0.05, * * P＜0.01 with the blank group; Compare with Chinese medicine composition II group,
▲P＜0.05,
▲ ▲P＜0.01.
3. brief summary
Recommend daily intaking amount 24g crude drug/60kg body weight to enlarge 5,10 and 30 times according to Chinese medicine composition I oral liquid composite powder crowd basic, normal, high three dosage groups are set, be 2.0g crude drug, 4.0g crude drug, 12.0g crude drug/kg body weight, other establishes blank group, Chinese medicine composition II control group.Adopt cleaning level healthy male mice continuous irrigation stomach to be tried thing, detect index of correlation after 45 days.Experimental result is judged as difference with P＜0.05 and has conspicuousness.Show through animal experiment study: the basic, normal, high dosage group of Chinese medicine composition I oral liquid mouse normal pressure hypoxia endurance time obviously is longer than the blank group.The middle and high dosage group of Chinese medicine composition I oral liquid mouse natrium nitrosum moderate time-to-live, cerebral ischemia anoxic time-to-live obviously are longer than the blank group.The middle and high dosage group of Chinese medicine composition I oral liquid mouse normal pressure hypoxia endurance time, natrium nitrosum moderate time-to-live, cerebral ischemia anoxic time-to-live obviously are longer than Chinese medicine composition II control group, think that Chinese medicine composition I oral liquid has the health care that improves anoxia endurance, and its raising anoxic tolerance function is better than Chinese medicine composition II group.
Embodiment 2
1 material and method
1.1 sample: being tried thing is that composition I I composite powder (American Ginseng, glossy ganoderma, Cordyceps sinensis, rose) is provided by Jiangzhong Pharmaceutical Co., Ltd., 1g composite powder dry powder is equivalent to total raw medicinal herbs 12.19g, and everyone is at recommended intake every day: 24g crude drug/60kg body weight.Tester is that composition I composite powder (American Ginseng, glossy ganoderma, cordyceps, rose) is provided by Jiangzhong Pharmaceutical Co., Ltd., and 1g composite powder dry powder is equivalent to total raw medicinal herbs 12.56g, and everyone is at recommended intake every day: 24g crude drug/60kg body weight.
1.2 animal used as test: the healthy male mice in kunming of cleaning level, body weight 18-22g, the Jiangxi College of Traditional Chinese Medicine Experimental Animal Center provides, credit number: SCXK (Jiangxi) 2006-0001.Animal feeding is in Jiangxi College of Traditional Chinese Medicine animal housing, environmental permit: SYXK (Jiangxi) 2004-0001,21～23 ℃ of feeding environment temperature, relative humidity 50～60%.
1.3 experimental technique
1.3.1 animal grouping: totally 150 of mouse, be divided into three batches and experimentize, every batch is divided into 5 groups at random, 10 every group.Test a collection of anti-anoxic experiment of normal pressure of carrying out; Test two batches and carry out natrium nitrosum moderate survival experiment; Test three batches and carry out the experiment of acute cerebral ischemia anoxic.
1.3.2 dosage design: be subjected to everyone recommended intake every day of reagent composition I I composite powder to be: the 200mL/60kg body weight, the total raw medicinal herbs of 120g is mixed with 1000mL composition I I, everyone is at recommended intake every day: 24g crude drug/60kg body weight, extrapolating mouse intake every day thus is: low dose group, 2.0g crude drug/kg body weight; Middle dosage group, 4.0g crude drug/kg body weight; High dose group, 12g crude drug/kg body weight is equivalent to 5,10 and 30 times of people's intake every day respectively.Sample is mixed with respective concentration with distilled water, and (the filling gastric juice of 0.0164g dry powder/mL, 0.0328g dry powder/mL, 0.0984g dry powder/mL) experimentizes, and the mouse stomach amount is pressed the 0.1mL/10g body weight and calculated.Everyone recommended intake every day of composition I is: 24g crude drug/60kg body weight, the dosage that is scaled mouse is 4.0g crude drug/kg body weight (be equivalent to people's intake every day 10 times), sample is mixed with 0.0318g dry powder/mL filling gastric juice with distilled water experimentizes, irritate the stomach amount and press the calculating of 0.1mL/10g body weight.Irritate stomach once a day and give, weigh in weekly and adjust to irritate the stomach amount, the continuous irrigation stomach is surveyed every index after 45 days, establish a blank group simultaneously, irritates body of stomach every day and amasss and respectively tried the identical distilled water of thing group.Experimental session animal ad lib, drinking-water.
1.3.3 the anti-anoxic experiment of normal pressure: irritate stomach after 45 days, after last is irritated stomach 1 hour, each group mouse is put into the 250mL port grinding bottle (1 every bottle) that fills the 5g soda lime respectively, seal bottleneck with vaseline, cover completely, make it air tight, immediately timing, with the breath stopped is index, observes mouse because of the dead time of anoxic.
1.3.4 natrium nitrosum moderate survival experiment: after last is irritated stomach 1 hour, each organized mouse by 240mg/kg lumbar injection natrium nitrosum (injection volume is 0.1mL/10g), timing immediately, record animals survived time.
1.3.5 acute cerebral ischemia anoxic experiment: after last is irritated stomach 1 hour, each treated animal (under the ether light anaesthesia) from neck by broken end only, immediately by behind the stopwatch record mouse broken end to the dwell time of breathing of dehiscing.
1.4 key instrument and reagent: 250mL port grinding bottle, stopwatch, 1mL syringe, scissors.Vaseline, soda lime, natrium nitrosum.
1.5 statistical method: all results are with mean
Standard deviation is represented, adopts SPSS15.0 software to carry out one-way analysis of variance, relatively the difference of each experimental group and control group.
1.6 judgment basis as a result: " health food check and assessment technique standard " (2003 editions) regulation: the anti-anoxic experiment of normal pressure, natrium nitrosum are poisoned and are appointed the binomial experimental result positive in survival experiment, three experiments of acute cerebral ischemia anoxic experiment, and this given the test agent of decidable has the effect of the anoxia tolerant function of raising.
2 results
2.1 composition I I is to the influence of mouse normal pressure hypoxia endurance time
Experimental result sees Table 1.Composition I I basic, normal, high dosage group mouse and composition I group mouse normal pressure hypoxia endurance time all obviously are longer than the blank group, and the middle and high dosage group of composition I I mouse normal pressure hypoxia endurance time all obviously is longer than the composition I control group.
Table 1 composition I I to the influence of mouse normal pressure hypoxia endurance time (
)
Compare * P＜0.05, * * P＜0.01 with the blank group; Compare with the composition I group,
▲P＜0.05,
▲ ▲P＜0.01.
2.2 composition I I is to the influence of moderate time-to-live of mouse natrium nitrosum
Experimental result sees Table 2.The middle and high dosage group of composition I I, the composition I control group mice natrium nitrosum moderate time-to-live all obviously is longer than the blank group, and the middle and high dosage group of the composition I I mouse natrium nitrosum moderate time-to-live all obviously is longer than the composition I control group.
Table 2 composition I I to the influence of moderate time-to-live of mouse natrium nitrosum (
)
Compare * P＜0.05, * * P＜0.01 with the blank group; Compare with the composition I group,
▲P＜0.05,
▲ ▲P＜0.01.
2.3 composition I I is to the influence of anoxic time-to-live of chmice acute cerebral ischemia
Experimental result sees Table 3.Middle and high dosage group of composition I I and composition I group mouse brain ischemic anoxia time-to-live all obviously are longer than the blank group, and the middle and high dosage group of the composition I I mouse brain ischemic anoxia time-to-live all obviously is longer than the composition I control group.
Table 3 composition I I to the influence of mouse brain ischemic anoxia time-to-live (
)
Compare * P＜0.05, * * P＜0.01 with the blank group; Compare with the composition I group,
▲P＜0.05,
▲ ▲P＜0.01.
3. brief summary
Recommend daily intaking amount 24g crude drug/60kg body weight to enlarge 5,10 and 30 times according to composition I I composite powder crowd basic, normal, high three dosage groups are set, be 2.0g crude drug, 4.0g crude drug, 12.0g crude drug/kg body weight, other establishes blank group, composition I control group.Adopt cleaning level healthy male mice continuous irrigation stomach to be tried thing, detect index of correlation after 45 days.Experimental result is judged as difference with P＜0.05 and has conspicuousness.Show through animal experiment study: the basic, normal, high dosage group of composition I I mouse normal pressure hypoxia endurance time obviously is longer than the blank group.The middle and high dosage group of composition I I mouse natrium nitrosum moderate time-to-live, cerebral ischemia anoxic time-to-live obviously are longer than the blank group.The middle and high dosage group of composition I I mouse normal pressure hypoxia endurance time, natrium nitrosum moderate time-to-live, cerebral ischemia anoxic time-to-live obviously are longer than the composition I control group, think that composition I I has the health care that improves anoxia endurance, and its raising anoxic tolerance function is better than the composition I group.
Embodiment 3
Embodiment 3
Get American Ginseng 350g, glossy ganoderma 400g, fermentation cordyceps Paecilomyces hepiali chen Paecilongces hepialli Chen et Dai, sp.nov 200g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrate is put the high speed centrifugation removal of impurities of cold back, add oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 4
Get American Ginseng 150g, glossy ganoderma 400g, fermentation cordyceps China is by hair spore Hirsutsua sinensis Liu, Guo, Yu et Zeng, sp.nov 150g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrate is put the high speed centrifugation removal of impurities of cold back, add oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 5
Get American Ginseng 350g, glossy ganoderma 250g, fermentation cordyceps (aweto-cephalosporin Cephalosporium sinensis Chen sp.nov) 300g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four the flavor soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 6
Get American Ginseng 250g, glossy ganoderma 300g, (the bat moth is by spore enzyme Mortiscrslla hepialid C.T.﹠amp for fermentation cordyceps; B.liu) 100g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrate is put the high speed centrifugation removal of impurities of cold back, add oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
RealExecute example 7
Get American Ginseng 450g, glossy ganoderma 100g, fermentation cordyceps (Chinese Paecilomyces varioti Paecilomyces sinensis Chen, Xiao et Shi, sp.nov) 100g, the section of American Ginseng, glossy ganoderma, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 8
Get American Ginseng 100g, glossy ganoderma 100g, fermentation cordyceps (the curved mould Tolypocladium sinensis of the neck C.lan Li of China) 500g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four the flavor soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 9
Get American Ginseng 300g, glossy ganoderma 400g, fermentation cordyceps (Hirsutella hepiali Chen et Shen Hirsutella hepialid Chen et Shen) 250g, rose 350g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four the flavor soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 10
Get American Ginseng 200g, glossy ganoderma 450g, fermentation cordyceps (the mould genus of spore fungi Mortierella SP) 150g, rose 200g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four the flavor soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 11
Get American Ginseng 400g, glossy ganoderma 250g, fermentation cordyceps (Gliocladiumroseum Gliocladium roseum (link) Thom) 250g, rose 120g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four the flavor soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 12
Get American Ginseng 100g, glossy ganoderma 100g, fermentation cordyceps (the mould genus of spore fungi Mortierella SP) 100g, rose 100g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four the flavor soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrate is put the high speed centrifugation removal of impurities of cold back, add oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 13
Get American Ginseng 100g, glossy ganoderma 200g, fermentation cordyceps (Chinese synnema spore Synnematium sinensis Yin ﹠amp; Shen) 300g, rose 100g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrate is put the high speed centrifugation removal of impurities of cold back, add oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 14
Get American Ginseng 100g, glossy ganoderma 300g, fermentation cordyceps (aweto-cephalosporin Cephalosporium sinensis Chen sp.nov) 200g, rose 200g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four the flavor soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 15
Get American Ginseng 100g, glossy ganoderma 300g, fermentation cordyceps (Hirsutella hepiali Chen et Shen Hirsutella hepialid Chen et Shen) 200g, rose 200g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four the flavor soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 16
Get American Ginseng 200g, glossy ganoderma 300g, fermentation cordyceps (the mould genus of spore fungi Mortierella SP) 200g, rose 200g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four the flavor soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 17
Get American Ginseng 200g, glossy ganoderma 400g, fermentation cordyceps 200g, rose 200g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 18
Get American Ginseng 200g, glossy ganoderma 500g, fermentation cordyceps 200g, rose 200g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 19
Get American Ginseng 300g, glossy ganoderma 400g, fermentation cordyceps 200g, rose 200g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 20
Get American Ginseng 100g, glossy ganoderma 300g, fermentation cordyceps 500g, rose 200g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 21
Get American Ginseng 400g, glossy ganoderma 300g, fermentation cordyceps 200g, rose 200g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 22
Get American Ginseng 400g, glossy ganoderma 400g, fermentation cordyceps 200g, rose 100g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 23
Get American Ginseng 300g, glossy ganoderma 100g, fermentation cordyceps 200g, rose 200g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 24
Get American Ginseng 300g, glossy ganoderma 300g, fermentation cordyceps 300g, rose 200g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 25
Get American Ginseng 500g, glossy ganoderma 300g, fermentation cordyceps 200g, rose 200g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 26
Get American Ginseng 500g, glossy ganoderma 500g, fermentation cordyceps 500g, rose 500g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 27
Get American Ginseng 500g, glossy ganoderma 100g, fermentation cordyceps 200g, rose 500g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 28
Get American Ginseng 300g, glossy ganoderma 400g, fermentation cordyceps 200g, rose 300g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, and decompression is condensed into cream clearly, spraying drying powder-forming is made composite powder.
Embodiment 29
Get American Ginseng 300g, glossy ganoderma 400g, fermentation cordyceps 200g, rose 300g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four the flavor soaked 1 hour, heating decocts 3 times, and 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, decompression is condensed into cream or spraying drying powder-forming, add tablet auxiliary material commonly used, mix, make various tablets by the tablet common process.
Embodiment 30
Get American Ginseng 300g, glossy ganoderma 400g, fermentation cordyceps 200g, rose 300g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four the flavor soaked 1 hour, heating decocts 3 times, and 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, decompression is condensed into cream or spraying drying powder-forming, add granule auxiliary material commonly used, mix, make granule by the granule common process.
Embodiment 31
Get American Ginseng 300g, glossy ganoderma 400g, fermentation cordyceps 200g, rose 300g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four the flavor soaked 1 hour, heating decocts 3 times, and 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, decompression is condensed into cream or spraying drying powder-forming, add pill auxiliary material commonly used, mix, make various pills by the pill common process.
Embodiment 32
Get American Ginseng 300g, glossy ganoderma 400g, fermentation cordyceps 200g, rose 300g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds syrup auxiliary material commonly used, mix, make syrup by the syrup common process.
Embodiment 33
Get American Ginseng 300g, glossy ganoderma 400g, fermentation cordyceps 200g, rose 300g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four the flavor soaked 1 hour, heating decocts 3 times, and 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, decompression is condensed into cream or spraying drying powder-forming, add capsule auxiliary material commonly used, mix, make capsule by the capsule common process.
Get American Ginseng 300g, glossy ganoderma 400g, fermentation cordyceps (Paecilomyces hepiali chen Paecilongces hepialli Chen et Dai, sp.nov) 200g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than three flavors soaked 0.5 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrate is put the high speed centrifugation removal of impurities of cold back, add oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 34
Get genseng 150g, glossy ganoderma 400g, (China is by hair spore Hirsutsua sinensis Liu for fermentation cordyceps, Guo, Yu et Zeng, sp.nov) 150g, American Ginseng, the glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 0.5 hour, heating decocts 3 times, 10 times of water gagings for the first time, extracted 2 hours, and each 1 hour later on, added 8 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 35
Get American Ginseng 300g, glossy ganoderma 400g, Cordyceps sinensis 6.7g and/or fermentation cordyceps (aweto-cephalosporin Cephalosporium sinensis Chen sp.nov) 300g, American Ginseng, the glossy ganoderma section, fermentation cordyceps places cloth bag, more than four the flavor soaked 0.5 hour, heating decocts 3 times, 15 times of water gagings for the first time, extracted 2 hours, and each 1 hour later on, added 8 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
RealExecute example 36
American Ginseng 300g, glossy ganoderma 400g, (the bat moth is by spore enzyme Mortiscrslla hepialid C.T.﹠amp for fermentation cordyceps; B.liu) 200g, rose 300g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1.2 hours later on, add 5 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrate is put the high speed centrifugation removal of impurities of cold back, add oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 37
Get American Ginseng 100g, glossy ganoderma 100g, fermentation cordyceps (Chinese Paecilomyces varioti Paecilomyces sinensis Chen, Xiao et Shi, sp.nov) 3g, rose 10g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 4 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 38
Get American Ginseng and/or genseng 100g, glossy ganoderma 250g, fermentation cordyceps (the curved mould Tolypocladium sinensis of the neck C.lan Li of China) 250g, rose 120g, American Ginseng, the glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavor or the five tastes, soaked 0.5 hour, heating decocts 3 times, 15 times of water gagings for the first time, extracted 2 hours, and each 1 hour later on, added 9 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 39
Get American Ginseng 10g, glossy ganoderma 20g, (China is by hair spore Hirsutsua sinensis Liu for fermentation cordyceps, Guo, Yu et Zeng, sp.nov) 3g, Cordyceps sinensis 3 g, rose 10g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1.5 hours, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 40
Get Radix Astragali 200g and/or Radix Codonopsis 160g, glossy ganoderma 300g, fermentation cordyceps (Hirsutella hepiali Chen et Shen Hirsutella hepialid Chen et Shen) 200g, rose 200g, American Ginseng, the glossy ganoderma section, fermentation cordyceps places cloth bag, more than three the flavor soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 5 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 41
Get American Ginseng 200g, glossy ganoderma 300g, fermentation cordyceps (the mould genus of spore fungi Mortierella SP) 200g, rose 200g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four the flavor soaked 0.5 hour, heating decocts 3 times, and 15 times of water gagings extracted 2 hours for the first time, each 1 hour later on, add 8 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrate is put the high speed centrifugation removal of impurities of cold back, add oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 42
Get Radix Astragali 400g, glossy ganoderma 350g, fermentation cordyceps 100g, rose 100g, the Radix Astragali, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1.4 hours later on, add 7 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 43
Get Radix Astragali 30g, glossy ganoderma 40g, fermentation cordyceps 20g, rose 30g, the Radix Astragali, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four flavors soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, and decompression is condensed into cream clearly, spraying drying powder-forming is made composite powder.
Embodiment 44
Get American Ginseng 300g, glossy ganoderma 400g, fermentation cordyceps 200g, rose 300g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four the flavor soaked 1 hour, heating decocts 3 times, and 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, decompression is condensed into cream or spraying drying powder-forming, add tablet auxiliary material commonly used, mix, make various tablets by the tablet common process.
Embodiment 45
Get American Ginseng 300g, glossy ganoderma 400g, fermentation cordyceps 200g, rose 300g, American Ginseng, glossy ganoderma section, fermentation cordyceps places cloth bag, more than four the flavor soaked 1 hour, heating decocts 3 times, and 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, decompression is condensed into cream or spraying drying powder-forming, add capsule auxiliary material commonly used, mix, make capsule by the capsule common process.
Embodiment 46
Get folium panacis japonici cum caule 250g, glossy ganoderma 300g, Cordyceps sinensis 80g, folium panacis japonici cum caule, glossy ganoderma section, Cordyceps sinensis is played cloth bag packing behind the powder, and all medicinal materials were soaked 1 hour, and heating decocts 3 times, 2 hours for the first time, each 1.5 hours later on, add 15 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 47
Get red ginseng 300g, glossy ganoderma 400g, Cordyceps sinensis 67g, cordyceps (Paecilomyces hepiali chen Paecilongces hepialli Chen et Dai, sp.nov) 200g, American Ginseng, glossy ganoderma section, Cordyceps sinensis are beaten behind the powder and the packing of cordyceps cloth bag, all medicinal materials were soaked 0.5 hour, heating decocts 2 times, and 15 times of water gagings extracted 2 hours for the first time, 1 hour for the second time, add 13 times of amounts of water, merge 2 times extracting liquid filtering, filtrate is concentrated in right amount, concentrate is put the high speed centrifugation removal of impurities of cold back, add oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 48
Get American Ginseng 450g, glossy ganoderma 200g, Cordyceps sinensis 90g, (China is by hair spore Hirsutsua sinensis Liu, Guo, Yu et Zeng for cordyceps, sp.nov) 600g, American Ginseng, glossy ganoderma section, Cordyceps sinensis are beaten behind the powder and the packing of cordyceps cloth bag, and all medicinal materials were soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of water gagings at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 49
Get genseng 100g, glossy ganoderma 800g, Cordyceps sinensis 30g, cordyceps (Gliocladiumroseum Gliocladium roseum (link) Thom) 300g, genseng, glossy ganoderma section, Cordyceps sinensis is beaten behind the powder and the packing of cordyceps cloth bag, all medicinal materials were soaked 1 hour, and heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrate is put the high speed centrifugation removal of impurities of cold back, add oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 50
Get American Ginseng 250g, glossy ganoderma 300g, Cordyceps sinensis 80g, cordyceps (the mould genus of spore fungi Mortierella SP) 900g, American Ginseng, glossy ganoderma section, Cordyceps sinensis is beaten behind the powder and the packing of cordyceps cloth bag, all medicinal materials were soaked 1 hour, and heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrate is put the high speed centrifugation removal of impurities of cold back, add oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 51
Get genseng 300g and/or Radix Codonopsis 300g, glossy ganoderma 400g, Cordyceps sinensis 20g, fermentation cordyceps (aweto-cephalosporin Cephalosporium sinensis Chen sp.nov) 33g, genseng, the glossy ganoderma section, Cordyceps sinensis is beaten behind the powder and the packing of cordyceps cloth bag, all medicinal materials were soaked 1 hour, and heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrate is put the high speed centrifugation removal of impurities of cold back, add oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 52
Get American Ginseng 100g, glossy ganoderma 200g, Cordyceps sinensis 30g, fermentation cordyceps cordyceps (the mould genus of spore fungi Mortierella SP) 30g, / and rose 100g, American Ginseng, glossy ganoderma section, Cordyceps sinensis are beaten behind the powder and the packing of cordyceps cloth bag, and all medicinal materials were soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of water gagings at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 53
Get genseng 900g, glossy ganoderma 900g, Cordyceps sinensis 900g, (China is by hair spore Hirsutsua sinensis Liu, Guo, Yu et Zeng for fermentation cordyceps, sp.nov) 900g/ and rose 600g, genseng, glossy ganoderma section, Cordyceps sinensis are beaten behind the powder and the packing of cordyceps cloth bag, and all medicinal materials were soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 54
Get American Ginseng 1500g and/or Radix Astragali 2000g, glossy ganoderma 1600g, Cordyceps sinensis 1200g, cordyceps (Paecilomyces hepiali chen Paecilongces hepialli Chen et Dai, sp.nov) 900g/and rose 900g, the American Ginseng and/or the Radix Astragali, glossy ganoderma section, Cordyceps sinensis are beaten behind the powder and the packing of cordyceps cloth bag, and all medicinal materials were soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Embodiment 55
Get American Ginseng 50g, glossy ganoderma 50g, Cordyceps sinensis 10g and/or fermentation cordyceps (Paecilomyces hepiali chen Paecilongces hepialli Chen et Dai, sp.nov) 10g, rose 50g, American Ginseng, the glossy ganoderma section, Cordyceps sinensis is pulverized and is placed in the cloth bag, and all medicinal materials were soaked 0.5 hour, heating decocts 2 times, 15 times of water gagings extracted 2 hours for the first time, 1 hour for the second time, add 13 times of amounts of water, merge 2 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, decompression is condensed into cream or spraying drying powder-forming, add pill auxiliary material commonly used, mix, make various pills by the pill common process.
Embodiment 56
Get American Ginseng 300g, glossy ganoderma 400g, Cordyceps sinensis 67g, fermentation cordyceps (Hirsutella hepiali Chen et Shen Hirsutella hepialid Chen et Shen) 200g, rose 300g, American Ginseng, the glossy ganoderma section, Cordyceps sinensis is pulverized the back and is placed cloth bag with cordyceps, above medicinal material was soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, and decompression is condensed into cream clearly, spraying drying powder-forming is made composite powder.
Embodiment 57
Get American Ginseng 300g, glossy ganoderma 300g, Cordyceps sinensis 67g and/or fermentation cordyceps (Paecilomyces hepiali chen Paecilongces hepialli Chen et Dai, sp.nov) 200g, rose 300g, American Ginseng, the glossy ganoderma section, Cordyceps sinensis is pulverized the back and/or is placed cloth bag with cordyceps, above medicinal material was soaked 1 hour, heating decocts 3 times, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge 3 times extracting liquid filtering, filtrate is concentrated in right amount, concentrate is put the high speed centrifugation removal of impurities of cold back, and decompression is condensed into cream or spraying drying powder-forming, adds granule auxiliary material commonly used, mix, make granule by the granule common process.
Embodiment 58
Get American Ginseng 300g, glossy ganoderma 400g, Cordyceps sinensis 67g, fermentation cordyceps (Chinese synnema spore Synnematium sinensis Yin ﹠amp; Shen) 200g, rose 300g, American Ginseng, glossy ganoderma section, Cordyceps sinensis is pulverized the back and/or is placed cloth bag with cordyceps, adding ethanol or methanol eddy extracts 1-2 time, each 1-2 hour, merge extract then, obtain alcohol extract behind recovery ethanol or the methyl alcohol; The dregs of a decoction add the water heating again and decoct 1～3 time, and each 1～2 hour, merge alcohol extract and aqueous extract, to filter, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, and is standby.Above medicinal material was soaked 1 hour, heating decocts 3 times, and 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merge alcohol extract and aqueous extract and filter, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, decompression is condensed into cream or spraying drying powder-forming, add capsule auxiliary material commonly used, mix, make capsule by the capsule common process.
Embodiment 59
Get American Ginseng 300g, glossy ganoderma 400g, Cordyceps sinensis 67g, American Ginseng, glossy ganoderma are cut into slices, and Cordyceps sinensis is pulverized and is placed in the cloth bag, and add alcohol reflux and extract 1-2 time, each 1-2 hour, merge extract then, obtain alcohol extract behind the recovery ethanol; The dregs of a decoction add the water heating again and decoct 1～3 time, and each 1～2 hour, merge alcohol extract and aqueous extract, to filter, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, and is standby.Above medicinal material was soaked 1.5 hours, heating decocts 1 time, 2 hours for the first time, each 1 hour later on, add 10 times of amounts of water at every turn, merging alcohol extract and aqueous extract filters, filtrate is concentrated in right amount, and concentrate is put the high speed centrifugation removal of impurities of cold back, adds oral liquid auxiliary material commonly used, mix, make the 20000ml oral liquid by the oral liquid common process.
Claims (7)
1. contain the raw material American Ginseng of following weight parts and/or 5～150 parts of gensengs, 1 ~ 120 part of Cordyceps sinensis and/or 1～90 part of fermentation cordyceps, 5～160 parts of glossy ganodermas, perhaps make pharmaceutical composition that active ingredient and pharmaceutically acceptable additives form and improve application in anoxia endurance health food and the medicine in preparation by the water of above-mentioned raw materials and/or alcohol extract.
2. contain 3 ~ 90 parts of the raw material genseng of following weight parts and/or 10～90 parts of American Ginsengs, 20～90 parts of glossy ganodermas, 3～60 parts of fermentation cordyceps and/or Cordyceps sinensis, perhaps make pharmaceutical composition that active ingredient and pharmaceutically acceptable additives form and improve application in anoxia endurance health food and the medicine in preparation by the water of above-mentioned raw materials and/or alcohol extract.
3. contain 6.7 parts of the raw material genseng of following weight parts and/or 30 parts of American Ginsengs, 40 parts of glossy ganodermas, 20 parts of fermentation cordyceps and/or Cordyceps sinensis, perhaps make pharmaceutical composition that active ingredient and pharmaceutically acceptable additives form and improve application in anoxia endurance health food and the medicine in preparation by the water of above-mentioned raw materials and/or alcohol extract.
4. contain the raw material American Ginseng of following weight parts and/or 5～150 parts of gensengs, 1 ~ 120 part of Cordyceps sinensis and/or 1～90 part of fermentation cordyceps, 5～160 parts of glossy ganodermas, 5～90 parts of roses, perhaps make pharmaceutical composition that active ingredient and pharmaceutically acceptable additives form and improve application in anoxia endurance health food and the medicine in preparation by the water of above-mentioned raw materials and/or alcohol extract.
5. contain the raw material genseng of following weight parts and/or 10～90 parts of American Ginsengs, 20～90 parts of glossy ganodermas, 3～60 parts of fermentation cordyceps and/or 3 ~ 90 parts of Cordyceps sinensis, 10～60 parts of roses, perhaps make pharmaceutical composition that active ingredient and pharmaceutically acceptable additives form and improve application in anoxia endurance health food and the medicine in preparation by the water of above-mentioned raw materials and/or alcohol extract.
6. contain the raw material genseng of following weight parts and/or 30 parts of American Ginsengs, 40 parts of glossy ganodermas, 20 parts of fermentation cordyceps and/or 6.7 parts of Cordyceps sinensis, 30 parts of roses, perhaps make pharmaceutical composition that active ingredient and pharmaceutically acceptable additives form and improve application in anoxia endurance health food and the medicine in preparation by the water of above-mentioned raw materials and/or alcohol extract.
7. according to the arbitrary described Chinese medicine composition of claim 1-6, it is characterized in that: also can add any or combination arbitrarily in 5～150 parts of 3～300 parts of the radix pseudostellariaes, 1～120 part of folium panacis japonici cum caule, 3～160 parts of Radix Codonopsis, 3～200 parts of the Radixs Astragali, the seed of Chinese dodder.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102088672A CN102228252A (en) | 2010-09-17 | 2010-09-17 | Application of Chinese medicinal composition in preparation of healthcare foods and medicines for improving hypoxia tolerance |
| JP2013528508A JP5946457B2 (en) | 2010-09-17 | 2011-09-16 | Application of herbal medicine composition to the preparation of health foods and medicines for the relief and prevention treatment of physical fatigue |
| US13/824,375 US8986750B2 (en) | 2010-09-17 | 2011-09-16 | Use of a traditional chinese medicine composition for manufacturing a health food or medicament for preventing and alleviating physical fatigue |
| PCT/CN2011/079731 WO2012034534A1 (en) | 2010-09-17 | 2011-09-16 | Use of the traditional chinese medicine composition for manufacturing a health food or medicament for preventing and alleviating physical fatigue |
| JP2016083531A JP6305457B2 (en) | 2010-09-17 | 2016-04-19 | Application of herbal medicine composition to the preparation of health foods and medicines for the relief and prevention treatment of physical fatigue |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102088672A CN102228252A (en) | 2010-09-17 | 2010-09-17 | Application of Chinese medicinal composition in preparation of healthcare foods and medicines for improving hypoxia tolerance |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010102850820A Division CN101999663A (en) | 2010-09-17 | 2010-09-17 | Application of traditional Chinese medicine combination in preparing healthcare food and medicine capable of releasing physical fatigue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102228252A true CN102228252A (en) | 2011-11-02 |
Family
ID=44840888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011102088672A Pending CN102228252A (en) | 2010-09-17 | 2010-09-17 | Application of Chinese medicinal composition in preparation of healthcare foods and medicines for improving hypoxia tolerance |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102228252A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013177948A1 (en) | 2012-05-29 | 2013-12-05 | 江中药业股份有限公司 | Application of composition in preparing health care product or medicine for preventing and treating leukopenia caused by radiotherapy and chemotherapy |
| WO2013177944A1 (en) | 2012-05-29 | 2013-12-05 | 江中药业股份有限公司 | Use of composition in preparing health care products or medicines for preventing and treating allergic diseases |
| WO2014040396A1 (en) * | 2012-09-13 | 2014-03-20 | 江中药业股份有限公司 | Traditional chinese medicine combination for regulating immune function and preparation method therefor |
| CN104042654A (en) * | 2013-03-12 | 2014-09-17 | 江中药业股份有限公司 | Application of composition in preparation of anti-HPV (human papillomavirus) health product or medicine or product |
| CN104257723A (en) * | 2014-09-29 | 2015-01-07 | 贵州茅台镇圣窖酒业股份有限公司 | Health wine containing antrodia camphorata and preparation method thereof |
| CN107446955A (en) * | 2017-08-25 | 2017-12-08 | 陕西省微生物研究所 | Pest-resistant soil conditioner and its production method using traditional Chinese medicine waste as matrix |
| CN113413424A (en) * | 2020-09-07 | 2021-09-21 | 深圳市桦健量子生物科技有限公司 | Preparation method and application of lucid ganoderma oral liquid |
-
2010
- 2010-09-17 CN CN2011102088672A patent/CN102228252A/en active Pending
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9744203B2 (en) | 2012-05-29 | 2017-08-29 | Jiangzhong Pharmaceutical Co., Ltd. | Application of composition in preparing health care product or medicine for preventing and treating leukopenia caused by radiotherapy and chemotherapy |
| WO2013177944A1 (en) | 2012-05-29 | 2013-12-05 | 江中药业股份有限公司 | Use of composition in preparing health care products or medicines for preventing and treating allergic diseases |
| CN103446201A (en) * | 2012-05-29 | 2013-12-18 | 江中药业股份有限公司 | Composition for prevention and treatment of allergic diseases and preparation method thereof |
| WO2013177948A1 (en) | 2012-05-29 | 2013-12-05 | 江中药业股份有限公司 | Application of composition in preparing health care product or medicine for preventing and treating leukopenia caused by radiotherapy and chemotherapy |
| US10086030B2 (en) | 2012-05-29 | 2018-10-02 | Jiangzhong Pharmaceutical Co., Ltd. | Use of composition in preparing health care products or medicines for preventing and treating allergic diseases |
| CN103446201B (en) * | 2012-05-29 | 2017-11-24 | 江中药业股份有限公司 | A kind of composition for preventing and treating anaphylactia and preparation method thereof |
| WO2014040396A1 (en) * | 2012-09-13 | 2014-03-20 | 江中药业股份有限公司 | Traditional chinese medicine combination for regulating immune function and preparation method therefor |
| US9775868B2 (en) | 2012-09-13 | 2017-10-03 | Jiangzhong Pharmaceutical Co., Ltd. | Traditional Chinese medicine combination for regulating immune function and preparation method therefor |
| US10537600B2 (en) | 2012-09-13 | 2020-01-21 | Jiangzhong Pharmaceuticals Co., Ltd. | Traditional Chinese medicine combination for regulating immune function and preparation method therefor |
| CN104042654A (en) * | 2013-03-12 | 2014-09-17 | 江中药业股份有限公司 | Application of composition in preparation of anti-HPV (human papillomavirus) health product or medicine or product |
| CN104257723A (en) * | 2014-09-29 | 2015-01-07 | 贵州茅台镇圣窖酒业股份有限公司 | Health wine containing antrodia camphorata and preparation method thereof |
| CN107446955A (en) * | 2017-08-25 | 2017-12-08 | 陕西省微生物研究所 | Pest-resistant soil conditioner and its production method using traditional Chinese medicine waste as matrix |
| CN113413424A (en) * | 2020-09-07 | 2021-09-21 | 深圳市桦健量子生物科技有限公司 | Preparation method and application of lucid ganoderma oral liquid |
| CN113413424B (en) * | 2020-09-07 | 2022-05-27 | 深圳市桦健量子生物科技有限公司 | Preparation method and application of lucid ganoderma oral liquid |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102406163B (en) | Application of traditional Chinese medicine composition in preparation of health food or medicament for preventing and relieving physical fatigue | |
| CN102274258A (en) | Traditional Chinese medicine composition for enhancing immune function of human bodies | |
| CN101292742B (en) | Health food for reinforcing immune function of human body and preparation technique thereof | |
| CN102274259A (en) | Traditional Chinese medicine composition for enhancing immune function of human bodies | |
| JP5946457B2 (en) | Application of herbal medicine composition to the preparation of health foods and medicines for the relief and prevention treatment of physical fatigue | |
| CN102228252A (en) | Application of Chinese medicinal composition in preparation of healthcare foods and medicines for improving hypoxia tolerance | |
| CN102145024B (en) | Fungal composition with effect of enhancing immunity and preparation method thereof | |
| CN1099992A (en) | Nourishing tea | |
| CN104435749B (en) | A kind of dendrobium candidum compound preparation and its preparation method and application | |
| CN111956753B (en) | Medicinal and edible traditional Chinese medicine composition as well as preparation method and application thereof | |
| CN104666892A (en) | Sealwort and ginseng formula for enhancing immunity and relieving fatigue and preparation method of formula | |
| CN105532998A (en) | Health-care tea containing cordyceps militaris and preparation method thereof | |
| CN101999663A (en) | Application of traditional Chinese medicine combination in preparing healthcare food and medicine capable of releasing physical fatigue | |
| CN103446206B (en) | Improve composition and its application of toxicity caused by Chemotherapy in Malignant Carcinoma Patients | |
| CN103960663A (en) | Health care food for enhancing immunologic function and preparation method of food | |
| CN105687480A (en) | Immunoregulatory traditional Chinese medicine composition and preparation | |
| US9861671B2 (en) | Composition for preventing and treating aids and preparation method thereof | |
| CN101954034B (en) | Chinese medicinal preparation for treating acquired immune deficiency syndrome and preparation method thereof | |
| CN104056054A (en) | Antioxidant and immunity-improving oral preparation and preparation method for same | |
| CN1144128A (en) | Pure traditional Chinese medicinal liquor with antisenile action | |
| CN106511915A (en) | Applications of compound traditional Chinese medicinal composition in preparing medicines for inhibiting skin melanoma lung metastasis | |
| US9744203B2 (en) | Application of composition in preparing health care product or medicine for preventing and treating leukopenia caused by radiotherapy and chemotherapy | |
| CN103230003B (en) | Health food with immunity boosting function and preparation method thereof | |
| CN110464796A (en) | It is a kind of for treating and/or preventing the Chinese medicine composition and its preparation method and application of hypoimmunity caused by chemicotherapy | |
| CN117085086B (en) | Qi and blood tonifying ferment and preparation process and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20111102 |