CN103416421A - Ternary active compound combinations - Google Patents

Ternary active compound combinations Download PDF

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Publication number
CN103416421A
CN103416421A CN2013103623512A CN201310362351A CN103416421A CN 103416421 A CN103416421 A CN 103416421A CN 2013103623512 A CN2013103623512 A CN 2013103623512A CN 201310362351 A CN201310362351 A CN 201310362351A CN 103416421 A CN103416421 A CN 103416421A
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plant
seed
compound
bond
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CN103416421B (en
Inventor
L·阿斯曼
D·施图布勒
U·威辰道福-诺伊曼
P·达门
H·亨格伯格
E·括普曼
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Bayer Intellectual Property GmbH
Bayer CropScience AG
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Bayer CropScience AG
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Priority claimed from EP07113347A external-priority patent/EP2018806A1/en
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01B—SOIL WORKING IN AGRICULTURE OR FORESTRY; PARTS, DETAILS, OR ACCESSORIES OF AGRICULTURAL MACHINES OR IMPLEMENTS, IN GENERAL
    • A01B79/00—Methods for working soil
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01C—PLANTING; SOWING; FERTILISING
    • A01C1/00—Apparatus, or methods of use thereof, for testing or treating seed, roots, or the like, prior to sowing or planting
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01C—PLANTING; SOWING; FERTILISING
    • A01C1/00—Apparatus, or methods of use thereof, for testing or treating seed, roots, or the like, prior to sowing or planting
    • A01C1/08—Immunising seed
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01G—HORTICULTURE; CULTIVATION OF VEGETABLES, FLOWERS, RICE, FRUIT, VINES, HOPS OR SEAWEED; FORESTRY; WATERING
    • A01G7/00—Botany in general
    • A01G7/06—Treatment of growing trees or plants, e.g. for preventing decay of wood, for tingeing flowers or wood, for prolonging the life of plants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/50—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids the nitrogen atom being doubly bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
    • A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
    • A01N41/10—Sulfones; Sulfoxides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/22—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom rings with more than six members
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles

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  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Soil Sciences (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Ecology (AREA)
  • Forests & Forestry (AREA)
  • Mechanical Engineering (AREA)
  • Botany (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Catching Or Destruction (AREA)

Abstract

The invention relates to active compound combinations, in particular within a fungicide or insecticide composition, which comprises (A) 3,4-dichloro-N-(2-cyanophenyl)-5-isothiazolecarboxamide and (B) imidacloprid and (C) one insecticidal or fungicidal active compound. Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi and/or microorganisms and/or pests of plants or crops, to the use of a combination according to the invention for the treatment of plant propagation, to a method for protecting a seed and not at least to the treated seed.

Description

Ternary active compound combinations
To be on July 15th, 2008 be called the dividing an application of No. 200880100589.5 applications for a patent for invention of " ternary active compound combinations " to the name that international office is submitted to, on January 27th, 2010 enters the China national stage to the application.
The present invention relates to active agent combinations (combination), the active agent combinations in bactericide or insecticides particularly, it comprises (A) 3, the chloro-N-of 4-bis-(2-cyano-phenyl)-5-isothiazole formamide (general isotianil by name (isotianil), Cas 224049-04-1) and (B) Imidacloprid (imidacloprid) and (C) a kind of desinsection or Fungicidal active compound.In addition; the invention still further relates to a kind of being used for the treatment of property or prophylactically prevent and treat the phytopathogen of plant or crop and/or the method for microorganism and/or insect; relate to the purposes of bond of the present invention for the treatment of plant propagation section, relate to a kind of method of protecting seed, and relate to treated seed.
Known (A) 3, the chloro-N-of 4-bis-(2-cyano-phenyl)-5-isothiazole formamide has sterilization and insecticidal properties.In addition, also find that Isothiazolcarboxylicacid acid derivatives is very suitable for the invasion and attack (US-A5240951 and JP-A06-009313) of protective plant antagonism undesirable plant pathogen and microorganism.Compound of the present invention (A) both had been suitable for transferring the defence of plant to undesirable plant pathogen and microbiological attack, also can be used as microbicide for directly preventing and treating phytopathogen and microorganism.In addition, compound (A) also has activity (WO99/24414) to the insect of infringement plant.
Compound (A) 3, the chloro-N-of 4-bis-(2-cyano-phenyl)-5-isothiazole formamide and preparation thereof are disclosed in WO99/24414.The activity of this compound is good; Yet, sometimes also unsatisfactory under low rate of application.
Compound (B) is Imidacloprid, and it is a kind of insecticidal active compound, is disclosed in EP-A0192060.Compound (C) is selected from following sterilization and insecticidal active compound: second worm nitrile (ethiprole, be known in DE-A19653417), ethiprole (fipronil, be known in EP-A00295117), thiacloprid (thiacloprid, be known in EP-A0235725), pleocidin (spinosad, be known in EP-A0375316), thiophene fluorine bacterium amine (thifluzamide is known in EP A0371950), the chloro-N of (S)-3- 1-2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl) ethyl] phenyl }-N 2-(1-methyl-2-methyl sulphonyl ethyl) phthalic amide (being known in EP-A1006107) and N-[2-(1,3-dimethylbutyl) phenyl]-5-is fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide (being known in WO03/010149).
Compound (B) is recorded in Publication about Document (WO2005/122796 with the binary bond of one of described compound (C); EP-A0871362, WO2005/036966, WO1999/060857; WO2007/101542; WO2006/114212) in.Also the bond of known isotianil and anabasine is applicable to prevent and treat phytopathogen (WO2005/009131).
In addition, because the environment and economy to modern fungicides and insecticide requires, the requirement of the formation of action spectrum, toxicity, selectivity, rate of application, residue and favourable preparative capacibility aspect---for example for---improves constantly, and the problem of resistance that for example the known activity compound produced that may exist, therefore, exploitation has an advantage with respect to known homologue at least in some aspects new bactericide and insecticide are long-range missions.
The invention provides the active agent combinations/composition that reaches at least in some aspects described target.
Surprisingly, have now found that, bond of the present invention not only makes the action spectrum of phytopathogen to be prevented and treated and/or microorganism and/or insect be able to the additive property raising, can be from the sphere of action of two aspect expanded compounds (A), compound (B) and compound (C) but also produced synergistic effect.At first, reduce the rate of application of compound (A), compound (B) and compound (C), kept same good effect simultaneously.Secondly, even when these three kinds of independent compounds are in low fully invalid rate of application scope, described bond still can obtain higher phytopathogen control efficiency.This makes on the one hand, has significantly widened the pedigree of the phytopathogen that can prevent and treat, on the other hand, has strengthened safety in utilization.
Yet, except the actual synergy aspect sterilization and insecticidal activity, Pesticidal combinations of the present invention also has other surprising advantageous property that more broadly also can be described as synergistic activity.The example of the described advantageous property that can mention has: for other phytopathogen and/or microorganism and/or insect---for example, for resistant strain---the sterilization of widening and insecticidal activity spectrum; The active component rate of application reduced; Enough controls by the present composition to nuisance, even be also like this under the complete invalid rate of application of independent compound; During preparation or the advantageous property while using, for example, at the advantageous property of grinding, screening, emulsification, dissolving or minute timing; The storage stability improved; Improved photostability; More favourable degradability; Improved toxicological properties or ecological toxicology performance; The characteristic of improved useful plants, comprise: emergence rate (emergence), crop yield, more flourishing root system, tiller that (tillering) increases, plant height increases, blade is larger, the basal leaf lethality is lower, it is stronger to tiller,, the required fertilizer of leaf look greener still less, required seed still less, tiller more voluminous, bloom more early, kernel maturity early, plant still less lodges (verse, lodginig), shoot growth improves, improved plant growing way and rudiment early; Perhaps arbitrarily other advantage well known to those skilled in the art.
Bond of the present invention also provides the interior absorption (systemicity) of improvement for reactive compound used.In fact, even some in Fungicidal compounds used do not have any interior absorption or gratifying interior absorption, these compounds also can show a kind of like this performance in the present composition.
Similarly, bond of the present invention can improve the persistence of the sterilization drug effect of used reactive compound.
It has also been found that, with in conjunction with or use when compound (A) that separately mode is carried out, compound (B) and compound (C), for independent individualized compound (A), compound (B) and compound (C) or aforementioned binary mixture (WO05/009131), can more effectively resist phytopathogen and/or microorganism and/or insect.
Another advantage of bond of the present invention is to obtain the drug effect of raising.
Therefore, the invention provides a kind of like this bond, it comprises:
(A) 3, the chloro-N-of 4-bis-(2-cyano-phenyl)-5-isothiazole formamide
With
(B) Imidacloprid; With
(C) another is selected from the reactive compound of following sterilization and insecticidal active compound: second worm nitrile, ethiprole, thiacloprid, pleocidin, thiophene fluorine bacterium amine, the chloro-N of (S)-3- 1-2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl) ethyl] phenyl }-N 2-(1-methyl-2-methyl sulphonyl ethyl) phthalic amide and N-[2-(1,3-dimethylbutyl) phenyl]-5-is fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide.
Compound (B) and most array (C) compound are referring to agricultural chemicals handbook (Pesticide Manual) the 13rd edition, 2003.Compound (C) is listed with common name.If there is no available common name before the application's priority date, compound (C) is listed with the IUPAC name.
Preferred bond is listed below:
● compound (A) 3, the chloro-N-of 4-bis-(2-cyano-phenyl)-5-isothiazole formamide and compound (B) Imidacloprid and compound (C) second worm nitrile,
● compound (A) 3, the chloro-N-of 4-bis-(2-cyano-phenyl)-5-isothiazole formamide and compound (B) Imidacloprid and compound (C) ethiprole,
● compound (A) 3, the chloro-N-of 4-bis-(2-cyano-phenyl)-5-isothiazole formamide and compound (B) Imidacloprid and compound (C) thiacloprid,
● compound (A) 3, the chloro-N-of 4-bis-(2-cyano-phenyl)-5-isothiazole formamide and compound (B) Imidacloprid and compound (C) pleocidin,
● compound (A) 3, the chloro-N-of 4-bis-(2-cyano-phenyl)-5-isothiazole formamide and compound (B) Imidacloprid and compound (C) thiophene fluorine bacterium amine,
● compound (A) 3, the chloro-N-of 4-bis-(2-cyano-phenyl)-5-isothiazole formamide and compound (B) Imidacloprid and compound (C) (S)-the chloro-N of 3- 1-2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl) ethyl] phenyl }-N 2-(1-methyl-2-methyl sulphonyl ethyl) phthalic amide,
● compound (A) 3, the chloro-N-of 4-bis-(2-cyano-phenyl)-5-isothiazole formamide and compound (B) Imidacloprid and compound (C) N-[2-(1, the 3-dimethylbutyl) phenyl]-5-is fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide.
The weight ratio of active compound component is chosen as the effect that can provide required, for example synergy.Generally, described weight ratio changes according to concrete reactive compound.Usually, the weight ratio between any two kinds of compounds is 100:1 to 1:100 independently of one another, preferred 75:1 to 1:75, more preferably 50:1 to 1:50, and 25:1 to 1:25 most preferably.Other part by weight between the adoptable any two kinds of compounds of the present invention is 250:1 to 1:250,200:1 to 1:200,150:1 to 1:150 independently of one another, and the preference degree of described ratio strengthens successively by given order.
Other weight ratio according to the present invention between spendable any two kinds of compounds is 90:1 to 1:90,80:1 to 1:80,70:1 to 1:70,60:1 to 1:60,40:1 to 1:40,30:1 to 1:30,10:1 to 1:10,5:1 to 1:5,4:1 to 1:4,3:1 to 1:3 independently of one another, and the preference degree of described ratio strengthens successively by given order.
When compound (A), compound (B) and compound (C) can exist with tautomeric form, described compound is in the situation that be interpreted as also comprising corresponding tautomeric form applicable in context, even they are not mentioned respectively one by one.
Compound (A), compound (B) and compound (C) with at least one basic center can generate for example acid-addition salts with for example following various acid: strong inorganic acid, inorganic acid for example, as perchloric acid, sulfuric acid, nitric acid, nitrous acid, phosphoric acid or halogen acids; Strong organic carboxyl acid, (as the halo) C that does not for example replace or replace 1-C 4Alkanecarboxylic acid is as acetic acid, and saturated or unsaturated dicarboxylic acids is as ethanedioic acid, malonic acid, succinic acid, cis-1, fumaric acid and phthalic acid, and hydroxycarboxylic acid is as ascorbic acid, lactic acid, malic acid, tartaric acid, citric acid or benzoic acid; Or organic sulfonic acid, as (as halo) C unsubstituted or that replace 1-C 4Alkane sulfonic acid or aryl sulfonic acid, for example methanesulfonic acid or p-methyl benzenesulfonic acid.Compound (A), compound (B) and compound (C) with at least one acid groups can for example generate salt, for example slaine, for example alkali metal salt or alkali salt, for example sodium salt, sylvite or magnesium salts with alkali; Perhaps with ammonia or organic amine, generate salt, described organic amine is morpholine, piperidines, pyrrolidines, single lower alkanols alkyl amine, two lower alkanols alkyl amine or three lower alkanols alkyl amine (for example ethamine, diethylamine, triethylamine or dimethyl propyl amine) or monohydroxy lower alkanols alkyl amine, two hydroxyl lower alkanols alkyl amine or trihydroxy lower alkanols alkyl amine (for example MEA, diethanol amine or triethanolamine) for example.In addition, can optionally form corresponding inner salt.In the present invention, favourable salt on preferred agrochemicals.In view of the free form of compound (A), compound (B) and compound (C) and the close relation between its salt form, in the situation that suitable and favourable, any while mentioning free compound (A), compound (B) and compound (C) or their salt in context, be interpreted as also comprising respectively corresponding salt or free compound (A), compound (B) and compound (C).This equally also is applicable to dynamic isomer and the salt thereof of compound (A), compound (B) and compound (C).
Term in the present invention " bond " means the various combinations of compound (A), compound (B) and compound (C), for example combination of following form: single " premix (ready-mix) " form; The form of the spraying mixture of the combination formed by the independent preparation of single-activity compound, for example " bucket is mixed "; And the independent form that is combined with during the active component sequential application, sequential application is for example used in several hours or several days one by one in the rationally short time.Preferably, the order of administration of compound (A), compound (B) and compound (C) is not necessary to practice the present invention.
Term in the present invention " pathogene " means plant or the hurtful all organisms of any plant part.
Term in the present invention " fungi " means all fungi organisms and false bacterium organism (chromista organism).
Term in the present invention " phytopathogen " means plant or the hurtful all fungi organisms of any plant part and false bacterium organism.Classification of fungi group's example has sac fungi (Ascomycota), basidiomycetes (Basidiomycota), chytrid (Chytridiomycota), imperfect fungi (Deuteromycota), polymerization bacterium (Glomeromycota), microsporidian (Microsporidia), zygomycete (Zygomycota) and imperfect fungus (anamorphic fungi).The example of false bacterium is oomycetes (Oomycota).
Term in the present invention " microorganism " means all bacterium organisms and protozoa organism.Example is plasmodiophora brassicae (Plasmodiophoromycetes).
Term in the present invention " virus " means plant or the hurtful all virus of any plant part.Example is DNA-, RNA and DNA and RNA retrovirus and subviral agent.
Term in the present invention " insect " means plant or hurtful all aschelminths (aschelminthes) organism of any plant part and general arthropods (panarthropoda) organism.Example is Nematoda (Nematoda), Arthropoda (Arthopoda), Hexapoda (Hexapoda) and arachnids (Arachnida).
Described reactive compound has strong microbiocidal activity, bactericidal activity and insecticidal activity in the present composition; and can be used for preventing and treating undesirable plant pathogen and/or microorganism and/or insect in crop protection, material protection, veterinary field, herding, and can be used as domestic pesticide.
In composition of the present invention, Fungicidal compounds can be used in crop protection, for example to prevent and treat phytopathogen and/or microorganism and/or insect, as plasmodiophora brassicae, oomycetes, chytrid, zygomycete, sac fungi, basidiomycetes and imperfect fungi.
In composition of the present invention, pesticide compound can be used in crop protection, for example to prevent and treat the pathogenic insect.
In composition of the present invention; killing the bacterium compound can be used in crop protection; for example to prevent and treat microorganism, as pseudomonas (Pseudomonadaceae), rhizobium (Rhizobiaceae), enterobacteria (Enterobacteriaceae), excellent bacillus (Corynebacteriaceae) and streptomycete (Streptomycetaceae).
Sterilization and disinsection bond of the present invention and/or composition can be used for therapeutic or prophylactically prevent and treat phytopathogen and/or microorganism and/or the insect of plant or crop.Therefore, another aspect of the present invention, a kind of therapeutic is provided or has has prophylactically prevented and treated the phytopathogen of plant or crop and/or the method for microorganism and/or insect, the method comprises uses a kind of fungicide insecticide composition of the present invention in the following manner: it is applied to the soil that seed, plant or fruit or plant growth maybe will be grown.
According to the present invention, can be processed all plants and plant part.Described plant refers to all plants and plant population, for example need with unwanted wild plant, cultivated species (comprising natural cultivated species) and botanical variety (no matter whether being subject to botanical variety or plant breeder to weigh protection).Cultivated species and botanical variety can be the plants that comprises genetically modified plants obtained by Sterile culture and method of breeding, described Sterile culture and method of breeding can be aided with or supplement with one or more biotechnology methods, for example, by using double haploid, protoplast fusion, random mutagenesis and directed mutagenesis, molecular labeling or genetic marker, or by biotechnology and genetic engineering method.
Described plant part refers to all grounds and under ground portion and the organ of plant, and for example bud, leaf, Hua Hegen, list for example leaf, needle, stem, branch, flower, fruit body, fruit and seed and root, bulb and rhizome in this regard.Crop and asexual and sexual propagation material, for example transplant, bulb, rhizome, sarment and seed, also belongs to plant part.
Term in the present invention " plant propagation material " means to can be used for all vegetable materials in the asexual or sexual propagation of plant.The example of plant propagation material is transplanted, bulb, rhizome, sarment, seed, fruit, grain, beanpod, fruit body, stem tuber and seedling.
For bond/composition of the present invention of crop protection opposing phytopathogen and/or microorganism and/or insect, contain effectively but the reactive compound of the present invention of the phytotoxic amount of tool not." effectively but not the phytotoxic amount of tool " is defined as a kind of like this amount of bond of the present invention, and it is enough on the one hand prevent and treat satisfactorily or eliminate fully the mushroom disease of plant and can cause on the other hand any significant phytotoxicity symptom.Described effective dose can change in a big way at one usually.This dosage depends on a plurality of factors, for example for fungi, plant, weather conditions, and the reactive compound in bond of the present invention.
In the plant that can protect by the inventive method, the main field crops that can mention has, for example corn, soybean, cotton, rape oilseeds (Brassica oilseeds, for example cabbage type rape (Brassica napus)---Canadian rape (canola) for example, turnip (Brassica rapa), leaf mustard (B.juncea)---leaf mustard (mustard) for example, and brassicacarinata (Brassica carinata)), rice, wheat, beet, sugarcane, oat, rye, barley, grain, triticale, flax, liane and various plant classification groups' various fruit and vegetables, for example (for example, a kind of fruit, such as apple, pear, etc. is as apple and pears, and drupe is as apricot for rose family genus kind of (a Rosaceae sp.), cherry, almond and peach, berry is strawberry for example), Ribesioidae sp., Juglandaceae belongs to kind of (a Juglandaceae sp.), Betulaceae belongs to kind of (a Betulaceae sp.), Anacardiaceae belongs to kind of (an Anacardiaceae sp.), Fagaceae belongs to kind of (a Fagaceae sp.), Moraceae belongs to kind of (a Moraceae sp.), Oleaceae belongs to kind of (an Oleaceae sp.), Actinidiaceae belongs to kind of (an Actinidaceae sp.), Lauraceae belongs to kind of (a Lauraceae sp.), Musaceae belongs to kind of (Musaceae sp.) (for example Banana tree and a plantation), Rubiaceae belongs to kind of (Rubiaceae sp.) (a for example coffee), Theaceae belongs to kind of (a Theaceae sp.), Sterculiaceae belongs to kind of (a Sterculiceae sp.), Rutaceae belongs to kind of (a Rutaceae sp.) (lemon for example, orange and grapefruit), Solanaceae belongs to kind of (a Solanaceae sp.) (tomato for example, potato, pepper, eggplant, colea), Liliaceae belongs to kind of (a Liliaceae sp.), composite family belongs to kind of (a Compositiae sp.) (lettuce for example, arithoke and witloof---comprise root witloof (root chicory), corn sow thistle (endive) or common witloof (common chicory)), Umbelliferae belongs to kind of (a Umbelliferae sp.) (carrot for example, parsley, celery and celeriac), Curcurbitaceae belong to kind of (a Cucurbitaceae sp.) (cucumber for example---comprise pickled with cucumber (pickling cucumber), pumpkin, watermelon, cucurbit and muskmelon), green onion section belongs to kind of (Alliaceae sp.) (for example onion and a leek), Cruciferae belongs to kind of (a Cruciferae sp.) (white cabbage for example, red cabbage, broccoli, cauliflower, brussels sprouts, a variety of Chinese cabbage, kohlrabi, radish (radish), horseradish, Chinese celery, Chinese cabbage), pulse family belongs to kind of (a Leguminosae sp.) (peanut for example, pea and Kidney bean---as climning bean and broad bean), Chenopodiaceae belongs to kind of (a Chenopodiaceae sp.) (fodder beet for example, foliage heet, spinach, table beet), composite family belongs to kind of (Asteraceae sp.) (a for example sunflower), Cruciferae (Brassicaceae sp.) (white cabbage for example, red cabbage, broccoli, cauliflower, brussels sprouts, a variety of Chinese cabbage, kohlrabi, radish and Canadian rape, rape, leaf mustard, horseradish and Chinese celery), pulse family (Fabacae sp.) (for example peanut and beans), Papilionaceae belongs to kind of (Papilionaceae sp.) (a for example soybean), Malvaceae (Malvaceae) (for example gumbo), Asparagaceae (Asparagaceae) (for example asparagus), gardening and forest crop, ornamental plants, and the homologue of the genetic modification of described crop.
Processing method of the present invention can be used for processing genetically modified organisms (GMO), for example plant or seed.Genetically modified plant (or genetically modified plants) is that heterologous gene stably is integrated into genomic plant.Such gene that is provided or assemble in the plant outside mainly is provided described word " heterologous gene ", in the time of in this gene is introduced core, chloroplast or mitochondrial genomes by express the protein paid close attention to or polypeptide or by lower or reticent one or more be present in endophytic other gene (for example using antisense technology, co-suppression technology or RNA interference-RNAi technology) thus give the transformed gene plant new or improved agronomy or other characteristic.The heterologous gene that is positioned at genome is also referred to as transgenosis.The transgenosis that particular location according to it in Plant Genome defines is called as transformation plant or transgenic line (transformation or transgenic event).
According to plant species or plant cultivars, its location and growth conditions (soil, weather, nutrient plant vegetative period, nutrition), processing of the present invention also can produce superadditivity (" working in coordination with ") effect.Can obtain thus the following effect that surpasses actual desired: for example can reduce the rate of application of reactive compound used according to the invention and composition and/or widen its activity profile and/or improve its activity, improve plant growth, improve high temperature or cold tolerance, raising is to arid or to the tolerance of salt content in water or in soil, improve Flowering quality, make to gather simpler and easy, hasting of maturity, improve the productive rate of gathering, fruit is larger, plant height is higher, the leaf look greener, bloom more early, improve the quality of the product of gathering and/or improve its nutritive value, improve the sugared concentration in fruit, improve bin stability and/or the processing characteristics of the product of gathering.
Under some rate of application, active agent combinations of the present invention also can have strengthening effect in plant corpus.Therefore, they also are suitable for adjusting vegeto-animal defense system, to resist the invasion and attack of undesirable plant pathogen and/or microorganism and/or virus.In the situation that suitable, this may be that bond of the present invention is resisted one of reason that for example activity of fungi improves.In this article, the implication of plant strengthening (induction of resistance) material is interpreted as the bond of a kind of like this material or material: the defense system that they can stimulating plant, thereby, when inoculating undesirable plant pathogen and/or microorganism and/or virus and/or insect subsequently, treated plant shows significant resistance to described undesirable plant pathogen and/or microorganism and/or virus and/or insect.In the present invention, undesirable plant pathogen and/or microorganism and/or virus are interpreted as meaning phytopathogen, bacterium and virus and/or insect.Therefore, material of the present invention is used in and processes the invasion and attack that interior protective plant of regular period is afterwards resisted above-mentioned pathogene.Usually continue 1 to 10 day after with reactive compound, processing plant the period of realizing protection, preferred 1-7 days.
The preferred plant to be processed of the present invention and plant cultivars comprise all plants with genetic material of giving advantageous particularly, the useful feature of described plant (no matter it is to obtain by breeding and/or biological technique method).
The preferred plant to be processed of the present invention and plant cultivars also can be coerced and have resistance one or more biologies, and described plant demonstrates for animal nuisance and microorganism nuisance---for example, for nematode, insect, acarid, phytopathogen, bacterium, virus and/or viroids---defensive preferably.
The present invention plant to be processed and plant cultivars also can be those plants that one or more abiotic stress had to resistance.The abiotic stress condition can comprise mineral exposure, ozone exposure, the high light exposure of the soil salinity, the increase of for example arid, low temperature exposure, hot exposure, osmotic stress, waterflooding, increase, the availability of restricted nitrogen nutrient, restricted phosphorus nutrient availability, shelter from heat or light and avoid.
The present invention plant to be processed and plant cultivars also can be those plants of the yield characteristics with raising.The productive rate of the raising of described plant can and be grown as the germination efficiency of water-use efficiency, water maintenance efficiency, improved nitrogen utilization, the carbon assimilation of raising, improved photosynthesis, raising and hasting of maturity by improved plant physiology function for example, growth and be produced.Productive rate also can be subject to improved families of plant structure (plant architecture) (coerce and non-stress condition under) impact, described improved families of plant structure includes but not limited to, pod cracking and the lodging resistance of the seed plumpness of the seed number of early flowering, the control of blooming for hybrid seed production, rice shoot vigor, plant size, internode number and distance, root growth, seed size, fruit size, pod size, pod number or spike number, each pod or fringe, seed quality, raising, the seed dispersal of reduction, reduction.Yield characteristics also comprises seed compositions, for example reduction of carbohydrate content, protein content, oil content and composition, nutritive value, anti-nutrient compounds, improved processing characteristics and good bin stability.
Have above-mentioned characteristic plant the non exhaustive property of example list in Table A.
Table A
Crop Characteristic GMO List of references
All Water-use efficiency Be WO2000/073475
All Use nitrogen efficiency Be WO1995/009911
All Use nitrogen efficiency Be WO1997/030163
All The photosynthesis improved Be WO2003/000066
Soybean Anti-nematode No WO1995/020669
Rape The pod cracking reduced Be WO2006/009649
Soybean Anti-aphid No WO2006/125065
Lettuce Anti-aphid No WO1997/046080
Rape Anti-Sclerotinia (Sclerotinia) No WO2006/135717
Tomato Anti-Botrytis (Botrytis) No WO2006/046861
Crop Characteristic GMO List of references
Lettuce Anti-dish downy mildew (Bremia) No US20070022496
Potato Anti-Ou Wenshi (Erwinia) No WO2004/049786
Cucumber Anti-Closterovirus (Closterovirus) No WO2002/022836
Capsicum Antiviral No WO2006/038794
The plant of processing according to the present invention can be the hybrid plant that gives expression to the hybrid vigour characteristic, and described characteristic can cause higher productive rate, vigor, health degree and usually to the resistance of biology and abiotic stress.Described plant is usually hybridized and is made by the male parent line (paternal line) of educating of a kind of selfing male sterile parent line (maternal) and another kind of selfing.Hybrid seed is usually gathered and is sold to the grower from male sterile plants.Male sterile plants (for example corn) sometimes can make by the eunuchs fringe, and machinery is removed male organ of multiplication (or male flower), and still, more generally, the genetic determinant of male sterility in Plant Genome obtains.In the case, especially when the product of wishing to gather from hybrid plant be kind of a period of the day from 11 p.m. to 1 a.m, guarantee hybrid plant male fertility recover normally useful fully.This can suitable can recover hybrid plant---contain and cause male sterile genetic determinant---[fertility of male fertility is realized by guaranteeing that paternal line has.The male sterile genetic determinant can be arranged in cytoplasm.The example of cytoplasmic male sterility (CMS) is described (WO92/05251, WO95/09910, WO98/27806, WO05/002324, WO06/021972 and US6,229,072) in for example Brassicas (Brassica species).But the male sterile genetic determinant also can be arranged in the nuclear gene group.Male sterile plants also can obtain as genetic engineering by the Plant Biotechnology rule.A kind of useful especially method that obtains male sterile plants has description in WO89/10396, and wherein for example ribalgilase is optionally expressed in the tapetal cell of stamen as barnase.Then fertilizability can by ribonuclease inhibitor for example the expression of barstar in tapetal cell recover (for example WO91/02069).
Plant or the plant cultivars (obtaining as genetic engineering by the Plant Biotechnology rule) according to the present invention, processed can be herbicide tolerant plants, the plant that one or more given weed killer herbicides is had to tolerance.Described plant can obtain by genetic transformation or the plant that contains the sudden change of giving described herbicide tolerant by selection.
Herbicide resistant plants has for example glyphosate (glyphosate) tolerant plants, the plant that herbicide glyphosate or its esters is had to tolerance.Can make plant there is tolerance to glyphosate by diverse ways.For example, the glyphosate tolerant plant can obtain by the encode gene-transformed plant of 5-enol pyruvylshikimate-3-phosphate synthase (5-enolpyruvylshikimate-3-phosphate synthase, EPSPS) of use.The example of described EPSPS gene has AroA gene (mutant the CT7) (people such as Comai of salmonella typhimurium (Salmonella typhimurium) bacterium, 1983, Science221, 370-371), the CP4 gene of Agrobacterium kind (Agrobacterium sp.) bacterium (people such as Barry, 1992, Curr.Topics Plant Physiol., 7, 139-145), the gene of the coding petunia EPSPS (people such as Shah, 1986, Science233, 478-481), the gene of the coding for tomato EPSPS (people such as Gasser, 1988, J.Biol.Chem., 263, 4280-4289) or the gene (WO01/66704) of coding Eleusine EPSPS.Can be also the EPSPS of the sudden change described in EP0837944, WO00/66746, WO00/66747 or WO02/26995 for example.The glyphosate tolerant plant also can obtain by the encode gene of glyphosate oxidoreductase of expression, as U.S. Patent No. 5,776, and 760 and 5,463, described in 175.The glyphosate tolerant plant also can obtain by the encode gene of glyphosate acetyl transferase of expression, for example, described in WO02/36782, WO03/092360, WO05/012515 and WO07/024782.The plant of the spontaneous mutation that the glyphosate tolerant plant also can contain said gene by selection obtains, for example, described in WO01/024615 or WO03/013226.
Other herbicide resistant plants has the plant that for example weed killer herbicide that suppresses glutamine synthase is had to tolerance, and described weed killer herbicide is bialaphos (bialaphos), careless fourth phosphine (phosphinothricin) or careless ammonium phosphine (glufosinate) for example.Described plant can be by the detoxify enzyme of this weed killer herbicide or have the glutamine synthase mutant of resistance to obtain to inhibitory action of expression.The enzyme that a kind of described efficient solution toxenzyme is the careless fourth phosphinothricin acetyl transferase of coding (bar or pat albumen that for example streptomycete (Streptomyces) is planted).The plant of expressing exogenous careless fourth phosphinothricin acetyl transferase is for example having description in U.S. Patent No. 5,561,236,5,648,477,5,646,024,5,273,894,5,637,489,5,276,268,5,739,082,5,908,810 and 7,112,665.
Other herbicide tolerant plants can be also the plant that the weed killer herbicide to suppressing hydroxyphenylpyruvic acid dioxygenase (HPPD) has tolerance.The hydroxyphenylpyruvic acid dioxygenase is the enzyme that catalysis ethyl-para-hydroxyphenyl ketone acid (HPP) changes into the reaction of alcapton.The HPPD inhibitor is had tolerance the naturally occurring resistance HPPD enzyme of plant available code gene or with the gene of the HPPD enzyme of encoding mutant, transformed, described in WO96/38567, WO99/24585 and WO99/24586.Although also can be transformed and obtained by use some HPPD inhibitor but still gene pairs plant that can form the enzyme of alcapton inhibited to natural HPPD enzyme of encoding the tolerance of HPPD inhibitor.Described plant and gene have description in WO99/34008 and WO02/36787.Plant, also can be improved by the encode gene-transformed plant of prephenate dehydrogenase of use, described in WO2004/024928 the tolerance of HPPD inhibitor except the gene with coding HPPD tolerance enzyme.
The plant that other herbicide tolerant plants has tolerance to acetolactate synthase (ALS) inhibitor in addition.Known ALS inhibitor comprises, for example sulfonylureas, imidazolone, triazolo pyrimidine class, pyrimidine radicals oxygen (sulphur) yl benzoic acid ester class (pyrimidinyoxy (thio) benzoates) and/or Herbicidal sulphonylamino carbonyl triazole quinoline ketone (sulfonylaminocarbonyltriazolinone) weed killer herbicide.Known ALS enzyme is (also referred to as acetohydroxy acid synthase, AHAS) different weed killer herbicides and weed killer herbicide group tolerance are given in the sudden change of difference in, as for example at Tranel and Wright(2002, Weed Science50:700-712) and U.S. Patent No. 5,605,011,5,378,824,5,141,870 and 5,013, described in 659.The preparation of sulfonylureas tolerant plants and imidazolinone-tolerant plant is in U.S. Patent No. 5,605, and 011,5,013,659,5,141,870,5,767,361,5,731,180,5,304,732,4,761,373,5,331,107,5,928,937 and 5,378,824; And be described in international publication text WO96/33270.Other imidazolinone-tolerant plant for example also is being described in WO2004/040012, WO2004/106529, WO2005/020673, WO2005/093093, WO2006/007373, WO2006/015376, WO2006/024351 and WO2006/060634.Other sulfonylureas tolerant plants and imidazolinone-tolerant plant also for example are being described in WO07/024782.
Other to imidazolone and/or sulfonylureas have tolerance plant can by mutagenesis, in the situation that weed killer herbicide exist and carry out cell and cultivate and select or mutation breeding obtains, for example United States Patent (USP) 5,084, in 082 in soybean, WO97/41218 to rice, United States Patent (USP) 5,773,702 and WO99/057965 in to the description in lettuce or WO01/065922, sunflower being carried out in beet, United States Patent (USP) 5,198,599.
Plant or the plant cultivars (obtaining as genetic engineering by the Plant Biotechnology rule) according to the present invention, processed also can be the genetically modified plants with insect-resistant, the plant that invasion and attack of some targeted insect is had resistance.Described plant can obtain by genetic transformation or the plant that contains the sudden change of giving described insect-resistant by selection.
" genetically modified plants with insect-resistant " used herein comprise and contain genetically modified any plant that at least one comprises the coded sequence of the following albumen of encoding:
1) insecticidal crystal protein of bacillus thuringiensis,Bt (Bacillus thuringiensis) or its desinsection part, such as the people such as Crickmore (1998, Microbiology and Molecular Biology Reviews, 62:807-813) in the thuringiensis bacillus toxin name, list, the insecticidal crystal protein upgraded by the people such as Crickmore (2005) is (online: http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/) or its desinsection part, Cry protide Cry1Ab for example, Cry1Ac, Cry1F, Cry2Ab, the albumen of Cry3Aa or Cry3Bb or its desinsection part, perhaps
2) under existing, the another kind of crystalline protein of bacillus thuringiensis,Bt or its part there is thuringiensis bacillus crystallin or its part of insecticidal activity; such as the binary toxin formed by Cry34 and the Cry35 crystalline protein (people such as Moellenbeck; 2001, Nat.Biotechnol.19,668-72; The people such as Schnepf 2006, Applied Environm.Microbiol.71,1765-1774); Perhaps
The hybrid insecticidal proteins of the part of the different insecticidal crystal proteins that 3) contain bacillus thuringiensis,Bt, as above-mentioned 1) the hybrid or above-mentioned 2 of albumen) the hybrid of albumen, the Cry1A.105 albumen (WO2007/027777) for example made by MON98034 corn strain; Perhaps
4) above-mentioned A1)-A3) any one, wherein for the scope that obtains the targeted insect kind that the insecticidal activity higher to the targeted insect kind and/or expansion act on and/or due in clone or conversion process, introduce change in coding DNA by some amino acid, a particularly 1-10 amino acid albumen with another kind of 49-Phe ,82-Ser,115-Arg,144-Met,145-Asn ,161-Arg,169-Met Human Connective tissue growth factor, for example the Cry3Bb1 albumen in MON863 or MON88017 corn strain or the Cry3A albumen in MIR604 corn strain;
5) the desinsection secretory protein of bacillus thuringiensis,Bt or Bacillus cercus (Bacillus cereus) or its desinsection part, listed nutritive insecticidal albumen (VIP) in following network address for example: http://www.lifesci.sussex.ac.uk/home/Neil_Crickmore/Bt/vip.html, for example albumen of VIP3Aa protide; Perhaps
6) there is the bacillus thuringiensis,Bt of insecticidal activity or the secretory protein of Bacillus cercus, the binary toxin (WO94/21795) for example formed by VIP1A and VIP2A albumen under the existence of the another kind of secretory protein of bacillus thuringiensis,Bt or Bacillus cercus; Perhaps
7) contain the hybrid insecticidal proteins from the part of the different secretory proteins of bacillus thuringiensis,Bt or Bacillus cercus, for example above-mentioned 1) the hybrid or above-mentioned 2 of albumen) the hybrid of albumen; Perhaps
8) above-mentioned 1)-3) any one, wherein for the scope that obtains the targeted insect kind that the insecticidal activity higher to the targeted insect kind and/or expansion act on and/or for example, owing to introducing the albumen of change in coding DNA (simultaneously still encoding insecticidal proteins) by some amino acid, a particularly 1-10 amino acid with another kind of 49-Phe ,82-Ser,115-Arg,144-Met,145-Asn ,161-Arg,169-Met Human Connective tissue growth factor, the VIP3Aa albumen in COT102 corn strain in clone or conversion process.
Certainly, genetically modified plants with insect-resistant used herein also comprise any plant that contains the combination of the gene of the albumen of any one in the above-mentioned 1-8 class of coding.In one embodiment, plant with insect-resistant comprises the transgenosis more than the albumen of any one in the above-mentioned 1-8 class of a kind of coding, thereby expands the scope of acted on targeted insect kind when the different albumen that uses for the different target caste; Perhaps for example, by using the different albumen that the same target caste had insecticidal activity but has the different modes of action---the different receptor binding sites that are bonded to insect---to carry out the generation of the insect-resistant of delay plant.
Plant or the plant cultivars (obtaining as genetic engineering by the Plant Biotechnology rule) according to the present invention, processed also can have tolerance to abiotic stress.Described plant can obtain by genetic transformation or the plant that contains the sudden change that can give described stress resistance by selection.Useful especially stress tolerant plants comprises:
A. contain the expression that can reduce polyadenous glycosides diphosphonic acid-ribose polymerase (PARP) gene in plant cell or plant and/or the genetically modified plant of its activity, described in WO00/04173 or EP04077984.5 or EP06009836.5.
B. for example, containing being improved the expression that can reduce PARG encoding gene in plant or plant cell of stress tolerance and/or the genetically modified plant of its activity, described in WO2004/090140.
The genetically modified plant of c. being encoded containing the enzyme of the plant function to the NADH salvage route that is improved stress tolerance, described plant function enzyme comprises nicotinamidase, nicotinic acid phosphoribosyl transferase, NAMN adenine transferase, NADH synzyme or nicotinamide phosphoribosyl transferase, for example, described in EP04077624.7 or WO2006/133827 or PCT/EP07/002433.
The change that the plant of processing according to the present invention or plant cultivars (obtaining as genetic engineering by the Plant Biotechnology rule) also can demonstrate quantity, quality and/or the bin stability of the product of gathering, and/or the change of the character of the concrete composition of the product of gathering, for example:
1) genetically modified plants of synthesis modification starch, the physico chemical property of this modified starch, particularly amylose content or amylose/amylopectin ratios, degree of branching, average chain length, side chain distribution, viscosity, gel strength, starch granularity and/or morphology of starch grain, compare change has occurred with the synthetic starch in wild-type plant cell or plant, thereby it can be more suitable for concrete application.The genetically modified plants of described synthesis modification starch are at for example EP0571427, WO95/04826, EP0719338, WO96/15248, WO96/19581, WO96/27674, WO97/11188, WO97/26362, WO97/32985, WO97/42328, WO97/44472, WO97/45545, WO98/27212, WO98/40503, WO99/58688, WO99/58690, WO99/58654, WO00/08184, WO00/08185, WO00/08175, WO00/28052, WO00/77229, WO01/12782, WO01/12826, WO02/101059, WO03/071860, WO2004/056999, WO2005/030942, WO2005/030941, WO2005/095632, WO2005/095617, WO2005/095619, WO2005/095618, WO2005/123927, WO2006/018319, WO2006/103107, WO2006/108702, WO2007/009823, WO00/22140, WO2006/063862, WO2006/072603, WO02/034923, EP06090134.5, EP06090228.5, EP06090227.7, EP07090007.1, EP07090009.7, WO01/14569, WO02/79410, WO03/33540, WO2004/078983, WO01/19975, WO95/26407, WO96/34968, WO98/20145, WO99/12950, WO99/66050, WO99/53072, US6734341, WO00/11192, WO98/22604, WO98/32326, WO01/98509, WO01/98509, WO2005/002359, US5824790, US6013861, WO94/04693, WO94/09144, WO94/11520, WO95/35026, in WO97/20936, disclose,
2) synthetic non-starch carbohydrate polymer or the synthetic genetically modified plants of comparing the non-starch carbohydrate polymer of the character with change with the wild-type plant that does not carry out genetic modification.Example has the plant of generation polyfructosan (polyfructose), especially inulin-type and levulan type polyfructosan, as open in EP0663956, WO96/01904, WO96/21023, WO98/39460 and WO99/24593; Produce the plant of α-Isosorbide-5-Nitrae-glucan, as open in WO95/31553, US2002031826, US6284479, US5712107, WO97/47806, WO97/47807, WO97/47808 and WO00/14249; Produce the plant of α-1,6 branched alpha-Isosorbide-5-Nitrae-glucan, as open in WO00/73422; Produce the plant of alternan, as open in WO00/47727, EP06077301.7, US5908975 and EP0728213,
3) produce the genetically modified plants of hyaluronan (hyaluronan), as for example disclosed in WO2006/032538, WO2007/039314, WO2007/039315, WO2007/039316, JP2006304779 and WO2005/012529.
The plant that the plant of processing according to the present invention or plant cultivars (can obtain as genetic engineering by the Plant Biotechnology rule) also can be the fiber properties with change, for example vegetable lamb.Described plant can obtain by the plant of genetic transformation or the sudden change that contains the fiber properties that can give described change by selection, and described plant comprises:
A) plant that contains the cellulose synthase gene that form changes, vegetable lamb for example, described in WO98/00549
B) contain rsw2 that form changes or the plant of rsw3 homologous nucleic acid, vegetable lamb for example, described in WO2004/053219
C) have the plant that the sucrose phosphonate ester synthetase of enhancing is expressed, vegetable lamb for example, described in WO01/17333
D) have the plant that the sucrose synthase of enhancing is expressed, vegetable lamb for example, described in WO02/45485
E) wherein the timing of fibrocyte base portion protoplasmic connection gate changes---for example, by fiber selectivity β 1, the downward of 3-dextranase---plant, vegetable lamb for example, described in WO2005/017157
F) have that reactive altered---for example, by the expression of (comprising nodC and chitin synthetase gene) of N-acetyl-glucosamine transferase gene---plant of fiber, vegetable lamb for example, described in WO2006/136351
The plant that the plant of processing according to the present invention or plant cultivars (can obtain as genetic engineering by the Plant Biotechnology rule) also can be the oily distribution characteristics with change, for example rape or relevant rape carex.Described plant can obtain by the plant of genetic transformation or the sudden change that contains the fiber properties that can give described change by selection, and described plant comprises:
A) produce the plant of the oil with high oleic acid content, rape plant for example, as for example US5,969,169, US5,840,946 or US6,323,392 or US6, described in 063,947
B) produce the plant of the oil with low linolenic content, rape plant for example, as US6,270828, US6,169,190 or US5, described in 965,755
C) produce the plant of the oil with low saturated fatty acid content, rape plant for example, as for example US patent 5,434, described in 283
The useful especially genetically modified plants that can process according to the present invention be the combination that contains transformation plant or transformation plant and be the plant of the application theme of non-control state (non-regulated status), this application is to (the Animal and Plant Health Inspection Service of animals and plants sanitary inspection administration of United States Department of Agriculture (USDA) in the U.S., APHIS) propose, no matter whether described application has been authorized or is still undecided.Whenever all can be from APHIS(4700River Road Riverdale, MD20737, the U.S.) locate easily to obtain this information---for example, from its website (URL http://www.aphis.usda.gov/brs/not_reg.html)---.In the application's submission day, the non-control state application that the pendent or APHIS of APHIS authorizes is listed those in table B, contains following information in table B:
-application: No. ID of application.For example, can find the technical description to transformation plant in the independent application documents that---from the APHIS website---obtain by this application number from APHIS.These are described in this and include this paper in way of reference.
The prolongation (extension of petition) of-application: with reference to extend request for original application.
-mechanism: the title of submitting the entity of this application to.
-be subject to the control product: the corresponding plants kind.
-transgenosis phenotype: the proterties of giving plant by transformation plant
-transformation plant or transform system: non-control status request for the title of strain (sometimes also be named as and be).
The various files of relevant this application that APHIS file: APHIS announces and the various files that can ask to APHIS.
Figure BDA0000368738930000191
Figure BDA0000368738930000211
Figure BDA0000368738930000221
Figure BDA0000368738930000231
Figure BDA0000368738930000241
Figure BDA0000368738930000251
Figure BDA0000368738930000261
Some other useful especially plant that contains single transformation plant or transformation plant combination, be listed in the database of various countries or regional management organization (for example, referring to http://gmoinfo.jrc.it/gmp_browse.aspx and http://www.agbios.com/dbase.php).
Other special genetically modified plants comprise and containing in agronomy neutrality or genetically modified plant vantage point, described in an arbitrary piece of writing in listed patent publication in table C.
Figure BDA0000368738930000271
Have above-mentioned characteristic plant the non exhaustive property of example list in Table A
Figure BDA0000368738930000281
Figure BDA0000368738930000291
The plant that the useful especially genetically modified plants that can process according to the present invention are the combination that contains transformation plant or transformation plant, described plant is listed in the database of various countries for example or regional management organization (referring to for example http://gmoinfo.jrc.it/gmp_browse.aspx and http://www.agbios.com/dbase.php).
The useful especially genetically modified plants that can process according to the present invention are listed in table B together with its trade (brand) name.
Table B
Figure BDA0000368738930000301
Figure BDA0000368738930000311
Figure BDA0000368738930000321
Figure BDA0000368738930000331
Some other special transgenosis rice plant comprises contains at least one genetically modified plant neutral in agronomy or useful position, as shown in table C.
Table C2
Figure BDA0000368738930000332
In an extremely special embodiment, described the phytopathogen of a kind of therapeutic or preventative control plant or crop and/or the method for microorganism and/or insect, the method comprises in the following manner and to use the bond of ((A) and (B)) or ((A) and (B) with (C)): it is applied to wherein to activity expression mechanism corresponding to seed, plant propagation material, plant or the fruit of a kind of genetically modified plant in form A, B or C.
In an extremely special embodiment, described the phytopathogen of a kind of therapeutic or preventative control plant or crop and/or the method for microorganism and/or insect, the method comprises in the following manner and to use the bond of ((A) and (B)) or ((A) and (B) with (C)): it is applied to wherein to activity expression mechanism corresponding to seed, plant propagation material, plant or the fruit of a kind of genetically modified plant in arbitrary form A, B or C.
On the other hand, provide a kind of composition that contains bond of the present invention.Preferably this sterilization and Pesticidal combination contain the upper acceptable additive of agricultural, solvent, carrier, surfactant or filler.
Term in the present invention " carrier " means natural or synthetic, organic or inorganic compound, reactive compound (A), reactive compound (B) and reactive compound (C) are easier to use when this compound is combined or is mixed, and particularly impose on plant part.Therefore the preferred inertia of this carrier and at least to should be agricultural upper acceptable.This carrier can be solid or liquid.
Suitable solid carrier is as follows:
Ammonium salt for example, with the natural rock powder as kaolin, clay, talcum, chalk, quartz, attapulgite, montmorillonite or diatomite, and synthetic Rock Powder is as silica, aluminium oxide and the silicate of polymolecularity, petroleum paraffin, solid fertilizer, water, alcohols---preferred butanols, organic solvent, mineral oil and vegetable oil and derivative thereof;
The suitable solid carrier of granule has: for example pulverizes and the natural rock of classification, and as calcite, marble, float stone, sepiolite, dolomite, and synthetic inorganic and organic dust particle; The particle of organic matter (for example paper, sawdust, coconut husk, corn stalk and tobacco rods);
Gaseous diluent or the carrier of liquefaction refer to be the liquid of gaseous state at normal temperatures and pressures, and aerosol spray for example, as halogenated hydrocarbons and butane, propane, nitrogen and carbonic acid gas.
The adhesive that can use in preparation has; carboxymethyl cellulose for example, the polymer of natural and synthetic powder, particle or latex shape, as gum Arabic, polyvinyl alcohol, polyvinyl acetate; with natural phospholipid as cephalin and lecithin, and synthetic phospholipid.Other additive can be mineral oil or vegetable oil and the wax class of optional modification.
Suitable filler has, for example water, polarity and nonpolar organic chemistry liquid, for example be selected from amine, acid amides, lactam (for example N-alkyl pyrrolidone) and lactone, sulfone and the sulfoxide (for example dimethyl sulfoxide (DMSO)) of aromatic hydrocarbon and non-aromatic hydrocarbon (for example paraffinic, alkyl benzene, Fluhyzon, chlorobenzene), alcohols and polyalcohol (if suitable, it can be also that replace, etherificate and/or esterification), ketone (for example acetone, cyclohexanone), ester (comprising fats and oils) and (gathering) ether, unsubstituted and replacement.
If filler used is water, also can make secondary solvent as organic solvent by use-case.The suitable liquid solvent mainly contains: aromatic species, for example dimethylbenzene, toluene or Fluhyzon, chlorinated aromatics and chlorination aliphatic hydrocarbon be chlorobenzene, vinyl chloride or carrene for example, aliphatic hydrocarbon is cyclohexane or paraffinic, for example petroleum distillate, mineral oil and vegetable oil for example, alcohols is butanols or ethylene glycol and ether and ester for example, ketone is acetone, MEK, methyl iso-butyl ketone (MIBK) or cyclohexanone for example, and intensive polar solvent is methyl-sulfoxide for example, and water.
The present composition also can contain additional compound.Particularly, said composition also can contain surfactant.Surfactant can be emulsifier, dispersant or the wetting agent of a kind of ionic or nonionic or the mixture of described surfactant.That can mention has a for example polyacrylate, lignosulfonates, phenolsulfonate or naphthalene sulfonate, oxirane and fatty alcohol or with fatty acid or with the condensation polymer of fatty amine, the phenol (particularly alkylphenol or aryl phenol) replaced, sulfosuccinate ester salt, taurine derivatives (particularly taurine Arrcostab), the phosphate of polyoxyethylenated alcohol or phenol, the fatty acid ester of polyalcohol, and contain sulfate radical, the derivative of the described compound of sulfonate radical and phosphate radical functional group, alkylaryl polyglycol ether for example, alkylsulfonate, alkyl sulfate, arylsulphonate, protein hydrolyzate, lignin sulfite waste liquor and methylcellulose.When while being water, must there be at least one surfactant in reactive compound and/or inert carrier when water insoluble and when used carrier agent (vector agent) usually.Preferred surfactant content can account for 5 % by weight-40 % by weight of composition.
Suitable emulsifier and/or blowing agent have: for example nonionic and anion emulsifier, and as polyoxyethylene fatty acid ester, polyoxyethylene aliphatic alcohol ether.Suitable dispersant is nonionic and/or ionic species, for example is selected from pure POE and/or POP ether, acid and/or POP or POE ester, alkylaryl and/or POP or POE ether, fat and/or POP-POE adduct, POP and/or POE polyol derivative, POE and/or POP/ sorbitan or sugared adduct, alkyl or aryl sulphate, sulfonate and phosphate or corresponding PO ether adduct.In addition, suitable oligomer or polymer, for example, based on vinyl monomer, acrylic acid, independent EO and/or PO or itself and for example (gather) alcohols or the combination of (gathering) amine.Also can use lignin and sulfonic acid thereof, cellulose, aromatic series and/or the aliphatic sulfonic acid of simple cellulose (simple cellulose) and modification and with the adduct of formaldehyde.Suitable dispersant is for example lignin sulfite waste liquor and methylcellulose.
Can use colouring agent, for example inorganic pigment is as iron oxide, titanium dioxide, Prussian blue (ferrocyanblue), as alizarin dyes, azo dyes and metal phthalocyanine dyestuff, reach trace element as iron, manganese, boron, copper, cobalt, molybdenum and zinc salt with organic pigment.
Optionally, also can comprise other additional compound, for example protective colloid, adhesive, thickener, thixotropic agent, bleeding agent, stabilizing agent, chelating agent.More generally, described reactive compound routinely preparation technique with any solid or liquid additive, be combined.
Usually, composition of the present invention can contain 0.05-99 % by weight, preferably 1-70 % by weight, the reactive compound of 10-50 % by weight most preferably.
Bond of the present invention or composition can itself, the type of service of its dosage form or preparation is thus used, for example aerosol, microcapsule suspending agent, cold mist agent (cold fogging concentrate), thermal fog, the micro-capsule granula, granula subtilis, the seed treatment suspending agent, ready to use solution, pulvis, missible oil, oil-in-water emulsion, water-in-oil emulsion, large granula, fine granule, the oil-dispersing property pulvis, oil suspending agent, finish, foaming agent (froths), paste, seed coat agent, colloidal suspending agent (suspending agent), outstanding newborn concentrating agents, aqueous solvent, suspending agent, soluble powder, granule, water-soluble granular formulation or tablet, the seed treatment water solube powder, wetting powder, natural and the synthetic material of dipping reactive compound, polymeric material and involucrum microcapsule formulations for seed, and the cold mist of ULV and hot mist preparation, (compression) gas, foaming agent, stylus, dry seeds is processed pulvis, seed treatment solution, the liquor of ultra low volume (ULV), the suspending agent of ultra low volume (ULV), water-dispersible granules or tablet, wet seed treatment water-dispersible powder.
Described preparation is by by reactive compound or active agent combinations and conventional additives---for example conventional filler and solvent or thinner, emulsifier, dispersant and/or adhesive or fixative, wetting agent, waterproofing agent---mixes with a kind of known way and is prepared, if suitable, add drier and UV stabilizing agent, colouring agent, pigment, defoamer, preservative, secondary thickener (secondary thicknener), adhesive, gibberellin and water and other processing aid.
Described composition not only comprise for example, be applied to pending plant or seed by suitable equipment (spraying or dusting device) use composition, and comprise and be applied to the dense commercial composite that must be diluted before crop.
After seedling, the phytopathogen of infringement plant and/or the control of microorganism and/or insect are mainly undertaken by with crop protection agents, processing the soil and plant acrial part.Consider that crop protection agents, on the healthy issuable impact of environment and human and animal, just making great efforts to reduce the amount of the reactive compound of using.
Active agent combinations of the present invention can its commercial preparation and the type of service that prepared by described preparation as the mixture with other active compound, use, described other reactive compound is insecticide, attractant, chemosterilant, bactericide, miticide, nematocide, fungicide, growth regulatory substance, weed killer herbicide, safener, fertilizer or semiochemical for example.
With active agent combinations of the present invention, the processing of plant and plant part is directly carried out with conventional treatment method or is undertaken by acting on its environment, habitat or storage areas, described conventional treatment method for example irrigates (perfusion), drip irrigation, spraying, vaporization (vaporizing), atomization (atomizing), broadcasts sowing, dusts, foams, is coated with (spreading-on), and as dry seeds process pulvis, solution seed treatment for, water-soluble powder for seed treatment, the seed treatment water-soluble powder wets; Or by crust, in the situation that propagating materials, especially in the situation that seed also can be undertaken by dry treatment, wet process, liquid handling, one or more layers dressing.In addition, also can use reactive compound by the ultra low volume method, or active agent preparations or reactive compound itself are injected to soil.
The rate of application of described bond can change according to the concrete reactive compound in for example type of service, agrotype, described bond, the type (if suitable) of plant propagation material, but should be able to make reactive compound in described bond be able to provide the effective dose of the activity (for example disease or control of insect) of required enhancing, it can be determined by test.
Processing method of the present invention also provide compound (A) and (B) with simultaneously, separately or mode in succession use.
In processing method of the present invention, the conventional active compound doses/rate of application used is usually and advantageously
-leaf surface treatment: 0.1 to 10,000g/ha(hectare), preferably 10 to 1,000g/ha, more preferably 25 to 300g/ha compound (A); 0.1 to 10,000g/ha, preferably 10 to 1,000g/ha, more preferably 50 to 300g/ha compound (B); 0.1 to 10,000g/ha, preferably 10 to 1,000g/ha, more preferably 50 to 300g/ha compound (C); In the situation that perfusion or drip irrigation use, especially when the use inert base for example rock wool or or during perlite, dosage even also can reduce;
-seed treatment: the compound (A) of every double centner seed 2 to 200g, preferred every double centner seed 3-150g; The compound (B) of every double centner seed 2 to 200g, preferred every double centner seed 3-150g; The compound (C) of every double centner seed 2 to 200g, preferred every double centner seed 3-150g;
-soil treatment: 0.1 to 10,000g/ha, preferred 1 to 5,000g/ha compound (A); 0.1 to 10,000g/ha, preferred 1 to 5,000g/ha compound (B); 0.1 to 10,000g/ha, preferred 1 to 5,000g/ha compound (C).
Here the form of a pointed dosage illustrative examples with the inventive method provides.Those skilled in the art will know that how to adjust application dosage, particularly according to the kind of pending plant or crop.
Bond of the present invention can be used to protective plant opposing insect and/or phytopathogen and/or microorganism and/or insect in certain section time range after conservation treatment.The time range that protective effect comes into force usually after with bond, processing plant, continue 1-28 days, preferably after 1-14 days or treatment of plant propagation material, be up to 200 days.
Processing method of the present invention also can be used for processing propagating materials for example stem tuber or rhizome, and seed, seedling or sprigging thing and plant or phytograft.This processing method also can be used for processing root.Processing method of the present invention also can be used for processing plant shoot and divides, for example trunk, stem or stem, leaf, flower and the fruit of the plant of paying close attention to.
Another aspect of the present invention is a kind of method of natural materials or their form processing of protective plant or animal origin, and described material is taken from the natural life circulation; The method comprises the bond of a kind of compound (A), compound (B) and compound (C) is applied to the natural materials of described plant or animal origin or their form processing with cooperative effective quantity.
The natural materials that preferred embodiment is a kind of protective plant source or the method for their form processing, described material is taken from the natural life circulation; The method comprises the bond of a kind of compound (A), compound (B) and compound (C) is applied to the natural materials of described plant origin or their form processing with cooperative effective quantity.
The method that further preferred embodiment is a kind of protection fruit (preferably the operatic circle, drupe, berry and citrus fruit) or their form processing, described fruit is taken from the natural life circulation; The method comprises the bond of a kind of compound (A), compound (B) and compound (C) is applied to the natural materials of described plant origin or their form processing with cooperative effective quantity.
The present invention includes a kind of method of simultaneously processing seed with compound (A), compound (B) and compound (C).The present invention also comprises a kind of method of processing respectively seed with compound (A), compound (B) and compound (C).
The present invention also comprises a kind of seed of having used compound (A), compound (B) and compound (C) simultaneously to process.The present invention also comprises a kind of seed of having used compound (A), compound (B) and compound (C) to process respectively.For rear a kind of seed, active ingredient can be applied in discrete layer.These layers can be optionally by other layer of separation that comprises or do not comprise active ingredient.
Bond of the present invention and/or composition are particularly suitable for processing seed.The seed of the infringement of the major part to cultivated species caused by insect and/or phytopathogen and/or microorganism and/or insect by infecting lay up period and sow seed after underground and plant germination during and germinate after seed occur.Due to just the root of growing plants and bud is responsive especially and or even a small amount of infringement all can cause the withered of whole strain plant, so this stage is especially crucial.Therefore people to by use suitable medicament protection seed and germinate in plant there is sizable interest.
By process plant seed pest control and/or phytopathogen and/or microorganism and/or insect for people long-term known to and be the theme of updating.But, many problems that solve are unsatisfactorily always arranged in the processing of seed.Therefore, wish to develop the method for such protection seed and germination plant, the method makes needn't be after planting or use in addition plant protection product after plant germination.Also wish to optimize the amount of institute's applying active substances, the infringement that does not make plant originally experience used reactive compound in order to protect as well as possible the invasion and attack of seed and germination plant opposing insect and/or phytopathogen and/or microorganism and/or insect.Particularly, process the method for seed and also should consider sterilization and the insecticidal properties that genetically modified plants are intrinsic, reach the best protection of seed and germination plant with the minimal consumption with plant protection product.
Therefore, the invention particularly relates to a kind of method infected of protecting seed and germination plant to avoid insect and/or phytopathogen and/or microorganism and/or insect, bond/compositions-treated of the present invention for wherein said seed.In addition, the invention still further relates to bond/composition of the present invention and resist the purposes of insect and/or phytopathogen and/or microorganism and/or insect for the treatment of seed with protection seed and germination plant.And, the invention still further relates to the seed that the protection for obtaining antagonism insect and/or phytopathogen and/or microorganism and/or insect uses bond/compositions-treated of the present invention to cross.
One of advantage of the present invention is; distinctive internal absorption characteristic due to bond/composition of the present invention; the processing of carrying out with these bond/compositions not only protects seed itself to avoid insect and/or phytopathogen and/or microorganism and/or insect infringement, and unearthed plant after the protection rudiment.Can save at seeding time in this way or thereafter soon to the cultivation thing direct processing.
Another advantage is, with each single reactive compound, compare, the collaborative increase of the sterilization of bond/composition of the present invention and insecticidal activity, this activity surpass single all reactive compounds of using activity add and.Make in this way the amount of optimizing the reactive compound of using become possibility.
Also can be looked at as advantage, mixture of the present invention also can be used for particularly following genetically modified seed, wherein by the plant of this seed germination, can express the protein for insect and phytopathogen and/or microorganism and/or insect.By using the described seed of chemicals treatment of the present invention; some insect and/or phytopathogen and/or microorganism and/or insect can be controlled by for example expressing insecticidal proteins; and surprisingly; use medicament of the present invention the synergistic activity appended to occur, this synergistic activity has further improved the effect to the protective effect of insect invasion and attack.
Medicament of the present invention is suitable for the seed of protection all types botanical variety on the books, its in agricultural, greenhouse, in forestry, bar excute a law in, in gardening or vineyard.Particularly, this is applicable to the seed of cereal (for example wheat, barley, rye, triticale, grain, oat, rice), corn, cotton, soybean, potato, sunflower, Kidney bean, coffee, beet (for example sugar beet, foliage heet and fodder beet), peanut, rape, rape seed, opium poppy, olive, coconut, cocoa, sugarcane or tobacco.Bond/composition of the present invention also is suitable for processing the seed of foregoing fruit plant and vegetables (for example tomato, cucumber, onion and lettuce), lawn, meadow and ornamental plants.Particularly importantly to the processing of the seed of wheat, barley, rye, triticale, oat, corn, rice, soybean, cotton, rape, rape seed.
As previously mentioned, the processing particular importance to transgenic seed with bond/composition of the present invention.This is applicable to usually contain the plant seed of at least one following heterologous gene, and described heterologous gene is controlled the expression of the polypeptide with specific insecticidal properties.Heterologous gene in transgenic seed can derive from microorganism for example bacillus (Bacillus), rhizobium (Rhizobium), pseudomonad (Pseudomonas), Serratia (Serratia), trichoderma (Trichoderma), Clavibacter, Paraglomus (Glomus) or Gliocladium (Gliocladium).The present invention is particularly suitable for processing the transgenic seed that contains at least one following heterologous gene, described heterologous gene derives from Bacillus, and its gene outcome shows the activity to European corn borer and/or corn root leaf A (western corn rootworm).Particularly preferably be the heterologous gene that derives from bacillus thuringiensis,Bt.
In the context of the present invention, bond/composition of the present invention separately or be applied to seed with suitable formulation.Preferably stable as to process seed under the state that is without prejudice during being enough to processing at seed.To the processing of seed usually can gather and sow between any time carry out.The conventional seed used for separating and removed the seed of spadix, shell, stem, pod, fine hair or pulp from plant.The seed used is that gathered, that purify and is dried to the seed of moisture lower than 15% w/w.Perhaps, also can use the dry rear seed by water treatment and then drying.
Usually during seed treatment, must be noted that: the amount that is applied to the bond/composition of the present invention of seed and/or other additive should be chosen as can not be damaged the germination of seed and can not damage the plant that emerges.Especially to when using with certain amount, showing the reactive compound of phytotoxic effect.
Bond/composition of the present invention can directly be used, and does not contain additional compound and is not diluted.Usually preferably bond/composition of the present invention is applied to seed with the form of dosage forms.Known and for example with Publication about Document, be described for those skilled in the art for the dosage forms of seed treatment and method: US4,272,417A, US4,245,432A, US4,808,430A, US5,876,739A, US2003/0176428A1, WO2002/080675A1, WO2002/028186A2.
Active agent combinations that can be used according to the invention and composition can change into conventional seed dressing preparation, for example solution, emulsion, suspending agent, pulvis, foaming agent, slurries or other seed coating material and ULV preparation.
Described preparation is by mixing preparation in a known way by reactive compound or active agent combinations with conventional additives, described conventional additives is conventional filler and solvent or thinner, colouring agent, wetting agent, dispersant, emulsifier, defoamer, preservative, secondary thickener, adhesive, gibberellin and optional water for example.
Can be present in the suitable colouring agent that the present invention dresses seed in preparation and comprise that all routines are for described purpose colouring agent.Both the pigment that is slightly soluble in water can be used, also water-soluble dyestuff can be used.The example that can mention comprises that known name is called the colouring agent of rhodamine B, C.I. pigment red 122 and C.I. solvent red 1.
Can be present in suitable wetting agent that the present invention dresses seed in preparation comprises and promotes the wetting and conventional all substances for active agriculture compound matter preparation.Can preferably use Fluhyzon-sulfonate, for example diisopropyl or diisobutyl naphthalene-sulfonate.
Can be present in suitable dispersant and/or the emulsifier that the present invention dresses seed in preparation and comprise all non-ionic, anion and cationic dispersant commonly used in the active agriculture compound matter preparation of summarizing above.
Can be present in the suitable defoamer that the present invention dresses seed in preparation and be included in all materials that suppress foam conventional in active agriculture compound matter preparation.Can preferably use silicone defoaming agent and dolomol.
Can be present in the suitable preservatives that the present invention dresses seed in preparation and be included as all substances that described purpose can be used in the agriculture composition.In the mode of example, that can mention has Dichlorophenol and a phenmethylol hemiformal.
Can be present in the suitable secondary thickener that the present invention dresses seed in preparation and be included as all substances that described purpose can be used in the agriculture composition.The preferred suitable clay that cellulose derivatives, acrylic acid derivative, xanthans, modification are arranged and Aerosil 200.
Can be present in the suitable adhesive that the present invention dresses seed in preparation and be included in spendable all conventional adhesives in the seed seed dressing.That can preferably mention has polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol and a tylose.
Can be present in the suitable gibberellin that the present invention dresses seed in preparation and preferably include gibberellin A1, A3(=gibberellic acid), A4 and A7, particularly preferably gibberellin A 3 (=gibberellic acid).The gibberellin of formula (II) is known, and the nomenclature of gibberellin can be at the following document of mentioning (referring to R.Wegler " Chemie der Pflanzenschutz-and
Figure BDA0000368738930000421
The 2nd volume, Springer Verlag, Berlin-Heidelberg-New York, 1970, the 401-412 pages) in find.
With seed dressing preparation of the present invention or the suitable mixing apparatus of processing seed by adding water preparation prepared therefrom, comprising can conventional all mixing apparatus for seed dressing.The concrete grammar adopted during seed dressing comprises to be introduced seed blender, will after seed dressing preparation itself or water in advance dilution, with concrete requirement, add and be mixed until preparation is evenly distributed on seed.Optionally, then carry out drying process.
In material protection, material of the present invention can be used for the safeguard industries material and avoids infecting of bad mushroom and/or microorganism and damage.
In the present invention, the implication of industrial materials is interpreted as the Manufactured material of the non-living body for industry.For example, treat to avoid that microorganism changes or the industrial materials of infringement can be adhesive, sizing material, paper and sheet material, fabric, carpet, leather, timber, coating and plastic products, cooling lubricant (cooling lubricant) and other can be subject to the material of microbial infection or infringement by active substance protection of the present invention.Can be by the production equipment parts of the breeding of mushroom and/or microorganism infringement, for example chilled(cooling) water return (CWR), cooling and heating system, air-conditioning and ventilating system, also in the scope of material to be protected.Within the scope of the present invention, industrial materials preferred adhesive, sizing material, paper and sheet material, leather, timber, coating, cooling lubricant and the heat exchanger fluid that can mention, particularly preferably timber.
Bond of the present invention can prevent unfavorable effect, for example rots, variable color and decolouring or mouldy (molding).
Processing method of the present invention also can be used for protecting stored article to avoid the invasion and attack of mushroom and microorganism.According to the present invention, term " stored article " is interpreted as referring to natural materials and the various form processing thereof of plant origin or animal origin, and it is taken from natural life and circulates and need long-term protection.The stored article (for example plant or its part) of the plant origin of that newly gather or form processing; for example stem, leaf, stem tuber, seed, fruit or grain; can obtain protection, described form processing is as pre-dry, wetting, that pulverize, that grind, form squeezing or that bake and bank up with earth.The definition of stored article also comprises timber, and thick timber form (for example construction timber, electric wire tower and fence) or finished commodities form (furniture of for example being made by timber or article) all can.The stored article of animal origin has rawhide, leather, fur, hair etc.Bond of the present invention can prevent the generation of unfavorable effect, for example rotten, variable color or mouldy.Preferably, " stored article " is interpreted as referring to natural materials and the form processing thereof of plant origin, more preferably fruit and form processing thereof, for example the operatic circle, drupe, berry and citrus fruit and form processing thereof.
In another preferred embodiment of the present invention, " stored article " is interpreted as referring to timber.Sterilization bond of the present invention or composition also can be used to resist be easy to be grown on timber or timber in the mushroom disease.All types of converted products that term " timber " means the timber of all seeds types and is intended to the described timber for building, for example whole timber, high density timber, laminate and plywood.The method of processing timber of the present invention mainly is, itself and one or more compound of the present invention or composition of the present invention are contacted; This for example comprise directly use, spray, flood, injection or any other applicable method.
In the disease of the plant that can prevent and treat by the inventive method or crop, that can mention has:
The powdery mildew disease, for example:
Blumeria (Blumeria) disease, caused by for example grass family dlumeria graminis (Blumeria graminis);
Podosphaera (Podosphaera) disease, caused by for example white cross hair list softgel shell (Podosphaera leucotricha);
Sphaerotheca (Sphaerotheca) disease, caused by for example garden balsam list softgel shell (Sphaerotheca fuliginea);
Uncinula (Uncinula) disease, caused by for example grape snag shell (Uncinula necator);
The rust disease, for example
Glue Rust (Gymnosporangium) disease, caused by for example brown size rest fungus (Gymnosporangium sabinae);
Camel spore rust belongs to (Hemileia) disease, by for example coffee rust (Hemileia vastatrix), is caused;
Layer rest fungus (Phakopsora) disease, caused by for example yam bean layer rest fungus (Phakopsora pachyrhizi) and mountain horseleech layer bacterium (Phakopsora meibomiae);
Handle rest fungus (Puccinia) disease, caused by for example Puccinia recondita (Puccinia recondita) and puccinia triticinia (Puccinia triticina);
Uromyces (Uromyces) disease, caused by for example wart top uromyce (Uromyces appendiculatus);
Oomycete class disease, for example
Dish downy mildew (Bremia) disease, caused by for example lettuce dish downy mildew (Bremia lactucae);
Downy mildew (Peronospora) disease, caused by for example pea downy mildew (Peronospora pisi) and Cruciferae downy mildew (Peronospora brassicae);
Epidemic disease mould (Phytophthora) disease, caused by for example phytophthora infestans (Phytophthora infestans);
Axle downy mildew (Plasmopara) disease, give birth to axle downy mildew (Plasmopara viticola) by for example grape and cause;
False downy mildew (Pseudoperonospora) disease, caused by for example careless false downy mildew (Pseudoperonospora humuli) and the false downy mildew of Cuba (Pseudoperonospora cubensis);
Rotten mould (Pythium) disease, caused by for example Pythium ultimum (Pythium ultimum);
Leaf spot, leaf spot blight and leaf blight disease, for example
Alternaria (Alternaria) disease, caused by for example early blight chain lattice spore (Alternaria solani);
Cercospora (Cercospora) disease, You Li gives birth to tail spore (Cercospora beticola) as the Chard dish and causes;
Cladosporium (Cladiosporium) disease, caused by for example cucumber branch spore (Cladiosporium cucumerinum);
Cochliobolus belongs to (Cochliobolus) disease, by for example standing grain cochliobolus (Cochliobolus sativus), is caused;
(conidial form (conidiaform): Drechslera (Drechslera), Syn: the long spore mould (Helminthosporium) of wriggling);
Colletotrichum (Colletotrichum) disease, caused by for example bean anthrax bacteria (Colletotrichum lindemuthianum);
The Cycloconium disease, caused by for example Cycloconium oleaginum;
Between the seat shell belong to (Diaporthe) disease, by for example between citrus a seat shell (Diaporthe citri) cause;
Elsinoe (Elsinoe) disease, caused by for example citrus Elsinochrome (Elsinoe fawcettii);
Coil long spore and belong to (Gloeosporium) disease, caused by for example happy long spore of colour disk (Gloeosporium laeticolor);
Small cluster shell belongs to (Glomerella) disease, by for example enclosing small cluster shell (Glomerella cingulata), causes;
Ball seat Pseudomonas (Guignardia) disease, caused by for example grape Guignardia (Guignardia bidwelli);
Leptosphaeria (Leptosphaeria) disease, caused by for example black shank bacterium (Leptosphaeria maculans);
Ruin greatly shell and belong to (Magnaporthe) disease, caused by for example Pyricularia oryzae (Magnaporthe grisea);
Mycosphaerella (Mycosphaerella) disease, caused by for example standing grain green-ball chamber bacterium (Mycosphaerella graminicola) and banana secret note leaf spot fungi (Mycosphaeralla fijiensis);
The Phaeosphaeria disease, caused by for example wheat glume blight bacterium (Phaeosphaeria nodorum);
Nuclear cavity Pseudomonas (Pyrenophora) disease, caused by for example round nuclear cavity bacteria (Pyrenophora teres);
Ramularia (Ramularia) disease, caused by for example Ramularia collo-cygni;
Rhynchosporium spp． (Rhynchosporium) disease, caused by for example rye beak spore (Rhynchosporium secalis);
The pin spore belongs to (Septoria) disease, by for example Septoria apii (Septoria apii), is caused;
Core coral Pseudomonas (Typhula) disease, caused by for example meat spore core coral bacterium (Typhula incarnata);
Venturia (Venturia) disease, caused by for example apple black star bacteria (Venturia inaequalis);
Root and stem disease evil, for example:
Corticium (Corticium) disease, caused by for example Corticium graminearum;
Fusarium (Fusarium) disease, caused by for example sharp sickle spore (Fusarium oxysporum);
Gaeumannomyces (Gaeumannomyces) disease, caused by for example wheat top softgel shell bacterium (Gaeumannomyces graminis);
Rhizoctonia (Rhizoctonia) disease, caused by for example Rhizoctonia solani Kuhn (Rhizoctonia solani);
Oculimacula(Tapesia) disease, caused by for example Oculimacula Tapesia acuformis;
Thiclaviopsis (Thielaviopsis) disease, caused by for example thielaviopsis sp (Thielaviopsis basicola);
For example, by spadix and panicled spike (the comprising corncob) disease that for example following pathogene causes:
The Alternaria disease, caused by for example Alternaria (Alternaria spp.);
Aspergillus (Aspergillus) disease, caused by for example aspergillus flavus (Aspergillus flavus);
Cladosporium (Cladosporium) disease, caused by for example Cladiosporium cladosporioides;
Claviceps (Claviceps) bacterial classification, for example ergot (Claviceps purpurea);
The Fusarium disease, caused by for example yellow sickle spore (Fusarium culmorum);
Gibberella (Gibberella) disease, caused by for example Gibberella zeae (Gibberella zeae);
Little setting-out shell belongs to (Monographella) disease, by for example avenging rotten little setting-out shell (Monographella nivalis), causes;
The sick disease of the black powder fringe of smut and raw meat, for example:
Axle Ustilago (Sphacelotheca) disease, caused by for example Sporisorium reilianum (Sphacelotheca reiliana);
Tilletia (Tilletia) disease, caused by for example Tilletia caries (Tilletia caries);
Urocystis (Urocystis) disease, caused by for example hidden smut (Urocystis occulta);
Smut (Ustilago) disease, caused by for example naked smut (Ustilago nuda);
Fruit rot and mildew, for example:
The aspergillus disease, caused by for example aspergillus flavus;
Botrytis (Botrytis) disease, caused by for example Botrytis cinerea (Botrytis cinerea);
Penicillium (Penicillium) disease, caused by for example penicillium expansum (Penicillium expansum) and Penicillium purpurogenum;
Sclerotinia (Sclerotinia) disease, caused by for example sclerotinite (Sclerotinia sclerotiorum);
Verticillium (Verticillium) disease, caused by for example Huang Verticillium (Verticillium alboatrum) that withers;
Kind pass with rotting of passing of soil, go rotten, wilting, rot and damping off disease,
Alternaria (Alternaria-Arten), give birth to chain lattice spores (Alternaria brassicicola) by for example rape and cause,
Aphanomyces (Aphanomyces-Arten), caused by for example root-rot silk capsule mould (Aphanomyces euteiches),
Ascochyta (Ascochyta-Arten), caused by for example Ascochyta lentis;
Aspergillus (Aspergillus-Arten), caused by for example aspergillus flavus (Aspergillus flavus),
Cladosporium (Cladosporium-Arten), caused by for example draft branch spore (Cladosporium herbarum),
Cochliobolus belongs to (Cochliobolus-Arten), by for example standing grain cochliobolus (Cochliobolus sativus), caused,
(conidial form (konidienform): Drechslera, Bipolaris Syn: the long spore of wriggling is mould);
Colletotrichum (Colletotrichum-Arten), caused by for example hair core anthrax-bacilus (Colletotrichum coccodes);
Fusarium (Fusarium-Arten), caused by for example yellow sickle spore (Fusarium culmorum),
Gibberella (Gibberella-Arten), caused by for example Gibberella zeae (Gibberella zeae),
Shell ball spore belongs to (Macrophomina-Arten), by for example Kidney bean shell ball spore (Macrophomina phaseolina), caused,
Monographella-Arten, cause by for example avenging rotten bright shuttle spore genus (Monographella nivalis),
Penicillium (Penicillium-Arten), caused by for example penicillium expansum (Penicillium expansum),
Phoma (Phoma-Arten), caused by for example black shin stem point mould (Phoma lingam),
Phomopsis (Phomopsis-Arten), caused by for example soybean Phomopsis (Phomopsis sojae),
Phytophthora (Phytophthora Arten), caused by for example Phytophthora cactorum (Phytophthora cactorum),
Nuclear cavity Pseudomonas (Pyrenophora-Arten), caused by for example wheat class nuclear cavity bacteria (Pyrenophora graminea),
Pyricularia Sacc. (Pyricularia-Arten), caused by for example Magnaporthe grisea (Pyricularia oryzae),
Rotten mould (Pythium-Arten), caused by for example Pythium ultimum (Pythium ultimum);
Rhizoctonia (Rhizoctonia-Arten), caused by for example Rhizoctonia solani Kuhn (Rhizoctonia solani),
Rhizopus (Rhizopus-Arten), caused by for example Rhizopus oryzae (Rhizopus oryzae),
Bulbil belongs to (Sclerotium-Arten), by for example Sclerotium rolfsii (Sclerotium rolfsii), caused,
Septoria (Septoria-Arten), caused by for example Septoria musiva (Septoria nodorum),
Core coral Pseudomonas (Typhula-Arten), caused by for example meat spore core coral bacterium (Typhula incarnata),
Verticillium Nees (Verticillium), caused by for example verticillium dahliae (Verticillium dahliae);
Ulcer, witches' broom and the disease disease of dying ack, for example:
Nectria (Nectria) disease, caused by for example apple shuttle scar germ (Nectria galligena);
The blight disease, for example:
Chain sclerotinia sclerotiorum belongs to (Monilinia) disease, by for example drupe chain sclerotinia sclerotiorum (Monilinia laxa), is caused;
Leaf blotch exanthema or leaf-curl disease, comprise the distortion of flower and fruit, for example:
Exoascus (Taphrina) disease, caused by for example peach external capsule bacterium (Taphrina deformans);
The degeneration disease of woody plant, for example:
The Esca disease, caused by for example Phaeomoniella clamydospora and Phaeoacremonium aleophilum and Fomitiporia mediterranea;
The disease of flower and seed, for example:
The Botrytis disease, caused by for example Botrytis cinerea;
The stem tuber disease, for example:
The Rhizoctonia disease, caused by for example Rhizoctonia solani Kuhn;
The long mould disease of spore of wriggling, caused by the long spore (Helminthosporium solani) of wriggling of for example eggplant.
By the disease that for example following bacterium organism causes,
Yellow unit cell (Xanthomanas) bacterial classification, for example pathogenic mutation (Xanthomonas campestris pv.Oryzae) of xanthomonas campestris paddy rice;
False unit cell (Pseudomonas) bacterial classification, for example pathogenic mutation (Pseudomonas syringae pv.Lachrymans) of pseudomonas syringae cucumber;
Ou Wenshi (Erwinia) bacterial classification, for example separate starch Erwinia (Erwinia amylovora).
Compound of the present invention is preferred for preventing and treating following soybean diseases:
The fungal disease of leaf, stem top, beanpod and seed, for example:
Chain lattice spore leaf spot (Alternaria spec.atrans tenuissima), anthracnose (Colletotrichum gloeosporoides dematium var.truncatum), brown spot (Soybean Brown Spot line septoria musiva (Septoria glycines)), tail spore leaf spot and leaf blight (Cercospora kikuchii (Cercospora kikuchii)), Choanephora leaf blight (choanephora leaf blight) (funnel hairpin mould (Choanephora infundibulifera trispora (Syn.))), imperfect fungus leaf spot (dactuliophora leaf spot) (Dactuliophora glycines), downy mildew (green soy bean reveals bacterium germ (Peronospora manshurica)), Drechslera epidemic disease (Drechslera glycini), frog eye (Germ To Soybean Frogeye Leaf Spot (Cercospora sojina)), flax spot Pseudomonas leaf spot (Leptosphaerulina leaf spot) (clover helminthosporium leaf spot bacterium (Leptosphaerulina trifolii)), phyllosticta leaf spot (Phyllostica leaf spot) (soybean grey scab bacterium (Phyllosticta sojaecola)), beanpod and cane blight (Phomopsis sojae), powdery mildew (scattered cross hair shell (Microsphaera diffusa)), YRENOCHAETA leaf spot (Pyrenochaeta leaf spot) (Pyrenochaeta glycines), rhizoctonia is epidemic disease on the ground, leaf blight and damping off (Rhizoctonia solani Kuhn), rust (yam bean layer rest fungus, mountain horseleech layer bacterium), shot hole (soybean scab circle spore (Sphaceloma glycines)), the mould leaf blight of the handle of crawling (Stemphylium leaf blight) (the handle spore of crawling mould (Stemphylium botryosum)), target spot (Target spot) (Corynespora cassicola bacterium (Corynespora cassiicola)),
The fungal disease of root and the lower portion of the stem, for example:
Black root rot (Caionectria bacterium (Calonectria crotalariae)), charcoal rot (Kidney bean shell ball spore bacterium (Macrophomina phaseolina)), sickle spore fusarium wilt or wilting, root rot and pod and collar maize ear rot (sharp sickle spore, straight beak sickle spore (Fusarium orthoceras), F.semitectum (Fusarium semitectum), scouring rush's sickle spore (Fusarium equiseti)), the mould root rot of lotus spore (Mycoleptodiscus root rot) (water hyacinth spore mould (Mycoleptodiscus terrestris)), sick (Neocosmospora) (the invading the new red shell bacterium of arteries and veins (Neocosmopspora vasinfecta)) of new red shell bacterium, pod blight and cane blight (soybean stem ulcer bacteria (Diaporthe phaseolorum)), stem canker (soybean north stem canker (Diaporthe phaseolorum var.caulivora)), the mould maize ear rot of epidemic disease (large male epidemic disease mould (Phytophthora megasperma)), brown stem rot (brown stem rot bacterium (Phialophora gregata)), rotten mildew (pythium rot) (melon and fruit corruption mould (Pythium aphanidermatum), abnormal female corruption mould (Pythium irregulare), pythium debaryanum (Pythium debaryanum), group's knot rotten mould (Pythium myriotylum), Pythium ultimum), the rhizoctonia root rot, stem rot and damping off (Rhizoctonia solani Kuhn), sclerotinite stem rot (Sclerotinia stem decay) (sclerotinite), sclerotinite southern blight (neat bulbil bacterium (Sclerotinia rolfsii)), thielaviopsis sp root rot (thielaviopsis sp).
Active agent combinations/composition of the present invention also can be used for preparation and is applicable to therapeutic ground or prophylactically treats human body or the mycotic composition of animal, and described mycosis is mycosis, skin disease, tinea capitis and candidiasis or the disease that caused by aspergillus, for example aspergillus fumigatus (Aspergillus fumigatus) for example.
Active agent combinations/composition of the present invention has good plant tolerance concurrently and favourable toxicity and good environmental resistance to warm blooded animal; be applicable to insect, arachnid, worm, nematode and mollusk that protective plant and plant organ, raising are gathered in productive rate, the quality of improving harvested material and control animal nuisance, particularly agricultural, gardening, herding, forest, park and leisure facilities, storage product and material protection and health field and run into.It can be preferably used as plant protection product.They to common sensitivity and resistance species and all or some developmental stage there is activity.Above-mentioned insect comprises:
Anoplura (Anoplura, Phthiraptera), for example Damalinia (Damalinia spp.), Haematopinus (Haematopinus spp.), Linognathus (Linognathus spp.), lice belong to (Pediculus spp.), Trichodectes (Trichodectes spp.).
Arachnids (Arachnida), for example, Acarus siro (Acarus siro), oranges and tangerines aceria (Aceria sheldoni), peronium Eriophyes (Aculops spp.), acupuncture Eriophyes (Aculus spp.), Amblyomma (Amblyomma spp.), Argas (Argas spp.), Boophilus (Boophilus spp.), short whisker Acarapis (Brevipalpus spp.), Bryobia praetiosa (Bryobia praetiosa), Chorioptes (Chorioptes spp.), Dermanyssus gallinae (Dermanyssus gallinae), Eotetranychus (Eotetranychus spp.), goitre mite on pears (Epitrimerus pyri), true Tetranychus (Eutetranychus spp.), Eriophyes (Eriophyes spp.), half Tarsonemus (Hemitarsonemus spp.), Hyalomma (Hyalomma spp.), hard tick belongs to (Ixodes spp.), latrodectus mactans (Latrodectus mactans), Metatetranychus spp., Oligonychus (Oligonychus spp.), Ornithodoros (Ornithodoros spp.), Panonychus citri belongs to (Panonychus spp.), the tangerine rust mite (Phyllocoptruta oleivora) that rues, Polyphagotarsonemus latus Banks (Polyphagotarsonemus latus), Psoroptes (Psoroptes spp.), Rh (Rhipicephalus spp.), the root mite belongs to (Rhizoglyphus spp.), itch mite belongs to (Sarcoptes spp.), Middle East gold scorpion (Scorpio maurus), Stenotarsonemus spp., Tarsonemus (Tarsonemus spp.), Tetranychus (Tetranychus spp.), Vasates lycopersici.
Bivalve mollusks (Bivalva) guiding principle, for example, the decorations shellfish belongs to (Dreissena spp.).
Lip foot order (Chilopoda), for example, ground Scolopendra (Geophilus spp.), Scutigera spp..
Coleoptera (Coleoptera), for example, acanthoscelides obtectus (Acanthoscelides obtectus), the beak rutelian belongs to (Adoretus spp.), willow firefly chrysomelid (Agelastica alni), click beetle belongs to (Agriotes spp.), the potato melolonthid (Amphimallon solstitialis), furniture death watch beetle (Anobium punctatum), Genus Anoplophora Hope (Anoplophora spp.), flower resembles genus (Anthonomus spp.), Anthrenus (Anthrenus spp.), Ah gill cockchafer belongs to (Apogonia spp.), Atomaria spp., moth-eaten belong to (the Attagenus spp.) of fur, dislike bar bean weevil (Bruchidius obtectus), bean weevil belongs to (Bruchus spp.), tortoise resembles genus (Ceuthorhynchus spp.), Cleonus mendicus, wide chest Agriotes spp (Conoderus spp.), collar resembles genus (Cosmopolites spp.), the brown New Zealand rib wing melolonthid (Costelytra zealandica), Curculio (Curculio spp.), the hidden beak of Yang Gan resembles (Cryptorhynchus lapathi), khapra beetle belongs to (Dermestes spp.), chrysomelid genus (Diabrotica spp.), epilachna genus (Epilachna spp.), tobacco boring worm (Faustinus cubae), globose spider beetle (Gibbium psylloides), black different pawl sugarcane cockchafer (Heteronychus arator), Hylamorpha elegans, North America house longhorn beetle (Hylotrupes bajulus), alfalfa leaf resembles (Hypera postica), Hypothenemus spp., the large brown hock gill cockchafer of sugarcane (Lachnosterna consanguinea), colorado potato beetle (Leptinotarsa decemlineata), rice root weevil (Lissorhoptrus oryzophilus), the cylinder beak resembles genus (Lixus spp.), moth-eaten belong to (the Lyctus spp.) of powder, pollen beetle (Meligethes aeneus), the west melolonthid in May (Melolontha melolontha), Migdolus spp., China ink day Bos (Monochamus spp.), Naupactus xanthographus, golden spider beetle (Niptus hololeucus), coconut palm moth rhinoceros cockchafer (Oryctes rhinoceros), saw-toothed grain beetle (Oryzaephilus surinamensis), black grape ear image (Otiorrhynchus sulcatus), little blue and white cockchafer (Oxycetonia jucunda), horseradish daikon leaf beetle (Phaedon cochleariae), food phyllobranchia cockchafer belongs to (Phyllophaga spp.), Japan popillia flavosellata fairmaire (Popillia japonica), weevil belongs to (Premnotrypes spp.), rape golden head flea beetle (Psylliodes chrysocephala), Ptinus (Ptinus spp.), dark-coloured ladybug (Rhizobius ventralis), lesser grain borer (Rhizopertha dominica), grain weevil belongs to (Sitophilus spp.), point Rhynchophorus (Sphenophorus spp.), stem resembles genus (Sternechus spp.), Symphyletes spp., yellow mealworm (Tenebrio molitor), Tribolium (Tribolium spp.), the spot khapra beetle belongs to (Trogoderma spp.), seed resembles genus (Tychius spp.), ridge tiger day Bos (Xylotrechus spp.), belong to (Zabrus spp.) apart from ground beetle.
Collembola (Collembola), for example, arms Onychiurus arcticus (Onychiurus armatus).
Dermaptera (Dermaptera), for example, European earwig (Forficula auricularia).
Sufficient order (Diplopoda) doubly, for example, Blaniulus guttulatus.
Diptera (Diptera), for example, Aedes (Aedes spp.), Anopheles (Anopheles spp.), garden march fly (Bibio hortulanus), calliphora erythrocephala (Calliphora erythrocephala), Mediterranean Ceratitis spp (Ceratitis capitata), Carysomyia (Chrysomyia spp.), Callitroga (Cochliomyia spp.), people torsalo (Cordylobia anthropophaga), Culex (Culex spp.), Cuterebra (Cuterebra spp.), the large trypetid of olive (Dacus oleae), human botfly (Dermatobia hominis), Drosophila (Drosophila spp.), Fannia (Fannia spp.), Gasterophilus (Gastrophilus spp.), Hylemyia (Hylemyia spp.), Hyppobosca spp., Hypoderma (Hypoderma spp.), Liriomyza (Liriomyza spp.), Lucilia (Lucilia spp.), Musca (Musca spp.), Bemisia spp (Nezara spp.), Oestrus (Oestrus spp.), Oscinella frit (Oscinella frit), lamb's-quarters spring fly (Pegomyia hyoscyami), Phorbia (Phorbia spp.), Genus Stomoxys (Stomoxys spp.), Gadfly (Tabanus spp.), Tannia spp., Europe daddy-longlegs (Tipula paludosa), Wohlfahrtia (Wohlfahrtia app.).
Gastropoda (Gastropoda), for example, Arion spp., Biomphalaria (Biomphalaria spp.), little Bulinus (Bulinus spp.), Agriolimax (Deroceras spp.), native snail belong to (Galba spp.), Lymnaea (Lymnaea spp.), Katayama (Oncomelania spp.), amber spiro spp (Succinea spp.).
Worm guiding principle (Helminths), for example, Ancylostoma duodenale (Ancylostoma duodenale), Sri Lanka hook worm (Ancylostoma ceylanicum), ancylostoma braziliense (Acylostoma braziliensis), Ancylostoma (Ancylostoma spp.), seemingly draw ascarid nematode (Ascaris lubricoides), Ascaris (Ascaris spp.), cloth Shandong, Malaysia nematode (Brugia malayi), cloth Shandong, Timor nematode (Brugia timori), Bunostomum (Bunostomum spp.), Chabertia belongs to (Chabertia spp.), branch testis fluke belongs to (Clonorchis spp.), Cooperia (Cooperia spp.), Dicrocoelium (Dicrocoelium spp.), dictyocaulus filaria (Dictyocaulus filaria), fish tapeworm (Diphyllobothrium latum), Guinea worm (Dracunculus medinensis), Echinococcus granulosus (Echinococcus granulosus), Echinococcus multilocularis (Echinococcus multilocularis), pinworm (Enterobius vermicularis), Faciola spp., blood Trichinella (Haemonchus spp.), Heterakis (Heterakis spp.), short and smallly nibble shell tapeworm (Hymenolepis nana), Metastrongylus apri belongs to (Hyostrongulus spp.), loa loa (Loa Loa), Nematodirus (Nematodirus spp.), oesophagostomum (Oesophagostomum spp.), Opisthorchis (Opisthorchis spp.), Onchocerca caecutiens (Onchocerca volvulus), this off-line Eimeria (Ostertagia spp.) difficult to understand, Paragonimus (Paragonimus spp.), Schistosomen spp., Fu Shi quasi-colubriformis (Strongyloides fuelleborni), strongyloides intestinalis (Strongyloides stercoralis), excrement Strongylus (Stronyloides spp.), taeniarhynchus saginatus (Taenia saginata), taeniasis suis (Taenia solium), trichina(Trichinella spiralis) (Trichinella spiralis), Trichinella nativa (Trichinella nativa), strain Bu Shi trichina (Trichinella britovi), south trichina (Trichinella nelsoni), Trichinella pseudopsiralis, Trichostrongylus (Trichostrongulus spp.), ascaris trichiurus (Trichuris trichuria), wuchereria bancrofti (Wuchereria bancrofti).
In addition, also can prevent and treat protozoa, for example eimeria (Eimeria).
Heteroptera (Heteroptera), for example, squash bug (Anasa tristis), intend beautiful stinkbug and belong to (Antestiopsis spp.), the soil chinch bug belongs to (Blissus spp.), pretty fleahopper belongs to (Calocoris spp.), Campylomma livida, different back of the body chinch bug belongs to (Cavelerius spp.), Cimex (Cimex spp.), Creontiades dilutus, pepper coried (Dasynus piperis), Dichelops furcatus, the long excellent lace bug (Diconocoris hewetti) of Hou Shi, red cotton bug belongs to (Dysdercus spp.), the America stinkbug belongs to (Euschistus spp.), Eurygasterspp belongs to (Eurygaster spp.), Heliopeltis spp., Horcias nobilellus, Leptocorisa spp belongs to (Leptocorisa spp.), leaf beak coried (Leptoglossus phyllopus), lygus bug belongs to (Lygus spp.), sugarcane is deceived chinch bug (Macropes excavatus), Miridae (Miridae), Bemisia spp, Oebalus spp., Pentomidae, side butt stinkbug (Piesma quadrata), the wall stinkbug belongs to (Piezodorus spp.), cotton pseudo-spot leg fleahopper (Psallus seriatus), Pseudacysta persea, Rhodnius (Rhodnius spp.), Sahlbergella singularis (Sahlbergella singularis), black stinkbug belongs to (Scotinophora spp.), pear crown network pentatomidae (Stephanitis nashi), Tibraca spp., Triatoma (Triatoma spp.).
Homoptera (Homoptera), for example, without net long tube Aphis (Acyrthosipon spp.), Aeneolamia spp., Aphalaridae (Agonoscena spp.), Aleurodes spp., sugarcane Aleyrodes (Aleurolobus barodensis), Aleurothrixus spp., Mango fruit leafhopper belongs to (Amrasca spp.), Anuraphis cardui, the kidney Aspidiotus belongs to (Aonidiella spp.), Soviet Union bloom aphid (Aphanostigma piri), Aphis (Aphis spp), grape leafhopper (Arboridia apicalis), the roundlet armored scale belongs to (Aspidiella spp.), Aspidiotus belongs to (Aspidiotus spp.), Atanus spp., the eggplant ditch is without net aphid (Aulacorthum solani), Aleyrodes (Bemisia spp.), Lee's short-tail aphid (Brachycaudus helichrysii), Brachycolus spp., cabbage aphid (Brevicoryne brassicae), little brown back rice plant hopper (Calligypona marginata), a beautiful Huang cicadellid (Carneocephala fulgida), cane powder angle aphid (Ceratovacuna lanigera), Cercopidae (Cercopidae), lecanium belongs to (Ceroplastes spp.), strawberry nail aphid (Chaetosiphon fragaefolii), sugarcane yellow snow armored scale (Chionaspis tegalensis), tea green leafhopper (Chlorita onukii), walnut blackspot aphid (Chromaphis juglandicola), dark brown Aspidiotus (Chrysomphalus ficus), corn leafhopper (Cicadulina mbila), Coccomytilus halli, soft a red-spotted lizard belongs to (Coccus spp.), the hidden knurl aphid of tea Fischer (Cryptomyzus ribis), Dalbulus spp., Dialeurodes spp., Diaphorina spp., white back of the body armored scale belongs to (Diaspis spp.), Doralis spp., carry out giant coccid and belong to (Drosicha spp.), western rounded tail Aphis (Dysaphis spp.), the ash mealybug belongs to (Dysmicoccus spp.), Empoasca flavescens (Empoasca spp.), woolly aphid belongs to (Eriosoma spp.), Erythroneura spp., Euscelis bilobatus, coffee ground mealybug (Geococcus coffeae), phony disease of peach poison leafhopper (Homalodisca coagulata), mealy plum aphid (Hyalopterus arundinis), cottonycushion scale belongs to (Icerya spp.), sheet angle leafhopper belongs to (Idiocerus spp.), flat beak leafhopper belongs to (Idioscopus spp.), small brown rice planthopper (Laodelphax striatellus), Lecanium spp., lepidosaphes shimer (Lepidosaphes spp.), radish aphid (Lipaphis erysimi), long tube Aphis (Macrosiphum spp.), Mahanarva fimbriolata, sorghum aphid (Melanaphis sacchari), Metcalfiella spp., wheat is without net aphid (Metopolophium dirhodum), the black flat wing spot of edge aphid (Monellia costalis), Monelliopsis pecanis, tumor aphid genus (Myzus spp.), lettuce is patched up Macrosiphus spp (Nasonovia ribisnigri), rice leafhopper belongs to (Nephotettix spp.), brown planthopper (Nilaparvata lugens), Oncometopia spp., Orthezia praelonga, red bayberry edge aleyrodid (Parabemisia myricae), Paratrioza spp., Parlatoria (Parlatoria spp.), Pemphigus (Pemphigus spp.), corn plant hopper (Peregrinus maidis), Phenacoccus (Phenacoccus spp.), Yang Ping wing woolly aphid (Phloeomyzus passerinii), phorodon aphid (Phorodon humuli), grape phylloxera belongs to (Phylloxera spp.), the brown point of sago cycas armored scale (Pinnaspis aspidistrae), stern line mealybug belongs to (Planococcus spp.), the former giant coccid of pyriform (Protopulvinaria pyriformis), white mulberry scale (Pseudaulacaspis pentagona), mealybug belongs to (Pseudococcus spp.), Psylla spp (Psylla spp.), tiny golden wasp belongs to (Pteromalus spp.), Pyrilla spp., the large bamboo hat with a conical crown and broad brim Aspidiotus belongs to (Quadraspidiotus spp.), Quesada gigas, flat thorn mealybug belongs to (Rastrococcus spp.), Rhopalosiphum (Rhopalosiphum spp.), black bourch belongs to (Saissetia spp.), Scaphoides titanus, greenbug (Schizaphis graminum), sago cycas thorn Aspidiotus (Selenaspidus articulatus), long clypeus plant hopper belongs to (Sogata spp.), white-backed planthopper (Sogatella furcifera), Sogatodes spp., Stictocephala festina, Tenalaphara malayensis, Tinocallis caryaefoliae, wide chest froghopper belongs to (Tomaspis spp.), sound Aphis (Toxoptera spp.), greenhouse whitefly (Trialeurodes vaporariorum), individual Psylla spp (Trioza spp.), jassids belongs to (Typhlocyba spp.), the point armored scale belongs to (Unaspis spp.), grape root nodule lice (Viteus vitifolii).
Hymenoptera (Hymenoptera), for example, Diprion (Diprion spp.), real tenthredinidae (Hoplocampa spp.), hair ant belong to (Lasius spp.), MonomoriumMayr (Monomorium pharaonis), Vespa (Vespa spp.).
Isopoda (Isopoda), for example, pillworm (Armadillidium vulgare), comb beach louse (Oniscus asellus), ball pillworm (Porcellio scaber).
Isoptera (Isoptera), for example, Reticulitermes (Reticulitermes spp.), odontotermes (Odontotermes spp.).
Lepidoptera (Lepidoptera), for example, Sang Jian Autographa spp (Acronicta major), hickie is tired of noctuid (Aedia leucomelas), Agrotis (Agrotis spp.), cotton leaf ripple noctuid (Alabama argillacea), dry very Noctua (Anticarsia spp.), Barathra brassicae, cotton lyonetid (Bucculatrix thurberiella), loose looper (Bupalus piniarius), the yellow volume of flax moth (Cacoecia podana), Capua reticulana, codling moth (Carpocapsa pomonella), winter geometrid moth (Cheimatobia brumata), straw borer spp (Chilo spp.), spruce bunworm (Choristoneura fumiferana), grape codling moth (Clysia ambiguella) (Clysia ambiguella), Cnaphalocerus spp., earias insulana (Earias insulana), Anagasta kuehniella (Ephestia kuehniella), pornography and drug moth (Euproctis chrysorrhoea), root eating insect belongs to (Euxoa spp.), the dirty Noctua (Feltia spp.) of cutting, greater wax moth (Galleria mellonella), genus heliothis (Helicoverpa spp.), Heliothis (Heliothis spp.), brownly knit moth (Hofmannophila pseudospretella), tea long paper moth (Homona magnanima), apple ermine moth (Hyponomeuta padella), greedy Noctua (Laphygma spp.), the thin moth of apple (Lithocolletis blancardella), green fruit winter noctuid (Lithophane antennata), the white grand root eating insect of beans (Loxagrotis albicosta), Euproctis (Lymantria spp.), malacosoma neustria (Malacosoma neustria), tomato moth (Mamestra brassicae), rice hair shin noctuid (Mocis repanda), mythimna separata (Mythimna separata), Oria spp., Oulema oryzae (Oulema oryzae), small noctuid (Panolis flammea), Pectinophora gossypiella (Pectinophora gossypiella), tangerine lyonetid (Phyllocnistis citrella), Pieris spp (Pieris spp.), diamond-back moth (Plutella xylostella), spodoptera (Prodenia spp.), Pseudaletia spp., soybean noctuid (Pseudoplusia includens), corn borer (Pyrausta nubilalis), Spodoptera (Spodoptera spp.), Thermesia gemmatalis, bag rain moth (Tinea pellionella), curtain rain moth (Tineola bisselliella), the green volume moth of oak (Tortrix viridana), powder Noctua (Trichoplusia spp.).
Orthoptera (Orthoptera), for example, the Xi (Acheta domesticus) of family, oriental cockroach (Blatta orientalis), blatta germanica (Blattella germanica), Gryllotalpa spp (Gryllotalpa spp.), leucophaea maderae (Leucophaea maderae), migratory locusts belong to (Locusta spp.), black locust belongs to (Melanoplus spp.), American cockroach (Periplaneta americana), desert locust (Schistocerca gregaria).
Siphonaptera (Siphonaptera), for example, Ceratophyllus (Ceratophyllus spp.), Xanthopsyllacheopis (Xenopsylla cheopis).
Comprehensive order (Symphyla), for example, kahikatea worm (Scutigerella immaculata).
Thrips (Thysanoptera), for example, rice thrips (Baliothrips biformis), Enneothrips flavens, flower thrips belong to (Frankliniella spp.), net Thrips (Heliothrips spp.), greenhouse bar hedge thrips (Hercinothrips femoralis), card Thrips (Kakothrips spp.), grape thrips (Rhipiphorothrips cruentatus), hard Thrips (Scirtothrips spp.), Taeniothrips cardamoni, Thrips (Thrips spp.).
Thysanoptera (Thysanura), for example, silverfish (Lepisma saccharina).
Plant nematode comprises, for example, and eel Turbatrix (Anguina spp.), Aphelenchoides (Aphelenchoides spp.), thorn Turbatrix (Belonoaimus spp.), Bursaphelenchus (Bursaphelenchus spp.), fuller's teasel stem eelworm (Ditylenchus dipsaci), ball Heterodera (Globodera spp.), helix Eimeria (Heliocotylenchus spp.), Heterodera (Heterodera spp.), minute hand Turbatrix (Longidorus spp.), Meloidogyne (Meloidogyne spp.), Pratylenchidae belongs to (Pratylenchus spp.), similar similes thorne (Radopholus similis), shallow bid spin line Eimeria (Rotylenchus spp.), burr Turbatrix (Trichodorus spp.), Tylenchorhynchus (Tylenchorhynchus spp.), pulvinulus sword Turbatrix (Tylenchulus spp.), the nematode (Tylenchulus semipenetrans) of partly puncturing, Xiphinema (Xiphinema spp.).
Active agent combinations of the present invention not only has activity to plant nuisance, health nuisance and storage product nuisance, and to parazoon (vermin and internal parasite), for example hard tick, soft ticks, itch mite, trombiculid, fly (bite and suck), parasitic fly larva, lice, hair lice, poultry louse and flea also have activity in field of veterinary.Described parasite comprises:
Anoplura (Anoplurida), for example Haematopinus, Linognathus, lice genus, Phtirus spp., pipe lice belong to (Solenopotes spp.)
Mallophaga (Mallophagida) and Amblycera (Amblycerina) and thin angle suborder (Ischnocerina), for example hair Trichodectes (Trimenopon spp.), Menopon (Menopon spp.), huge Trichodectes (Trinoton spp.), Bovicola (Bovicola spp.), Werneckiella spp., Lepikentron spp., Damalinia, Trichodectes, Felicola (Felicola spp.)
Diptera and Nematocera (Nematocerina) and Brachycera (Brachycerina), for example Aedes, Anopheles, Culex, Simulium (Simulium spp.), Eusimulium (Eusimulium spp.), owl midge (Phlebotomus spp.), Lutzomyia (Lutzomyia spp.), Bitting midge (Culicoides spp.), Chrysops (Chrysops spp.), knurl Gadfly (Hybomitra spp.), Atylotus (Atylotus spp.), Gadfly, Chrysozona (Haematopota spp.), Philipomyia spp., honeybee Hippobosca (Braula spp.), Musca, Hydrotaea (Hydrotaea spp.), Genus Stomoxys, Haematobia (Haematobia spp.), fly does not belong to (Morellia spp.), Fannia, Glossina (Glossina spp.), Calliphora (Calliphora spp.), Lucilia, Carysomyia, Wohlfahrtia, Sarcophaga (Sarcophaga spp.), Oestrus, Hypoderma, Gasterophilus (Gasterophilus spp.), Hippobosca (Hippobosca spp.), Lipoptena (Lipoptena spp.) and Melophagus (Melophagus spp.)
Siphonaptera (Siphonapterida), for example flea belongs to (Pulex spp.), Ctenocephalus (Ctenocephalides spp.), objective flea belongs to (Xenopsylla spp.) and Ceratophyllus
Heteroptera (Heteropterida), for example Cimex, Triatoma, Rhodnius and Triatoma (Panstrongylus spp.)
Blattaria (Blattarida), for example oriental cockroach, American cockroach, blatta germanica and Supella (Supella spp.)
Acari (Acar, Acarina) and rear valve order (Metastigmate) and Mesostigmata (Mesostigmata), Argas for example, Ornithodoros (Ornithodorus spp.), residual beak tick belongs to (Otobius spp.), hard tick belongs to, Amblyomma, Boophilus, Dermacentor (Dermacentor spp.), Haemophysalis spp., Hyalomma, Rh, Dermanyssus (Dermanyssus spp.), sting sharp mite and belong to (Raillietia spp.), Pneumonyssus (Pneumonyssus spp.), chest thorn mite belongs to (Sternostoma spp.) and Vespacarus (Varroa spp.)
Axle Acarina (Actinedida) (front valve suborder (Prostigmata)) and flour mite order (Acaridida) (Astigmata (Astigmata)), for example honeybee shield mite belongs to (Acarapis spp.), Cheyletiella (Cheyletiella spp.), Ornithocheyletia (Ornithocheyletia spp.), Myobia (Myobia spp.), Psorergates (Psorergates spp.), Demodex (Demodex spp.), Trombidium (Trombicula spp.), Listrophorus spp., Tyroglyphus (Acarus spp.), Tyrophagus (Tyrophagus spp.), Caloglyphus (Caloglyphus spp.), under neck, mite belongs to (Hypodectes spp.), the wing mite belongs to (Pterolichus spp.), Psoroptes, Chorioptes, the ear itch mite belongs to (Otodectes spp.), itch mite belongs to, Notoedres (Notoedres spp.), the lump mite belongs to (Knemidocoptes spp.), Cytodites (Cytodites spp.) and Laminosioptes (Laminosioptes spp.).
Active agent combinations/composition of the present invention also is applicable to the arthropods of the following animal of control invasion and attack: Agricultural Output domestic animal, for example ox, sheep, goat, horse, pig, donkey, camel, buffalo, rabbit, family chicken, turkey, duck, goose and honeybee; Other pet animal, for example dog, cat, cage bird and pet fish; And so-called experimental animal, for example hamster, cavy, rat and mouse.By preventing and treating described arthropods, situation dead and that output (meat, milk, hair, skin, egg, honey etc.) reduces is deserved to reduce, thereby but the active agent combinations of the application of the invention makes animal feeding more economical, easier.
Active agent combinations/composition of the present invention by following form in a known way for veterinary applications and animal feeding: by for example tablet, capsule, potus, gavage medicine, granule, paste, pill, the mode of feeding (feed-through) method and suppository carries out administration in intestines; By such as injection (in intramuscular, subcutaneous, intravenous, peritonaeum etc.), implant and carry out parenteral; Pass through nasal administration; By for example soaking or taking a shower, spraying, sprinkle the form percutaneous drug delivery watered with drop, cleaning, dusting, and by means of the moldings that comprises reactive compound such as necklace, ear tag, tail tag, limbs ligature (limb band), halter, concentrator marker etc.
During for domestic animal, poultry, pet animal etc., the preparation (for example pulvis, emulsion, free flowing composition) that active agent combinations of the present invention can be used as the reactive compound that comprises 1 to 80 % by weight amount is directly used or dilutes 100 to 10000 times and use afterwards, or they can chemical Medicatedbath lotion (chemical bath) form use.
In addition, found that active agent combinations of the present invention has strong insecticidal action to the insect of damaging industrial materials.
Mode with example and preferred and without any restrictions property can propose following insect:
Beetle, for example North America house longhorn beetle, Chlorophorus pilosis, the furniture death watch beetle, report dead death watch beetle (Xestobium rufovillosum), Ptilinus pectinicornis (Ptilinus pecticornis), Dendrobium pertinex, pine death watch beetle (Ernobius mollis), Priobium carpini, Lyctus brunneus Stephens (Lyctus brunneus), Africa powder moth-eaten (Lyctus africanus), south powder moth-eaten (Lyctus planicollis), quercitron moth-eaten (Lyctus linearis), pubescence powder moth-eaten (Lyctus pubescens), Trogoxylon aequale, minthea rugicollis (Minthes rugicollis), material bark beetle kind (Xyleborus spec.), Tryptodendron spec., coffee black long moth-eaten (Apate monachus), Mongolian oak long moth-eaten (Bostrychus capucins), brown different wing long moth-eaten (Heterobostrychus brunneus), long moth-eaten plant (the Sinoxylon spec.) of sour jujube, dinoderus minutus (Dinoderus minutus),
Hymenopteran (Hymenopterons), for example large wood wasp (Sirex juvencus), the large wood wasp of fir (Urocerus gigas), safe wood wasp (Urocerus gigas taignus), the Urocerus augur of strengthening;
Termite, European kalotermitid (Kalotermes flavicollis) for example, a fiber crops heap sand termite (Cryptotermes brevis), ash point different termite (Heterotermes indicola), American-European reticulitermes flavipe (Reticulitermes flavipes), Sang Te reticulitermes flavipe (Reticulitermes santonensis), southern Europe reticulate pattern termite (Reticulitermes lucifugus), Darwin Australia termite (Mastotermes darwiniensis), the ancient termite (Zootermopsis nevadensis) in Nevada, coptotermes formosanus (Coptotermes formosanus),
Moth (Bristletail), for example silverfish.
In the present invention, the implication of industrial materials is interpreted as non-living body (non-living) material, for example, is preferably plastics, adhesive, sizing material, paper and sheet material, leather, timber and timber fabricated product, and coating composition.
If suitable, describedly with composition, can contain other insecticide, also can contain one or more bactericide and if suitable.
The possible additive about other, can be with reference to above-mentioned insecticide and bactericide.
Active agent combinations/composition of the present invention can be used for object, particularly hull, sieve, net, building, harbour and the signal system that protection contacts with salt solution or brackish water equally, in case produce dirt.
In addition, active agent combinations/composition of the present invention can be used as antifouling composition individually or with other reactive compound in combination.
In family expenses, health and storage product protection; active agent combinations/composition of the present invention also is suitable for preventing and treating the animal pest existed in confined space; particularly insect, arachnid and acarid, described confined space such as residence, factory floor, office, compartment etc.They can prevent and treat these insects for family expenses desinsection product individually or with other reactive compound and auxiliary agent in combination.They all have activity to the species of sensitivity and resistance and to whole developmental stage.These insects comprise:
Scorpionida (Scorpionidea), for example yellow scorpion (Buthus occitanus) in Mediterranean.
Acarina, adobe tick (Argas persicus) for example, argas reflexus (Argas reflexus), tongue mite subspecies (Bryobia ssp.), Dermanyssus gallinae, sweet mite (Glyciphagus domesticus) is had a liking for by family, tampan tick (Ornithodorus moubat), brown dog tick (Rhipicephalus sanguineus), eutrombicula alfreddugesi (Trombicula alfreddugesi), Neutrombicula autumnalis, the spy has a liking for skin mite (Dermatophagoides pteronissimus), method is had a liking for skin mite (Dermatophagoides forinae).
Araneida (Araneae), for example catching bird spider (Aviculariidae), circle spider (Araneidae).
Opiliones (Opiliones), for example chelifer (Pseudoscorpiones chelifer), the blind spider of the Chang Shin of Pseudoscorpiones cheiridium, (Opiliones phalangium).
Isopoda, for example comb beach louse, ball pillworm.
Doubly sufficient order, for example Blaniulus guttulatus, mountain cricket Eimeria (Polydesmus spp.).
Lip foot order, for example Scolopendra.
Silverfish order (Zygentoma), for example the comb silverfish belongs to (Ctenolepisma spp.), silverfish, robber fireworm (Lepismodes inquilinus).
Blattaria, for example oriental cockroach, blatta germanica, Asia Lian (Blattella asahinai), leucophaea maderae, angle abdomen Lian belong to (Panchlora spp.), wooden Lian belongs to (Parcoblatta spp.), Australian cockroach (Periplaneta australasiae), American cockroach, large brown large Lian (Periplaneta brunnea), smoke Perilpaneta americana (Periplaneta fuliginosa), brown belt blattaria (Supella longipalpa).
Jump order (Saltatoria), for example Xi of family.
Dermaptera, for example European earwig.
Isoptera, for example kalotermitid belongs to (Kalotermes spp.), Reticulitermes.
Corrodentia (Psocoptera), for example Lepinatus spp., powder corrodent belong to (Liposcelis spp.).
Coleoptera (Coleoptera), for example Anthrenus, the moth-eaten genus of fur, khapra beetle genus, a long ostomatid (Latheticus oryzae), hidden instep cuckoo Eimeria (Necrobia spp.), Ptinus, lesser grain borer, grain weevil (Sitophilus granarius), rice weevil (Sitophilus oryzae), corn weevil (Sitophilus zeamais), Stegobium paniceum (Stegobium paniceum).
Diptera, Aedes aegypti (Aedes aegypti) for example, aedes albopictus (Aedes albopictus), aedes taeniorhynchus (Aedes taeniorhynchus), Anopheles, calliphora erythrocephala, great number fiber crops horsefly (Chrysozona pluvialis), five band Culex pipiens pallens (Culex quinquefasciatus), northern house (Culex pipiens), ring beak culex (Culex tarsalis), Drosophila (Drosophila spp.), Fannia canicularis (Fannia canicularis), housefly (Musca domestica), owl midge, flesh fly (Sarcophaga carnaria), Simulium, tatukira (Stomoxys calcitrans), the Europe daddy-longlegs.
Lepidoptera, for example lesser wax-moth (Achroia grisella), greater wax moth, Indian meal moth (Plodia interpunctella), stopper rain moth (Tinea cloacella), bag rain moth, curtain rain moth.
Siphonaptera, for example ctenocephalides canis (Ctenocephalides canis), ctenocephalides felis (Ctenocephalides felis), Pulex irritans (Pulex irritans), chigo (Tunga penetrans), Xanthopsyllacheopis.
Hymenoptera, for example blazon hunchbacked ant (Camponotus herculeanus), black smelly ant (Lasius fuliginosus), black ant (Lasius niger), Lasius umbratus, MonomoriumMayr, Paravespula spp., Pavement Ant (Tetramorium caespitum).
Anoplura (Anoplura), for example head louse (Pediculus humanus capitis), body louse (Pediculus humanus corporis), Pemphigus spp., Phylloera vastatrix, crab louse (Phthirus pubis).
Heteroptera, for example cimex hemipterus (Cimex hemipterus), bed bug (Cimex lectularius), phodnius prolixus (Rhodinus prolixus), invasion triatomid (Triatoma infestans).
In the family expenses field of pesticides, they can use individually or with other suitable reactive compound in combination, and described suitable reactive compound is the reactive compound of phosphoric acid ester, carbamates, pyrethroid, anabasine, growth regulator or other known insecticides kind for example.
They can be following form use: aerosol, with no pressure spray product be pump spraying and atomizer spray, automatic atomising system, Alevaire, foaming agent, gel for example, have by the evaporant of the evaporant product of the evaporating plate of cellulose or polymer, liquid evaporant, gel and film evaporant, impeller driven, unpowered or passive vapo(u)rization system, catch moth paper, catch the moth bag and catch moth glue, as granule or powder agent, for shedding in bait or Poison bait station (bait station).
In addition, bond of the present invention and composition also can be used for reducing plant and the vegetable material of gathering in the content of mycotoxin, thereby and reduce the content of mycotoxin in the food made by it and animal feed.
Can be especially but propose nonexclusively following mycotoxin:
Deoxynivalenol (Deoxynivalenole, DON), nivalenol (Nivalenole), 15-Ac-DON, 3-Ac-DON, T2-and HT2-toxin, fumonisins (Fumonisines), zearalenone (Zearalenone), moniliformin (Moniliformine), fusarine (Fusarine), anguidin (Diaceotoxyscirpenole, DAS), white muscardine fungi toxin (Beauvericine), enniatine (Enniatine), Fusaroproliferine, Fusarenole, ochracin (Ochratoxines), patulin (Patuline), ergot alkaloid (Ergotalkaloides) and aflatoxin (Aflatoxines), they cause by for example following fungal disease: Fusarium, for example orange sickle spore (Fusarium acuminatum), oat sickle spore (F.avenaceum), F.crookwellense, yellow sickle spore (F.culmorum), F.graminearum schw (F.graminearum) (Gibberella zeae (Gibberella zeae)), scouring rush's sickle spore (F.equiseti), F.fujikoroi, banana sickle-like bacteria (F.musarum), point sickle spore (F.oxysporum), proliferation sickle-like bacteria (F.proliferatum), annual bluegrass sickle spore (F.poae), F.pseudograminearum, elder sickle spore (F.sambucinum), Lu grass sickle spore (F.scirpi), F.semitectum (F.semitectum), eggplant sickle spore (F.solani), intend branch spore sickle spore (F.sporotricholides), F.langsethiae, glue fusarium oxysporum (F.subglutinans), fusarium tricinctum (F.tricinctum), fusarium moniliforme (F.verticillioides) and other fungal disease, and aspergillus kind, Penicillium kind, purple ergot (Claviceps purpurea), Stachybotrys (Stachybotrys spec.) are planted etc.
The extraordinary bactericidal effect of bond of the present invention or composition is shown in following examples.Although single reactive compound only shows weak sterilization drug effect, the drug effect that bond of the present invention or compositions table reveal be greater than simply adding of each compound drug effect and.
If the sterilization drug effect of bond of the present invention or composition is greater than the expection drug effect according to the bond of two or three reactive compound of S.R.Colby, there is the synergistic effect of bactericide, described S.R.Colby expection drug effect (" Calculation of the synergistic and antagonistic responses of herbicide combinations ", Weeds1967,15,20-22) by as follows, calculated:
If
The actual measurement drug effect of the compound (A) that X is given dose (m ppm),
The actual measurement drug effect of the compound (B) that Y is given dose (n ppm),
The actual measurement drug effect of the compound (C) that Z is given dose (r ppm),
The compound (A) that E1 is m and n ppm given dose and the actual measurement drug effect together with compound (B),
Actual measurement drug effect together with the compound (A) that E2 is m, n and r ppm given dose, compound (B) and compound (C),
The Colby formula of binary mixture can as followsly define:
Figure BDA0000368738930000651
The Colby formula of ternary compound can as followsly define:
Figure BDA0000368738930000652
Drug effect is in %.0% drug effect means the drug effect corresponding to control group, and 100% drug effect means not observe disease.
In the situation that actual observation to bactericidal effect be greater than the expection drug effect of calculating with the Colby formula, bond of the present invention or composition have superadditivity, can be observed synergistic effect.
The present invention is by the explanation of following examples example.
Embodiment 1
Piricularia oryzae test (rice)/preventative
Solvent: 50 weight portion DMFs
Emulsifier: 1 weight portion alkylaryl polyglycol ether
For preparing suitable active agent preparations, the reactive compound of 1 weight portion is mixed with solvent and the emulsifier of described amount, and water is diluted to desired concn by dope.
For carrying out the prophylactic activity test, with active agent preparations, with described rate of application, spray immature plant.After spraying layer exsiccation, with the conidial suspension of piricularia oryzae (Pyricularia oryzae), spray plant.Subsequently plant is put into to 100% relative atmospheric humidity, the greenhouse of 25 ℃.
Inoculate and after 10 days, this test is assessed.0% means to be equivalent to the drug effect of control group, and 100% drug effect means not observe disease.
Table 1
Piricularia oryzae test (rice)/preventative
Figure BDA0000368738930000661
Figure BDA0000368738930000662
Figure BDA0000368738930000671
Figure BDA0000368738930000672
Embodiment 2
Dlumeria graminis test (barley)/5 are day preventative
Solvent: 50 weight portion DMAs
Emulsifier: 1 weight portion alkylaryl polyglycol ether
For preparing suitable active agent preparations, the reactive compound of 1 weight portion or active agent combinations are mixed with solvent and the emulsifier of described amount, and water is diluted to desired concn by dope.
For carrying out the prophylactic activity test, with the preparation of reactive compound or active agent combinations, with described rate of application, spray immature plant.
Sprinkling is used latter 5 days, and the spore of grass family dlumeria graminis (Blumeria graminis f.sp.hordei) is sprinkling upon on this plant.
Plant is put into to temperature is about 20 ℃, relatively atmospheric humidity is about 80% greenhouse, grow to promote mycotic spore.
Inoculating latter 7 days is assessed this test.0% means to be equivalent to the drug effect of control group, and 100% drug effect means not observe disease.
Table 2
Dlumeria graminis test (barley)/5 are day preventative
Figure BDA0000368738930000691
Figure BDA0000368738930000711
The drug effect formula of the bond of two kinds of compounds
The expection drug effect of the bond of two kinds of given compounds is calculated as follows (referring to Colby, S.R., " Calculating Synergistic and antagonistic Responses of Herbicide Combinations ", Weeds15, the 20-22 page, 1967):
If
X means for the % lethality with the untreated control group mPpm or mThe drug effect of the test compound A of g/ha concentration,
Y means for the % lethality with the untreated control group nPpm or nThe drug effect of the test compound B of g/ha concentration,
Z means for the % lethality with the untreated control group oPpm or oThe drug effect of the test compound C of g/ha concentration,
E for the % lethality of untreated control group, mean with M, n and oPpm or M, N and oThe drug effect of the mixture of g/ha administered compound A, B and C,
{。##.##1},
If the actual measurement desinsection drug effect of bond is higher than calculated value " E ", the bond of described two kinds of compounds has superadditivity, has synergistic effect.
Embodiment 3
The cotton bollworm test
Solvent: the dimethyl formamide of 7 weight portions
Emulsifier: the alkylaryl polyglycol ether of 2 weight portions
For preparing suitable active agent preparations, the reactive compound of 1 weight portion is mixed with solvent and the emulsifier of described amount, and this dope is diluted to desired concn with the water that contains emulsifier.
Soybean (Glycine max) leaf sprays processing with the active agent preparations of desired concn, even and infect with cotton bollworm (Heliothis armigera) larva when blade is moist.
After the time period of appointment, determine the lethality in %.100% means that all caterpillars are killed; 0% means to be killed without caterpillar.
In this test, for example, the application shows synergistic effect below in conjunction with thing and independent Compound Phase ratio:
Table 3: cotton bollworm test
The desinsection drug effect of obs.*=actual measurement
The drug effect that cal.**=calculates with the Colby formula
Embodiment 4
Brown planthopper-test
Solvent: the dimethyl formamide of 7 weight portions
Emulsifier: the alkylaryl polyglycol ether of 2 weight portions
For preparing suitable active agent preparations, the reactive compound of 1 weight portion is mixed with solvent and the emulsifier of described amount, and this dope is diluted to desired concn with the water that contains emulsifier.
Rice (Oryza sativa) plant is sprayed processing with the active agent preparations of desired concn, even and infect with brown planthopper (Nilaparvata lugens) larva when blade is moist.
After the time period of appointment, determine the lethality in %.100% means that all brown planthopper larvas are killed; 0% means to be killed without the brown planthopper larva.
In this test, for example, the application shows synergistic effect below in conjunction with thing and independent Compound Phase ratio:
Table 4: brown planthopper test
Figure BDA0000368738930000731
The desinsection drug effect of obs.*=actual measurement
The drug effect that cal.**=calculates with the Colby formula
Embodiment 5
Horseradish daikon leaf beetle-test
Solvent: the dimethyl formamide of 7 weight portions
Emulsifier: the alkylaryl polyglycol ether of 2 weight portions
For preparing suitable active agent preparations, the reactive compound of 1 weight portion is mixed with solvent and the emulsifier of described amount, and this dope is diluted to desired concn with the water that contains emulsifier.
Wild cabbage (Brassica oleracea) leaf sprays processing with the active agent preparations of desired concn, even and infect with the larva of horseradish daikon leaf beetle (Phaedon cochleariae) when blade is moist.
After the time period of appointment, determine the lethality in %.100% means that all horseradish ape leaf larvas are killed; 0% means to be killed without horseradish ape leaf larva.
In this test, for example, the application shows synergistic effect below in conjunction with thing and independent Compound Phase ratio:
Table 5-1: horseradish daikon leaf beetle-test
The desinsection drug effect of obs.*=actual measurement
The drug effect that cal.**=calculates with the Colby formula
Table 5-2: horseradish daikon leaf beetle-test
Figure BDA0000368738930000742
Figure BDA0000368738930000751
The desinsection drug effect of obs.*=actual measurement
The drug effect that cal.**=calculates with the Colby formula
Embodiment 6
The greedy noctuid test in meadow
Solvent: the dimethyl formamide of 7 weight portions
Emulsifier: the alkylaryl polyglycol ether of 2 weight portions
For preparing suitable active agent preparations, the reactive compound of 1 weight portion is mixed with solvent and the emulsifier of described amount, and this dope is diluted to desired concn with the water that contains emulsifier.
Wild cabbage (Brassica oleracea) leaf is processed by the active agent preparations that immerses desired concn, even and infect with the larva of the greedy noctuid (Spodoptera frugiperda) in meadow when blade is moist.
After the time period of appointment, determine the lethality in %.100% means that all caterpillars are killed; 0% means to be killed without caterpillar.
In this test, for example, the application shows synergistic effect below in conjunction with thing and independent Compound Phase ratio:
Table D: the greedy noctuid test in meadow
The desinsection drug effect of obs.*=actual measurement
The drug effect that cal.**=calculates with the Colby formula

Claims (17)

1. a bond comprises:
(A) isotianil
With
(B) Imidacloprid
With
(C) another is selected from the reactive compound of following sterilization and insecticidal active compound: second worm nitrile, ethiprole, the chloro-N1-{2-methyl-4-[1 of (S)-3-; 2; 2; 2-tetrafluoro-1-(trifluoromethyl) ethyl] phenyl }-N2-(1-methyl-2-methyl sulphonyl ethyl) phthalic amide and N-[2-(1; the 3-dimethylbutyl) phenyl]-5-is fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide.
2. the bond of claim 1, wherein any two kinds of components (A), (B) or (C) between weight ratio be 1:250 to 250:1 independently of one another.
3. the bond of claim 1, wherein any two kinds of components (A), (B) or (C) between weight ratio be 1:100 to 100:1 independently of one another.
4. claim 1 or 2 bond, comprise (A) 3, the chloro-N-of 4-bis-(2-cyano-phenyl)-5-isothiazole formamide and (B) Imidacloprid and (C) second worm nitrile.
5. claim 1 or 2 bond, also comprise auxiliary agent.
6. claim 1 or 2 bond, also comprise solvent, carrier or surfactant.
7. claim 1 or 2 bond, also comprise filler.
8. a therapeutic or the phytopathogen of preventative control plant or crop and/or the method for microorganism and/or insect, the bactericide and/or the insecticides that comprise any one in right to use requirement 1 to 7 in the following manner: it is applied to plant propagation material, plant, or described plant growth or soil to be grown.
9. the method for claim 8, comprise that right to use in the following manner requires the bond of any one in 1 to 7: it is applied to seed.
10. the method for claim 8, comprise that right to use in the following manner requires the bond of any one in 1 to 7: it is applied to the fruit of described plant.
11. the method for claim 8 or 9, comprise simultaneously or one after the other administered compound (A), (B) and (C).
12. the method for claim 8 or 9, wherein in claim 1 to 7, the amount of the bond/composition of any one is 0.1g/ha to 10kg/ha for blade face and soil treatment, for seed treatment, is 2 to 200g/100kg seeds.
13. in claim 1 to 7, the bond of any one is for the treatment of the purposes of seed.
14. the purposes of claim 13, for the treatment of transgenic seed.
15. the bud of the plant of protecting seed and/or being grown up to by seed and leaf make it avoid the method for insect or bacterium infringement, the method comprises with the bond of any one in a kind of claim 1 to 7 processes unseeded seed.
16. the method for claim 15, wherein said compound (A), (B) and (C) processing simultaneously for seed.
17. the method for claim 15, wherein said compound (A), (B) and (C) separately processing for seed.
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104830847A (en) * 2015-04-30 2015-08-12 北京大北农科技集团股份有限公司 Nucleic acid sequence for detecting corn plant DBN9936, and detection method thereof
CN104846084A (en) * 2015-04-30 2015-08-19 北京大北农科技集团股份有限公司 Nucleic acid sequence for detecting corn plant DBN9927 and detection method of nucleic acid sequence
CN104878097A (en) * 2015-04-30 2015-09-02 北京大北农科技集团股份有限公司 Nucleotide sequence and detection method for detecting corn plant DBN9981

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101765372B (en) * 2007-07-27 2013-09-04 拜尔农作物科学股份公司 Ternary active compound combinations
EP2070416A1 (en) * 2007-12-11 2009-06-17 Bayer CropScience AG Use of substance combinations for combating animal pests
EP2070414A1 (en) * 2007-12-11 2009-06-17 Bayer CropScience AG Active compound combinations
EP2070415A1 (en) * 2007-12-11 2009-06-17 Bayer CropScience AG Active compound combinations
TWI584732B (en) * 2008-12-19 2017-06-01 拜耳作物科學股份有限公司 Active compound combinations
MX2012003602A (en) * 2009-10-15 2012-04-19 Bayer Cropscience Ag Active compound combinations.
HUE042585T2 (en) 2011-06-17 2019-07-29 Hanmi Science Co Ltd A conjugate comprising oxyntomodulin and an immunoglobulin fragment, and use thereof
JP5760781B2 (en) * 2011-07-13 2015-08-12 住友化学株式会社 Harmful arthropod control composition and harmful arthropod control method
UA117905C2 (en) * 2012-01-21 2018-10-25 Байєр Інтеллектуал Проперті Гмбх Use of host defense inducers for controlling bacterial harmful organisms in useful plants
SG10201602801YA (en) 2012-11-06 2016-05-30 Hanmi Pharm Ind Co Ltd Liquid formulation of protein conjugate comprising the oxyntomodulin and an immunoglobulin fragment
CN103004810A (en) * 2012-12-11 2013-04-03 青岛东生药业有限公司 Seed treatment dispersible powder and preparing method thereof
SG11201507232QA (en) * 2013-03-15 2015-10-29 Adama Makhteshim Ltd Termiticide composition and methods for treating termites
CN103420884B (en) * 2013-05-17 2015-12-02 南开大学 There is bisamide derivatives and the preparations and applicatio of optical activity and rotamerism
TWI772252B (en) 2014-09-16 2022-08-01 南韓商韓美藥品股份有限公司 Use of a long acting glp-1/glucagon receptor dual agonist for the treatment of non-alcoholic fatty liver disease
KR102418477B1 (en) 2014-12-30 2022-07-08 한미약품 주식회사 Gluagon Derivatives
CN105165853B (en) * 2015-09-10 2017-05-03 京博农化科技股份有限公司 Pesticide bactericide
CN107094776A (en) * 2017-05-06 2017-08-29 北京科发伟业农药技术中心 Bactericidal composition containing isotianil
CN107047572A (en) * 2017-05-13 2017-08-18 北京科发伟业农药技术中心 Composition containing isotianil and smart furalaxyl

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19750012A1 (en) * 1997-11-12 1999-05-20 Bayer Ag Isothiazole carboxamides
DE19823396A1 (en) * 1998-05-26 1999-12-02 Bayer Ag Synergistic insecticidal mixtures
JP3358024B2 (en) * 1998-11-30 2002-12-16 日本農薬株式会社 Phthalamide derivatives or salts thereof, agricultural and horticultural insecticides, and methods of using the same
CZ299375B6 (en) * 1998-11-30 2008-07-09 Nihon Nohyaku Co., Ltd. Phthalimide derivatives or salts thereof, agricultural- horticultural insecticidal agent and application method thereof
CN1150824C (en) * 2001-04-12 2004-05-26 江苏龙灯化学有限公司 Composite herbicide with synergistic action for wheat field
WO2002087334A1 (en) * 2001-04-17 2002-11-07 Nihon Nohyaku Co., Ltd. Pest control agent composition and method of using the same
JP4348669B2 (en) * 2001-04-17 2009-10-21 日本農薬株式会社 Pest control composition and method of using the same
DE10136065A1 (en) * 2001-07-25 2003-02-13 Bayer Cropscience Ag pyrazolylcarboxanilides
DE10333371A1 (en) * 2003-07-23 2005-02-10 Bayer Ag Fungicidal drug combinations
DE10347440A1 (en) * 2003-10-13 2005-05-04 Bayer Cropscience Ag Synergistic insecticidal mixtures
JP2007529435A (en) * 2004-03-16 2007-10-25 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト Insecticidal composition and method for seed treatment
DE102004038329A1 (en) * 2004-06-16 2005-12-29 Bayer Cropscience Ag Synergistic insecticidal mixtures
CN100496243C (en) * 2004-06-16 2009-06-10 拜尔农作物科学股份公司 Synergistic insecticidal mixtures
DE102005022147A1 (en) * 2005-04-28 2006-11-02 Bayer Cropscience Ag Active agent combination, useful to e.g. combat animal parasites and phytopathogenic fungus, comprises a carboxyamide compound and/or at least an active agent e.g. acetylcholine-receptor-agonist/antagonist
JP2007161603A (en) * 2005-12-09 2007-06-28 Bayer Cropscience Kk Pest-controlling agent for paddy field
JP2008100946A (en) * 2006-10-19 2008-05-01 Bayer Cropscience Ag Fungicidal and insecticidal composition
CN101765372B (en) * 2007-07-27 2013-09-04 拜尔农作物科学股份公司 Ternary active compound combinations

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104830847A (en) * 2015-04-30 2015-08-12 北京大北农科技集团股份有限公司 Nucleic acid sequence for detecting corn plant DBN9936, and detection method thereof
CN104846084A (en) * 2015-04-30 2015-08-19 北京大北农科技集团股份有限公司 Nucleic acid sequence for detecting corn plant DBN9927 and detection method of nucleic acid sequence
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CN104830847B (en) * 2015-04-30 2019-01-11 北京大北农科技集团股份有限公司 For detecting the nucleic acid sequence and its detection method of corn plant DBN9936

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