CN103300946A - Manufacturing method for personalized bracket for repairing of center plane across mandibular defect - Google Patents
Manufacturing method for personalized bracket for repairing of center plane across mandibular defect Download PDFInfo
- Publication number
- CN103300946A CN103300946A CN2013102617463A CN201310261746A CN103300946A CN 103300946 A CN103300946 A CN 103300946A CN 2013102617463 A CN2013102617463 A CN 2013102617463A CN 201310261746 A CN201310261746 A CN 201310261746A CN 103300946 A CN103300946 A CN 103300946A
- Authority
- CN
- China
- Prior art keywords
- bone
- mandibular
- model
- personalized
- reparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Prostheses (AREA)
Abstract
The invention discloses a manufacturing method for a personalized bracket for the repairing of a center plane across mandibular defect. The method comprising the following steps: designing a repairing model for a personalized profile and an internal microstructure of an individual defect through CT scanning in combination with a curved surface reperforating way; acquiring a repair body for the defect area through a cutting algorithm; manufacturing the repair body through BOOL arithmetic design via an EBSM method; implanting a three-dimensional reticular metallic support in the mandible defect area; fixing the repair body and two bone stumps through titanium bolts; adding ossifying material and autologous bone marrow stromal cells; and stitching soft tissues and conducting implant implanting after the completion of ossifying, so as to complete denture restoration. The method provided by the invention can better promote and guide the growth of the bones, has a good synosteosis effect for the implant and the around bones, and is suitable for long-term repairing.
Description
Technical field
The present invention relates to a kind of mandibular defect reparation manufacture method of tissue engineering bracket.
Background technology
In recent years, the jaw face that causes owing to reasons such as tumor, infection, vehicle accidents particularly descends jaw defect to have the trend that increases year by year, only just have 1,500,000 people need carry out the craniomaxillofacial surgery operation in European every year and carry out the bone reparation, it is the operation of mandibular bone that a large portion is wherein arranged.
Present mandibular defect prosthesis mainly adopts autologous bone transplanting and metallic plate dummy to implant two kinds of restorative procedures, the autologous bone transplanting reparation can cause the secondary wound of getting bony site, and the confession bone is big or small limited, when implanting simultaneously because vascularization operation is very difficult, cause the implant blood supply insufficiency, cause absorbing very difficult control from the body bone implant, influence repairing effect.Metallic plate is implanted when repairing, though at present according to the personalized customization technology of patient self skeletal structure comparative maturity, the reparation of metal implant can provide support, recover outward appearance, but the later stage can not carry out Dental Implant, therefore can not recover the interlock function, and the inner structure Design of implant, optimize and manufacturing is faced with many difficulties, cause after the implant surgery metallic plate implant and the synosteosis poor effect of skeleton on every side, thus the permanent effect of repairing of influence.
Organizational project is structure and the function relationship that the principle of application project and life sciences and method are familiar with mammals tissue (normal or pathological state under), and development artificial bio-membrane's material is in order to repair, keep or improve its function.Organizational project is to transplant mutually as face and produce the Science and Technology of functional organization and organ, integrated different ambits such as image measurement technology such as CT/MRI, three-dimensional reconstruction technology, rapid prototyping technology, material engineering technology, biotechnology.Its basic principle is that tissue can be separated on one's body from patient, grows in the organization bracket that special material is made and expansion, finally forms the three-dimensional tissue of carriage direct.Like this, the three-dimensional tissue of generation can be transplanted among the same patient, to substitute the function of pathological tissues.
Tissue can regenerate structural formation property of mainly being organization bracket and the bioreactor function under the rack seed cell effect.Support by such as structural elements such as hole, fiber, film by at random, fractal or period profile rule combines, can be replicated and make by engineering method.When an engineering three-dimensional tissue structures is used to develop artificial alternate sets and knits, can carry out the engineering structure design to the biomaterial in the supporting structure, to optimize structure and to satisfy certain nutritional condition.But the reparation of present organizational project on the stem cells technology basis is because timbering material all adopts absorbable material, absorbing comparatively fast to provide good mechanics to support, can only repair less than 3cm damaged, can not repair and surpass the damaged of 4 tooth positions (greater than 3cm), particularly mandibular defect strides across the damaged reparation of central plane.
The difficult point of lower jaw defect repair is that prosthesis must recover patient's appearance and masticatory function, therefore tissue engineering technique has specific (special) requirements to profile, material and the structure of support and implant, be used at present mandibular defect surpass 4 tooth positions namely more than 3cm and the reparation field of the damaged mandibular bone of the damaged wound that strides across central plane also do not have mature technique can supply usefulness.
Summary of the invention
At the problem that exists in the present mandibular defect reparation, the present invention proposes the manufacture method that a kind of novel reparation mandibular defect strides across the personalized support of central plane, it provides the personalized support that is complementary with patient's face structure, and induces new bone growth to realize the reparation of tooth and the recovery of patient's face by the biological activity of support.
The reparation mandibular defect strides across the manufacture method of the personalized support of central plane, it is characterized in that may further comprise the steps:
(1) the CT image of taking position, patient oral cavity carries out the CT data acquisition;
(2) data of utilizing three-dimensional reconstruction software to gather according to CT are rebuild the mandibular bone skeleton model at position, patient oral cavity;
(3) repairing model of mandibular bone design utilizes the mode of curved surface perforations adding to repair, and namely the curvature according to the defect area peripheral curved surface changes, and design repairing curved surface makes it and the border curvature of curved surface is continuous on every side, obtains complete repairing model; Osteotomy line in described mandibular bone skeleton model acquisition defect area utilizes this osteotomy line on described repairing model the prosthesis cutting and separating to be come out, and the profile of the prosthesis of acquisition is the profile of personalized support; With the elementary cell of Descartes's quadrature truss structure as personalized internal stent UNICOM, obtain the computing framework in internal communication hole by the array operation to X, Y, three coordinate directions of Z respectively then, its mesexine is corresponding with the bearing capacity of Compact bone near the support stress of occlusal area, obtains inner netted structural model;
(4) prosthesis and inner netted structural model are carried out Boolean calculation, obtain the parameter of personalized support;
(5) according to the parameter of the above-mentioned personalized support that calculates, employing has the metal material of biocompatibility, produce personalized support through rapid shaping, the timbering material of described biocompatibility be for can add osteogenic materials, autologous bone marrow stroma stem cell and BMP thereon, the material of surface coverage absorbable biological film.
Described CT data acquisition is for to carry out Spiral CT scan to mandibular bone, and the plane of scanning motion is parallel to orbitomeatal plane, and sweep limits to inferior border of mandible, obtains the original fault image of patient from supraorbital margin.
Described three-dimensional reconstruction model preferably uses three-dimensional reconstruction software 3DMSR that the data that CT gathers are carried out three-dimensional reconstruction, change it image of stereoeffect directly perceived into, obtain the mandibular bone threedimensional model of STL form, view data Input Software MIMICS10.1 with the STL form, identify and rebuild Compact bone, spongy bone, tooth and nervus mandibularis pipe target area by the definition gray threshold, data importing Geomagic Studio4.0 after will in Mimics10.1, handling, delete mandibular bone part in addition, obtain the three-dimensional reconstruction model of complete mandibular bone.
Preferably in ICEM CFD software, divide grid when obtaining inner netted structural model, obtain three-dimensional grid model, model comprises node number and tetrahedron element number, and each node of model has 3 degree of freedom, comprise the movement on x, y, the z direction, the cell type of model is SOLID185; In the setting model compact bone and spongy bone material character continuously, homogenizing, isotropism, the Compact bone elastic modelling quantity is 16000-18000MPa, spongy bone is 800-1200MPa, the Poisson's ratio of compact bone and spongy bone is 0.27-0.33.
Described cancellated centre-to-centre spacing scope near through hole between the internal communication hole of dental bed part is 1-6mm, and described cancellated centre-to-centre spacing away from through hole between the internal communication hole of dental bed part is 6-10mm.
Described rapid shaping preferably adopts EBSM electron beam constituency to melt technology.
Described metal material is preferably titanium.
Described osteogenic materials is preferably hydroxyapatite.
Described absorbable biological film is preferably the Bio-guide film.
Stride across the personalized support that the manufacture method of the personalized support of central plane is made according to above-mentioned mandibular defect.
Technique effect
Personalized support of the present invention be personalized profile that individuality is damaged, internal microstructure by CT scan in conjunction with software modeling, after BOOL computing design, create by the EBSM method, implant three-dimensional netted metal rack in the mandibular defect district, dummy and two bone stumps are fixed with titanium screw, add osteogenic materials and autologous bone marrow stroma stem cell, surface coverage absorbable biological film, soft tissue is sewed up; Carry out implantation body's implantation after finishing skeletonization, finish the artificial tooth reparation at last.Described personalized profile is prepared by following method: (1) reconstructs the archetype of mandibular bone, (2) design repairing model, (3) dummy of acquisition defect area, described internal microstructure is to retrain the micro structure of changing the geometrical constraint designed regular of coming according to mechanics and biology, and described geometrical constraint refers to porosity, aperture.
Concrete, described method is after reconstructing the archetype of mandibular bone by patient CT data, utilize the mode of curved surface perforations adding to design repairing model, obtain the dummy of defect area then by cutting algorithm, obtain personalized profile, again by the BOOL computing between support external shape and the internal microstructure, create by the EBSM method, after adding the processing of osteogenic materials (hydroxyapatite) and autologous bone marrow stroma stem cell, operation implants and carries out bone reconstruction reparation, finally recovers patient's repertoire by the tooth plantation.
Beneficial effect of the present invention mainly shows: can produce fast and have good biocompatibility and bioactive metal material, add osteogenic materials (hydroxyapatite) and autologous bone marrow stroma stem cell and (extract bone marrow before the art, separate stem cells, cultivation; Allogeneic stem cell that in due course can the application of stem cells storehouse) implants after handling, be used for the engineered reparation of mandibular defect.Using the curved surface perforations adding designs the support of profile and can recover patient's outer harmony in the exterior appearance preferably at the situation that mandibular defect strides across central plane, and distribute by support density reasonable in design and to make it both to have better stress structure and have better biological activity simultaneously and can be filled to bone material and stem cell etc. and induce new bone growth, the tissue that finally makes bone defect regeneration and support are completed into and look like structure as the armored concrete, after finishing the Dental Implant reparation, patient's oral cavity function is recovered fully.One aspect of the present invention has solved prior art and has used metal rack and the synosteosis poor effect of skeleton on every side, can't realize tissue regeneration, and use autologous bone transplanting to cause secondary wound and problem rambunctious, also having solved the three-dimensional netted metal rack of present organizational project on the other hand applies to clinical also very difficult, the three-dimensional netted metal rack intensity of organizational project and profile are difficult to satisfy clinical utilization, also namely overcome general tissue engineering technique and can't realize the problem of good adaptation mandibular bone structure, for the reparation of mandibular bone provides a kind of more efficient methods.
Support of the present invention can better promote and guide osteogenesis; In addition support has been carried out mechanical analysis, the hole density degree of support is also had corresponding control, stressed big position is encrypted some and can better be supported, the more sparse osseous tissue that allows in stressed little position is more grown into, simultaneously can save material, save cost, convenient processing.
The present invention utilizes Tsing-Hua University laser fast forming center at electron beam constituency melt deposition (electron beam selective melting, EBSM) basis of technology and system development and experience, at complicated metal structure, particularly the demand of many metal gradients constitutional detail manufacturing is developed the electron beam constituency fusing bimetallic quick shaping manufacturing system with two kinds of metal dusts confession powder functions; Simultaneously, personalization manufacturing and the biology performance evaluation thereof at the decorative sursery titanium alloy implant conducts a research.Its maximum formation of parts size 200mm * 200mm * 200mm, shop powder thickness 0.05mm～0.5mm, beam power 3kW, bundle speckle positioning accuracy ± 0.2mm can realize vector scan and raster pattern image scanning.Finish the research of the electron beam constituency fusing manufacturing process of titanium alloy jawbone implant devices, device has good personality matching structure and bioelectric interface; The material good biocompatibility of device has no side effect; Dense samples intensity reaches more than the 900MPa.
Description of drawings
Fig. 1 is embodiment mandibular defect sketch map;
Fig. 2 is the sketch map of personalized support;
Fig. 3 is installed on the sketch map in affected part for personalized support.
The specific embodiment
The present invention the present invention is further explained below in conjunction with the specific embodiment in order better to explain.
As shown in Figure 1, defective is positioned at lower jaw right side incisor to left side mandibular ramus and condyle shape teat branch, the about 8-10cm of size.
At first the mandibular bone fault location is carried out Spiral CT scan: the MX-8000 type spiral CT that adopts Philips company to produce scans, and the plane of scanning motion is parallel to orbitomeatal plane, and sweep limits to inferior border of mandible, obtains the original fault image of patient from supraorbital margin.The three-dimensional reconstruction software 3DMSR (3-Dimensional Medicine Surface Rendering) that uses three-dimensional visualization technique again, utilizes Ji Mafei company independently to write carries out three-dimensional reconstruction with these discrete datas, change it into stereoeffect directly perceived image, obtain the mandibular bone threedimensional model of STL form;
View data Input Software MIMICS10.1 with the STL form, identify and rebuild Compact bone, spongy bone, tooth and nervus mandibularis pipe target area by the definition gray threshold, data importing Geomagic Studio4.0 after will in Mimics10.1, handling, delete mandibular bone part in addition, obtain the three-dimensional reconstruction model of complete mandibular bone;
Utilize the mode of curved surface perforations adding to repair, according to the curvature variation of defect area peripheral curved surface, design repairing curved surface makes it and the border curvature of curved surface is continuous on every side; Osteotomy line in described mandibular bone skeleton model acquisition defect area utilizes this osteotomy line on described repairing model the prosthesis cutting and separating to be come out, and the profile of the prosthesis of acquisition is the profile of personalized support; Divide grid in ICEM CFD software, obtain three-dimensional grid model, model comprises node number and tetrahedron element number, and each node of model has 3 degree of freedom, comprises the movement on x, y, the z direction, and the cell type of model is SOLID185; In the setting model compact bone and spongy bone material character continuously, homogenizing, isotropism, the Compact bone elastic modelling quantity is 17000MPa, spongy bone is 1000MPa, the Poisson's ratio of compact bone and spongy bone is 0.30; With the elementary cell of Descartes's quadrature truss structure as inner UNICOM, obtain the computing framework in internal communication hole by the array operation to X, Y, three coordinate directions of Z respectively then; Prosthesis and internal structure model are carried out Boolean calculation, obtain the forming data of personalized support.Wherein cancellated centre-to-centre spacing scope near through hole between the internal communication hole of dental bed part is distributed in 1-6mm, and described cancellated centre-to-centre spacing scope away from through hole between the internal communication hole of dental bed part is distributed in 6-10mm.
The titanium metal material that has biocompatibility according to the forming data of the above-mentioned personalized support that calculates by employing melts the technology rapid shaping by EBSM electron beam constituency and produces personalized support.
Implant three-dimensional netted metal rack in the mandibular defect district, dummy and two bone stumps are fixed with titanium screw, add osteogenic materials hydroxyapatite and autologous bone marrow stroma stem cell (extraction bone marrow before the art, separate stem cells, cultivation at described personalized support; Allogeneic stem cell that in due course can the application of stem cells storehouse) and BMP, osteogenic materials requires to be full of support, the autologous bone marrow stroma stem cell need permeate osteogenic materials, BMP is an amount of, surface coverage absorbable biological film Bio-guide film, the size of absorbable biological film is foundation with the length of support.
Soft tissue is sewed up; Finish the artificial tooth root implantation body that carries out pure titanium behind the skeletonization and implant, finish the artificial tooth reparation at last.
Claims (10)
1. repair the manufacture method that mandibular defect strides across the personalized support of central plane, it is characterized in that may further comprise the steps:
(1) the CT image of taking position, patient oral cavity carries out the CT data acquisition;
(2) data of utilizing three-dimensional reconstruction software to gather according to CT are rebuild the mandibular bone skeleton model at position, patient oral cavity;
(3) repairing model of mandibular bone design utilizes the mode of curved surface perforations adding to repair, and namely the curvature according to the defect area peripheral curved surface changes, and design repairing curved surface makes it and the border curvature of curved surface is continuous on every side, obtains complete repairing model; Osteotomy line in described mandibular bone skeleton model acquisition defect area utilizes this osteotomy line on described repairing model the prosthesis cutting and separating to be come out, and the profile of the prosthesis of acquisition is the profile of personalized support; With the elementary cell of Descartes's quadrature truss structure as personalized internal stent UNICOM, obtain the computing framework in internal communication hole by the array operation to X, Y, three coordinate directions of Z respectively then, its mesexine is corresponding with the bearing capacity of Compact bone near the support stress of occlusal area, obtains inner netted structural model;
(4) prosthesis and inner netted structural model are carried out Boolean calculation, obtain the parameter of personalized support;
(5) according to the parameter of the above-mentioned personalized support that calculates, employing has the metal material of biocompatibility, produce personalized support through rapid shaping, the timbering material of described biocompatibility be for can add osteogenic materials, autologous bone marrow stroma stem cell and BMP thereon, the material of surface coverage absorbable biological film.
2. reparation mandibular defect according to claim 1 strides across the manufacture method of the personalized support of central plane, it is characterized in that described CT data acquisition is for to carry out Spiral CT scan to mandibular bone, the plane of scanning motion is parallel to orbitomeatal plane, sweep limits to inferior border of mandible, obtains the original fault image of patient from supraorbital margin.
3. reparation mandibular defect according to claim 1 strides across the manufacture method of the personalized support of central plane, it is characterized in that described three-dimensional reconstruction model carries out three-dimensional reconstruction for using three-dimensional reconstruction software 3DMSR with the data that CT gathers, change it image of stereoeffect directly perceived into, obtain the mandibular bone threedimensional model of STL form, view data Input Software MIMICS10.1 with the STL form, identify and rebuild Compact bone by the definition gray threshold, spongy bone, tooth and nervus mandibularis pipe target area, data importing Geomagic Studio4.0 after will in Mimics10.1, handling, delete mandibular bone part in addition, obtain the three-dimensional reconstruction model of complete mandibular bone.
4. reparation mandibular defect according to claim 1 strides across the manufacture method of the personalized support of central plane, in ICEM CFD software, divide grid when it is characterized in that obtaining inner netted structural model, obtain three-dimensional grid model, model comprises node number and tetrahedron element number, each node of model has 3 degree of freedom, comprise the movement on x, y, the z direction, the cell type of model is SOLID185; In the setting model compact bone and spongy bone material character continuously, homogenizing, isotropism, the Compact bone elastic modelling quantity is 16000-18000MPa, spongy bone is 800-1200MPa, the Poisson's ratio of compact bone and spongy bone is 0.27-0.33.
5. reparation mandibular defect according to claim 4 strides across the manufacture method of the personalized support of central plane, it is characterized in that described cancellated centre-to-centre spacing near through hole between the internal communication hole of dental bed part is 1-6mm, described cancellated centre-to-centre spacing away from through hole between the internal communication hole of dental bed part is 6-10mm.
6. reparation mandibular defect according to claim 1 strides across the manufacture method of the personalized support of central plane, it is characterized in that described rapid shaping adopts EBSM electron beam constituency to melt technology.
7. reparation mandibular defect according to claim 1 strides across the manufacture method of the personalized support of central plane, it is characterized in that described metal material is titanium.
8. reparation mandibular defect according to claim 1 strides across the manufacture method of the personalized support of central plane, it is characterized in that described osteogenic materials is hydroxyapatite.
9. reparation mandibular defect according to claim 1 strides across the manufacture method of the personalized support of central plane, it is characterized in that at described absorbable biological film be the Bio-guide film.
10. stride across the personalized support that the manufacture method of the personalized support of central plane is made according to the arbitrary described reparation mandibular defect of claim 1-9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013102617463A CN103300946A (en) | 2013-06-27 | 2013-06-27 | Manufacturing method for personalized bracket for repairing of center plane across mandibular defect |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013102617463A CN103300946A (en) | 2013-06-27 | 2013-06-27 | Manufacturing method for personalized bracket for repairing of center plane across mandibular defect |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103300946A true CN103300946A (en) | 2013-09-18 |
Family
ID=49126963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2013102617463A Pending CN103300946A (en) | 2013-06-27 | 2013-06-27 | Manufacturing method for personalized bracket for repairing of center plane across mandibular defect |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103300946A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103479450A (en) * | 2013-10-16 | 2014-01-01 | 中国人民解放军总医院 | Condyle prosthesis and manufacturing method thereof |
| CN103750923A (en) * | 2013-12-20 | 2014-04-30 | 中山大学附属口腔医院 | Artificial temporal-mandibular joint based on selective laser melting technology and manufacturing method thereof |
| CN103919631A (en) * | 2014-04-28 | 2014-07-16 | 四川大学 | Manufacturing method for jaw defect individual restoration |
| CN105455925A (en) * | 2016-01-11 | 2016-04-06 | 佛山市安齿生物科技有限公司 | Method for preparing bone repair implant on basis of selective laser melting technology |
| CN105997306A (en) * | 2016-04-25 | 2016-10-12 | 北京工业大学 | Design method for filling porous grid structure in bone implantation body |
| CN109549727A (en) * | 2019-01-07 | 2019-04-02 | 韶关市丹雪牙科技术开发有限公司 | A kind of artificial tooth that repairing effect is good |
| CN110613533A (en) * | 2019-09-23 | 2019-12-27 | 浙江工业大学 | PEKK personalized implant design and manufacturing method for repairing mandibular shaft body box-shaped defect and implant |
| CN111511900A (en) * | 2017-11-09 | 2020-08-07 | 南加利福尼亚大学阿尔弗雷德·E·曼恩生物医学工程研究所 | Stem cells and devices for bone regeneration |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5489305A (en) * | 1994-10-03 | 1996-02-06 | Timesh, Inc. | Mandibular prostheses |
| US20050203628A1 (en) * | 2004-03-11 | 2005-09-15 | Elsalanty Mohammed E. | Mandibular bone transport reconstruction plate |
| CN1669538A (en) * | 2005-04-08 | 2005-09-21 | 卢建熙 | Artificial bone with biology imitating structure, preparation method and application thereof |
| CN101224140A (en) * | 2008-02-20 | 2008-07-23 | 北京吉马飞科技发展有限公司 | Adjusting redundancy realizing method of individuation Ti alloy skull and jaw face bone restoration |
| CN101637414A (en) * | 2009-08-27 | 2010-02-03 | 北京吉马飞科技发展有限公司 | Integral repair stent of eye sockets, cheekbones and maxillary bone and manufacturing method thereof |
| CN101642393A (en) * | 2009-08-27 | 2010-02-10 | 北京吉马飞科技发展有限公司 | Jawbone repair support and manufacture method thereof |
| CN102415920A (en) * | 2011-07-27 | 2012-04-18 | 浙江工业大学 | Manufacturing method of individual stent used for mandibular defect tissue engineering repair |
-
2013
- 2013-06-27 CN CN2013102617463A patent/CN103300946A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5489305A (en) * | 1994-10-03 | 1996-02-06 | Timesh, Inc. | Mandibular prostheses |
| US20050203628A1 (en) * | 2004-03-11 | 2005-09-15 | Elsalanty Mohammed E. | Mandibular bone transport reconstruction plate |
| CN1669538A (en) * | 2005-04-08 | 2005-09-21 | 卢建熙 | Artificial bone with biology imitating structure, preparation method and application thereof |
| CN101224140A (en) * | 2008-02-20 | 2008-07-23 | 北京吉马飞科技发展有限公司 | Adjusting redundancy realizing method of individuation Ti alloy skull and jaw face bone restoration |
| CN101637414A (en) * | 2009-08-27 | 2010-02-03 | 北京吉马飞科技发展有限公司 | Integral repair stent of eye sockets, cheekbones and maxillary bone and manufacturing method thereof |
| CN101642393A (en) * | 2009-08-27 | 2010-02-10 | 北京吉马飞科技发展有限公司 | Jawbone repair support and manufacture method thereof |
| CN102415920A (en) * | 2011-07-27 | 2012-04-18 | 浙江工业大学 | Manufacturing method of individual stent used for mandibular defect tissue engineering repair |
Non-Patent Citations (2)
| Title |
|---|
| 张劲 等: ""下颌骨截骨整形手术三维有限元模型的建立"", 《中国美容医学》, vol. 19, no. 3, 31 March 2010 (2010-03-31) * |
| 王忠东 等: ""个体化钛支架复合珊瑚羟基磷灰石和重组人骨形成蛋白2修复兔下颌骨缺损"", 《中华口腔医学研究杂志（电子版）》, vol. 6, no. 4, 31 August 2012 (2012-08-31) * |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103479450A (en) * | 2013-10-16 | 2014-01-01 | 中国人民解放军总医院 | Condyle prosthesis and manufacturing method thereof |
| CN103750923A (en) * | 2013-12-20 | 2014-04-30 | 中山大学附属口腔医院 | Artificial temporal-mandibular joint based on selective laser melting technology and manufacturing method thereof |
| CN103919631A (en) * | 2014-04-28 | 2014-07-16 | 四川大学 | Manufacturing method for jaw defect individual restoration |
| CN103919631B (en) * | 2014-04-28 | 2016-01-20 | 四川大学 | A kind of preparation method of jaw defect individualized therapy body |
| CN105455925A (en) * | 2016-01-11 | 2016-04-06 | 佛山市安齿生物科技有限公司 | Method for preparing bone repair implant on basis of selective laser melting technology |
| CN105997306B (en) * | 2016-04-25 | 2017-12-01 | 北京工业大学 | A kind of bone, which implants, fills the design method of perforated grill structure |
| CN105997306A (en) * | 2016-04-25 | 2016-10-12 | 北京工业大学 | Design method for filling porous grid structure in bone implantation body |
| CN111511900A (en) * | 2017-11-09 | 2020-08-07 | 南加利福尼亚大学阿尔弗雷德·E·曼恩生物医学工程研究所 | Stem cells and devices for bone regeneration |
| US11484625B2 (en) | 2017-11-09 | 2022-11-01 | Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California | Stem cells and devices for bone regeneration |
| CN109549727A (en) * | 2019-01-07 | 2019-04-02 | 韶关市丹雪牙科技术开发有限公司 | A kind of artificial tooth that repairing effect is good |
| CN109549727B (en) * | 2019-01-07 | 2024-03-26 | 韶关市丹雪牙科技术开发有限公司 | False tooth with good repairing effect |
| CN110613533A (en) * | 2019-09-23 | 2019-12-27 | 浙江工业大学 | PEKK personalized implant design and manufacturing method for repairing mandibular shaft body box-shaped defect and implant |
| CN110613533B (en) * | 2019-09-23 | 2023-11-07 | 浙江工业大学 | PEKK personalized implant design and manufacturing method for mandibular box defect repair and implant |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103315829B (en) | Repair the manufacture method of side mandibular defect more than the personalized support in 4 tooth positions | |
| CN103300946A (en) | Manufacturing method for personalized bracket for repairing of center plane across mandibular defect | |
| CN102415920A (en) | Manufacturing method of individual stent used for mandibular defect tissue engineering repair | |
| CN103919631B (en) | A kind of preparation method of jaw defect individualized therapy body | |
| CN109172049A (en) | A kind of porous network structure orthopaedics based on the connection of laminated sheet bar repairs the designing and manufacturing method and implant of implant | |
| CN109223248A (en) | A kind of skull repairing body and preparation method thereof inducing bone tissue regeneration | |
| CN100574725C (en) | Promote customization flexible titanium mandibular bone substitute of bone remodeling and preparation method thereof | |
| CN105930617A (en) | Method for designing and forming stiffness-controllable bone tumor defect repair implant | |
| CN105997306A (en) | Design method for filling porous grid structure in bone implantation body | |
| CN110613533A (en) | PEKK personalized implant design and manufacturing method for repairing mandibular shaft body box-shaped defect and implant | |
| CN104107097A (en) | Macroscopic-microcosmic-nanometer hierarchical mechanical compatible bone restoration and preparation thereof | |
| CN101259046A (en) | Titanium individuation mandibula prosthesis and preparation | |
| CN203988499U (en) | The net bag type mandibular bone implants of applying three-dimensional printing technique | |
| CN101536936B (en) | Stereolithography-based process for manufacturing porous structure of bionic scaffold | |
| CN110101914A (en) | A kind of Prevascularized two-phase artificial bone scaffold and preparation method thereof | |
| CN106580520A (en) | Implant and method for manufacturing mandibular implant with PEKK (polyetherketoneketone) supporting and fixing units and tissue engineering growth unit | |
| CN112107394A (en) | Implant for maxillofacial bone defect repair and preparation method thereof | |
| CN103479450A (en) | Condyle prosthesis and manufacturing method thereof | |
| Liu et al. | Digital design of scaffold for mandibular defect repair based on tissue engineering | |
| CN111986310B (en) | Design method of mandibular porous implant taking soft tissue attachment and bone growth into consideration and porous implant | |
| CN103908357B (en) | Artificial skeletal structure | |
| CN211271408U (en) | PEKK personalized implant for mandibular shaft box defect repair | |
| CN207286182U (en) | Repair titanium net-titanium plate complex of large-scale mandibular defect | |
| CN204683842U (en) | Repair the personalized support that mandibular defect strides across central plane | |
| CN215192628U (en) | Mandibular implant with vascular microcirculation pathways and guided bone growth |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20130918 |
|
| RJ01 | Rejection of invention patent application after publication |