CN102415920A - Manufacturing method of individual stent used for mandibular defect tissue engineering repair - Google Patents
Manufacturing method of individual stent used for mandibular defect tissue engineering repair Download PDFInfo
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- CN102415920A CN102415920A CN2011102121685A CN201110212168A CN102415920A CN 102415920 A CN102415920 A CN 102415920A CN 2011102121685 A CN2011102121685 A CN 2011102121685A CN 201110212168 A CN201110212168 A CN 201110212168A CN 102415920 A CN102415920 A CN 102415920A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
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- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
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- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
The invention relates to a manufacturing method of an individual stent used for mandibular defect tissue engineering repair. After an original model of a mandible is rebuilt through CT (computed tomography) data of a patient, a repair model is designed in a mirror algorithm or curved surface reperforating mode, then a dummy of a defect area is obtained in a cutting algorithm to obtain an individual appearance, and the individual stent made of a biological material is manufactured in an SLS (selective laser sintering) method through BOOL operation between the external shape and the internal microstructure of the stent. The invention provides the manufacturing method of the individual stent used for the mandibular defect tissue engineering repair, which has a good synosteosis effect of an implant and surrounding skeleton and is conductive to long-lasting repair.
Description
Technical field
The present invention relates to the manufacturing approach of a kind of mandibular defect reparation with tissue engineering bracket.
Background technology
Organizational project is structure and the function relationship that principle and the method for application project and life sciences is familiar with mammals tissue (normal or pathological state under), and development artificial bio-membrane's material is so that recover, keep or improve its function.Organizational project is as the Science and Technology that produces functional organization and organ towards transplanting, integrated different ambits such as image measurement technology such as CT/MRI, three-dimensional reconstruction technology, rapid prototyping technology, material engineering technology, biotechnology.Its basic principle is that tissue can be separated from patient on one's body, in the organization bracket that special material is processed, grows and expansion, finally forms the three-dimensional tissue of carriage direct.Like this, the three-dimensional tissue of generation can be transplanted among the same patient, to substitute the function of pathological tissues.
Structural formability and the bioreactor function of support under the seed cell effect that tissue can be regenerated and mainly is organization bracket.Support by such as structural elements such as hole, fiber, film through at random, fractal or period profile rule combines, can be replicated and make through engineering method.When an engineering three-dimensional tissue structures is used to develop artificial alternate sets and knits, can carry out the engineering structure design to the biomaterial in the supporting structure, to optimize structure and to satisfy the certain nutrition condition.
In recent years; The jaw face that causes owing to reasons such as tumor, infection, vehicle accidents particularly descends jaw defect to have the trend that increases year by year; Only just have 1,500,000 people need carry out the reconstruction of craniomaxillofacial surgery operation carrying out bone every year in Europe, and it is the operation of mandibular bone that a large portion is wherein arranged.The difficult point of lower jaw defect repair is that prosthesis must recover functions such as chewing of patient's appearance and oral cavity, and therefore profile and the structure to implant has specific (special) requirements.Main autologous bone transplanting and the metal restoration of adopting of present lower jaw defect repair operation implanted two kinds of repair modes; The autologous bone transplanting reparation can cause the secondary wound of getting bony site; And the limited size of confession bone, because the vascularization operation is very difficult, cause implant blood to supply deficiency when implanting simultaneously; Cause absorbing very difficult control, influence repairing effect from the body bone implant.When metal implant is repaired; Though at present according to the personalized customization technology of patient self skeletal structure comparative maturity; But inner structure Design of implant and manufacturing face many difficulties; Cause after the implant surgery metal implant and the synosteosis poor effect of skeleton on every side, thus the permanent effect of repairing of influence.
To the problem that exists in the present mandibular defect reparation; The present invention proposes a kind of personalized support that is complementary with the patient ' structure; Biomaterial rapid shaping through having good biocompatibility creates; After biological culture and implant surgery, be used for the engineered reparation of mandibular defect.Use this support and can recover patient's outer harmony in the exterior appearance preferably on the one hand; On the other hand, through scaffold degradation and guide new bone growth, the bone defect is replaced fully by the skeleton that patient self generates, after accomplishing Dental Implant and repairing, patient's oral cavity function is recovered fully.
Summary of the invention
For the metal implant after the implant surgery that overcomes existing mandibular defect repair process and the synosteosis poor effect of skeleton on every side; The deficiency of the permanent effect of repairing of influence, the present invention provides the manufacturing approach that a kind of implant is respond well with the synosteosis of skeleton on every side, help the permanent personalized support of repairing that is used for the engineered reparation of mandibular defect.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of manufacturing approach that is used for the personalized support of the engineered reparation of mandibular defect; After reconstructing the archetype of mandibular bone through patient CT data; Utilize the mode of mirror image algorithm or curved surface perforations adding to design repairing model; Obtain the dummy of defect area then through cutting algorithm, obtain personalized profile, again through the BOOL computing between support external shape and the internal microstructure; Obtain designing a model of individual character support, produce personalized support through the SLS method with biomaterial at last.
Further, said manufacturing approach may further comprise the steps:
1) CT data acquisition: the CT image of taking position, patient oral cavity;
2) reconstructing three-dimensional model of mandibular bone prototype: utilize the skeleton model at position, three-dimensional reconstruction software rebuild patient oral cavity, reconstruction model comprises tooth, nervus mandibularis pipe;
3) repairing model of mandibular bone design: the regional location according to the mandibular defect place is different, and two kinds of recovery scenarios are provided:
(3.1) do not have span centre heart symmetrical plane when defect area, the skeleton that utilizes mirror method will be good for side is symmetric to Ipsilateral, and replaces damaged skeleton, obtains complete repairing model through the model merge algorithm;
(3.2) striden across Center Symmetry Plane when defect area, utilized the mode of curved surface perforations adding to repair, promptly the curvature according to the defect area peripheral curved surface changes, and design repairs that curved surface makes it and the border curvature of curved surface is continuous on every side;
4) design prosthesis; Obtain the profile of personalized support: section bone line that will on the model of mandibular bone original shape, design defect area; Utilize this section bone line on repairing model, the prosthesis cutting and separating to be come out, the profile of this prosthesis is the profile of personalized support;
5) the inside loose structure of design support: Descartes's quadrature truss structure at first generates elementary cell as the elementary cell in internal communication hole, obtains the computing framework in internal communication hole through the array operation to X, Y, three coordinate directions of Z respectively then;
6) prosthesis and internal structure model are carried out Boolean calculation, obtain personalized support;
7) utilize SLS rapid shaping manufacturing approach, adopt biomaterial to produce personalized support.
Further, in the said step (3.2), in the perforations adding process,, utilize mirror image model to repair data as the auxiliary part that obtains if hole size exceeds preset value.
Technical conceive of the present invention is: personalized support be with personalized profile, internal microstructure after BOOL computing design; Create through the SLS method; After In vitro culture and biological method processing, operation implants and carries out bone reconstruction reparation, finally plants the personalized support that recovers patient oral cavity repertoire through tooth; Said personalized profile is prepared by following method: (1) reconstructs the archetype of mandibular bone; (2) design repairing model, (3) obtain the dummy of defect area, and said internal microstructure is according to mechanics and retrains the micro structure of changing the geometrical constraint designed regular of coming biology; Said In vitro culture adds somatomedin and osteoprogenitor cell in the personalized support and carries out, and said geometrical constraint is meant porosity, aperture.
Concrete; Described method is after reconstructing the archetype of mandibular bone through patient CT data, to utilize the mode of mirror image algorithm or curved surface perforations adding to design repairing model, obtains the dummy of defect area then through cutting algorithm; Obtain personalized profile; Through the BOOL computing between support external shape and the internal microstructure, create again, after adding somatomedin and osteoprogenitor cell carry out In vitro culture and biological method processing through the SLS method; Operation implants and carries out bone reconstruction reparation, finally recovers patient's repertoire through the tooth plantation.
Beneficial effect of the present invention mainly shows: can produce the biomaterial with good biocompatibility fast, after biological culture and implant surgery, be used for the engineered reparation of mandibular defect.Use the outer harmony in the exterior appearance that this support can recover the patient preferably; And through scaffold degradation and guide new bone growth; The bone defect is replaced by the skeleton that patient self generates fully, after accomplishing the Dental Implant reparation, patient's oral cavity function is recovered fully.
Description of drawings
Fig. 1 is the location drawing of defect area.
Fig. 2 is based on the repairing model design drawing of mirror image algorithm, wherein, (a) is archetype, (b) is mirror image model, (c) is the defect repair body, (d) is repairing model.
Fig. 3 is a repairing model design drawing of utilizing mirror image and perforations adding, wherein, (a) is archetype, (b) is mirror image model, (c) is the defect repair body, (d) is pooled model, (e) is perforations adding; (f) be repairing model.
Fig. 4 is prosthesis figure.
Fig. 5 is quadrature truss structure figure.
Fig. 6 is supporting structure elementary cell figure.
Fig. 7 is an internal structure computing frame diagram.
Fig. 8 is personalized support figure.
The specific embodiment
Below in conjunction with accompanying drawing the present invention is further described.
With reference to Fig. 1; A kind of manufacturing approach that is used for the personalized support of the engineered reparation of mandibular defect; After reconstructing the archetype of mandibular bone through patient CT data, utilize the mode of mirror image algorithm or curved surface perforations adding to design repairing model, obtain the dummy of defect area then through cutting algorithm; Obtain personalized profile; Through the BOOL computing between support external shape and the internal microstructure, obtain designing a model of individual character support again, produce personalized support through the SLS method with biomaterial at last.
In the present embodiment, manufacturing approach is applied in the defect repair process of mandibular bone, specifically may further comprise the steps:
1) CT data acquisition: the CT image of taking position, patient oral cavity;
2) reconstructing three-dimensional model of mandibular bone prototype: utilize the skeleton model at position, three-dimensional reconstruction software rebuild patient oral cavity, reconstruction model comprises tooth, nervus mandibularis pipe;
3) repairing model of mandibular bone design: the regional location according to mandibular defect shown in Figure 1 place is different, and two kinds of repairing model methods for designing are provided.
(3.1) when defect area is positioned at 1 shown in Fig. 1 and 2 zones; Because defect does not have span centre heart symmetrical plane; So the skeleton that utilizes mirror method will be good for side is symmetric to Ipsilateral, and replace damaged skeleton, obtain complete repairing model through the model merge algorithm.As shown in Figure 2.
(3.2) when defect area is positioned at the zone of the 3rd shown in Fig. 1; Because defect has striden across Center Symmetry Plane; So utilize the mode of curved surface perforations adding to repair, promptly the curvature according to the defect area peripheral curved surface changes, and design repairing curved surface makes it and the border curvature of curved surface is continuous on every side.In the perforations adding process,, can utilize mirror image model to repair data, to improve the verity of the curved surface of being mended as the auxiliary part that obtains if hole is bigger.As shown in Figure 3.
4) design prosthesis, obtain the profile of personalized support: will on the model of mandibular bone original shape, design section bone line of defect area, and utilize this section bone line on repairing model, the prosthesis cutting and separating to be come out.The profile of this prosthesis is the profile of personalized support, and is as shown in Figure 4.
5) the inside loose structure of design support: Descartes's quadrature truss structure shown in Figure 5 changes the porosity of support as the elementary cell in internal communication hole through two parameters of centre-to-centre spacing t of diameter of round spindle r among the adjusting figure and two circular shafts.At first generate elementary cell shown in Figure 6, obtain the computing framework in internal communication hole through array operation respectively then to X, Y, three coordinate directions of Z, as shown in Figure 7.
6) prosthesis and internal structure model are carried out Boolean calculation, obtain personalized support, as shown in Figure 8.
7) utilizing SLS rapid shaping manufacturing approach, is biomaterial to gather ethyl acetate (PCL), produces personalized support.
8) after this support process In vitro culture and body are implanted into, can be used for the defect repair of mandibular bone.
Claims (3)
1. manufacturing approach that is used for the personalized support of the engineered reparation of mandibular defect; It is characterized in that: after reconstructing the archetype of mandibular bone through patient CT data; Utilize the mode of mirror image algorithm or curved surface perforations adding to design repairing model; Obtain the dummy of defect area then through cutting algorithm, obtain personalized profile, again through the BOOL computing between support external shape and the internal microstructure; Obtain designing a model of individual character support, produce personalized support through the SLS method with biomaterial at last.
2. the manufacturing approach that is used for the personalized support of the engineered reparation of mandibular defect as claimed in claim 1 is characterized in that: said manufacturing approach may further comprise the steps:
1) CT data acquisition: the CT image of taking position, patient oral cavity;
2) reconstructing three-dimensional model of mandibular bone prototype: utilize the skeleton model at position, three-dimensional reconstruction software rebuild patient oral cavity, reconstruction model comprises tooth, nervus mandibularis pipe;
3) repairing model of mandibular bone design: the regional location according to the mandibular defect place is different, and two kinds of recovery scenarios are provided:
(3.1) do not have span centre heart symmetrical plane when defect area, the skeleton that utilizes mirror method will be good for side is symmetric to Ipsilateral, and replaces damaged skeleton, obtains complete repairing model through the model merge algorithm;
(3.2) striden across Center Symmetry Plane when defect area, utilized the mode of curved surface perforations adding to repair, promptly the curvature according to the defect area peripheral curved surface changes, and design repairs that curved surface makes it and the border curvature of curved surface is continuous on every side;
4) design prosthesis; Obtain the profile of personalized support: section bone line that will on the model of mandibular bone original shape, design defect area; Utilize this section bone line on repairing model, the prosthesis cutting and separating to be come out, the profile of this prosthesis is the profile of personalized support;
5) the inside loose structure of design support: Descartes's quadrature truss structure at first generates elementary cell as the elementary cell in internal communication hole, obtains the computing framework in internal communication hole through the array operation to X, Y, three coordinate directions of Z respectively then;
6) prosthesis and internal structure model are carried out Boolean calculation, obtain personalized support;
7) utilize SLS rapid shaping manufacturing approach, adopt biomaterial to produce personalized support.
3. the manufacturing approach that is used for the personalized support of the engineered reparation of mandibular defect as claimed in claim 2; It is characterized in that: in the said step (3.2); In the perforations adding process,, utilize mirror image model to repair data as the auxiliary part that obtains if hole size exceeds preset value.
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| CN2011102121685A CN102415920A (en) | 2011-07-27 | 2011-07-27 | Manufacturing method of individual stent used for mandibular defect tissue engineering repair |
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| CN2011102121685A CN102415920A (en) | 2011-07-27 | 2011-07-27 | Manufacturing method of individual stent used for mandibular defect tissue engineering repair |
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Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102805675A (en) * | 2012-08-13 | 2012-12-05 | 杭州电子科技大学 | Biological manufacturing and constructing method of customized artificial larynx |
| CN103300946A (en) * | 2013-06-27 | 2013-09-18 | 中国人民解放军总医院 | Manufacturing method for personalized bracket for repairing of center plane across mandibular defect |
| CN103315829A (en) * | 2013-06-27 | 2013-09-25 | 中国人民解放军总医院 | Manufacturing method of individualized stent for repairing defect of more than four tooth positions on one side of low jawbone |
| CN103479450A (en) * | 2013-10-16 | 2014-01-01 | 中国人民解放军总医院 | Condyle prosthesis and manufacturing method thereof |
| CN103919631A (en) * | 2014-04-28 | 2014-07-16 | 四川大学 | Manufacturing method for jaw defect individual restoration |
| CN105147416A (en) * | 2015-09-23 | 2015-12-16 | 深圳市艾科赛龙科技有限公司 | Construction method and construction system of tissue and organ defect portion bridging object |
| CN105213068A (en) * | 2015-09-21 | 2016-01-06 | 浙江工业大学 | Metal increases oral cavity prosthesis rack making method and the prosthesis support thereof of material manufacture |
| CN105596116A (en) * | 2015-11-05 | 2016-05-25 | 宝鸡文理学院 | Personalized hard tissue defect restoration body and manufacturing method thereof |
| CN105848593A (en) * | 2013-05-22 | 2016-08-10 | 诺贝尔生物服务公司 | Method for making a surgical guide for bone harvesting |
| CN106860917A (en) * | 2017-02-13 | 2017-06-20 | 北京大学口腔医学院 | A kind of personalized 3D printing bone tissue engineering scaffold containing mosaic texture |
| CN110613533A (en) * | 2019-09-23 | 2019-12-27 | 浙江工业大学 | PEKK personalized implant design and manufacturing method for repairing mandibular shaft body box-shaped defect and implant |
| CN111588517A (en) * | 2020-04-27 | 2020-08-28 | 安徽医科大学第二附属医院 | System for repairing bone defects |
| CN111759541A (en) * | 2020-06-11 | 2020-10-13 | 北京航天控制仪器研究所 | Method for forming full mandible prosthesis with variable-density porous structure |
| CN112006816A (en) * | 2020-07-30 | 2020-12-01 | 北京科技大学 | Porous gradient scaffold with mixed structural units and preparation method thereof |
| CN112006815A (en) * | 2020-07-30 | 2020-12-01 | 北京科技大学 | Porous gradient scaffold for bone repair and preparation method thereof |
| CN113768666A (en) * | 2021-09-08 | 2021-12-10 | 佳木斯大学 | Preparation method of bionic mandible support based on TPMS (tire pressure monitor System) design for 3D printing |
| CN113768665A (en) * | 2020-06-10 | 2021-12-10 | 上海交通大学医学院附属第九人民医院 | Bone defect repair support, construction method, preparation method, computer-readable storage medium and equipment |
| CN113768668A (en) * | 2021-09-08 | 2021-12-10 | 佳木斯大学 | Modeling method for designing personalized medical mandible model based on TPMS |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1523530A (en) * | 2003-09-10 | 2004-08-25 | 北京工业大学 | Method for preparing titanium alloy skull dummy |
| CN1588378A (en) * | 2004-08-06 | 2005-03-02 | 上海大学 | Establishing method for bionic tray computer model with internal micro hole |
| CN1609899A (en) * | 2004-10-27 | 2005-04-27 | 上海大学 | Bionic stent generating method based on CT picture |
| US20050273165A1 (en) * | 2004-06-04 | 2005-12-08 | Bryan Griffiths | Soft tissue spacer |
| CN101138651A (en) * | 2007-09-14 | 2008-03-12 | 华中科技大学 | Method of preparing organization bracket performing selectivity laser sintering by using macromolecule microsphere |
| CN101259046A (en) * | 2007-03-07 | 2008-09-10 | 上海双申医疗器械有限公司 | Titanium individuation mandibula prosthesis and preparation |
| CN101719172A (en) * | 2009-11-03 | 2010-06-02 | 上海大学 | Method for constructing microporous structure of bionic support |
-
2011
- 2011-07-27 CN CN2011102121685A patent/CN102415920A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1523530A (en) * | 2003-09-10 | 2004-08-25 | 北京工业大学 | Method for preparing titanium alloy skull dummy |
| US20050273165A1 (en) * | 2004-06-04 | 2005-12-08 | Bryan Griffiths | Soft tissue spacer |
| CN1588378A (en) * | 2004-08-06 | 2005-03-02 | 上海大学 | Establishing method for bionic tray computer model with internal micro hole |
| CN1609899A (en) * | 2004-10-27 | 2005-04-27 | 上海大学 | Bionic stent generating method based on CT picture |
| CN101259046A (en) * | 2007-03-07 | 2008-09-10 | 上海双申医疗器械有限公司 | Titanium individuation mandibula prosthesis and preparation |
| CN101138651A (en) * | 2007-09-14 | 2008-03-12 | 华中科技大学 | Method of preparing organization bracket performing selectivity laser sintering by using macromolecule microsphere |
| CN101719172A (en) * | 2009-11-03 | 2010-06-02 | 上海大学 | Method for constructing microporous structure of bionic support |
Non-Patent Citations (1)
| Title |
|---|
| 吴纪楠等: "基于快速成型技术制作个体化下颌人工骨的临床应用", 《中华口腔医学研究杂志（电子版）》, vol. 5, no. 2, 30 April 2011 (2011-04-30) * |
Cited By (26)
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| CN102805675B (en) * | 2012-08-13 | 2014-12-31 | 杭州电子科技大学 | Biological manufacturing and constructing method of customized artificial larynx |
| CN102805675A (en) * | 2012-08-13 | 2012-12-05 | 杭州电子科技大学 | Biological manufacturing and constructing method of customized artificial larynx |
| CN105848593B (en) * | 2013-05-22 | 2018-08-10 | 诺贝尔生物服务公司 | The method for making the surgical guide taken for bone |
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| CN103300946A (en) * | 2013-06-27 | 2013-09-18 | 中国人民解放军总医院 | Manufacturing method for personalized bracket for repairing of center plane across mandibular defect |
| CN103315829A (en) * | 2013-06-27 | 2013-09-25 | 中国人民解放军总医院 | Manufacturing method of individualized stent for repairing defect of more than four tooth positions on one side of low jawbone |
| CN103479450A (en) * | 2013-10-16 | 2014-01-01 | 中国人民解放军总医院 | Condyle prosthesis and manufacturing method thereof |
| CN103919631A (en) * | 2014-04-28 | 2014-07-16 | 四川大学 | Manufacturing method for jaw defect individual restoration |
| CN103919631B (en) * | 2014-04-28 | 2016-01-20 | 四川大学 | A kind of preparation method of jaw defect individualized therapy body |
| CN105213068B (en) * | 2015-09-21 | 2017-04-12 | 浙江工业大学 | Dental prosthesis stent made of metal additives and method for manufacturing dental prosthesis stent made of metal additives |
| CN105213068A (en) * | 2015-09-21 | 2016-01-06 | 浙江工业大学 | Metal increases oral cavity prosthesis rack making method and the prosthesis support thereof of material manufacture |
| CN105147416A (en) * | 2015-09-23 | 2015-12-16 | 深圳市艾科赛龙科技有限公司 | Construction method and construction system of tissue and organ defect portion bridging object |
| CN105596116A (en) * | 2015-11-05 | 2016-05-25 | 宝鸡文理学院 | Personalized hard tissue defect restoration body and manufacturing method thereof |
| CN106860917A (en) * | 2017-02-13 | 2017-06-20 | 北京大学口腔医学院 | A kind of personalized 3D printing bone tissue engineering scaffold containing mosaic texture |
| CN110613533A (en) * | 2019-09-23 | 2019-12-27 | 浙江工业大学 | PEKK personalized implant design and manufacturing method for repairing mandibular shaft body box-shaped defect and implant |
| CN110613533B (en) * | 2019-09-23 | 2023-11-07 | 浙江工业大学 | PEKK personalized implant design and manufacturing method for mandibular box defect repair and implant |
| CN111588517A (en) * | 2020-04-27 | 2020-08-28 | 安徽医科大学第二附属医院 | System for repairing bone defects |
| CN113768665A (en) * | 2020-06-10 | 2021-12-10 | 上海交通大学医学院附属第九人民医院 | Bone defect repair support, construction method, preparation method, computer-readable storage medium and equipment |
| CN111759541A (en) * | 2020-06-11 | 2020-10-13 | 北京航天控制仪器研究所 | Method for forming full mandible prosthesis with variable-density porous structure |
| CN111759541B (en) * | 2020-06-11 | 2023-05-09 | 北京航天控制仪器研究所 | Forming method of full mandibular prosthesis with variable-density porous structure |
| CN112006816A (en) * | 2020-07-30 | 2020-12-01 | 北京科技大学 | Porous gradient scaffold with mixed structural units and preparation method thereof |
| CN112006815A (en) * | 2020-07-30 | 2020-12-01 | 北京科技大学 | Porous gradient scaffold for bone repair and preparation method thereof |
| CN112006816B (en) * | 2020-07-30 | 2022-06-03 | 北京科技大学 | Porous gradient scaffold with mixed structural units and preparation method thereof |
| CN113768666A (en) * | 2021-09-08 | 2021-12-10 | 佳木斯大学 | Preparation method of bionic mandible support based on TPMS (tire pressure monitor System) design for 3D printing |
| CN113768668A (en) * | 2021-09-08 | 2021-12-10 | 佳木斯大学 | Modeling method for designing personalized medical mandible model based on TPMS |
| CN113768666B (en) * | 2021-09-08 | 2024-01-02 | 佳木斯大学 | Preparation method of 3D printing bionic mandible support based on TPMS design |
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Application publication date: 20120418 |