CN103211805A - Chlorhexidine gluconate composite disinfectant - Google Patents
Chlorhexidine gluconate composite disinfectant Download PDFInfo
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- CN103211805A CN103211805A CN2013101372774A CN201310137277A CN103211805A CN 103211805 A CN103211805 A CN 103211805A CN 2013101372774 A CN2013101372774 A CN 2013101372774A CN 201310137277 A CN201310137277 A CN 201310137277A CN 103211805 A CN103211805 A CN 103211805A
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- chlorhexidine gluconate
- composite disinfectant
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- amine oxide
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Abstract
The invention aims to provide a chlorhexidine gluconate composite disinfectant. The chlorhexidine gluconate composite disinfectant is prepared from chlorhexidine gluconate, coco fatty acid diethanol amide, lemon essence, delta-gluconolactone, hydroxyethyl cellulose, isopropanol, lauryl amine oxide, wool grease, tridecanol, and water for injection. The chlorhexidine gluconate composite disinfectant can perform comprehensive disinfection treatment on infection of skin, wound, trauma and burn before and after a surgery, can comprehensively disinfect the surgical instruments, has wide bacteriostatic and bactericidal effects and high effects, has a killing effect on all gram-positive bacterium, gram-negative bacterium, fungus, acid-fast bacteria, germs and viruses, is still effective in presence of serum and blood, causes no irritation to skin tissues, and is convenient and safe to use.
Description
[technical field]
The present invention relates to a kind of medical disinfecting liquid, relate in particular to a kind of sterilization and the cleaning and sterilizing of wound, the sterilization of operating theater instruments and disinfectant solution that preservation, doctor's perioperatively handwashing disinfection are used that is used for pre-surgical skin.
[background technology]
Chlorhexidine gluconate is a disinfection preservative, its bacteriostasis and sterilization effect broad-spectrum, and effect is strong, stronger to gram positive bacteria than the antibacterial action of negative bacterium, than quaternary cationic surfactant is strong, also effective to fungus, but invalid to acid fast bacteria, brood cell and virus.
The chlorhexidine gluconate disinfectant solution of Shi Yonging in the market, kind is single, and specific aim is not strong, and sterilization effect is limited, is difficult to satisfy existing diversification composite disinfecting sterilization requirement.Simultaneously, the preparation degree of accuracy can not get guaranteeing, and the pathogenic bacteria in the product and microorganism can not get effective control.Bring very big potential safety hazard for patient or end user.Along with the development of society, the raising of people's health care consciousness, also more and more higher to the requirement of disinfectant solution.
[summary of the invention]
The purpose of this invention is to provide a kind of chlorhexidine gluconate composite disinfectant, it can carry out comprehensive disinfection treatment to perioperatively skin, wound, wound and burn infection, can carry out comprehensive disinfection to operating theater instruments and handle.
The technical scheme that the present invention takes is as follows:
A kind of chlorhexidine gluconate composite disinfectant, it is formulated by chlorhexidine gluconate, lauric acid amide of ethanol, Fructus Citri Limoniae essence, gluconic acid lactone, hydroxyethyl-cellulose, isopropyl alcohol, lauryl amine oxide, lanoline, tridecyl alcohol and water for injection, wherein, the weight percentage of each component is: chlorhexidine gluconate 1%-5%; Lauric acid amide of ethanol 0.1%-2%; Fructus Citri Limoniae essence 0.01%-1%; Gluconic acid lactone 0.01%-1%; Hydroxyethyl-cellulose 0.01%-1%; Isopropyl alcohol 1%-10%; Lauryl amine oxide 0.1%-3%; Lanoline 0.01%-1%; Tridecyl alcohol 0.01%-1%.
Further, the weight percentage of each component is among the present invention: chlorhexidine gluconate 4%;
Lauric acid amide of ethanol 0.1%; Fructus Citri Limoniae essence 0.02%; Gluconic acid lactone 0.01%;
Hydroxyethyl-cellulose 0.01%; Isopropyl alcohol 1%; Lauryl amine oxide 0.1%; Lanoline 0.01%; Tridecyl alcohol 0.01%; Water for injection 94.74%.
Chlorhexidine gluconate is a disinfection preservative, and its bacteriostasis and sterilization effect is wide and strong, and is stronger than the anti-mattress effect of negative mattress to the Gram-positive mattress, is strong than quaternary cationic surfactant, also effective to fungus, but invalid to acid fast bacteria, brood cell and virus.
The lauric acid amide of ethanol Oleum Cocois is a raw material, after refine, directly or indirectly synthesizes with the diethanolamine reaction, and be high-quality non-ionic surface active agent.Make an addition in the products such as shampoo, bath gel, liquid detergent, liquid detergent, handwashing liquid and make suds booster, foam stabilizer, thickening agent, the emulsifying detergent that deoils.This product belongs to non-ionic surface active agent, does not have cloud point.Character be faint yellow to amber thick liquid, soluble in water, have functions such as good foaming, steady bubble, infiltration decontamination, anti-hard water.Belong to non-ionic surface active agent, the compatibility thickening effect is obvious especially with it when anion surfactant is acidity, can with kinds of surface activating agent compatibility.Can strengthen cleaning effect, can be used as additive, foam tranquilizer, foaming aids, be mainly used in the manufacturing of shampoo and liquid detergent.In water, form a kind of opaque vaporific solution, can be transparent fully under certain stirring, under finite concentration, can be dissolved in fully in different types of surfactant, in low-carbon (LC) and high-carbon, also can dissolve fully.
Gluconic acid lactone this product is white crystals or crystalline powder, sometimes some stink slightly.Taste begins sweet, is slightly acescency afterwards.As protein coagulating agent, acidic flavoring agent, bulking agent, antistaling agent and cosmetics, toothpaste production.
Hydroxyethyl-cellulose is as a kind of surfactant of nonionic, except that having thickening, suspension, bonding, floatingization, film forming, dispersion, water conservation and providing the protective colloid action, also has following character:
1. HEC dissolves in hot water or cold water, and high temperature or boil does not precipitate, and makes it have large-scale dissolubility and viscosity characteristics, and non-hot gelation;
2. nonionic own can with other water-soluble polymers on a large scale, surfactant, salt coexistence is a kind of good colloid thickening agent that contains the high concentration electrolyte solution;
3. water holding capacity exceeds one times than methylcellulose, has flow adjustment preferably;
4. to compare dispersibility the poorest for the dispersibility of HEC and methylcellulose of generally acknowledging and hydroxypropyl emthylcellulose, but the protecting colloid ability is the strongest.
Isopropyl alcohol another name dimethylcarbinol, 2-propanol are also made IPA in the industry.It is the isomers of normal propyl alcohol.Colourless transparent liquid has the abnormal smells from the patient like ethanol and acetone mixture.Most organic solvents such as water-soluble, pure, ether, benzene, chloroform.Isopropyl alcohol is important chemical product and raw material.Be mainly used in pharmacy, cosmetics, plastics, spice, coating etc.
Lauryl amine oxide this product is mainly used in dish washing detergent and industrial liquid bleach, and surely bubble effect of foam enhancing is arranged, and can improve the compatibility of thickening agent and the stability in the large of product.As foam booster, conditioner, thickening agent and the antistatic additive of shampoo, liquid detergent and foam bath, the raw material of still synthetic amphoteric surfactant.
The lanoline ointment base.It is the important source material of superior cosmetics and medicine.Be mainly used in the senior grease proofing of manufacturing machine industry, rheumatism plaster in the medical industry, zinc oxide adhesive plaster, the synthetic fibers of chemical fibre industry and synthetic resin, the chapstick of daily chemical industry, the synthetic fibers of chemical fibre industry and synthetic resin, the chapstick of daily chemical industry, cold cream, senior fancy soap.Lanoline includes 20% cholesterol, can be extracted, and produces hormone for medical industry and uses.Lanoline is time-honored raw material, and this reproducible resource has many potential value.Purposes aspect medicine and cosmetics is quite extensive.
Tridecyl alcohol is used for the raw material of all kinds of solvents such as lubricating oil, surfactant, pesticide, printing ink.
Formulated with the rustless steel Agitation Tank of special-purpose sealing in the workshop that reaches the GMP standard-required according to weight ratio.Mixture after the preparation is chlorhexidine gluconate content in the general instrument test final products through accurate test instrunment-high-efficient liquid phase color, guarantees that the content of the chlorhexidine gluconate in the final products is not less than 1%～4%.The present invention is particularly suitable for and the supporting use of medical hand-washing brush, product of the present invention is formulated in the workshop that reaches the GMP standard-required, through special handling or sterilization, security of products, aseptic and stability have fully been guaranteed, these products can directly use after unpacking and adorning, and have avoided the cross-contamination and the infection of intermediate link.
The present invention uses checking through reality, its bacteriostasis and sterilization effect broad-spectrum, and effect is strong, gram positive bacteria, gram negative bacteria, fungus, acid fast bacteria, brood cell and virus all there is killing effect, serum is arranged, still effective when blood exists, to the skin histology nonirritant, safety easy to use.
Use the present invention can produce the medical wet paper towel of various same specifications, the cotton rod of medical immersion, medical immersion dressing, these curable products all pass through sterilization treatment in process of production, thereby fully guarantee security of products and stability, these products can directly use after unpacking and adorning, and have avoided the cross-contamination and the infection of intermediate link.
[specific embodiment]
Illustrate the specific embodiment of the present invention below:
Embodiment one:
A kind of benzalkonium chloride disinfectant solution, it is formulated by chlorhexidine gluconate, lauric acid amide of ethanol, Fructus Citri Limoniae essence, gluconic acid lactone, hydroxyethyl-cellulose, isopropyl alcohol, lauryl amine oxide, lanoline, tridecyl alcohol and water for injection, and the each component weight percentage is: chlorhexidine gluconate 4%, lauric acid amide of ethanol 0.1%, Fructus Citri Limoniae essence 0.02%, gluconic acid lactone 0.01%, hydroxyethyl-cellulose 0.01%, isopropyl alcohol 1%, lauryl amine oxide 0.1%, lanoline 0.01%, tridecyl alcohol 0.01%, water for injection 94.74%.
The preparation step of the present invention is poly-as follows:
The first step is pressed the proportioning of each component and is prepared raw material, is example with 100 kilograms:
Each component weight such as following table
| The component title | The percentage composition ratio of component | Weight |
| Chlorhexidine gluconate | 4% | 4kg |
| The coconut oil diethanol is washed amine | 0.1% | 0.1kg |
| Fructus Citri Limoniae essence | 0.02% | 0.02kg |
| Gluconic acid lactone | 0.01% | 0.01kg |
| Hydroxyethyl-cellulose | 0.01% | 0.01kg |
| Isopropyl alcohol | 1% | 1kg |
| The dodecyl amine oxide | 0.1% | 0.1kg |
| Lanoline | 0.01% | 0.01kg |
| Tridecyl alcohol | 0.01% | 0.01kg |
| Water for injection | 94.74% | 94.74kg |
Second step took by weighing coconut oil diethanolamine, each 100g of dodecyl base amine oxide, added fully dissolving in the 10kg water for injection;
The 3rd step took by weighing tridecyl alcohol 10g, and isopropyl alcohol 1kg is poured into isopropyl alcohol in the tridecyl alcohol and dissolves;
The 4th step took by weighing gluconic acid lactone, each 10g of lanoline, joined in the 2kg water for injection and dissolved;
The 5th step took by weighing hydroxyethyl-cellulose 10g, with the dissolving of 10kg water for injection;
The 6th step took by weighing Fructus Citri Limoniae essence 20g, with the dissolving of 2kg water for injection;
In the 7th step, take by weighing concentration and be 20% chlorhexidine gluconate 20kg;
The 8th step, the solution unification that step 2 obtains to step 7 is poured in the mixing agitator tank, the storing containers that reuse 54.74kg water for injection rinse step 2 to be added is used to the step 7, washings all add and mix in the agitator tank, carry out mixing and stirring and get final product.
In this example, step 2 to step 7 can be carried out synchronously, because the concentration of chlorhexidine gluconate raw material is 20%, when therefore preparing burden, concentration is that the injected volume of 20% chlorhexidine gluconate raw material should be 20kg, and the weight that is converted to pure chlorhexidine gluconate like this is 4kg.
Embodiment two:
A kind of chlorhexidine gluconate composite disinfectant, it is formulated by chlorhexidine gluconate, lauric acid amide of ethanol, Fructus Citri Limoniae essence, gluconic acid lactone, hydroxyethyl-cellulose, isopropyl alcohol, lauryl amine oxide, lanoline, tridecyl alcohol and water for injection, and the weight percentage of each component is: chlorhexidine gluconate 1%; Lauric acid amide of ethanol 0.1%; Fructus Citri Limoniae essence 0.01%; Gluconic acid lactone 0.01%; Hydroxyethyl-cellulose 0.01%; Isopropyl alcohol 1%; Lauryl amine oxide 0.1%; Lanoline 0.01%; Tridecyl alcohol 0.01%.
Embodiment three:
A kind of chlorhexidine gluconate composite disinfectant, it is formulated by chlorhexidine gluconate, lauric acid amide of ethanol, Fructus Citri Limoniae essence, gluconic acid lactone, hydroxyethyl-cellulose, isopropyl alcohol, lauryl amine oxide, lanoline, tridecyl alcohol and water for injection, and the weight percentage of each component is: chlorhexidine gluconate 5%; Lauric acid amide of ethanol 10%; Fructus Citri Limoniae essence 5%; Gluconic acid lactone 5%; Hydroxyethyl-cellulose 5%; Isopropyl alcohol 30%; Lauryl amine oxide 10%; Lanoline 10%; Tridecyl alcohol 5%.
The compound method of embodiment two and embodiment three and embodiment one only are varying in weight of each component and water for injection roughly the same.
Claims (2)
1. chlorhexidine gluconate composite disinfectant, it is characterized in that: formulated by chlorhexidine gluconate, lauric acid amide of ethanol, Fructus Citri Limoniae essence, gluconic acid lactone, hydroxyethyl-cellulose, isopropyl alcohol, lauryl amine oxide, lanoline, tridecyl alcohol and water for injection, wherein, the weight percentage of each component is: chlorhexidine gluconate 1%-5%; Lauric acid amide of ethanol 0.1%-2%; Fructus Citri Limoniae essence 0.01%-1%; Gluconic acid lactone 0.01%-1%; Hydroxyethyl-cellulose 0.01%-1%; Isopropyl alcohol 1%-10%; Lauryl amine oxide 0.1%-3%; Lanoline 0.01%-1%; Tridecyl alcohol 0.01%-1%.
2. according to the described chlorhexidine gluconate composite disinfectant of claim 1, it is characterized in that: wherein the weight percentage of each component is: chlorhexidine gluconate 4%; Lauric acid amide of ethanol 0.1%; Fructus Citri Limoniae essence 0.02%; Gluconic acid lactone 0.01%; Hydroxyethyl-cellulose 0.01%; Isopropyl alcohol 1%; Lauryl amine oxide 0.1%; Lanoline 0.01%; Tridecyl alcohol 0.01%; Water for injection 94.74%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013101372774A CN103211805A (en) | 2013-04-18 | 2013-04-18 | Chlorhexidine gluconate composite disinfectant |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013101372774A CN103211805A (en) | 2013-04-18 | 2013-04-18 | Chlorhexidine gluconate composite disinfectant |
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| CN103211805A true CN103211805A (en) | 2013-07-24 |
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| CN2013101372774A Pending CN103211805A (en) | 2013-04-18 | 2013-04-18 | Chlorhexidine gluconate composite disinfectant |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362157A (en) * | 2015-12-15 | 2016-03-02 | 山东消博士消毒科技股份有限公司 | Antibacterial liquid soap for washing hands in surgical operation and preparation technology of antibacterial liquid soap |
| WO2017202442A1 (en) * | 2016-05-23 | 2017-11-30 | Ecolab Usa Inc. | Manual pre-cleaner and disinfectant for reprocessing of surgical instruments and flexible endoscopes |
| RU2696259C2 (en) * | 2017-10-23 | 2019-08-01 | Общество С Ограниченной Ответственностью "Сан Системз" | Solubilization of the chlorhexidine base, antiseptic and disinfectant compositions |
| US11033517B2 (en) * | 2013-12-12 | 2021-06-15 | Innovation Technologies, Inc. | Materials and methods for controlling infections |
-
2013
- 2013-04-18 CN CN2013101372774A patent/CN103211805A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 邱凯: "氯己定类消毒剂的研究进展", 《中国消毒学杂志》 * |
| 郭强等: "洗必泰醇溶液对手消毒效果的观察", 《中国消毒学杂志》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11033517B2 (en) * | 2013-12-12 | 2021-06-15 | Innovation Technologies, Inc. | Materials and methods for controlling infections |
| US11559503B2 (en) | 2013-12-12 | 2023-01-24 | Innovation Technologies, Inc. | Materials and methods for controlling infections |
| CN105362157A (en) * | 2015-12-15 | 2016-03-02 | 山东消博士消毒科技股份有限公司 | Antibacterial liquid soap for washing hands in surgical operation and preparation technology of antibacterial liquid soap |
| CN105362157B (en) * | 2015-12-15 | 2018-05-08 | 山东消博士消毒科技股份有限公司 | The antibacterial soap lye and its preparation process washed one's hands for surgical operation |
| WO2017202442A1 (en) * | 2016-05-23 | 2017-11-30 | Ecolab Usa Inc. | Manual pre-cleaner and disinfectant for reprocessing of surgical instruments and flexible endoscopes |
| RU2696259C2 (en) * | 2017-10-23 | 2019-08-01 | Общество С Ограниченной Ответственностью "Сан Системз" | Solubilization of the chlorhexidine base, antiseptic and disinfectant compositions |
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Application publication date: 20130724 |