CN103048271A - Portable type bi-modal imaging method employing combined photoacoustic imaging and optical coherence tomography and system of method - Google Patents
Portable type bi-modal imaging method employing combined photoacoustic imaging and optical coherence tomography and system of method Download PDFInfo
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- CN103048271A CN103048271A CN2012105614392A CN201210561439A CN103048271A CN 103048271 A CN103048271 A CN 103048271A CN 2012105614392 A CN2012105614392 A CN 2012105614392A CN 201210561439 A CN201210561439 A CN 201210561439A CN 103048271 A CN103048271 A CN 103048271A
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Abstract
The invention provides a portable type bi-modal imaging method employing combined photoacoustic imaging and optical coherence tomography, and a system of the method. The system comprises a laser diode, a driving power supply, a signal generator, a lock phase amplifier, a photoelectric detector, an optical fiber coupler, a light emitting diode, a signal processor, a three-dimensional translation platform, optical fibers, a lens assembly, a reflecting mirror, a color selective mirror, a light path casing and a sample platform and can achieve bi-modal imaging combining combined photoacoustic imaging and optical coherence tomography. The method and the system miniaturize a photoacoustic imaging system, and the photoacoustic imaging system and an optical coherence tomography system are combined to form the integral portable type system, so that integration, miniaturization and practicality of the bi-modal imaging are achieved.
Description
Technical field
The present invention relates to a kind of multi-modality imaging technology, particularly relate to dual mode portable attitude formation method and the system thereof of a kind of combined photoacoustic imaging and optical coherent chromatographic imaging.
Background technology
Single mode image technology commonly used has pure optical imagery (fluorescence imaging, light-scattering chromatography imaging etc.), sciagraphy, radio nuclide imaging and magnetic resonance imaging etc. at present, but these imaging means can only come imaging according to the variation of the in a certain respect characteristic of sample, can not many-sidedly obtain abundant information and the internal association thereof of sample, have certain application limitation.
Such as optical coherent chromatographic imaging (Optical Coherence Tomography, OCT) only reflect that sample is to the scattering of light characteristic, but in general sample is very small to the variation of reflection of light rate, and along with the penetration depth of light increases, the strong scattering of light in sample causes its imaging space resolution to descend rapidly, therefore OCT generally can only reach the investigation depth of 1-5 millimeter, but several microns to tens microns of resolutions; Photoacoustic imaging (Photoacoustic Imaging, PAI) only reflect that sample is to the Optical Absorption characteristic, it adopts broad band ultrasonic detector detection ultrasound wave to replace detecting scattered photon in the pure optical imagery, effectively avoided the strong scattering impact of sample on light, generally can reach 2-5 centimetre investigation depth, and resolution tens is to hundreds of micron amount; Ultrasonic imaging (Ultrasonic Imaging, USI) only reflects the acoustic impedance characteristic of sample, and it has the advantage of high-penetrability, but image contrast is very low, and easily causes erroneous judgement disconnected because the pseudoreflex phenomenon appears in example interface Multi reflection and secondary lobe interference.
Multi-modality imaging is a kind of trend of current image technology development, the image technology of different modalities mutually combines, and can provide more abundant image information, such as the USI/PAI technology, but the acoustic impedance information of USI image sampling, but the optical absorption information of simultaneously PAI image sampling.The single mode imaging can only observe an aspect information, and multi-modality imaging can observe the information of two even two above aspects simultaneously, and this is most important to the interaction between the different system in the research object.
Summary of the invention
The dual mode portable attitude formation method and the system thereof that the purpose of this invention is to provide a kind of combined photoacoustic imaging and optical coherent chromatographic imaging, it is portable integrated with the image technology of photoacoustic imaging and two kinds of difference in functionalitys of optical coherent chromatographic imaging, can reach two kinds of image mode Parallel applications.
The dual mode portable attitude formation method of combined photoacoustic imaging of the present invention and optical coherent chromatographic imaging may further comprise the steps:
1, the amplitude modulation laser of laser diode emission is derived by optical fiber, is radiated on the sample after lens combination, dichronic mirror and lens combination focus on, and is inspired photoacoustic signal;
2, the weak coherent laser that sends of light emitting diode is derived by optical fiber, be divided into two-way through fiber coupler, wherein one road light is derived by optical fiber for surveying light, be radiated on the sample after lens combination, dichronic mirror and lens combination focus on, reflection is by being radiated on the photodetector behind lens combination, dichronic mirror, lens combination, optical fiber, fiber coupler and the optical fiber;
3, continuous laser another Lu Guangwei reference light behind optical fiber and fiber coupler of sending of light emitting diode is radiated on the catoptron through optical fiber and lens combination, and reflection is by being radiated on the photodetector behind lens combination, optical fiber, fiber coupler and the optical fiber;
4, the interference light after the detection light that is reflected back and reference light are relevant is detected by photodetector, gathers the inlet signal processor behind lock-in amplifier;
5, the D translation platform drives the sample stage that upper surface is placed with sample and does two-dimension translational scanning.
Mode I: above-mentioned steps 1-5 can effectively survey the photoacoustic signal that propagates into sample surfaces, i.e. surface longitudinal wave and surface acoustic wave, thus realize photoacoustic imaging to sample.
Mode II: above-mentioned steps 2-5 can effectively survey the shallow surface of sample to the scattering of light characteristic, thereby realizes the optical coherent chromatographic imaging to the shallow table of sample.
Combination I and mode II can realize the bimodal imaging of combined photoacoustic imaging and optical coherent chromatographic imaging.
A kind of dual mode portable attitude imaging system that realizes combined photoacoustic imaging and optical coherent chromatographic imaging, comprise control and processing unit, light splitting and focusing unit, described control and processing unit comprise laser diode, driving power, signal generator, lock-in amplifier, photodetector, light emitting diode, signal processor, the D translation platform, described light splitting and focusing unit comprise fiber coupler, optical fiber, lens combination, catoptron, dichronic mirror, the light path shell, sample stage, laser diode, driving power is connected with signal generator successively wire, signal generator also is connected with the lock-in amplifier wire, photodetector, lock-in amplifier, signal processor successively wire connects, signal processor is connected with D translation platform wire, the D translation platform also with catoptron, sample stage connects, fiber coupler by optical fiber respectively with light emitting diode, photodetector connects.
Described lens combination can be formed by one or more lens combination respectively.
Described catoptron can be driven by the D translation platform and do the one dimension translation.
Be placed with sample on the described sample stage, and can do two-dimension translational by the drive of D translation platform.
The invention has the beneficial effects as follows:
(1) light source of the present invention adopts respectively light emitting diode and the laser diode of miniaturization, effectively raises portability and the practicality of system architecture;
(2) the present invention is combined into integrated bimodal system with photoacoustic imaging system and optical coherence tomography system, has realized the integral structure of two kinds of image modes, can survey simultaneously sample to Optical Absorption characteristic and scattering properties;
(3) the present invention is a unit with the light path part organic assembling of photoacoustic imaging and optical coherent chromatographic imaging, effectively reduces complexity and the instability of system architecture;
(4) photoacoustic imaging of the present invention and optical coherent chromatographic imaging all adopt dorsad detection mode, effectively raise operability and the scope of application of system, can be widely used in the fields such as film detection, gemstone testing, industrial flaw detection, medical image.
Description of drawings
Fig. 1 is structural representation of the present invention.
Embodiment
Below in conjunction with accompanying drawing the present invention is specified:
Embodiment 1
The structure of present embodiment as shown in Figure 1, the name of each element is called: 1, laser diode, 2, driving power, 3, signal generator, 4, lock-in amplifier, 5, photodetector, 6, fiber coupler, 7, light emitting diode, 8, signal processor, 9, D translation platform, 10, main road optical fiber, 11, one road optical fiber, 12, two road optical fiber, 13, three road optical fiber, 14, four road optical fiber, 15, lens under the side, 16, lens on the side, 17, upper lens, 18, lower lens, 19, catoptron, 20, dichronic mirror, 21, light path shell, 22, sample stage, 23, sample.
Laser diode 1 is selected the GH0781JA2C model of Japanese sharp company, and the continuous laser wavelength that it sends is 784nm, and output power is 120mW; Driving power 2 is selected the LDC220 model of U.S. Thorlabs company, and amplitude-modulated signal is that the frequency that signal generator 3 produces is the 10V sine wave signal of 5.5MHz; Light emitting diode 7 is selected the optical fiber output type super-radiance light emitting diode SLD-101 of the high light science and technology in Beijing, and centre wavelength is 750-1600nm, and spectrum width is 20-80nm, and output power is 0.2-25mW.
The dual mode portable attitude imaging system of the realization combined photoacoustic imaging of present embodiment and optical coherent chromatographic imaging, comprise control and processing unit, light splitting and focusing unit, control comprises laser diode with processing unit, driving power, signal generator, lock-in amplifier, photodetector, light emitting diode, signal processor, the D translation platform, light splitting and focusing unit comprise fiber coupler, optical fiber, lens combination, catoptron, dichronic mirror, the light path shell, sample stage, laser diode, driving power is connected with signal generator successively wire, signal generator also is connected with the lock-in amplifier wire, photodetector, lock-in amplifier, signal processor successively wire connects, signal processor is connected with D translation platform wire, the D translation platform also with catoptron, sample stage connects, fiber coupler by optical fiber respectively with light emitting diode, photodetector connects, upper lens place the top of dichronic mirror, lower lens place the below of dichronic mirror, lens place the side of dichronic mirror under the side, lens under the side, upper lens, lower lens, dichronic mirror places in the light path shell, and the position of lens and catoptron can not set on the side.
Described lens combination can be formed by one or more lens combination respectively.
Described catoptron can be driven by the D translation platform and do the one dimension translation.
Be placed with sample on the described sample stage, and can do two-dimension translational by the drive of D translation platform.
The dual mode portable attitude formation method of the realization combined photoacoustic imaging of present embodiment and optical coherent chromatographic imaging, concrete operation step is:
1, the amplitude modulation laser of laser diode 1 emission is derived by main road optical fiber 10, is radiated on the sample 23 after upper lens 17, dichronic mirror 20 and lower lens 18 focus on, and is inspired photoacoustic signal;
2, the weak coherent laser that sends of light emitting diode 7 is derived by four road optical fiber 14, be divided into two-way through fiber coupler 6, wherein one road light is derived by three road optical fiber 13 for surveying light, be radiated on the sample 23 after lens under the side 15, dichronic mirror 20 and lower lens 18 focus on, reflection is by being radiated on the photodetector 5 behind lens 15, three road optical fiber 13, fiber coupler 6 and two road optical fiber 12 under lower lens 18, dichronic mirror 20, the side;
3, continuous laser another Lu Guangwei reference light behind four road optical fiber 14 and fiber coupler 6 of sending of light emitting diode 7, lens 16 are radiated on the catoptron 19 on one road optical fiber 11 and side, and reflection is by being radiated on the photodetector 5 behind lens on the side 16, one road optical fiber 11, fiber coupler 6 and two road optical fiber 12;
4, the interference light after the detection light that is reflected back and reference light are relevant is detected by photodetector 5, gathers inlet signal processor 8 behind lock-in amplifier 4;
5, D translation platform 9 drives the sample stage 22 that upper surfaces are placed with sample 23 and does two-dimension translational scanning.
The mode I: repeating step 1-5 can effectively survey the photoacoustic signal that propagates into sample surfaces, i.e. surface longitudinal wave and surface acoustic wave, thus realize photoacoustic imaging to sample.
The mode II: repeating step 2-5 can effectively survey the shallow surface of sample to the scattering of light characteristic, thereby realizes the optical coherent chromatographic imaging to the shallow table of sample.
Combination I and mode II can realize the bimodal imaging of combined photoacoustic imaging and optical coherent chromatographic imaging.
Claims (5)
1. the dual mode portable attitude formation method of a combined photoacoustic imaging and optical coherent chromatographic imaging, it is characterized in that: it may further comprise the steps:
(a), the amplitude modulation laser of laser diode (1) emission derived by main road optical fiber (10), is radiated on the sample (23) after upper lens (17), dichronic mirror (20) and lower lens (18) focusing, is inspired photoacoustic signal;
(b), the weak coherent laser that sends of light emitting diode (7) is derived by four road optical fiber (14), be divided into two-way through fiber coupler (6), wherein one road light is derived by three road optical fiber (13) for surveying light, be radiated on the sample (23) after lens under the side (15), dichronic mirror (20) and lower lens (18) focus on, reflection is by being radiated on the photodetector (5) behind lens (15), three road optical fiber (13), fiber coupler (6) and two road optical fiber (12) under lower lens (18), dichronic mirror (20), the side;
(c), continuous laser another Lu Guangwei reference light behind four road optical fiber (14) and fiber coupler (6) of sending of light emitting diode (7), be radiated on the catoptron (19) through lens (16) on one road optical fiber (11) and the side, reflection is by being radiated on the photodetector (5) behind lens on the side (16), one road optical fiber (11), fiber coupler (6) and two road optical fiber (12);
(d), the interference light after the detection light that is reflected back and reference light are relevant is detected collection inlet signal processor (8) behind lock-in amplifier (4), the bimodal imaging of realization combined photoacoustic imaging and optical coherent chromatographic imaging by photodetector (5);
(e), D translation platform (9) drives the sample stage (22) that upper surface is placed with sample (23) and does two-dimension translational scanning.
2. the system of the dual mode portable attitude imaging of a combined photoacoustic imaging and optical coherent chromatographic imaging, it is characterized in that: it comprises control and processing unit, light splitting and focusing unit, and described control and processing unit comprise laser diode (1), driving power (2), signal generator (3), lock-in amplifier (4), photodetector (5), light emitting diode (7), signal processor (8), D translation platform (9); Described light splitting and focusing unit comprise under fiber coupler (6), main road optical fiber (10), one road optical fiber (11), two road optical fiber (12), three road optical fiber (13), four road optical fiber (14), the side lens (16), upper lens (17), lower lens (18), catoptron (19), dichronic mirror (20), light path shell (21), sample stage (22) on lens (15), the side; Laser diode (1), driving power (2) is connected with signal generator (3) successively wire, signal generator (3) also is connected with lock-in amplifier (4) wire, photodetector (5), lock-in amplifier (4), signal processor (8) successively wire connects, signal processor (8) is connected with D translation platform (9) wire, D translation platform (9) also with catoptron (19), sample stage (22) connects, and fiber coupler (6) is by two road optical fiber (12), four road optical fiber (14) respectively with light emitting diode (7), photodetector (5) connects; Upper lens (17) place the top of dichronic mirror (20), lower lens (18) place the below of dichronic mirror (20), lens under the side (15) place the side of dichronic mirror (20), and lens under the side (15), upper lens (17), lower lens (18), dichronic mirror (20) place in the light path shell (21).
3. the system of the dual mode portable attitude imaging of combined photoacoustic imaging according to claim 2 and optical coherent chromatographic imaging, it is characterized in that: lens (16), upper lens (17), lower lens (18) are formed by one or more lens combination respectively on lens under the described side (15), the side.
4. the system of the dual mode portable attitude imaging of combined photoacoustic imaging according to claim 2 and optical coherent chromatographic imaging is characterized in that: described catoptron (19) is driven by D translation platform (9) and does the one dimension translation.
5. the system of the dual mode portable attitude imaging of combined photoacoustic imaging according to claim 2 and optical coherent chromatographic imaging is characterized in that: be placed with sample (23) on the described sample stage (22), and do two-dimension translational by D translation platform (9) drive.
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| CN106932363A (en) * | 2017-03-10 | 2017-07-07 | 南京市计量监督检测院 | A kind of diamond purity detecting system and method |
| CN107411708A (en) * | 2017-05-22 | 2017-12-01 | 上海交通大学 | A kind of optical coherence tomography and photoacoustic imaging bimodal endoscope |
| CN108375547A (en) * | 2018-01-12 | 2018-08-07 | 华南师范大学 | Multispectral optoacoustic and optical coherence tomography bimodal imaging device and method |
| CN109030750A (en) * | 2018-09-14 | 2018-12-18 | 天津大学 | A kind of multi-modal tomography control method |
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| CN110623645A (en) * | 2019-10-18 | 2019-12-31 | 南昌航空大学 | Optical coherence tomography and photoacoustic imaging integrated device |
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| CN114018823A (en) * | 2021-09-18 | 2022-02-08 | 宝宇(武汉)激光技术有限公司 | Excitation and reception integrated laser ultrasonic flaw detection equipment and method |
| CN115815792A (en) * | 2023-02-17 | 2023-03-21 | 山东省科学院激光研究所 | Visual laser processing system and method |
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Application publication date: 20130417 |