CN110623645A - Optical coherence tomography and photoacoustic imaging integrated device - Google Patents
Optical coherence tomography and photoacoustic imaging integrated device Download PDFInfo
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- 238000003384 imaging method Methods 0.000 title claims abstract description 53
- 238000012014 optical coherence tomography Methods 0.000 title claims abstract description 27
- 210000004556 brain Anatomy 0.000 claims abstract description 18
- 238000012545 processing Methods 0.000 claims abstract description 8
- 238000003325 tomography Methods 0.000 claims abstract description 8
- 239000013307 optical fiber Substances 0.000 claims description 18
- 239000002033 PVDF binder Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims description 6
- 238000010408 sweeping Methods 0.000 claims description 4
- 210000005013 brain tissue Anatomy 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 230000035945 sensitivity Effects 0.000 claims description 3
- 230000001678 irradiating effect Effects 0.000 claims description 2
- 238000001514 detection method Methods 0.000 abstract description 5
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 230000003925 brain function Effects 0.000 description 2
- 230000003727 cerebral blood flow Effects 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000008557 oxygen metabolism Effects 0.000 description 2
- 230000002123 temporal effect Effects 0.000 description 2
- 208000014644 Brain disease Diseases 0.000 description 1
- 206010008088 Cerebral artery embolism Diseases 0.000 description 1
- 238000013528 artificial neural network Methods 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001149 cognitive effect Effects 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000002599 functional magnetic resonance imaging Methods 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011503 in vivo imaging Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 201000010849 intracranial embolism Diseases 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002610 neuroimaging Methods 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 238000012831 peritoneal equilibrium test Methods 0.000 description 1
- 238000012636 positron electron tomography Methods 0.000 description 1
- 238000012877 positron emission topography Methods 0.000 description 1
- 238000002603 single-photon emission computed tomography Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/0035—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02028—Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/06—Measuring blood flow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/488—Diagnostic techniques involving Doppler signals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/40—Animals
Abstract
An optical coherence tomography and photoacoustic imaging integrated device is characterized in that sample light and reference light are interfered, interference light signals are converted into electric signals through a photoelectric balance detector, data acquisition is carried out through a 12-bit data acquisition card, and image reconstruction is carried out through a correlation algorithm to obtain two-dimensional or three-dimensional tomography. The photoacoustic imaging is characterized in that a 532nm pulse laser emits laser, the beam spot diameter is increased through a beam expanding system, the beam spot diameter is irradiated to the brain of a mouse sample after passing through a semi-transparent semi-reflecting mirror, and a digital oscilloscope displays, records and sends amplified electric signals to a PC (personal computer) end for signal processing to form image information. The invention has the advantages that: the detection is convenient, no damage is caused to biological tissues, deep tissue information can be obtained more quickly, and the resolution ratio is high.
Description
Technical Field
The invention relates to an optical detection integrated device, in particular to an optical coherence tomography and photoacoustic imaging integrated device.
Background
The invention is used as an optical system device, mainly integrates an optical coherence tomography system and a photoacoustic imaging system, is used for functional vascular imaging of neurons of biological tissues and neural network blood, and is an important tool for researching brain intelligence and brain diseases. At present, cerebral embolism diseases become a fatal disease with high morbidity, which affects life safety, and development of an imaging system with high spatial-temporal resolution on the brain is very important. At present, the imaging of the hemodynamic change (such as blood flow and blood oxygen) in the brain mainly adopts the brain function imaging such as PET, SPECT, fMRI, computed tomography and the like, but the existing brain function imaging technology is difficult to realize the in-vivo imaging with high space-time resolution at the same time. The invention is based on the idea that a multi-mode imaging platform integrating an optical coherence tomography system and a photoacoustic imaging system is innovatively used for realizing dynamic function imaging of high frame frequency, high spatial and temporal resolution, in-vivo whole cerebral vessel structure, blood oxygen and blood flow, providing technical support for brain science and brain-like intelligent technology research, establishing a database of structure and function information of whole brain spatial and temporal connection, realizing a visualization platform under a mass data environment of data acquisition, coding representation, compression, storage, reconstruction and display, realizing efficient compression and decompression, quick retrieval and three-dimensional reconstruction display of two-dimensional and three-dimensional brain imaging images, and providing platform support for research and application of brain cognitive mechanism, human brain anatomical research, influence of various diseases on the brain and the like.
Disclosure of Invention
The invention aims to provide an integrated device of optical coherence tomography and photoacoustic imaging.
An optical coherence tomography and photoacoustic imaging integrated device adopts the following technical scheme: the specific process is that a 1700nm frequency-sweeping laser emits laser beams, the laser beams are divided into sample light and reference light through a 90:10 optical fiber coupler, wherein the reference light is collimated into parallel light through a collimator through an optical fiber circulator, the parallel light is focused to a reflecting light generated by a plane reflector through a convex lens and returns to the 50:50 optical fiber coupler; sample light enters the brain of a mouse for detecting a sample after passing through an optical fiber circulator and a laser scanning galvanometer and then is focused by a scanning lens, meanwhile, back scattering light generated by brain tissues of the mouse returns to an optical fiber coupler through a light path to generate interference with reference light, an interference light signal is converted into an electrical signal through a photoelectric balance detector, data acquisition is carried out by a 12-bit data acquisition card, image reconstruction is carried out through a related algorithm, and two-dimensional or three-dimensional tomography imaging is obtained. The photoacoustic imaging method comprises the steps that a 532nm pulse laser emits laser, the diameter of a light beam spot is increased through a beam expanding system, the light beam spot passes through a semi-transparent semi-reflecting mirror and then irradiates the brain of a sample mouse, a photoacoustic signal generated by irradiating the brain of the sample mouse through a reflecting mirror is received by a needle-shaped polyvinylidene fluoride (PVDF) hydrophone, the received photoacoustic signal is converted into an electric signal through an amplifier and then amplified, and the amplified electric signal is displayed, recorded and sent to a PC (personal computer) terminal for signal processing to form image information.
The invention designs an optical coherence tomography and photoacoustic imaging integrated device, which is characterized in that a photoacoustic coherence tomography system and a photoacoustic imaging system are integrated into a multi-mode imaging platform.
The invention relates to an optical coherence tomography and photoacoustic imaging integrated device, which is characterized in that a 1700nm swept-frequency laser of an optical coherence tomography technology is used as a system light source, the scanning speed of the light source is 200KHZ, the bandwidth is 100nm, and the sensitivity is more than 100 dB.
The invention relates to an optical coherence tomography and photoacoustic imaging integrated device, which is characterized in that a mode of combining high-speed multi-channel data acquisition and multi-wavelength laser excitation is adopted to realize ultrafast photoacoustic imaging of KHZ-level frame frequency, and the device is used for rapid detection of cerebral blood flow (the depth is more than 5mm) and blood oxygen (the depth is 3-5 mm).
The invention relates to an optical coherence tomography and photoacoustic imaging integrated device, which is characterized in that a Doppler OCT-photoacoustic multi-mode imaging system and method are combined with deep D-OCT imaging and ultrafast photoacoustic tomography technologies, and high-resolution structure, blood oxygen metabolism and blood flow distribution imaging of capillaries with mm-level imaging depth, mum-level imaging precision and kHZ-level imaging frame frequency can be obtained.
The invention relates to an integrated device for optical coherence tomography and photoacoustic imaging, wherein a 12-bit data acquisition card (18) adopts an ATS9373-D6 high-speed data acquisition card, the single-channel acquisition rate is 4GS/s, the FFT processing of a double-channel 12-bit waveform digital PCIE bus, the external frequency conversion clock range is 1-500MHz, the internal clock range is 1KHz to 500MHz, the input voltage range is +/-40 mV to +/-V, and the driving program design of asynchronous DMA equipment is adopted.
The invention has the advantages that: the detection is convenient, no damage is caused to biological tissues, deep tissue information can be obtained more quickly, and the resolution ratio is high.
Drawings
FIG. 1 is a system diagram of the optical nondestructive inspection method of the present invention.
In the figure, a 1700nm swept laser (01), a 90:10 fiber coupler (02), a fiber circulator (03), a collimator (04), a convex lens (05), a reflecting mirror (06), a laser scanning galvanometer (07), a scanning lens (08), a reflecting mirror (09), a semi-transmitting semi-reflecting lens (10), a beam expanding system (11), a 50:50 fiber coupler (12), a photoelectric balance detector (13), an Nd: YAG pulse laser (14), needle-shaped polyvinylidene fluoride hydrophone (15), amplifier (16), 4-channel digital oscilloscope (17) and 12-bit data acquisition system (18).
Detailed Description
An optical coherence tomography and photoacoustic imaging integrated device comprises the specific processes that a laser beam is emitted by a 1700nm frequency-sweeping laser 01 and is divided into sample light and reference light through a 90:10 optical fiber coupler 02, wherein the reference light passes through an optical fiber circulator 03, the reference light is collimated into parallel light through a collimator 04, the parallel light is focused through a convex lens 05 to a plane reflector 06, and the reflected light returns to the 50:50 optical fiber coupler 12; the sample light passes through the optical fiber circulator 03, passes through the laser scanning galvanometer 07, is focused by the scanning lens 08 to enter the brain of a mouse for detecting a sample, meanwhile, the back scattering light generated by the brain tissue of the mouse returns to the optical fiber coupler 12 through the optical path to interfere with the reference light, the interference light signal is converted into an electrical signal through the photoelectric balance detector 13, the data acquisition card 18 of 12 bits is used for data acquisition, and the image reconstruction is carried out through a related algorithm to obtain two-dimensional or three-dimensional tomography. The photoacoustic imaging method includes the steps that a 532nm pulse laser 14 emits laser, the beam spot diameter is increased through a beam expanding system 11, the light passes through a semi-transparent semi-reflecting mirror 10 and then irradiates the brain of a sample mouse, photoacoustic signals generated by the fact that transmitted light passes through a reflecting mirror 09 and irradiates the brain of the sample mouse are received by needle-shaped polyvinylidene fluoride hydrophone PVDF15, the received photoacoustic signals are converted into electric signals through an amplifier 16 and then amplified, and the amplified electric signals are displayed, recorded and sent to a PC (personal computer) end for signal processing to form image information.
The invention designs an optical coherence tomography and photoacoustic imaging integrated device, which is characterized in that a photoacoustic coherence tomography system and a photoacoustic imaging system are integrated into a multi-mode imaging platform.
The invention relates to an integrated device of optical coherence tomography and photoacoustic imaging, which is characterized in that a laser with 1700nm wavelength is used as a system light source in the optical coherence tomography, the scanning speed of the light source is 200KHZ, the bandwidth is 100nm, and the sensitivity is more than 100 dB.
The invention relates to an optical coherence tomography and photoacoustic imaging integrated device, which is characterized in that a mode of combining high-speed multi-channel data acquisition and multi-wavelength laser excitation is adopted to realize ultrafast photoacoustic imaging of KHZ-level frame frequency and is used for rapid detection of cerebral blood flow depth of more than 5mm and blood oxygen depth of 3-5 mm.
The invention relates to an optical coherence tomography and photoacoustic imaging integrated device, which is characterized in that a Doppler OCT-photoacoustic multi-mode imaging system and method are combined with deep D-OCT imaging and ultrafast photoacoustic tomography technologies, and high-resolution structure, blood oxygen metabolism and blood flow distribution imaging of capillaries with mm-level imaging depth, mum-level imaging precision and kHZ-level imaging frame frequency can be obtained.
The invention relates to an optical coherence tomography and photoacoustic imaging integrated device, which is characterized in that an ATS9373-D6 high-speed data acquisition card is adopted for data processing of an OCT imaging system, the single-channel acquisition rate is 4GS/s, the FFT processing of a double-channel 12-bit waveform digital PCIE bus is adopted, the external frequency conversion clock range is 1-500MHz, the internal clock range is 1KHz to 500MHz, the input voltage range is +/-40 mV to +/-V, and the driving program design of asynchronous DMA equipment is adopted.
Claims (3)
1. The integrated device for optical coherence tomography and photoacoustic imaging is characterized by comprising a 1700nm frequency-sweeping laser (01), a 90:10 optical fiber coupler (02), an optical fiber circulator (03), a collimator (04), a convex lens (05), a reflecting mirror (06), a laser scanning galvanometer (07), a scanning lens (08), a reflecting mirror (09), a semi-transmitting and semi-reflecting lens (10), a beam expanding system (11), a 50:50 optical fiber coupler (12), a photoelectric balance detector (13) and an Nd: YAG pulse laser (14), needle-shaped polyvinylidene fluoride hydrophone (15), amplifier (16), 4-channel digital oscilloscope (17) and 12-bit data acquisition system (18); the specific process is that a laser beam is emitted by a 1700nm frequency-sweeping laser (01), the laser beam is divided into sample light and reference light through a 90:10 optical fiber coupler (02), wherein the reference light is collimated into parallel light through a collimator (04) through an optical fiber circulator (03) and then the parallel light is focused to a plane reflector (06) through a convex lens (05) to generate reflected light which returns to a 50:50 optical fiber coupler (12); sample light enters the brain of a detected sample mouse after passing through an optical fiber circulator (03) and a laser scanning galvanometer (07) and then is focused by a scanning lens (08), meanwhile, back scattering light generated by the brain tissue of the mouse returns to an optical fiber coupler (12) through a light path to generate interference with reference light, the interference light signal is converted into an electric signal through a photoelectric balance detector (13), data acquisition is carried out through a 12-bit data acquisition card (18), image reconstruction is carried out through a correlation algorithm to obtain two-dimensional or three-dimensional tomography, photoacoustic imaging emits laser through a 532nm pulse laser (14), the diameter of a light spot of the light beam is increased through a beam expanding system (11), the sample mouse brain is irradiated after passing through a semi-transparent semi-reflective mirror (10), the photoacoustic signal generated by irradiating the brain of the sample mouse through a reflecting mirror (09) is received by a needle-shaped polyvinylidene fluoride hydrophone (15), the received photoacoustic signal is converted into an electric signal through an amplifier (16) and then amplified, and the amplified electric signal is displayed, recorded and sent to a PC (personal computer) end for signal processing by a digital oscilloscope (17) to form image information.
2. An integrated optical coherence tomography and photoacoustic imaging apparatus according to claim 1, wherein the 1700nm swept-frequency laser (01) is used as the system light source, the scanning speed of the light source is 200KHZ, the bandwidth is 100nm, and the sensitivity is >100 dB.
3. The integrated device for optical coherence tomography and photoacoustic imaging according to claim 1, wherein the 12-bit data acquisition card (18) is an ATS9373-D6 high-speed data acquisition card, the single-channel acquisition rate is 4GS/s, the FFT processing of a dual-channel 12-bit waveform digital PCIE bus, the external frequency conversion clock range is 1-500MHz, the internal clock range is 1KHz to 500MHz, the input voltage range is ± 40mV to ± V, and the driving program design of asynchronous DMA equipment is adopted.
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Cited By (4)
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| CN111035368A (en) * | 2020-01-07 | 2020-04-21 | 上海科技大学 | Single-channel real-time photoacoustic tomography imaging system and method |
| CN113466869A (en) * | 2021-06-15 | 2021-10-01 | 青岛海洋科学与技术国家实验室发展中心 | Underwater target detection method based on laser induced sound |
| CN114403810A (en) * | 2022-01-24 | 2022-04-29 | 武汉资联虹康科技股份有限公司 | Intelligent head-wearing near-infrared brain function imaging system based on Internet of things |
| CN115316959A (en) * | 2022-10-13 | 2022-11-11 | 浙江大学医学中心(余杭) | Three-color multi-channel optical fiber brain information recording system |
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