CA2567806C - Procede de resolution rapide du clopidogrel base et un procede de preparation de la forme polymorphique i du bisulfate de clopidogrel - Google Patents
Procede de resolution rapide du clopidogrel base et un procede de preparation de la forme polymorphique i du bisulfate de clopidogrel Download PDFInfo
- Publication number
- CA2567806C CA2567806C CA2567806A CA2567806A CA2567806C CA 2567806 C CA2567806 C CA 2567806C CA 2567806 A CA2567806 A CA 2567806A CA 2567806 A CA2567806 A CA 2567806A CA 2567806 C CA2567806 C CA 2567806C
- Authority
- CA
- Canada
- Prior art keywords
- clopidogrel
- solvent
- ether
- base
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IN2005/000048 WO2006087729A1 (fr) | 2005-02-15 | 2005-02-15 | Procede de resolution rapide destine a une base de clopidogrel et procede de preparation de la forme i polymorphique de l'hydrogenosulfate de clopidogrel |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2567806A1 CA2567806A1 (fr) | 2006-08-24 |
CA2567806C true CA2567806C (fr) | 2011-04-26 |
Family
ID=36644897
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2567806A Expired - Fee Related CA2567806C (fr) | 2005-02-15 | 2005-02-15 | Procede de resolution rapide du clopidogrel base et un procede de preparation de la forme polymorphique i du bisulfate de clopidogrel |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1848720A1 (fr) |
AU (1) | AU2005327776A1 (fr) |
CA (1) | CA2567806C (fr) |
WO (1) | WO2006087729A1 (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL382055A1 (pl) * | 2007-03-23 | 2008-09-29 | Koźluk Tomasz Nobilus Ent | Sposób wytwarzania formy krystalicznej 1 wodorosiarczanu klopidogrelu |
WO2008146249A1 (fr) * | 2007-05-30 | 2008-12-04 | Wockhardt Research Centre | Procédé d'élaboration de clopidogrel |
EP2107061A1 (fr) | 2008-04-02 | 2009-10-07 | Krka Tovarna Zdravil, D.D., Novo Mesto | Procédé de préparation de clopidogrel enrichi optiquement |
WO2011042804A2 (fr) | 2009-10-08 | 2011-04-14 | Jubliant Life Sciences Limited | Procédé perfectionné pour la préparation de la forme i d'hydrogénosulfate de clopidogrel |
KR101710922B1 (ko) | 2015-06-03 | 2017-02-28 | 경동제약 주식회사 | 클로피도그렐 황산염 결정형 i형의 제조방법 |
CN107383055A (zh) * | 2017-08-03 | 2017-11-24 | 江苏汉斯通药业有限公司 | 硫酸氢氯吡格雷的合成方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2623810B2 (fr) * | 1987-02-17 | 1992-01-24 | Sanofi Sa | Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant |
FR2779726B1 (fr) * | 1998-06-15 | 2001-05-18 | Sanofi Sa | Forme polymorphe de l'hydrogenosulfate de clopidogrel |
IL166593A0 (en) * | 2002-08-02 | 2006-01-15 | Racemization and enantiomer separation of clopidogrel | |
US6800759B2 (en) * | 2002-08-02 | 2004-10-05 | Teva Pharmaceutical Industries Ltd. | Racemization and enantiomer separation of clopidogrel |
EP1606231A1 (fr) * | 2003-02-03 | 2005-12-21 | Nadkarni, Sunil Sadanand | Procede de preparation de clopidogrel, ses sels et compositions pharmaceutiques |
-
2005
- 2005-02-15 AU AU2005327776A patent/AU2005327776A1/en not_active Abandoned
- 2005-02-15 WO PCT/IN2005/000048 patent/WO2006087729A1/fr active Application Filing
- 2005-02-15 EP EP05747156A patent/EP1848720A1/fr not_active Withdrawn
- 2005-02-15 CA CA2567806A patent/CA2567806C/fr not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2567806A1 (fr) | 2006-08-24 |
WO2006087729A1 (fr) | 2006-08-24 |
EP1848720A1 (fr) | 2007-10-31 |
AU2005327776A1 (en) | 2006-08-24 |
WO2006087729B1 (fr) | 2006-11-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1483269B1 (fr) | Racemisation et separation enatiomerique du clopidrogel | |
US7446200B2 (en) | Rapid resolution process of clopidogrel base and a process for preparation of clopidogrel bisulfate polymorph-form I | |
US6800759B2 (en) | Racemization and enantiomer separation of clopidogrel | |
CA2567806C (fr) | Procede de resolution rapide du clopidogrel base et un procede de preparation de la forme polymorphique i du bisulfate de clopidogrel | |
US20090099363A1 (en) | Process for the preparation of polymorphic forms of clopidogrel hydrogen sulfate | |
WO2005012300A1 (fr) | Procede nouveau de preparation de bisulfate de (+)-(s)-clopidogrel de forme i | |
US20060047121A1 (en) | Novel process for preparation of clopidogrel bisulfate polymorph - Form I | |
AU2009264395B2 (en) | Process for the preparation of clopidogrel hydrogen sulfate crystalline form I | |
EP1551414B1 (fr) | Procede de preparation de forme i de l'olanzapine | |
EP2491044A1 (fr) | Procede ameliore de preparation de la forme cristalline 1 du bisulfate de clopidrogel | |
WO2008093357A2 (fr) | Procédé de préparation d'une forme 1 cristalline d'un sulfate d'hydrogène de clopidogrel | |
PL204820B1 (pl) | Sposób wytwarzania kwasu (R)-(-)-2-hydroksy-2-(2-chlorofenylo)octowego oraz sole diastereoizomeryczne | |
KR20070106674A (ko) | 클로피도그렐 염기의 급속 분리 방법 및 클로피도그렐비설페이트 다형체-폼 i의 제조 방법 | |
WO2009080469A1 (fr) | Procédé de préparation de bisulfate de clopidogrel de forme i | |
WO2010046476A1 (fr) | Procédé de préparation de s-clopidogrel |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20140217 |