ZA992484B - A process for the preparation of 4-(Des-dimethylamino)-tetracyclines. - Google Patents
A process for the preparation of 4-(Des-dimethylamino)-tetracyclines.Info
- Publication number
- ZA992484B ZA992484B ZA9902484A ZA992484A ZA992484B ZA 992484 B ZA992484 B ZA 992484B ZA 9902484 A ZA9902484 A ZA 9902484A ZA 992484 A ZA992484 A ZA 992484A ZA 992484 B ZA992484 B ZA 992484B
- Authority
- ZA
- South Africa
- Prior art keywords
- tetracyclines
- preparation
- desdimethylamino
- dimethylamino
- des
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PT102160A PT102160B (pt) | 1998-05-26 | 1998-05-26 | Processo para a preparacao de 4-(des-dimetilamino)-tetraciclinas |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA992484B true ZA992484B (en) | 1999-10-05 |
Family
ID=20085765
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA9902484A ZA992484B (en) | 1998-05-26 | 1999-03-31 | A process for the preparation of 4-(Des-dimethylamino)-tetracyclines. |
Country Status (17)
Country | Link |
---|---|
US (1) | US6143161A (de) |
EP (1) | EP0962552B1 (de) |
JP (1) | JP2000034264A (de) |
KR (1) | KR19990087905A (de) |
CN (1) | CN1192016C (de) |
AT (1) | ATE213788T1 (de) |
AU (1) | AU746608B2 (de) |
CA (1) | CA2272598C (de) |
DE (1) | DE69900927T2 (de) |
ES (1) | ES2173706T3 (de) |
HU (1) | HUP9900761A3 (de) |
IL (1) | IL129244A (de) |
IN (1) | IN192877B (de) |
NO (1) | NO325059B1 (de) |
NZ (1) | NZ334940A (de) |
PT (1) | PT102160B (de) |
ZA (1) | ZA992484B (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101171408B1 (ko) | 2004-05-21 | 2012-08-08 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 테트라사이클린 및 이의 유사체의 합성 |
AU2007235279B2 (en) * | 2006-04-07 | 2012-12-06 | President And Fellows Of Harvard College | Synthesis of tetracyclines and analogues thereof |
EP2479169B1 (de) | 2006-10-11 | 2014-12-03 | President and Fellows of Harvard College | Synthese eines Enon-Zwischenprodukts |
EP2424834B1 (de) | 2009-04-30 | 2018-07-11 | President and Fellows of Harvard College | Synthese von tetracyclinen und deren zwischenprodukte |
PT108978B (pt) | 2015-11-24 | 2020-03-09 | Hovione Farm S A | Sais de tetraciclinas |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1349043A (en) * | 1971-04-05 | 1974-03-27 | Pliva Pharm & Chem Works | Process for the preparation of 6-demethyl-6-deoxy-6-methylene tetracyclines |
JP3016587B2 (ja) * | 1989-12-04 | 2000-03-06 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 非ステロイド抗炎症剤及びテトラサイクリンの配合 |
US5308839A (en) * | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
US5223248A (en) * | 1991-02-11 | 1993-06-29 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing antiplaque properties |
CA2094874C (en) * | 1992-04-27 | 2003-02-11 | Thomas F. Mcnamara | Non-antibacterial tetracycline compositons possessing antiplaque properties |
JPH069523A (ja) * | 1992-06-18 | 1994-01-18 | Kuraray Co Ltd | 4−デジメチルアミノテトラサイクリンの精製法 |
DK0599397T3 (da) * | 1992-11-17 | 1996-09-16 | Univ New York State Res Found | Tetracycliner, herunder non-mikrobielle, kemisk-modificerede tetracycliner, inhiberer overdreven collagentværbinding ved diabetes |
US5552297A (en) * | 1993-12-21 | 1996-09-03 | Abbott Laboratories | Lead detection method and reggents utilizing aminolevulinic acid dehydratase and tertiary phosphines |
US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
-
1998
- 1998-05-26 PT PT102160A patent/PT102160B/pt not_active IP Right Cessation
-
1999
- 1999-03-25 HU HU9900761A patent/HUP9900761A3/hu unknown
- 1999-03-26 AU AU22444/99A patent/AU746608B2/en not_active Ceased
- 1999-03-30 NZ NZ334940A patent/NZ334940A/xx unknown
- 1999-03-30 IL IL12924499A patent/IL129244A/xx not_active IP Right Cessation
- 1999-03-31 ZA ZA9902484A patent/ZA992484B/xx unknown
- 1999-04-01 AT AT99302600T patent/ATE213788T1/de active
- 1999-04-01 ES ES99302600T patent/ES2173706T3/es not_active Expired - Lifetime
- 1999-04-01 EP EP99302600A patent/EP0962552B1/de not_active Expired - Lifetime
- 1999-04-01 DE DE69900927T patent/DE69900927T2/de not_active Expired - Lifetime
- 1999-04-09 IN IN555DE1999 patent/IN192877B/en unknown
- 1999-04-09 KR KR1019990012481A patent/KR19990087905A/ko not_active Application Discontinuation
- 1999-04-13 JP JP11105105A patent/JP2000034264A/ja active Pending
- 1999-04-21 CN CNB991051548A patent/CN1192016C/zh not_active Expired - Fee Related
- 1999-04-29 NO NO19992072A patent/NO325059B1/no not_active IP Right Cessation
- 1999-05-21 CA CA002272598A patent/CA2272598C/en not_active Expired - Fee Related
- 1999-05-24 US US09/317,396 patent/US6143161A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NZ334940A (en) | 2000-05-26 |
HUP9900761A2 (hu) | 1999-12-28 |
DE69900927T2 (de) | 2002-08-29 |
EP0962552A1 (de) | 1999-12-08 |
JP2000034264A (ja) | 2000-02-02 |
CN1192016C (zh) | 2005-03-09 |
EP0962552B1 (de) | 2002-02-27 |
NO992072D0 (no) | 1999-04-29 |
PT102160A (pt) | 1999-11-30 |
US6143161A (en) | 2000-11-07 |
ATE213788T1 (de) | 2002-03-15 |
CA2272598A1 (en) | 1999-11-26 |
PT102160B (pt) | 2001-04-30 |
IN192877B (de) | 2004-05-29 |
KR19990087905A (ko) | 1999-12-27 |
HUP9900761A3 (en) | 2000-06-28 |
IL129244A (en) | 2003-01-12 |
CN1236775A (zh) | 1999-12-01 |
AU2244499A (en) | 1999-12-02 |
AU746608B2 (en) | 2002-05-02 |
DE69900927D1 (de) | 2002-04-04 |
NO992072L (no) | 1999-11-29 |
ES2173706T3 (es) | 2002-10-16 |
IL129244A0 (en) | 2000-02-17 |
CA2272598C (en) | 2008-01-22 |
HU9900761D0 (en) | 1999-05-28 |
NO325059B1 (no) | 2008-01-21 |
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