ZA988820B - Use of delta-aminolaevulinic acid for the preparation of a topical medicament for the integral diagnosis and/or therapy of tumours in hollow organs - Google Patents
Use of delta-aminolaevulinic acid for the preparation of a topical medicament for the integral diagnosis and/or therapy of tumours in hollow organsInfo
- Publication number
- ZA988820B ZA988820B ZA988820A ZA988820A ZA988820B ZA 988820 B ZA988820 B ZA 988820B ZA 988820 A ZA988820 A ZA 988820A ZA 988820 A ZA988820 A ZA 988820A ZA 988820 B ZA988820 B ZA 988820B
- Authority
- ZA
- South Africa
- Prior art keywords
- tumours
- delta
- therapy
- hollow organs
- preparation
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 238000003745 diagnosis Methods 0.000 title abstract 2
- 210000000056 organ Anatomy 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 230000000699 topical effect Effects 0.000 title 1
- RPAJSBKBKSSMLJ-DFWYDOINSA-N (2s)-2-aminopentanedioic acid;hydrochloride Chemical class Cl.OC(=O)[C@@H](N)CCC(O)=O RPAJSBKBKSSMLJ-DFWYDOINSA-N 0.000 abstract 1
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 abstract 1
- 229910000397 disodium phosphate Inorganic materials 0.000 abstract 1
- 235000019800 disodium phosphate Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates to a topically applied medicament for the integral diagnosis and/or treatment of tumours in hollow organs, with a delta -aminolevulinic acid base. The inventive medicament contains a physiologically compatible acid and sodium hydrogen phosphate as a buffer in addition to the active agent in an aqueous solution, and has a pH value of 4.8 to 5.2. The medicament is stable and particularly compatible.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19744811A DE19744811C2 (en) | 1997-10-02 | 1997-10-02 | Use of delta-aminolevulinic acid for the production of a topical medicament for the integral diagnosis and / or therapy of tumors in hollow organs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA988820B true ZA988820B (en) | 1999-04-06 |
Family
ID=7845169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA988820A ZA988820B (en) | 1997-10-02 | 1998-09-28 | Use of delta-aminolaevulinic acid for the preparation of a topical medicament for the integral diagnosis and/or therapy of tumours in hollow organs |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1019037B9 (en) |
| JP (1) | JP2001518498A (en) |
| AT (1) | ATE203903T1 (en) |
| AU (1) | AU729973B2 (en) |
| DE (2) | DE19744811C2 (en) |
| DK (1) | DK1019037T3 (en) |
| ES (1) | ES2159967T3 (en) |
| GR (1) | GR3036481T3 (en) |
| NZ (1) | NZ503802A (en) |
| PT (1) | PT1019037E (en) |
| TR (1) | TR200000890T2 (en) |
| WO (1) | WO1999017764A1 (en) |
| ZA (1) | ZA988820B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040009212A1 (en) * | 2002-01-30 | 2004-01-15 | Pharma Power Biotec Co. Ltd. | Mucoadhesive thermoresponsive medicament-carrier composition |
| JP5081121B2 (en) * | 2008-10-17 | 2012-11-21 | 株式会社ミルボン | Hair restorer composition |
| JPWO2018043240A1 (en) * | 2016-09-02 | 2019-06-24 | Ｓｂｉファーマ株式会社 | Aqueous preparation containing 5-aminolevulinic acids |
| RU2630124C1 (en) * | 2016-10-06 | 2017-09-05 | федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации | Method of intraoperative diagnostics and treatment of malignant neoplasms of abdominal cavity organs |
| CN115671059B (en) * | 2022-11-17 | 2024-06-11 | 兆科药业（合肥）有限公司 | Aminovaleric acid hydrochloride freeze-dried preparation and preparation method thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5446070A (en) * | 1991-02-27 | 1995-08-29 | Nover Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| US5026825A (en) * | 1988-09-08 | 1991-06-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Intranasal calcitonin formulations |
| US5079262A (en) * | 1989-07-28 | 1992-01-07 | Queen's University At Kingston | Method of detection and treatment of malignant and non-malignant lesions utilizing 5-aminolevulinic acid |
| FR2690340B1 (en) * | 1992-04-24 | 1995-02-24 | Scr Newmed | New process for stabilizing liquid pharmaceutical preparations and the pharmaceutical compositions thus stabilized resulting therefrom. |
| DE4228106A1 (en) * | 1992-08-24 | 1994-03-03 | Medac Klinische Spezialpraep | Tumour diagnosis and treatment in organs, esp. urinary system - comprises admin. of gamma-amino-levulinic acid as photosensitiser, detection, and treatment by irradiation with neodymium-yttrium-aluminium-garnet laser |
| DE4320871C2 (en) * | 1993-06-24 | 1995-05-04 | Beiersdorf Ag | Cosmetic and dermatological preparations containing delta-aminolevulinic acid |
| PH31226A (en) * | 1993-08-19 | 1998-05-12 | Blazley Design Pty Ltd | Explosion resistant building structures. |
| GB9318841D0 (en) * | 1993-09-10 | 1993-10-27 | Res Foundation Of The Norwegia | Composition |
| MX9504023A (en) * | 1994-09-20 | 1997-05-31 | Johnson & Johnson | Transdermally active pharmaceutical composition containing 5-aminolaevulinic acid. |
-
1997
- 1997-10-02 DE DE19744811A patent/DE19744811C2/en not_active Expired - Fee Related
-
1998
- 1998-09-21 PT PT80100771T patent/PT1019037E/en unknown
- 1998-09-21 JP JP2000514635A patent/JP2001518498A/en active Pending
- 1998-09-21 DK DK98952606T patent/DK1019037T3/en active
- 1998-09-21 AT AT98952606T patent/ATE203903T1/en not_active IP Right Cessation
- 1998-09-21 TR TR2000/00890T patent/TR200000890T2/en unknown
- 1998-09-21 WO PCT/EP1998/005979 patent/WO1999017764A1/en active IP Right Grant
- 1998-09-21 DE DE59801192T patent/DE59801192D1/en not_active Expired - Lifetime
- 1998-09-21 ES ES98952606T patent/ES2159967T3/en not_active Expired - Lifetime
- 1998-09-21 AU AU10242/99A patent/AU729973B2/en not_active Ceased
- 1998-09-21 NZ NZ503802A patent/NZ503802A/en unknown
- 1998-09-21 EP EP98952606A patent/EP1019037B9/en not_active Expired - Lifetime
- 1998-09-28 ZA ZA988820A patent/ZA988820B/en unknown
-
2001
- 2001-08-30 GR GR20010401340T patent/GR3036481T3/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU1024299A (en) | 1999-04-27 |
| PT1019037E (en) | 2001-11-30 |
| EP1019037B1 (en) | 2001-08-08 |
| JP2001518498A (en) | 2001-10-16 |
| NZ503802A (en) | 2000-12-22 |
| DE19744811A1 (en) | 1999-04-15 |
| DK1019037T3 (en) | 2001-10-01 |
| AU729973B2 (en) | 2001-02-15 |
| GR3036481T3 (en) | 2001-11-30 |
| TR200000890T2 (en) | 2000-08-21 |
| EP1019037A1 (en) | 2000-07-19 |
| EP1019037B9 (en) | 2002-04-17 |
| DE59801192D1 (en) | 2001-09-13 |
| WO1999017764A1 (en) | 1999-04-15 |
| DE19744811C2 (en) | 1999-11-18 |
| ES2159967T3 (en) | 2001-10-16 |
| ATE203903T1 (en) | 2001-08-15 |
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