ZA977833B - N-substituted-2-amino-4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylate inhibitory activity. - Google Patents

N-substituted-2-amino-4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylate inhibitory activity.

Info

Publication number
ZA977833B
ZA977833B ZA9707833A ZA977833A ZA977833B ZA 977833 B ZA977833 B ZA 977833B ZA 9707833 A ZA9707833 A ZA 9707833A ZA 977833 A ZA977833 A ZA 977833A ZA 977833 B ZA977833 B ZA 977833B
Authority
ZA
South Africa
Prior art keywords
hydroxylate
kynurenine
oxo
phenyl
amino
Prior art date
Application number
ZA9707833A
Other languages
English (en)
Inventor
Mario Varasi
Antonio Giordani
Massimo Cini
Carmela Speciale
Alberto Bianchetti
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of ZA977833B publication Critical patent/ZA977833B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA9707833A 1996-09-03 1997-09-01 N-substituted-2-amino-4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylate inhibitory activity. ZA977833B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9618349.6A GB9618349D0 (en) 1996-09-03 1996-09-03 N-substituted 2-amino-4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibitory activity

Publications (1)

Publication Number Publication Date
ZA977833B true ZA977833B (en) 1998-03-02

Family

ID=10799321

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9707833A ZA977833B (en) 1996-09-03 1997-09-01 N-substituted-2-amino-4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylate inhibitory activity.

Country Status (9)

Country Link
US (1) US6207709B1 (fr)
EP (1) EP0931056A1 (fr)
JP (1) JP2001501179A (fr)
AR (1) AR009484A1 (fr)
AU (1) AU4117297A (fr)
CA (1) CA2263250A1 (fr)
GB (1) GB9618349D0 (fr)
WO (1) WO1998009938A1 (fr)
ZA (1) ZA977833B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9725055D0 (en) * 1997-11-26 1998-01-28 Pharmacia & Upjohn Spa 1,3,4-thiadiazoles compounds
US6541521B1 (en) 1999-07-12 2003-04-01 Warner-Lambert Company Benzene butyric acids and their derivatives as inhibitors of matrix metalloproteinases
IT1317049B1 (it) * 2000-06-23 2003-05-26 Sigma Tau Ind Farmaceuti Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv.
JP2005060311A (ja) * 2003-08-13 2005-03-10 Mochida Pharmaceut Co Ltd Ｎ−（ベンゾイル）アミノ酸誘導体を有効成分とするニューロパシー性疼痛治療剤
KR100560845B1 (ko) 2003-10-09 2006-03-13 에스케이 텔레콤주식회사 Ｍｍ-ｍｂ 단말기의 모뎀 간 절체 방법
DK2420494T3 (en) 2006-08-16 2015-01-12 J David Gladstone Inst A Testamentary Trust Established Under The Will Of J David Gladstone Use of thiadiazole compounds as inhibitors of kynurenine 3-monooxygenase
DK2054397T3 (en) 2006-08-16 2016-01-18 J David Gladstone Inst A Testamentary Trust Established Under The Will Of J David Gladstone SMALL MOLECULAR INHIBITORS OF KYNURENIN-3-MONOOXYGENASE
US11229810B2 (en) * 2017-05-17 2022-01-25 University Of Virginia Patent Foundation Methods and systems for producing neuronal lesions using magnetic resonance and acoustic energy
KR20200061381A (ko) 2017-10-05 2020-06-02 바이오젠 인크. 알파-카르복스아미드 피롤리딘 유도체를 제조하기 위한 공정
CN118026866A (zh) 2018-02-09 2024-05-14 维斯塔津治疗公司 4-氯代犬尿氨酸及中间体的合成
MX2021012421A (es) * 2019-04-10 2022-02-10 Biogen Inc Procesos para preparar derivados de pirrolidina alfa-carboxamida.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4758661A (en) * 1986-06-24 1988-07-19 Merck & Co., Inc. Chiral synthesis of (+)-trans-1a,2,3,4a,5,6-hexahydro-9-hydroxy-4-propyl-4H-naphth[1,2-b]-1,4-oxazine
US5495044A (en) * 1991-04-18 1996-02-27 University Of Georgia Research Foundation, Inc. Inhibitors of kynureninase
IT1265101B1 (it) * 1993-07-23 1996-10-30 Erba Carlo Spa Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico
US5519055A (en) * 1993-08-06 1996-05-21 University Of Maryland At Baltimore Substituted kynurenines and process for their preparation
GB9521486D0 (en) * 1995-10-20 1995-12-20 Pharmacia Spa Fluoro-substituted benzoylpropionic acid derivatives

Also Published As

Publication number Publication date
GB9618349D0 (en) 1996-10-16
WO1998009938A1 (fr) 1998-03-12
US6207709B1 (en) 2001-03-27
CA2263250A1 (fr) 1998-03-12
JP2001501179A (ja) 2001-01-30
EP0931056A1 (fr) 1999-07-28
AR009484A1 (es) 2000-04-26
AU4117297A (en) 1998-03-26

Similar Documents

Publication Publication Date Title
HK1036408A1 (en) Indolyl-3-glyoxylic acid derivatives with antitumoral activity.
ZA987126B (en) Aryloxyarylsulfonylamino hydroxamic acid derivatives.
ZA979593B (en) Naphthyridine derivatives.
ZA97521B (en) 19-Nor-pregnene derivatives.
ZA974893B (en) New benzimidazole derivatives with antihistaminic activity.
AU763636C (en) 1-cycloalkyl-1,8-naphthyridin-4-one derivatives with phosphodiesterase IV inhibitory activity
ZA978045B (en) New benzamidine derivatives.
ZA969177B (en) 4-Phenyl-4-oxo-2-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity
ZA969179B (en) 4-Phenyl-4-oxo-2-butenoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity
HK1018457A1 (en) Alkylaminobenzothiazole and-benzoxazole derivatives.
EP0680079A3 (fr) Structure topographique en couches minces à profil conique.
IL126624A0 (en) 3-descladinose-2, 3-anhydroerythromycin derivatives
HK1034969A1 (en) Dihydroxyhexanoic acid derivatives.
MXPA99001777A (es) Dihidropirones con actividad antiviral mejorada.
ZA977833B (en) N-substituted-2-amino-4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylate inhibitory activity.
HK1039331A1 (en) Novel imidazoles with anti-inflammatory activity.
CY2333B1 (en) 10-Aminoaliphatyl-dibenz (b,f) oxepins with antineur odegenarative activity.
ZA974953B (en) Substituted pyrazolylpyrazole derivatives.
ZA978086B (en) New pyranoside derivatives.
ZA982436B (en) Thiazolimine derivatives.
AU5067098A (en) Pyridocarbazole derivatives with cgmp-pde inhibitory activity
AU3969697A (en) Quinolinium derivatives having fungicidal activity
ZA977791B (en) GLP-1 derivatives.
CY2322B1 (en) Benzoaeguequinoline derivatives.
ZA971167B (en) Heterocyclyl-ergoline derivatives.