ZA9710930B - Process for the production of metal-complex carboxylic acid amides - Google Patents
Process for the production of metal-complex carboxylic acid amidesInfo
- Publication number
- ZA9710930B ZA9710930B ZA9710930A ZA9710930A ZA9710930B ZA 9710930 B ZA9710930 B ZA 9710930B ZA 9710930 A ZA9710930 A ZA 9710930A ZA 9710930 A ZA9710930 A ZA 9710930A ZA 9710930 B ZA9710930 B ZA 9710930B
- Authority
- ZA
- South Africa
- Prior art keywords
- carboxylic acid
- complex carboxylic
- acid amides
- production
- metal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
- A61K49/128—Linear polymers, e.g. dextran, inulin, PEG comprising multiple complex or complex-forming groups, being either part of the linear polymeric backbone or being pending groups covalently linked to the linear polymeric backbone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
- A61K49/143—Peptides, e.g. proteins the protein being an albumin, e.g. HSA, BSA, ovalbumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
- A61K49/146—Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The invention relates to a method for producing metal complex carboxylic acid amides characterized in that a metal complex carboxylic acid mixture consisting of metal complex carboxylic acid and at least one solubilizing substance is pretreated in dimethylsulfoxide (DSMO) with a dehydrating reagent, optionally by adding a coupling adjuvant and made to react with a amine of general formula (I): A(NH2)n, wherein A means the radical of a natural or synthetic amine and n stands for the figures 1 to 100.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19652386A DE19652386A1 (en) | 1996-12-04 | 1996-12-04 | Process for the preparation of metal complex carboxamides |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA9710930B true ZA9710930B (en) | 1998-09-08 |
Family
ID=7814928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA9710930A ZA9710930B (en) | 1996-12-04 | 1997-12-04 | Process for the production of metal-complex carboxylic acid amides |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0946525B1 (en) |
JP (1) | JP4278182B2 (en) |
AT (1) | ATE263758T1 (en) |
AU (1) | AU5556698A (en) |
DE (2) | DE19652386A1 (en) |
DK (1) | DK0946525T3 (en) |
ES (1) | ES2218711T3 (en) |
NO (1) | NO312724B1 (en) |
PT (1) | PT946525E (en) |
TW (1) | TW438804B (en) |
WO (1) | WO1998024775A1 (en) |
ZA (1) | ZA9710930B (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19905094C1 (en) * | 1999-02-01 | 2000-10-12 | Schering Ag | Gadolinium (III) complexes and their use for two-step forms of radiation therapy and pharmaceutical compositions containing them |
DE10105014C2 (en) * | 2001-01-26 | 2003-03-27 | Schering Ag | New process for the production of DTPA monoamides |
FR2856063B1 (en) * | 2003-06-13 | 2005-10-07 | Air Liquide | PROCESS FOR THE PREPARATION OF CIS-8B-METHYLDECAHYDRO-2A, 4A, 6A, 8A-TETRAAZACYCLOPENTA [FG] ACENAPHTHYLENE, OR CIS-DECAHYDRO-2A, 4A, 6A, 8A-TETRAAZACYCLOPENTA [FG] ACENAPHTHYLENE, CYCLENE, AND CYCLENES FUNCTIONALISED |
DE102007002726A1 (en) | 2007-01-18 | 2008-07-31 | Bayer Schering Pharma Aktiengesellschaft | New cascade polymer complexes, processes for their preparation and pharmaceutical compositions containing them |
DE102007058220A1 (en) | 2007-12-03 | 2009-06-04 | Bayer Schering Pharma Aktiengesellschaft | New metal complexes useful e.g. for manufacturing agent for X-ray diagnostics and magnetic resonance tomography-diagnostics of brain infarcts and liver tumor, and/or space-process in liver and abdomen tumors and musculoskeletal tumors |
KR101334780B1 (en) | 2010-08-13 | 2013-12-02 | 한국생명공학연구원 | Iodine-containing radial-shape macromolecular compounds, preparation method thereof and contrast medium compositions for CT comprising the same |
WO2014124943A1 (en) | 2013-02-12 | 2014-08-21 | Bayer Pharma Aktiengesellschaft | Metal chelate compounds for binding to the platelet specific glycoprotein iib/iiia |
EP3101012A1 (en) * | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
KR102464647B1 (en) | 2016-11-28 | 2022-11-08 | 바이엘 파마 악티엔게젤샤프트 | High Relaxation Gadolinium Chelate Compounds for Use in Magnetic Resonance Imaging |
CN113164628A (en) | 2018-11-23 | 2021-07-23 | 拜耳股份有限公司 | Contrast medium preparation and preparation method thereof |
CN111004623B (en) * | 2019-12-20 | 2023-07-18 | 河北科技大学 | Porphyrin fluorescent material and preparation method thereof |
EP4360660A1 (en) | 2022-10-24 | 2024-05-01 | Bayer AG | Process for the preparation of a gadolinium contrast agent |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5316757A (en) * | 1984-10-18 | 1994-05-31 | Board Of Regents, The University Of Texas System | Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups |
DE3625417C2 (en) * | 1986-07-28 | 1998-10-08 | Schering Ag | Tetraazacyclododecane derivatives |
DE4218744C2 (en) * | 1992-06-04 | 1997-11-06 | Schering Ag | Process for the preparation of N-β-hydroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecane and N-β-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecane derivatives and their metal complexes |
-
1996
- 1996-12-04 DE DE19652386A patent/DE19652386A1/en not_active Withdrawn
-
1997
- 1997-11-25 TW TW086117683A patent/TW438804B/en not_active IP Right Cessation
- 1997-11-26 JP JP52514998A patent/JP4278182B2/en not_active Expired - Fee Related
- 1997-11-26 DK DK97951981T patent/DK0946525T3/en active
- 1997-11-26 DE DE59711504T patent/DE59711504D1/en not_active Expired - Lifetime
- 1997-11-26 AU AU55566/98A patent/AU5556698A/en not_active Abandoned
- 1997-11-26 PT PT97951981T patent/PT946525E/en unknown
- 1997-11-26 WO PCT/EP1997/006594 patent/WO1998024775A1/en active IP Right Grant
- 1997-11-26 EP EP97951981A patent/EP0946525B1/en not_active Expired - Lifetime
- 1997-11-26 ES ES97951981T patent/ES2218711T3/en not_active Expired - Lifetime
- 1997-11-26 AT AT97951981T patent/ATE263758T1/en not_active IP Right Cessation
- 1997-12-04 ZA ZA9710930A patent/ZA9710930B/en unknown
-
1999
- 1999-06-03 NO NO19992710A patent/NO312724B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO992710L (en) | 1999-06-03 |
TW438804B (en) | 2001-06-07 |
AU5556698A (en) | 1998-06-29 |
NO312724B1 (en) | 2002-06-24 |
DK0946525T3 (en) | 2004-08-02 |
ATE263758T1 (en) | 2004-04-15 |
NO992710D0 (en) | 1999-06-03 |
EP0946525A1 (en) | 1999-10-06 |
DE59711504D1 (en) | 2004-05-13 |
PT946525E (en) | 2004-08-31 |
WO1998024775A1 (en) | 1998-06-11 |
DE19652386A1 (en) | 1998-06-10 |
ES2218711T3 (en) | 2004-11-16 |
JP4278182B2 (en) | 2009-06-10 |
EP0946525B1 (en) | 2004-04-07 |
JP2001504844A (en) | 2001-04-10 |
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