DK0946525T3 - Process for the preparation of metal complex carboxylic acid amides - Google Patents

Process for the preparation of metal complex carboxylic acid amides

Info

Publication number
DK0946525T3
DK0946525T3 DK97951981T DK97951981T DK0946525T3 DK 0946525 T3 DK0946525 T3 DK 0946525T3 DK 97951981 T DK97951981 T DK 97951981T DK 97951981 T DK97951981 T DK 97951981T DK 0946525 T3 DK0946525 T3 DK 0946525T3
Authority
DK
Denmark
Prior art keywords
carboxylic acid
metal complex
complex carboxylic
acid amides
preparation
Prior art date
Application number
DK97951981T
Other languages
Danish (da)
Inventor
Heribert Schmitt-Willich
Johannes Platzek
Bernd Raduechel
Klaus-Dieter Graske
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0946525T3 publication Critical patent/DK0946525T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • A61K49/128—Linear polymers, e.g. dextran, inulin, PEG comprising multiple complex or complex-forming groups, being either part of the linear polymeric backbone or being pending groups covalently linked to the linear polymeric backbone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/143—Peptides, e.g. proteins the protein being an albumin, e.g. HSA, BSA, ovalbumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/146—Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention relates to a method for producing metal complex carboxylic acid amides characterized in that a metal complex carboxylic acid mixture consisting of metal complex carboxylic acid and at least one solubilizing substance is pretreated in dimethylsulfoxide (DSMO) with a dehydrating reagent, optionally by adding a coupling adjuvant and made to react with a amine of general formula (I): A(NH2)n, wherein A means the radical of a natural or synthetic amine and n stands for the figures 1 to 100.
DK97951981T 1996-12-04 1997-11-26 Process for the preparation of metal complex carboxylic acid amides DK0946525T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19652386A DE19652386A1 (en) 1996-12-04 1996-12-04 Process for the preparation of metal complex carboxamides
PCT/EP1997/006594 WO1998024775A1 (en) 1996-12-04 1997-11-26 Method for producing metal complex carboxylic acid amides

Publications (1)

Publication Number Publication Date
DK0946525T3 true DK0946525T3 (en) 2004-08-02

Family

ID=7814928

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97951981T DK0946525T3 (en) 1996-12-04 1997-11-26 Process for the preparation of metal complex carboxylic acid amides

Country Status (12)

Country Link
EP (1) EP0946525B1 (en)
JP (1) JP4278182B2 (en)
AT (1) ATE263758T1 (en)
AU (1) AU5556698A (en)
DE (2) DE19652386A1 (en)
DK (1) DK0946525T3 (en)
ES (1) ES2218711T3 (en)
NO (1) NO312724B1 (en)
PT (1) PT946525E (en)
TW (1) TW438804B (en)
WO (1) WO1998024775A1 (en)
ZA (1) ZA9710930B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19905094C1 (en) * 1999-02-01 2000-10-12 Schering Ag Gadolinium (III) complexes and their use for two-step forms of radiation therapy and pharmaceutical compositions containing them
DE10105014C2 (en) * 2001-01-26 2003-03-27 Schering Ag New process for the production of DTPA monoamides
FR2856063B1 (en) * 2003-06-13 2005-10-07 Air Liquide PROCESS FOR THE PREPARATION OF CIS-8B-METHYLDECAHYDRO-2A, 4A, 6A, 8A-TETRAAZACYCLOPENTA [FG] ACENAPHTHYLENE, OR CIS-DECAHYDRO-2A, 4A, 6A, 8A-TETRAAZACYCLOPENTA [FG] ACENAPHTHYLENE, CYCLENE, AND CYCLENES FUNCTIONALISED
DE102007002726A1 (en) 2007-01-18 2008-07-31 Bayer Schering Pharma Aktiengesellschaft New cascade polymer complexes, processes for their preparation and pharmaceutical compositions containing them
DE102007058220A1 (en) 2007-12-03 2009-06-04 Bayer Schering Pharma Aktiengesellschaft New metal complexes useful e.g. for manufacturing agent for X-ray diagnostics and magnetic resonance tomography-diagnostics of brain infarcts and liver tumor, and/or space-process in liver and abdomen tumors and musculoskeletal tumors
KR101334780B1 (en) 2010-08-13 2013-12-02 한국생명공학연구원 Iodine-containing radial-shape macromolecular compounds, preparation method thereof and contrast medium compositions for CT comprising the same
CA2900595A1 (en) 2013-02-12 2014-08-21 Bayer Pharma Aktiengesellschaft Metal chelate compounds for binding to the platelet specific glycoprotein iib/iiia
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
CA3044877A1 (en) 2016-11-28 2018-05-31 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
JOP20210114A1 (en) 2018-11-23 2023-01-30 Bayer Ag Formulation of contrast media and process of preparation thereof
CN111004623B (en) * 2019-12-20 2023-07-18 河北科技大学 Porphyrin fluorescent material and preparation method thereof
EP4360660A1 (en) 2022-10-24 2024-05-01 Bayer AG Process for the preparation of a gadolinium contrast agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5316757A (en) * 1984-10-18 1994-05-31 Board Of Regents, The University Of Texas System Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
DE3625417C2 (en) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecane derivatives
DE4218744C2 (en) * 1992-06-04 1997-11-06 Schering Ag Process for the preparation of N-β-hydroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecane and N-β-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecane derivatives and their metal complexes

Also Published As

Publication number Publication date
ATE263758T1 (en) 2004-04-15
WO1998024775A1 (en) 1998-06-11
EP0946525B1 (en) 2004-04-07
AU5556698A (en) 1998-06-29
TW438804B (en) 2001-06-07
EP0946525A1 (en) 1999-10-06
JP4278182B2 (en) 2009-06-10
DE59711504D1 (en) 2004-05-13
NO992710D0 (en) 1999-06-03
JP2001504844A (en) 2001-04-10
PT946525E (en) 2004-08-31
ES2218711T3 (en) 2004-11-16
NO992710L (en) 1999-06-03
NO312724B1 (en) 2002-06-24
DE19652386A1 (en) 1998-06-10
ZA9710930B (en) 1998-09-08

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