ZA9610781B - 2,7-substituted octahydro-pyrrolo(1,2-A)pyrazine derivatives. - Google Patents

2,7-substituted octahydro-pyrrolo(1,2-A)pyrazine derivatives.

Info

Publication number
ZA9610781B
ZA9610781B ZA9610781A ZA9610781A ZA9610781B ZA 9610781 B ZA9610781 B ZA 9610781B ZA 9610781 A ZA9610781 A ZA 9610781A ZA 9610781 A ZA9610781 A ZA 9610781A ZA 9610781 B ZA9610781 B ZA 9610781B
Authority
ZA
South Africa
Prior art keywords
pyrrolo
pyrazine derivatives
substituted octahydro
octahydro
substituted
Prior art date
Application number
ZA9610781A
Other languages
English (en)
Inventor
Mark A Sanner
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA9610781B publication Critical patent/ZA9610781B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Ophthalmology & Optometry (AREA)
  • Toxicology (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA9610781A 1995-12-21 1996-12-20 2,7-substituted octahydro-pyrrolo(1,2-A)pyrazine derivatives. ZA9610781B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US898895P 1995-12-21 1995-12-21

Publications (1)

Publication Number Publication Date
ZA9610781B true ZA9610781B (en) 1998-06-22

Family

ID=21734893

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9610781A ZA9610781B (en) 1995-12-21 1996-12-20 2,7-substituted octahydro-pyrrolo(1,2-A)pyrazine derivatives.

Country Status (33)

Country Link
US (1) US5714487A (fr)
EP (1) EP0874849B1 (fr)
JP (1) JP3204456B2 (fr)
KR (1) KR100286786B1 (fr)
CN (1) CN1061350C (fr)
AR (1) AR005102A1 (fr)
AT (1) ATE205846T1 (fr)
AU (1) AU704578B2 (fr)
BR (1) BR9612246A (fr)
CA (1) CA2240594C (fr)
CO (1) CO4480107A1 (fr)
CZ (1) CZ192998A3 (fr)
DE (1) DE69615404T2 (fr)
DK (1) DK0874849T3 (fr)
ES (1) ES2161377T3 (fr)
GR (1) GR3037060T3 (fr)
GT (1) GT199600101A (fr)
HU (1) HUP9900611A3 (fr)
IL (1) IL124453A0 (fr)
MA (1) MA26413A1 (fr)
MX (1) MX9805088A (fr)
NO (1) NO309936B1 (fr)
NZ (1) NZ320537A (fr)
PE (1) PE25998A1 (fr)
PL (1) PL327539A1 (fr)
PT (1) PT874849E (fr)
RU (1) RU2162470C2 (fr)
SI (1) SI0874849T1 (fr)
TN (1) TNSN96164A1 (fr)
TR (1) TR199801161T2 (fr)
TW (1) TW479058B (fr)
WO (1) WO1997023482A1 (fr)
ZA (1) ZA9610781B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6281216B1 (en) * 1998-02-09 2001-08-28 Duphar International Research B.V. 2-aminoquinoline derivatives having d4-agonistic activity
EP0982030A3 (fr) 1998-08-17 2000-05-10 Pfizer Products Inc. Derives de 2,7-octahydro substitue-pyrrolo 1,2-a]pyrazine comme ligands des recepteurs 5ht 1a
AU767089B2 (en) * 1999-02-05 2003-10-30 Pharmacia & Upjohn Company Process to prepare (5R)-(methylamino)-5,6-dihydro-4H- imidazo(4,5,1-ij)-quinolin-2(1H)-one
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
US7253165B2 (en) 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
CA2383332C (fr) * 1999-09-14 2006-01-10 Aventis Pharmaceuticals Inc. Derives benzisoxazolyle, pyridoisoxazolyle- et benzthienyle du propyle a substitution phenoxy, antagonistes du d4
TW200801005A (en) * 2005-08-15 2008-01-01 Astrazeneca Ab Acetylenic piperazines as metabotropic glutamate receptor antagonists
US7728031B2 (en) * 2006-02-24 2010-06-01 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole derivatives
WO2013049164A1 (fr) * 2011-09-29 2013-04-04 Abbvie Inc. Octahydropyrrolo[1,2-a]pyrazines substituées utilisées en tant qu'inhibiteurs des canaux calciques
US11612924B2 (en) * 2018-03-28 2023-03-28 Sintokogio, Ltd. Electric lifting apparatus and roll press machine
EP3846806A4 (fr) * 2018-09-04 2022-06-08 Pipeline Therapeutics, Inc. Antagonistes du récepteur m1 de l'acétylcholine muscarinique
US11752149B2 (en) 2019-12-02 2023-09-12 Pipeline Therapeutics, Inc. Muscarinic acetylcholine M1 receptor antagonists

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4400511A (en) * 1982-05-07 1983-08-23 American Home Products Corporation 2-Substituted octahydropyrrolo(1,2-A)-pyrazine-3-carboxylic acids
WO1990008148A1 (fr) * 1989-01-23 1990-07-26 Pfizer Inc. Agents anxiolytiques bis-aza-bicycliques
US5122515A (en) * 1990-06-19 1992-06-16 Smith Ross C Nutrient composition containing dipeptides and method for administering the same
JP3058945B2 (ja) * 1990-10-26 2000-07-04 三共株式会社 Ｎ−（３，３−ジ置換アクリロイル）ピペラジン誘導体
US5670522A (en) * 1992-10-23 1997-09-23 Merck Sharp & Dohme Limited Dopamine receptor subtype ligands
WO1994010145A1 (fr) * 1992-10-23 1994-05-11 Merck Sharp & Dohme Limited Ligands pour les sous-types de recepteurs de dopamine
DE69530988T2 (de) * 1994-08-05 2003-12-04 Pfizer Benzimidazolderivate mit dopaminerger wirkung
WO1996010571A1 (fr) * 1994-09-30 1996-04-11 Pfizer Inc. Derives d'octahydro 1-h-pyrido[1,2-a] pyrazine substituee en 2,7

Also Published As

Publication number Publication date
AR005102A1 (es) 1999-04-14
RU2162470C2 (ru) 2001-01-27
HUP9900611A2 (hu) 1999-08-30
CZ192998A3 (cs) 1999-05-12
ATE205846T1 (de) 2001-10-15
DE69615404T2 (de) 2002-06-06
KR19990076616A (ko) 1999-10-15
NO309936B1 (no) 2001-04-23
CN1061350C (zh) 2001-01-31
EP0874849A1 (fr) 1998-11-04
GR3037060T3 (en) 2002-01-31
JPH11508920A (ja) 1999-08-03
IL124453A0 (en) 1998-12-06
KR100286786B1 (ko) 2001-04-16
PL327539A1 (en) 1998-12-21
PT874849E (pt) 2002-01-30
NO982843L (no) 1998-06-19
ES2161377T3 (es) 2001-12-01
PE25998A1 (es) 1998-05-19
DE69615404D1 (de) 2001-10-25
US5714487A (en) 1998-02-03
TNSN96164A1 (fr) 2005-03-15
CA2240594C (fr) 2001-07-24
CO4480107A1 (es) 1997-07-09
TR199801161T2 (xx) 1998-10-21
JP3204456B2 (ja) 2001-09-04
SI0874849T1 (fr) 2001-12-31
MX9805088A (es) 1998-10-31
AU7328096A (en) 1997-07-17
MA26413A1 (fr) 2004-12-20
CA2240594A1 (fr) 1997-07-03
TW479058B (en) 2002-03-11
NZ320537A (en) 1999-03-29
DK0874849T3 (da) 2001-11-19
NO982843D0 (no) 1998-06-19
WO1997023482A1 (fr) 1997-07-03
CN1205704A (zh) 1999-01-20
HUP9900611A3 (en) 2000-09-28
BR9612246A (pt) 1999-07-13
EP0874849B1 (fr) 2001-09-19
GT199600101A (es) 1998-06-12
AU704578B2 (en) 1999-04-29

Similar Documents

Publication Publication Date Title
PH30897A (en) 1-5 Benzodiazepine derivatives.
AU5276696A (en) Imidazo{1,2-a}pyridine derivatives
MX9202838A (es) Imidazo[1,5-a]quinoxalinas.
EP0648770A3 (fr) Pyrrolo(3,4-c)pyrroles.
AP9701076A0 (en) Substituted 6,6-hetero bicyclic derivatives
HK1018439A1 (en) 5h-thiazolo (3,2-a) pyrimidine derivatives
AU5280998A (en) 8-substituted-1,3,8-triaza-spiro(4.5)decan-4-on derivatives
MXPA00007634A (es) Nuevos compuestos de triazol (4,5-d) pirimidina.
ZA9610781B (en) 2,7-substituted octahydro-pyrrolo(1,2-A)pyrazine derivatives.
AU694871B2 (en) Tricyclic 5,6-dihydro-9H-pyrazolo(3,4-c)1,2,4-triazolo (4,3-a)pyridines
ZA945238B (en) 1,5 Benzodiazepine derivatives.
ZA972829B (en) Novel pyrimido [1,2-a]indoles.
AU698867B2 (en) Fused imidazo 1,2-a pyridines
AU5172296A (en) Pyrimido{4,5-b}indoles
HUP0003692A3 (en) Pyrimido[4,5-b]indolyl-alkanecarboxamide derivatives
AU4435489A (en) Triazolo (4,3a) pyrazine derivatives
AU7105894A (en) 1,2,3,4-tetrahydropyrrolo{1,2-a}pyrazines
AU1129295A (en) Certain tricyclic substituted diazabicyclo{3.2.1} octane derivatives
GB9223108D0 (en) Hexahydropyrrolo (2,3-b)indole derivatives
AU5972290A (en) 3-cyclopentyl-7H-1,2,3-triazolo(4,5-d)pyrimidin-7-one derivatives
AU3005195A (en) N-pyridinyl(1,2,4)triazolo(1,5-c)pyrimidine-2-sulfonamide herbicides
AU673258B2 (en) Indolo(2,3-b)quinoxaline derivative
HU9204124D0 (en) 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-pyrrholo/2,3-b/-indole-tetrahydro-isoquinoline-urea derivatives
AU6344396A (en) 5,6,7,8-tetrahydropyrimido{4,5-b}azepine derivatives
ZA966559B (en) Imidazopyridine derivatives.