ZA959473B - Pharmaceutical composition for oral administation of flavonoids - Google Patents

Pharmaceutical composition for oral administation of flavonoids

Info

Publication number
ZA959473B
ZA959473B ZA959473A ZA959473A ZA959473B ZA 959473 B ZA959473 B ZA 959473B ZA 959473 A ZA959473 A ZA 959473A ZA 959473 A ZA959473 A ZA 959473A ZA 959473 B ZA959473 B ZA 959473B
Authority
ZA
South Africa
Prior art keywords
flavonoids
pharmaceutical composition
micronised
pref
oral
Prior art date
Application number
ZA959473A
Inventor
Bruno Huet De Barochez
Noel Piot
Alain Cuine
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of ZA959473B publication Critical patent/ZA959473B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)

Abstract

Oral compsns. contain a rutaceous flavonoid, partic. micronised diosmin (I), as an effervescent granulate in the form of tablets or sachets. The compsn. pref. comprises 0.1-5 g (I) which is pref. micronised to a particle size of 0.1-10 mu m. The effervescent formulation is achieved by use of a carboxylic acid and one or more carbonates. Other ingredients include sweeteners, flavourings and carriers. The small amt. of water present in (I) is used to start a single phase granulation process.
ZA959473A 1994-11-08 1995-11-08 Pharmaceutical composition for oral administation of flavonoids ZA959473B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9413336A FR2726469B1 (en) 1994-11-08 1994-11-08 PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION OF FLAVONOIDS

Publications (1)

Publication Number Publication Date
ZA959473B true ZA959473B (en) 1996-05-15

Family

ID=9468588

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA959473A ZA959473B (en) 1994-11-08 1995-11-08 Pharmaceutical composition for oral administation of flavonoids

Country Status (18)

Country Link
EP (1) EP0711560B1 (en)
JP (1) JP3022952B2 (en)
KR (1) KR960016901A (en)
CN (1) CN1131538A (en)
AT (1) ATE202480T1 (en)
AU (1) AU706027B2 (en)
CA (1) CA2162299C (en)
CY (1) CY2265B1 (en)
DE (1) DE69521477T2 (en)
DK (1) DK0711560T3 (en)
ES (1) ES2160145T3 (en)
FI (1) FI117123B (en)
FR (1) FR2726469B1 (en)
GR (1) GR3036244T3 (en)
NO (1) NO311402B1 (en)
NZ (1) NZ280418A (en)
PT (1) PT711560E (en)
ZA (1) ZA959473B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1011151A3 (en) * 1997-05-13 1999-05-04 Jose Remacle Use of a pharmaceutical composition for treating and / or preventing ischemia.
US6350470B1 (en) * 1998-04-29 2002-02-26 Cima Labs Inc. Effervescent drug delivery system for oral administration
JP4273277B2 (en) * 1999-06-30 2009-06-03 大塚製薬株式会社 Oligosaccharide supplement composition
JP2001158796A (en) * 1999-11-30 2001-06-12 Toyo Seito Kk Method for producing alpha-glucosyldiosmin and flavonoid composition
FR2845597B1 (en) * 2002-10-11 2005-03-11 Innothera Lab Sa DRY ORAL FORMULATION CONTAINING DIOSMINE AS A PHARMACEUTICAL FORM OF A TABLET TO BE CROQUERED
DE60318237T2 (en) 2002-10-24 2008-12-18 Immupharm A/S PHARMACEUTICAL COMPOSITIONS CONTAINING FLAVONOIDS AND MENTHOL
AT501682A1 (en) 2005-01-14 2006-10-15 Hermine Dr Engl METHOD FOR PRODUCING AN ACTIVE SUBSTANCE MIXTURE
ITMI20050517A1 (en) 2005-03-30 2006-09-30 Therapicon Srl PHARMACEUTICAL COMPOSITION OF A TYPICAL MICROCRYSTALLINE FRACTION OF FLAVONOIDS
ITMI20051942A1 (en) * 2005-10-14 2007-04-15 S I I T S R L Servizio Interna GALATTOGENIC COMPOSITIONS BASED ON SILIMARINE
US20070122363A1 (en) * 2005-11-26 2007-05-31 Giniger Martin S Corporeal delivery of carotenoids
MX2007011002A (en) * 2007-09-07 2009-03-09 World Trade Imp Export Wtie Ag Pharmaceutical composition combining various venotonic and vasoprotective agents for the treatment of chronic venous insufficiency.
CN102469816A (en) * 2009-08-10 2012-05-23 斯托克里-丰康普公司 Method for suspending a flavonoid in a beverage
MD3987C2 (en) * 2009-09-03 2010-07-31 Георге АНГЕЛИЧ Use of Diosmine for the treatment of advancing hepatic cirrhosis associated with cardiac insufficiency
MD3986C2 (en) * 2009-09-23 2010-07-31 Георге АНГЕЛИЧ Use of Diosmine for the treatment of portal gastropathies in the hepatic cirrhosis
MD4231C1 (en) * 2012-11-08 2014-01-31 Георге АНГЕЛИЧ Medicament based on troxerutin and carbazochrome for the treatment of portal gastropathies in hepatic cirrhosis
MD4232C1 (en) * 2012-11-08 2014-01-31 Георге АНГЕЛИЧ Medicament based on troxerutin and carbazochrome for the treatment of progressive hepatic cirrhosis associated with heart failure
FR2999934B1 (en) * 2012-12-21 2015-02-20 Servier Lab PHARMACEUTICAL COMPOSITION IN THE FORM OF AN ORAL SUSPENSION COMPRISING A FLAVONOIC FRACTION AND XANTHAN GUM
BR112017005362A2 (en) 2014-09-17 2018-01-23 Steerlife India Private Ltd composition, oral solid dosage form, process for preparing porous effervescent granules, dual screw processor, and porous effervescent granules.
US11219594B2 (en) 2015-12-12 2022-01-11 Steerlife India Private Limited Effervescent compositions of metformin and processes for preparation thereof
FR3083980B1 (en) * 2018-07-20 2021-04-16 Servier Lab PHARMACEUTICAL COMPOSITION IN THE FORM OF A CHEWABLE TABLET OF DIOSMINE OR A FLAVONOIC FRACTION
US10639294B2 (en) 2018-10-02 2020-05-05 Janssen Pharmaceutica Nv Pharmaceutical compositions comprising a hydroxyethylquercetin glucuronide metabolite
US11304968B2 (en) 2018-11-16 2022-04-19 Janssen Pharmaceutica Nv Pharmaceutical compositions comprising a hydroxyethylquercetin glucuronide
WO2021123341A1 (en) 2019-12-20 2021-06-24 Krka, D.D., Novo Mesto Composition comprising diosmin

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6967M (en) * 1968-01-22 1969-05-19
JPS52156913A (en) * 1976-06-21 1977-12-27 Toko Yakuhin Kogyo Kk Production of injectionable medicine
RO81345B1 (en) * 1980-07-28 1983-02-28 Nicolae Oita Medicament for peripheral cardiovascular insufficiency
AU575930B2 (en) * 1984-03-01 1988-08-11 Hamilton Laboratories Pty. Ltd. Treatment of high protein oedemas in animals
FR2577437A1 (en) * 1985-02-21 1986-08-22 Corbiere Jerome New process for dissolving chemical compounds and aqueous preparations thus obtained
IT1201149B (en) * 1987-01-14 1989-01-27 Indena Spa BIOFLAVONOID COMPLEXES WITH PHOSPHOLIPIDS, THEIR PREPARATION, USE AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS
FR2634376B1 (en) * 1988-07-21 1992-04-17 Farmalyoc NOVEL SOLID AND POROUS UNIT FORM COMPRISING MICROPARTICLES AND / OR NANOPARTICLES, AS WELL AS ITS PREPARATION
FR2661610B1 (en) * 1990-05-02 1994-09-30 Rhone Poulenc Sante NOVEL LYOPHILIZED FORM OF DIOSMINE AND ITS PREPARATION.
FR2661830B1 (en) * 1990-05-11 1992-09-04 Corbiere Jerome NOVEL PHARMACEUTICAL COMPOSITIONS BASED ON FLAVONOSIDE.
FR2668705A1 (en) * 1990-11-06 1992-05-07 Bouchara Sa Novel skin preparations having a phlebotonic action and process for preparing them

Also Published As

Publication number Publication date
CA2162299C (en) 2008-09-09
ATE202480T1 (en) 2001-07-15
CN1131538A (en) 1996-09-25
CY2265B1 (en) 2003-07-04
NZ280418A (en) 1997-03-24
AU3669595A (en) 1996-05-16
PT711560E (en) 2001-10-30
JP3022952B2 (en) 2000-03-21
FR2726469B1 (en) 1996-12-13
GR3036244T3 (en) 2001-10-31
NO954455D0 (en) 1995-11-07
FI955310A (en) 1996-05-09
DE69521477D1 (en) 2001-08-02
JPH08208469A (en) 1996-08-13
DE69521477T2 (en) 2002-04-18
ES2160145T3 (en) 2001-11-01
KR960016901A (en) 1996-06-17
EP0711560A1 (en) 1996-05-15
FR2726469A1 (en) 1996-05-10
DK0711560T3 (en) 2001-09-03
EP0711560B1 (en) 2001-06-27
FI117123B (en) 2006-06-30
NO311402B1 (en) 2001-11-26
FI955310A0 (en) 1995-11-06
NO954455L (en) 1996-05-09
AU706027B2 (en) 1999-06-10
CA2162299A1 (en) 1996-05-09

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