ZA958644B - New dipeptide derivatives processes for the preparation thereof and pharmaceutical compositions containing them - Google Patents

New dipeptide derivatives processes for the preparation thereof and pharmaceutical compositions containing them

Info

Publication number
ZA958644B
ZA958644B ZA958644A ZA958644A ZA958644B ZA 958644 B ZA958644 B ZA 958644B ZA 958644 A ZA958644 A ZA 958644A ZA 958644 A ZA958644 A ZA 958644A ZA 958644 B ZA958644 B ZA 958644B
Authority
ZA
South Africa
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
dipeptide derivatives
derivatives processes
Prior art date
Application number
ZA958644A
Inventor
Silvia Konetschny-Rapp
Hans-Willi Krell
Ulrich Martin
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of ZA958644B publication Critical patent/ZA958644B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Compounds of formula (I) in which R<1> and R<2> are hydroxy or an acyloxy group and R<3> is hydrogen, where R<2> and R<3> together may also signify a valency line. Process for their production from cyanobacteria of the Oscillatoria agardhii genus, and medicaments containing said compounds with a thrombin and trypsin inhibiting action.
ZA958644A 1994-10-14 1995-10-13 New dipeptide derivatives processes for the preparation thereof and pharmaceutical compositions containing them ZA958644B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4436772A DE4436772A1 (en) 1994-10-14 1994-10-14 New dipeptide derivative, process for its preparation and medicinal products containing this compound

Publications (1)

Publication Number Publication Date
ZA958644B true ZA958644B (en) 1997-04-14

Family

ID=6530791

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA958644A ZA958644B (en) 1994-10-14 1995-10-13 New dipeptide derivatives processes for the preparation thereof and pharmaceutical compositions containing them

Country Status (9)

Country Link
EP (1) EP0788510B1 (en)
JP (1) JPH10507191A (en)
AT (1) ATE189229T1 (en)
AU (1) AU3804795A (en)
CA (1) CA2202379A1 (en)
DE (2) DE4436772A1 (en)
IL (1) IL115585A (en)
WO (1) WO1996011941A1 (en)
ZA (1) ZA958644B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716869B2 (en) 2001-12-17 2004-04-06 Pharmacia Corporation Protease inhibitors of the coagulation cascade isolated from Dysidea sponges
KR101086259B1 (en) 2004-12-22 2011-11-24 에스케이케미칼주식회사 Composition comprising Oscillatoria agardhii extracts for prevention and treatment of cancer and method of preparing the extracts

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3505555A1 (en) * 1985-02-18 1986-09-11 Behringwerke Ag, 3550 Marburg NEW OLIGOPEPTIDYLARGININOL DERIVATIVES AND THEIR HOMOLOGOLOGY, METHOD FOR THE PRODUCTION THEREOF, THE USE THEREOF AND MEANS CONTAINING THEM
SE9103612D0 (en) * 1991-12-04 1991-12-04 Astra Ab NEW PEPTIDE DERIVATIVES

Also Published As

Publication number Publication date
DE4436772A1 (en) 1996-04-18
EP0788510A1 (en) 1997-08-13
ATE189229T1 (en) 2000-02-15
EP0788510B1 (en) 2000-01-26
IL115585A (en) 1999-09-22
IL115585A0 (en) 1996-01-19
AU3804795A (en) 1996-05-06
DE59507710D1 (en) 2000-03-02
CA2202379A1 (en) 1996-04-25
WO1996011941A1 (en) 1996-04-25
JPH10507191A (en) 1998-07-14

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