ZA955342B - Ortho-amino-substituted benzoylguanidines a process for their preparation their use as a medicament or diagnostic agent and also a medicament containing them - Google Patents

Ortho-amino-substituted benzoylguanidines a process for their preparation their use as a medicament or diagnostic agent and also a medicament containing them

Info

Publication number
ZA955342B
ZA955342B ZA955342A ZA955342A ZA955342B ZA 955342 B ZA955342 B ZA 955342B ZA 955342 A ZA955342 A ZA 955342A ZA 955342 A ZA955342 A ZA 955342A ZA 955342 B ZA955342 B ZA 955342B
Authority
ZA
South Africa
Prior art keywords
medicament
ortho
amino
preparation
diagnostic agent
Prior art date
Application number
ZA955342A
Inventor
Jan-Robert Schwark
Heinz-Werner Kleemann
Hans-Jochen Lang
Andreas Weichert
Wolfgang Scholz
Udo Albus
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA955342B publication Critical patent/ZA955342B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA955342A 1994-06-29 1995-06-28 Ortho-amino-substituted benzoylguanidines a process for their preparation their use as a medicament or diagnostic agent and also a medicament containing them ZA955342B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4422685A DE4422685A1 (en) 1994-06-29 1994-06-29 Ortho-amino-substituted benzoylguanidines, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them

Publications (1)

Publication Number Publication Date
ZA955342B true ZA955342B (en) 1996-02-13

Family

ID=6521760

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA955342A ZA955342B (en) 1994-06-29 1995-06-28 Ortho-amino-substituted benzoylguanidines a process for their preparation their use as a medicament or diagnostic agent and also a medicament containing them

Country Status (17)

Country Link
EP (1) EP0690048A1 (en)
JP (1) JPH0812643A (en)
CN (1) CN1119183A (en)
AU (1) AU2330095A (en)
CA (1) CA2152878A1 (en)
CZ (1) CZ169295A3 (en)
DE (1) DE4422685A1 (en)
FI (1) FI953173A (en)
HU (1) HUT72413A (en)
IL (1) IL114377A0 (en)
NO (1) NO952596L (en)
NZ (1) NZ272449A (en)
PL (1) PL309386A1 (en)
SI (1) SI9500211A (en)
SK (1) SK84195A3 (en)
TW (1) TW273545B (en)
ZA (1) ZA955342B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4430212A1 (en) * 1994-08-28 1996-02-29 Merck Patent Gmbh Ortho-substituted benzoic acid derivatives
EP0765867A1 (en) * 1995-09-27 1997-04-02 Hoechst Aktiengesellschaft Substituted benzoyl guanidines, process for their preparation, their use as antiarrhythmics or diagnostic agent as well as pharmaceuticals containing them
DE19540995A1 (en) * 1995-11-03 1997-05-07 Hoechst Ag Substituted sulfonimidamides, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
DE19542306A1 (en) * 1995-11-14 1997-05-15 Hoechst Ag Sulfonylamino-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
PL316439A1 (en) * 1995-11-20 1997-05-26 Hoechst Ag Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19546736A1 (en) * 1995-12-14 1997-06-19 Hoechst Ag Substituted chromanylsulfonyl (thio) ureas, process for their preparation and their use in the manufacture of pharmaceutical preparations
WO1997027183A1 (en) * 1996-01-26 1997-07-31 Fujisawa Pharmaceutical Co., Ltd. Guanidine derivatives
DE19621319A1 (en) * 1996-05-28 1997-12-04 Hoechst Ag Bis-ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent and medicament containing them
DE19622370A1 (en) * 1996-06-04 1997-12-11 Hoechst Ag Ortho-substituted benzoylguanidines, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them
DE19737224A1 (en) 1997-08-27 1999-03-18 Hoechst Marion Roussel De Gmbh Pharmaceutical preparation for cardiovascular treatment
DE19738604A1 (en) * 1997-09-04 1999-03-11 Hoechst Marion Roussel De Gmbh Use of Na<+>/H<+> exchange inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB966816A (en) * 1961-09-05 1964-08-19 Ciba Ltd New guanidines and process for their preparation
US3780027A (en) 1970-04-29 1973-12-18 Merck & Co Inc Anthranilic acid derivatives
ATE158278T1 (en) * 1992-02-15 1997-10-15 Hoechst Ag ORTHO-SUBSTITUTED BENZOYLGUANIDINES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICATION OR DIAGNOSTIC AND A MEDICINE CONTAINING THEM
ES2100435T3 (en) * 1992-12-16 1997-06-16 Hoechst Ag 3,5-SUBSTITUTED AMINOBENZOILGUANIDINES, PROCEDURE FOR ITS PREPARATION, ITS USE AS A MEDICINAL PRODUCT OR DIAGNOSTIC AGENT, AS WELL AS A MEDICINAL PRODUCT CONTAINING THEM.
DE4318658A1 (en) * 1993-06-04 1994-12-08 Hoechst Ag Substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, and medicament containing them

Also Published As

Publication number Publication date
AU2330095A (en) 1996-01-11
HU9501925D0 (en) 1995-08-28
PL309386A1 (en) 1996-01-08
NZ272449A (en) 1996-07-26
NO952596L (en) 1996-01-02
NO952596D0 (en) 1995-06-28
EP0690048A1 (en) 1996-01-03
DE4422685A1 (en) 1996-01-04
CA2152878A1 (en) 1995-12-30
FI953173A0 (en) 1995-06-27
TW273545B (en) 1996-04-01
JPH0812643A (en) 1996-01-16
FI953173A (en) 1995-12-30
IL114377A0 (en) 1995-10-31
SI9500211A (en) 1996-02-29
HUT72413A (en) 1996-04-29
SK84195A3 (en) 1996-10-02
CN1119183A (en) 1996-03-27
CZ169295A3 (en) 1996-05-15

Similar Documents

Publication Publication Date Title
ZA969211B (en) Substituted sulfonimidamides processes for their preparation their use as a medicament or diagnostic and medicament comprising them
IL116940A0 (en) Basically-substituted benzoylguanidines a process for preparing them their use as a medicament or diagnostic agent and a medicament containing them
IL118327A0 (en) Fluorophenyl-substituted alkenylcarboxylic acid guanidides process for their preparation their use as a medicament or diagnostic and medicament containing them
IL119293A0 (en) Substituted benzoylguanidines a process for their preparation their use as medicament or diagnostic agent and medicament comprising them
IL118278A0 (en) Substituted benzyloxycarbonyl-guanidines process for their preparation their use as a medicament or diagnostic and medicament containing them
IL114377A0 (en) Ortho-amino- substituted benzoylguanidines a process for their preparation their use as a medicament or diagnostic agent and also a medicament containing them
IL120924A0 (en) Substituted 2-naphthoylguanidines process for their preparation their use as a medicament or diagnostic and medicaments containing them
ZA961231B (en) Substituted benzenesulfonyllureas and -thioureas process for their preparation their use as a medicament or diagnostic and medicament containing them
HRP970304A2 (en) Ortho-substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicaments containing them
IL118887A0 (en) 4-fluoroalkyl-substituted benzoylguanidines process for their preparation their use as a medicament or diagnostic and medicament containing them
ZA959972B (en) Substituted benzoylguanidines process for their preparation their use as a medicament or diagnostic and medicament containing them
ZA969521B (en) Sulfonylamino-substituted benzoylguanidines a process for their preparation their use as medicament or diagnostic aid and medicament containing them
IL120925A0 (en) Substituted 1-naphthoylguanidines process for their preparation their use as a medicament or diagnostic and medicaments containing them
IL120214A0 (en) Substituted thiophenylalkenylcarboxylic acid guanidides process for their preparation their use as a medicament or diagnostic and medicament containing them
IL121085A0 (en) Ortho-substituted benzoylguanidines process for their preparation their use as a medicament or diagnostic and medicaments comprising them
HRP970293A2 (en) Bis-ortho-substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicaments containing them
IL120259A0 (en) Ortho-substituted benzoylguanidines process for their preparation their use as a medicament or diagnostic and medicament containing them
ZA96644B (en) Basically-substituted benzolyguanidines a process for preparing them their use as a medicament or diagnostic agent and medicament containing them
IL116980A0 (en) Substituted thiophenylsulfonylureas and -thioureas processes for their preparation their use as a medicament or diagnostic and medicament containing them
IL120358A0 (en) Ortho-substituted benzoylguanidines process for their preparation their use as a medicament or diagnostic and medicaments comprising them
IL120093A0 (en) Substituted diaryldicarboxylic acid diguanidides processes for their preparation their use as a medicament or diagnostic and medicament containing them
ZA982688B (en) Ortho-substituted benzoylguanidines process for their preparation their use as a medicament or diagnostic and medicament comprising them
IL120359A0 (en) Ortho-substituted benzoylguanidines process for their preparation their use as a medicament or diagnostic and medicaments comprising them
ZA934719B (en) 3,4,5-Substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic and medicament containing them
ZA969673B (en) Substituted benzenedicarboxylic acid diguanides process for their preparation their use as a medicament or diagnostic and medicament containing them