ZA952418B - Pharmaceutical compositions permitting the prolonged release of trimetazidine after oral administration - Google Patents
Pharmaceutical compositions permitting the prolonged release of trimetazidine after oral administrationInfo
- Publication number
- ZA952418B ZA952418B ZA952418A ZA952418A ZA952418B ZA 952418 B ZA952418 B ZA 952418B ZA 952418 A ZA952418 A ZA 952418A ZA 952418 A ZA952418 A ZA 952418A ZA 952418 B ZA952418 B ZA 952418B
- Authority
- ZA
- South Africa
- Prior art keywords
- trimetazidine
- pharmaceutical compositions
- oral administration
- prolonged release
- compositions permitting
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Compsn. for prolonged liberation of trimetazidine (II) or its salts, uses a polymer insoluble in water and a plasticiser to control liberation.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9403434A FR2717687B1 (en) | 1994-03-24 | 1994-03-24 | Pharmaceutical compositions for the sustained release of trimetazidine after oral administration. |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA952418B true ZA952418B (en) | 1995-12-18 |
Family
ID=9461361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA952418A ZA952418B (en) | 1994-03-24 | 1995-03-24 | Pharmaceutical compositions permitting the prolonged release of trimetazidine after oral administration |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0673649B1 (en) |
JP (1) | JP3017040B2 (en) |
CN (1) | CN1056057C (en) |
AT (1) | ATE216583T1 (en) |
AU (1) | AU684893B2 (en) |
CA (1) | CA2145248C (en) |
DE (1) | DE69526467T2 (en) |
DK (1) | DK0673649T3 (en) |
ES (1) | ES2176296T3 (en) |
FI (1) | FI116881B (en) |
FR (1) | FR2717687B1 (en) |
NO (1) | NO306450B1 (en) |
NZ (1) | NZ270791A (en) |
PT (1) | PT673649E (en) |
ZA (1) | ZA952418B (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2802424B1 (en) * | 1999-12-17 | 2002-02-15 | Adir | MATRIX TABLET FOR THE EXTENDED RELEASE OF TRIMETAZIDINE AFTER ORAL ADMINISTRATION |
ATE442852T1 (en) * | 2000-10-05 | 2009-10-15 | Usv Ltd | DELAYED-RELEASE MEDICINAL COMPRISING TRIMETAZIDINE AND METHOD FOR THE PRODUCTION |
FR2818549B1 (en) * | 2000-12-26 | 2003-02-07 | Servier Lab | SOLID THERMOFORMABLE PHARMACEUTICAL COMPOSITION FOR THE CONTROLLED RELEASE OF TRIMETAZIDINE |
AU2002356425A1 (en) * | 2001-11-21 | 2003-06-10 | Themis Laboratories Private Limited | A process for manufacture of a sustained release composition containing microbe |
FR2885807B1 (en) * | 2005-05-18 | 2008-05-16 | Mg Pharma | SOLID PHARMACEUTICAL COMPOSITION WITH PROLONGED RELEASE OF 1- (2,3,4-TRIMETHOXYBENZYL) PIPERAZINE, AND PREPARATION METHOD |
WO2007116243A2 (en) * | 2006-04-10 | 2007-10-18 | Mintails Limited | Method for treating fibromyalgia and related conditions |
EP2200591A2 (en) | 2007-09-11 | 2010-06-30 | Ranbaxy Laboratories Limited | Controlled release pharmaceutical dosage forms of trimetazidine |
JP2012515757A (en) | 2009-01-20 | 2012-07-12 | マイクロ ラブス リミテッド | Trimetazidine controlled release solid pharmaceutical composition and method for producing the same |
PL2391353T3 (en) * | 2009-01-30 | 2016-09-30 | Pharmaceutical compositions of trimetazidine | |
TR201001902A2 (en) | 2010-03-12 | 2011-04-21 | Ali̇ Rai̇f İlaç Sanayi̇ Ve Ti̇caret A.Ş. | Trimetazidine tablets with extended release |
US20110274751A1 (en) | 2010-05-04 | 2011-11-10 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Trimetazidine formulation with different release profiles |
EP2386302A1 (en) | 2010-05-11 | 2011-11-16 | Ranbaxy Laboratories Limited | A controlled release pharmaceutical dosage form of trimetazidine and processes for the preparation thereof |
BG1345U1 (en) * | 2010-05-20 | 2010-08-31 | "Адифарм" Ад | Modified-release pharmaceutical formulation |
EP2491930A1 (en) | 2011-02-25 | 2012-08-29 | Deva Holding Anonim Sirketi | Pharmaceutical combination of betahistine and trimetazidine |
CN102133195A (en) * | 2011-03-17 | 2011-07-27 | 王国栋 | Trimetazidine dihydrochloride sustained control release pellet and preparation method thereof |
CN102319225B (en) * | 2011-09-23 | 2013-04-03 | 广州白云山光华制药股份有限公司 | Trimetazidine hydrochloride sustained release tablet and preparation method thereof |
FR2986431B1 (en) | 2012-02-03 | 2017-03-17 | Servier Lab | PROLONGED RELEASE OF TRIMETAZIDINE PHARMACEUTICAL COMPOSITION, PROCESS FOR THE PRODUCTION THEREOF AND USE IN THERAPEUTIC TREATMENTS |
CN102764261A (en) * | 2012-07-30 | 2012-11-07 | 沈阳药科大学 | Oral composition controlling release of trimetazidine dihydrochloride and preparation method of oral composition |
CN103565751A (en) * | 2013-10-17 | 2014-02-12 | 广州帝奇医药技术有限公司 | Long-acting sustained-release pellet and preparation method thereof |
US20190381034A1 (en) * | 2018-06-14 | 2019-12-19 | Ming Fang | Pharmaceutical composition and method for acute on chronic liver failure and related liver diseases |
CN110237053A (en) * | 2019-07-26 | 2019-09-17 | 湖北欣泽霏药业有限公司 | A kind of trimetazidine hydrochloride sustained-release pellet and preparation method thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2490963B1 (en) * | 1980-09-30 | 1986-04-18 | Science Union & Cie | NOVEL THERAPEUTIC COMPOSITION WITH ANTI-ISCHEMIC ACTION CONTAINING TRIMETHOXY 2, 3, 4-BENZYL 1-PIPERAZINE |
DE3686275T2 (en) * | 1985-01-11 | 1993-03-18 | Teijin Ltd | PREPARED PRODUCTS WITH DELAYED RELEASE. |
JPH0625055B2 (en) * | 1985-03-18 | 1994-04-06 | 日本ケミフア株式会社 | Persistent tablets |
US5260066A (en) * | 1992-01-16 | 1993-11-09 | Srchem Incorporated | Cryogel bandage containing therapeutic agent |
US5417983A (en) * | 1992-02-19 | 1995-05-23 | Sagami Chemical Research Center | Drug release controlling material responsive to changes in temperature |
-
1994
- 1994-03-24 FR FR9403434A patent/FR2717687B1/en not_active Expired - Fee Related
-
1995
- 1995-03-22 AU AU15029/95A patent/AU684893B2/en not_active Expired
- 1995-03-22 EP EP95400628A patent/EP0673649B1/en not_active Expired - Lifetime
- 1995-03-22 CA CA002145248A patent/CA2145248C/en not_active Expired - Lifetime
- 1995-03-22 FI FI951357A patent/FI116881B/en not_active IP Right Cessation
- 1995-03-22 DK DK95400628T patent/DK0673649T3/en active
- 1995-03-22 PT PT95400628T patent/PT673649E/en unknown
- 1995-03-22 AT AT95400628T patent/ATE216583T1/en active
- 1995-03-22 DE DE69526467T patent/DE69526467T2/en not_active Expired - Lifetime
- 1995-03-22 ES ES95400628T patent/ES2176296T3/en not_active Expired - Lifetime
- 1995-03-23 NZ NZ270791A patent/NZ270791A/en not_active IP Right Cessation
- 1995-03-23 NO NO951110A patent/NO306450B1/en not_active IP Right Cessation
- 1995-03-24 ZA ZA952418A patent/ZA952418B/en unknown
- 1995-03-24 CN CN95103558A patent/CN1056057C/en not_active Expired - Lifetime
- 1995-03-24 JP JP7065788A patent/JP3017040B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
NZ270791A (en) | 1996-07-26 |
EP0673649A1 (en) | 1995-09-27 |
CN1056057C (en) | 2000-09-06 |
ATE216583T1 (en) | 2002-05-15 |
CA2145248A1 (en) | 1995-09-25 |
NO306450B1 (en) | 1999-11-08 |
AU684893B2 (en) | 1998-01-08 |
JPH07258086A (en) | 1995-10-09 |
EP0673649B1 (en) | 2002-04-24 |
PT673649E (en) | 2002-08-30 |
FR2717687B1 (en) | 1996-06-14 |
CN1124140A (en) | 1996-06-12 |
FI116881B (en) | 2006-03-31 |
DE69526467T2 (en) | 2002-12-05 |
NO951110L (en) | 1995-09-25 |
JP3017040B2 (en) | 2000-03-06 |
DK0673649T3 (en) | 2002-08-05 |
FI951357A (en) | 1995-09-25 |
CA2145248C (en) | 2004-01-06 |
AU1502995A (en) | 1995-10-05 |
FR2717687A1 (en) | 1995-09-29 |
DE69526467D1 (en) | 2002-05-29 |
FI951357A0 (en) | 1995-03-22 |
ES2176296T3 (en) | 2002-12-01 |
NO951110D0 (en) | 1995-03-23 |
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