ZA925507B - A process for the 14a-hydroxylation of avermectin compounds - Google Patents

A process for the 14a-hydroxylation of avermectin compounds

Info

Publication number
ZA925507B
ZA925507B ZA925507A ZA925507A ZA925507B ZA 925507 B ZA925507 B ZA 925507B ZA 925507 A ZA925507 A ZA 925507A ZA 925507 A ZA925507 A ZA 925507A ZA 925507 B ZA925507 B ZA 925507B
Authority
ZA
South Africa
Prior art keywords
hydroxylation
avermectin compounds
avermectin
compounds
Prior art date
Application number
ZA925507A
Other languages
English (en)
Inventor
Byron H Arison
H Arison Byron
Marvin D Schulman
D Schulman Marvin
Noel M Young
M Young Noel
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ZA925507B publication Critical patent/ZA925507B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/445—The saccharide radical is condensed with a heterocyclic radical, e.g. everninomycin, papulacandin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ZA925507A 1991-07-23 1992-07-22 A process for the 14a-hydroxylation of avermectin compounds ZA925507B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73440991A 1991-07-23 1991-07-23

Publications (1)

Publication Number Publication Date
ZA925507B true ZA925507B (en) 1993-03-31

Family

ID=24951584

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA925507A ZA925507B (en) 1991-07-23 1992-07-22 A process for the 14a-hydroxylation of avermectin compounds

Country Status (5)

Country Link
EP (1) EP0524686A1 (fr)
JP (1) JPH0684378B2 (fr)
AU (1) AU2047492A (fr)
CA (1) CA2074328A1 (fr)
ZA (1) ZA925507B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09148026A (ja) * 1995-11-24 1997-06-06 Yazaki Corp 相対回転部材間継電装置
US6265571B1 (en) 1999-07-12 2001-07-24 Magellan Laboratories, Inc. Purification process for anti-parasitic fermentation product

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
JPS5632481A (en) * 1979-08-23 1981-04-01 Sankyo Co Ltd Antibiotic b-41d, its preparation, and acaricide and anthelminthic agent and repellent containing the same as active constituent
US4582852A (en) * 1983-11-02 1986-04-15 Ciba-Geigy Corporation 14- and 15-hydroxy milbemycin derivatives for controlling plant and animal parasites
US5225338A (en) * 1990-09-24 1993-07-06 Merck & Co., Inc. Microbial preparation of 13β-13-deoxy-22,23-dihydro avermectin-B1A/B1B aglycone

Also Published As

Publication number Publication date
JPH0684378B2 (ja) 1994-10-26
JPH0654696A (ja) 1994-03-01
CA2074328A1 (fr) 1993-01-24
EP0524686A1 (fr) 1993-01-27
AU2047492A (en) 1993-01-28

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