ZA922017B - Methods and substances for recruiting therapeutic agents to solid tissues - Google Patents
Methods and substances for recruiting therapeutic agents to solid tissuesInfo
- Publication number
- ZA922017B ZA922017B ZA922017A ZA922017A ZA922017B ZA 922017 B ZA922017 B ZA 922017B ZA 922017 A ZA922017 A ZA 922017A ZA 922017 A ZA922017 A ZA 922017A ZA 922017 B ZA922017 B ZA 922017B
- Authority
- ZA
- South Africa
- Prior art keywords
- recruiting
- substances
- methods
- therapeutic agents
- solid tissues
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 239000007787 solid Substances 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6875—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
- A61K47/6879—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin the immunoglobulin having two or more different antigen-binding sites, e.g. bispecific or multispecific immunoglobulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
- A61K47/6913—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome the liposome being modified on its surface by an antibody
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67565491A | 1991-03-27 | 1991-03-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA922017B true ZA922017B (en) | 1993-03-31 |
Family
ID=24711439
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA922017A ZA922017B (en) | 1991-03-27 | 1992-03-19 | Methods and substances for recruiting therapeutic agents to solid tissues |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0506124A1 (ja) |
JP (1) | JPH05117164A (ja) |
AU (1) | AU640863B2 (ja) |
CA (1) | CA2062582C (ja) |
ZA (1) | ZA922017B (ja) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5869620A (en) * | 1986-09-02 | 1999-02-09 | Enzon, Inc. | Multivalent antigen-binding proteins |
US5637481A (en) * | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
US5621083A (en) * | 1991-11-04 | 1997-04-15 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
US6146850A (en) | 1991-11-04 | 2000-11-14 | Xoma Corporation | Proteins encoding gelonin sequences |
US5837491A (en) * | 1991-11-04 | 1998-11-17 | Xoma Corporation | Polynucleotides encoding gelonin sequences |
US6025165A (en) * | 1991-11-25 | 2000-02-15 | Enzon, Inc. | Methods for producing multivalent antigen-binding proteins |
GB9200417D0 (en) * | 1992-01-09 | 1992-02-26 | Bagshawe Kenneth D | Cytotoxic drug therapy |
GB9200415D0 (en) * | 1992-01-09 | 1992-02-26 | Bagshawe Kenneth D | Inactivation of cytotoxic drugs |
US6329507B1 (en) * | 1992-08-21 | 2001-12-11 | The Dow Chemical Company | Dimer and multimer forms of single chain polypeptides |
WO1994007921A1 (en) * | 1992-09-25 | 1994-04-14 | Commonwealth Scientific And Industrial Research Organisation | Target binding polypeptide |
US5837821A (en) * | 1992-11-04 | 1998-11-17 | City Of Hope | Antibody construct |
AU5670194A (en) * | 1992-11-20 | 1994-06-22 | Enzon, Inc. | Linker for linked fusion polypeptides |
GB9225453D0 (en) | 1992-12-04 | 1993-01-27 | Medical Res Council | Binding proteins |
SG55079A1 (en) * | 1992-12-11 | 1998-12-21 | Dow Chemical Co | Multivalent single chain antibodies |
CA2162689C (en) * | 1993-05-12 | 2000-07-18 | Marc D. Better | Immunotoxins comprising gelonin and an antibody |
AUPO591797A0 (en) | 1997-03-27 | 1997-04-24 | Commonwealth Scientific And Industrial Research Organisation | High avidity polyvalent and polyspecific reagents |
US7445802B2 (en) | 2000-12-26 | 2008-11-04 | Yeda Research And Development Co. Ltd | Site-specific in situ generation of allicin using a targeted alliinase delivery system for the treatment of cancers, tumors, infectious diseases and other allicin-sensitive diseases |
ES2276735T3 (es) * | 2001-09-14 | 2007-07-01 | Affimed Therapeutics Ag | Anticuerpos fv multimericos de cadena sencilla en tandem. |
WO2010085495A1 (en) | 2009-01-21 | 2010-07-29 | Amgen Inc. | Compositions and methods of treating inflammatory and autoimmune diseases |
EP2895197B1 (en) | 2012-09-12 | 2020-02-26 | Ramot at Tel-Aviv University Ltd. | Immunoparticles and methods of generating and using same |
US9546203B2 (en) | 2013-03-14 | 2017-01-17 | Amgen Inc. | Aglycosylated Fc-containing polypeptides with cysteine substitutions |
IL283764B2 (en) | 2015-04-10 | 2024-01-01 | Amgen Inc | Interleukin for the expansion of myotonic control T-2 cells |
US11708421B2 (en) | 2016-07-18 | 2023-07-25 | Ramot At Tel-Aviv University Ltd. | Modular platform for targeted therapeutics |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0149709B2 (en) * | 1983-07-29 | 1995-11-29 | Milton David Goldenberg | Method for enhancing target specificity of antibody localization and clearance of non-target diagnostic and therapeutic principles |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
EP0623679B1 (en) * | 1987-05-21 | 2003-06-25 | Micromet AG | Targeted multifunctional proteins |
-
1992
- 1992-03-10 CA CA002062582A patent/CA2062582C/en not_active Expired - Fee Related
- 1992-03-18 AU AU12992/92A patent/AU640863B2/en not_active Ceased
- 1992-03-19 ZA ZA922017A patent/ZA922017B/xx unknown
- 1992-03-27 JP JP4101629A patent/JPH05117164A/ja active Pending
- 1992-03-27 EP EP92105380A patent/EP0506124A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU1299292A (en) | 1992-10-15 |
CA2062582C (en) | 1996-03-26 |
AU640863B2 (en) | 1993-09-02 |
EP0506124A1 (en) | 1992-09-30 |
CA2062582A1 (en) | 1992-09-28 |
JPH05117164A (ja) | 1993-05-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA922017B (en) | Methods and substances for recruiting therapeutic agents to solid tissues | |
GB2221390B (en) | Niacin-containing composition and its therapeutic use | |
IL105914A0 (en) | Methods and compositions for in vivo gene therapy | |
HK1094148A1 (en) | Synergistic therapeutic compositions and methods | |
GR3031288T3 (en) | Tissue moisturizing composition and method | |
GB9206736D0 (en) | Improvements of organic compounds and their use in pharmaceutical compositions | |
GB9515775D0 (en) | Piperidine derivatives and their use as therapeutic agents | |
GB9518115D0 (en) | Triazole derivatives and their use as therapeutic agents | |
EP0330496A3 (en) | Skin treatment composition | |
SG42865A1 (en) | Therapeutic compositions and methods | |
GB9219425D0 (en) | Therapeutic agent and its use | |
GB2281863B (en) | Improvements in relation to medical diathermy | |
AP9300575A0 (en) | Piperidine derivatives their preparation and their application in therapy | |
AU7793791A (en) | Pharmaceutical composition for use in treating pain | |
GB2294637B (en) | Therapeutic compositions and methods of use | |
IL91451A0 (en) | Pharmaceutical compositions comprising azapiron compounds and their use in the treatment of addiction | |
IL107726A0 (en) | Pyrrole derivatives their preparation and their therapeutic use | |
ZA893261B (en) | Synergistic combinations and their use as therapeutic agents | |
GR890100642A (en) | Ultra mild skin cleansing composition | |
GB9218715D0 (en) | Synergistic biologically skin moisturizer | |
GB2223014B (en) | Heterocyclic compounds and their use in pharmaceutical compositions | |
GB9219776D0 (en) | New compounds for use in the treatment of cancer | |
HU9401579D0 (en) | Methods for administering biological agents and microparticle compositions | |
ZA938746B (en) | Pyrrole derivatives their preparation and their therapeutic use | |
GB8907588D0 (en) | Therapeutic compound and composition |