ZA913721B - Antiviral agents - Google Patents

Antiviral agents

Info

Publication number
ZA913721B
ZA913721B ZA913721A ZA913721A ZA913721B ZA 913721 B ZA913721 B ZA 913721B ZA 913721 A ZA913721 A ZA 913721A ZA 913721 A ZA913721 A ZA 913721A ZA 913721 B ZA913721 B ZA 913721B
Authority
ZA
South Africa
Prior art keywords
antiviral agents
antiviral
agents
Prior art date
Application number
ZA913721A
Other languages
English (en)
Inventor
Hans Maag
Maag Hans
Ernest J Prisbe
J Prisbe Ernest
Julien P H Verheyden
P H Verheyden Julien
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of ZA913721B publication Critical patent/ZA913721B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/20Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ZA913721A 1990-05-17 1991-05-16 Antiviral agents ZA913721B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52477390A 1990-05-17 1990-05-17

Publications (1)

Publication Number Publication Date
ZA913721B true ZA913721B (en) 1992-02-26

Family

ID=24090612

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA913721A ZA913721B (en) 1990-05-17 1991-05-16 Antiviral agents

Country Status (11)

Country Link
EP (1) EP0457326A1 (xx)
JP (1) JPH04226999A (xx)
KR (1) KR910020027A (xx)
AU (1) AU7623991A (xx)
CA (1) CA2042795A1 (xx)
FI (1) FI912376A (xx)
IE (1) IE911673A1 (xx)
IL (1) IL98164A0 (xx)
NO (1) NO911936L (xx)
NZ (1) NZ238166A (xx)
ZA (1) ZA913721B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0594667T3 (da) * 1991-07-05 2001-11-12 Pro Neuron Inc Behandling af kemoterapeutiske og antivirale, aktive stoffers toksiske virkning med acylerede pyrimidinnucleosider
US5446137B1 (en) * 1993-12-09 1998-10-06 Behringwerke Ag Oligonucleotides containing 4'-substituted nucleotides
JP2002322192A (ja) * 2000-08-10 2002-11-08 Sankyo Co Ltd 2’−o,4’−c−架橋ヌクレオシドトリリン酸体
EP1411954B1 (en) 2000-10-18 2010-12-15 Pharmasset, Inc. Modified nucleosides for treatment of viral infections and abnormal cellular proliferation
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
TWI294882B (en) * 2002-12-09 2008-03-21 Hoffmann La Roche Anhydrous crystalline azido cytosine hemisulfate derivative
WO2004062676A1 (en) * 2003-01-09 2004-07-29 F. Hoffmann-La Roche Ag -modified nucleoside derivatives for treating flaviviridae infections
US7429572B2 (en) 2003-05-30 2008-09-30 Pharmasset, Inc. Modified fluorinated nucleoside analogues
CN101023094B (zh) 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
SI3109244T1 (sl) 2004-09-14 2019-06-28 Gilead Pharmasset Llc Priprava 2'fluoro-2'-alkil-substituiranih ali drugih neobvezno substituiranih ribofuranozil pirimidinov in purinov in njihovih derivatov
CN102924549A (zh) 2005-09-26 2013-02-13 吉利德制药有限责任公司 作为抗病毒剂的修饰的4'-核苷
SI2084175T1 (sl) * 2006-10-10 2011-05-31 Medivir Ab Hcv nukleozidni inhibitor
EP2619215B1 (en) 2010-09-22 2018-09-05 Alios Biopharma, Inc. Azido nucleosides and nucleotide analogs
MX356509B (es) 2011-12-22 2018-05-30 Alios Biopharma Inc Nucleósidos sustituidos, nucleótidos y análogos de los mismos.
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
CN110540555B (zh) * 2018-05-28 2023-01-24 江苏恒瑞医药股份有限公司 一种游离核苷磷酸的方法
CN109893536B (zh) * 2018-07-02 2021-04-27 河南真实生物科技有限公司 4’-取代核苷的晶型、制备和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910885A (en) * 1974-03-12 1975-10-07 Syntex Inc 4-Alkoxy nucleosides and intermediates therefore
EP0371366A1 (en) * 1988-11-21 1990-06-06 Syntex (U.S.A.) Inc. Antiviral agents

Also Published As

Publication number Publication date
CA2042795A1 (en) 1991-11-18
AU7623991A (en) 1991-11-21
NO911936D0 (no) 1991-05-16
IE911673A1 (en) 1991-11-20
JPH04226999A (ja) 1992-08-17
NO911936L (no) 1991-11-18
IL98164A0 (en) 1992-06-21
EP0457326A1 (en) 1991-11-21
FI912376A0 (fi) 1991-05-16
KR910020027A (ko) 1991-12-19
NZ238166A (en) 1993-09-27
FI912376A (fi) 1991-11-18

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