ZA90394B - Alkylated polyethylenimine derivatives,process for their preparation,their use as pharmaceuticals and pharmaceutical preparations - Google Patents

Alkylated polyethylenimine derivatives,process for their preparation,their use as pharmaceuticals and pharmaceutical preparations

Info

Publication number
ZA90394B
ZA90394B ZA90394A ZA90394A ZA90394B ZA 90394 B ZA90394 B ZA 90394B ZA 90394 A ZA90394 A ZA 90394A ZA 90394 A ZA90394 A ZA 90394A ZA 90394 B ZA90394 B ZA 90394B
Authority
ZA
South Africa
Prior art keywords
pharmaceuticals
preparation
pharmaceutical preparations
polyethylenimine derivatives
alkylated polyethylenimine
Prior art date
Application number
ZA90394A
Inventor
Walter Heitz
Heitz Walter
Thomas Fischer
Fischer Thomas
Bela Kerekjarto
Kerekjarto Bela
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA90394B publication Critical patent/ZA90394B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C08G73/0213—Preparatory process
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/3481—Organic compounds containing oxygen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/3535—Organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Medicinal Preparation (AREA)
  • Liquid Developers In Electrophotography (AREA)
  • Professional, Industrial, Or Sporting Protective Garments (AREA)

Abstract

The novel uncrosslinked and crosslinked alkylated polyethyleneimines can be used as hypolipidaemics due to their gallic acid-binding activity.
ZA90394A 1989-01-20 1990-01-19 Alkylated polyethylenimine derivatives,process for their preparation,their use as pharmaceuticals and pharmaceutical preparations ZA90394B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3901527A DE3901527A1 (en) 1989-01-20 1989-01-20 ALKYLATED POLYETHYLENE IMIN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICINAL PRODUCTS AND PHARMACEUTICAL PREPARATIONS

Publications (1)

Publication Number Publication Date
ZA90394B true ZA90394B (en) 1991-04-24

Family

ID=6372414

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA90394A ZA90394B (en) 1989-01-20 1990-01-19 Alkylated polyethylenimine derivatives,process for their preparation,their use as pharmaceuticals and pharmaceutical preparations

Country Status (15)

Country Link
EP (1) EP0379161B1 (en)
JP (1) JPH02232229A (en)
AT (1) ATE111931T1 (en)
AU (1) AU624215B2 (en)
CA (1) CA2008114A1 (en)
DE (2) DE3901527A1 (en)
DK (1) DK0379161T3 (en)
ES (1) ES2063173T3 (en)
FI (1) FI900297A0 (en)
IE (1) IE65618B1 (en)
IL (1) IL93098A0 (en)
NO (1) NO900279L (en)
NZ (1) NZ232149A (en)
PT (1) PT92880B (en)
ZA (1) ZA90394B (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0534304A1 (en) * 1991-09-21 1993-03-31 Hoechst Aktiengesellschaft Cycloalkylated polyethylenimines and their use as hypolipemic agents
EP0534316A1 (en) * 1991-09-21 1993-03-31 Hoechst Aktiengesellschaft Use of alkylated polyethylenimines to concentrate bile acids
EP0622078B1 (en) * 1992-01-14 1999-09-01 Hisamitsu Pharmaceutical Co., Inc. Cholesterol level depressant
DK0563731T3 (en) * 1992-03-28 1996-03-18 Hoechst Ag Drugs containing polyhydromethylene derivatives, process for their preparation and use
DE59304725D1 (en) * 1992-07-22 1997-01-23 Hoechst Ag Crosslinked, nitrogen-containing vinyl copolymers, processes for their preparation and the use of these compounds
ATE159262T1 (en) * 1992-07-22 1997-11-15 Hoechst Ag POLYVINYLAMINE DERIVATIVES HAVING HYDROPHILIC CENTERS, METHOD FOR THE PRODUCTION THEREOF AND THE USE OF THE COMPOUNDS AS MEDICINAL PRODUCTS, ACTIVE CARRIERS AND FOOD ADDITIVES
US5667775A (en) 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5496545A (en) * 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
TW474813B (en) 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6107494A (en) * 1994-09-13 2000-08-22 G.D. Searle And Company Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US20030069601A1 (en) 1998-12-15 2003-04-10 Closys Corporation Clotting cascade initiating apparatus and methods of use
DE69908643T2 (en) 1998-12-23 2004-05-13 G.D. Searle Llc, Chicago COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND NICOTIC ACID DERIVATIVES FOR CARDIOVASCULAR INDICATIONS
CN1342089A (en) 1998-12-23 2002-03-27 G.D.瑟尔有限公司 Combinations of ileal bile acid transport inhibitors and cholestery ester transfer protein inhibitors for cardiovascular disease
EA200100707A1 (en) 1998-12-23 2001-12-24 Джи.Ди.Сирл Ллс COMBINATIONS OF INHIBITORS OF TRANSPORT OF BILK ACIDS IN THE SUBJECTIVE AND FIBRIN ACID DERIVATIVES FOR THE CARDIOVASCULAR INDICATIONS
WO2000038723A1 (en) 1998-12-23 2000-07-06 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
EP1340509A1 (en) 1998-12-23 2003-09-03 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
WO2000038722A1 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS
BR9916484A (en) 1998-12-23 2002-01-22 Searle Llc Combinations of ileal bile acid transport inhibitors and bile acid sequestering agents in cardiovascular indications
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
US6794544B2 (en) 2000-03-10 2004-09-21 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
DE10065710A1 (en) * 2000-12-29 2002-07-04 Bayer Ag Medicament containing a polyamine as an active substance
JP2005518347A (en) 2001-11-02 2005-06-23 ジー．ディー． サール エルエルシー Novel mono- and difluorobenzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
CA2471639A1 (en) 2002-01-17 2003-07-31 Pharmacia Corporation Novel alkyl/aryl hydroxy or keto thiepines.
GB0221942D0 (en) * 2002-09-20 2002-10-30 Univ Strathclyde Drug delivery
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
US8986669B2 (en) 2005-09-02 2015-03-24 Genzyme Corporation Method for removing phosphate and polymer used therefore
EP3000460A1 (en) 2005-09-15 2016-03-30 Genzyme Corporation Sachet formulation for amine polymers
US10231721B2 (en) 2010-06-24 2019-03-19 St. Croix Surgical Systems, Llc Failsafe percutaneous wound barrier
MA41202A (en) 2014-12-18 2017-10-24 Genzyme Corp CROSS-LINKED POLYDIALLYMINE COPOLYMERS FOR THE TREATMENT OF TYPE 2 DIABETES
CN110907543A (en) * 2019-09-29 2020-03-24 重庆健能医药开发有限公司 Experimental method for adsorbing bile acid of hydrotalcite chewable tablet

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* Cited by examiner, † Cited by third party
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US3251778A (en) * 1960-08-04 1966-05-17 Petrolite Corp Process of preventing scale
US3332841A (en) * 1961-10-04 1967-07-25 Lilly Co Eli Method of treating hyperacidity
JPS5548221A (en) * 1978-10-04 1980-04-05 Nippon Oil Co Ltd Preparation of polyhexamethyleneimine
JPS5566513A (en) * 1978-11-14 1980-05-20 Ono Pharmaceut Co Ltd Drug for arteriosclerosis comprising high polymer compound as active constituent
JPS62243620A (en) * 1986-04-17 1987-10-24 Asahi Chem Ind Co Ltd Surface-modified wholly aromatic polyamide formed article and production thereof

Also Published As

Publication number Publication date
EP0379161A3 (en) 1991-07-31
AU624215B2 (en) 1992-06-04
CA2008114A1 (en) 1990-07-20
IL93098A0 (en) 1990-11-05
IE900214L (en) 1990-07-20
NO900279L (en) 1990-07-23
NZ232149A (en) 1991-12-23
PT92880A (en) 1990-07-31
FI900297A0 (en) 1990-01-18
ES2063173T3 (en) 1995-01-01
DK0379161T3 (en) 1995-01-16
JPH02232229A (en) 1990-09-14
NO900279D0 (en) 1990-01-19
DE59007178D1 (en) 1994-10-27
AU4861890A (en) 1990-07-26
ATE111931T1 (en) 1994-10-15
DE3901527A1 (en) 1990-07-26
IE65618B1 (en) 1995-11-01
EP0379161B1 (en) 1994-09-21
PT92880B (en) 1995-12-29
EP0379161A2 (en) 1990-07-25

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