IE900214L - Alkylated polyethylenimine derivatives, process for their¹preparation, their use as pharmaceuticals and pharmaceutical¹preparations - Google Patents

Alkylated polyethylenimine derivatives, process for their¹preparation, their use as pharmaceuticals and pharmaceutical¹preparations

Info

Publication number
IE900214L
IE900214L IE900214A IE21490A IE900214L IE 900214 L IE900214 L IE 900214L IE 900214 A IE900214 A IE 900214A IE 21490 A IE21490 A IE 21490A IE 900214 L IE900214 L IE 900214L
Authority
IE
Ireland
Prior art keywords
pharmaceuticals
polyethylenimine derivatives
alkylated polyethylenimine
alkylated
derivatives
Prior art date
Application number
IE900214A
Other versions
IE65618B1 (en
Inventor
Walter Heitz
Thomas Fischer
Bela Kerekjarto
Original Assignee
Timothy Gerard Vaughan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Timothy Gerard Vaughan filed Critical Timothy Gerard Vaughan
Publication of IE900214L publication Critical patent/IE900214L/en
Publication of IE65618B1 publication Critical patent/IE65618B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C08G73/0213—Preparatory process
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/3481—Organic compounds containing oxygen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
    • A23L3/3463—Organic compounds; Microorganisms; Enzymes
    • A23L3/3535—Organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Food Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nutrition Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Professional, Industrial, Or Sporting Protective Garments (AREA)
  • Liquid Developers In Electrophotography (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

Abstract

The novel uncrosslinked and crosslinked alkylated polyethyleneimines can be used as hypolipidaemics due to their gallic acid-binding activity.
IE21490A 1989-01-20 1990-01-19 Alkylated polyethylenimine derivatives process for their preparation their use as pharmaceuticals and pharmaceutical preparations IE65618B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3901527A DE3901527A1 (en) 1989-01-20 1989-01-20 ALKYLATED POLYETHYLENE IMIN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICINAL PRODUCTS AND PHARMACEUTICAL PREPARATIONS

Publications (2)

Publication Number Publication Date
IE900214L true IE900214L (en) 1990-07-20
IE65618B1 IE65618B1 (en) 1995-11-01

Family

ID=6372414

Family Applications (1)

Application Number Title Priority Date Filing Date
IE21490A IE65618B1 (en) 1989-01-20 1990-01-19 Alkylated polyethylenimine derivatives process for their preparation their use as pharmaceuticals and pharmaceutical preparations

Country Status (15)

Country Link
EP (1) EP0379161B1 (en)
JP (1) JPH02232229A (en)
AT (1) ATE111931T1 (en)
AU (1) AU624215B2 (en)
CA (1) CA2008114A1 (en)
DE (2) DE3901527A1 (en)
DK (1) DK0379161T3 (en)
ES (1) ES2063173T3 (en)
FI (1) FI900297A0 (en)
IE (1) IE65618B1 (en)
IL (1) IL93098A0 (en)
NO (1) NO900279L (en)
NZ (1) NZ232149A (en)
PT (1) PT92880B (en)
ZA (1) ZA90394B (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0534316A1 (en) * 1991-09-21 1993-03-31 Hoechst Aktiengesellschaft Use of alkylated polyethylenimines to concentrate bile acids
EP0534304A1 (en) * 1991-09-21 1993-03-31 Hoechst Aktiengesellschaft Cycloalkylated polyethylenimines and their use as hypolipemic agents
WO1993013781A1 (en) * 1992-01-14 1993-07-22 Hisamitsu Pharmaceutical Co., Inc. Cholesterol level depressant
ATE130193T1 (en) * 1992-03-28 1995-12-15 Hoechst Ag MEDICINAL PRODUCTS MADE OF POLYHYDROXYMETHYLENE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF.
ES2110543T3 (en) * 1992-07-22 1998-02-16 Hoechst Ag DERIVATIVES OF POLI (VINYL-AMINES) THAT HAVE HYDROPHILIC CENTERS, PROCEDURE FOR THEIR PREPARATION AS WELL AS THE USE OF THE COMPOUNDS AS MEDICINES, VEHICLES OF ACTIVE SUBSTANCES AND AUXILIARY FOOD INGREDIENTS.
EP0580079B1 (en) * 1992-07-22 1996-12-11 Hoechst Aktiengesellschaft Crosslinked, nitrogen-containing vinyl copolymers, process for their manufacture and use of these compounds
US5667775A (en) 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5496545A (en) * 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
TW474813B (en) 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6107494A (en) * 1994-09-13 2000-08-22 G.D. Searle And Company Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US20030069601A1 (en) 1998-12-15 2003-04-10 Closys Corporation Clotting cascade initiating apparatus and methods of use
AU2157400A (en) 1998-12-23 2000-07-31 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications
EA004877B1 (en) 1998-12-23 2004-08-26 Джи.Ди.Сирл Ллс Combinations of ileal bile acid transport inhibitors and bile acid sequestering agents for cardiovascular indications
CZ20012342A3 (en) 1998-12-23 2001-12-12 G. D. Searle Llc Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications
US6489366B1 (en) 1998-12-23 2002-12-03 G. D. Searle, Llc Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
HUP0201972A3 (en) 1998-12-23 2005-06-28 G D Searle Llc Chicago Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
JP2002533409A (en) 1998-12-23 2002-10-08 ジー．ディー．サール エルエルシー Combination of cholesteryl ester transfer protein inhibitor and bile acid sequestrant for cardiovascular applications
EA009466B1 (en) 1998-12-23 2007-12-28 Джи.Ди. Сирл Ллс Protein inhibitors transferring cholesteryl ester
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
JP2003528830A (en) 2000-03-10 2003-09-30 ファルマシア・コーポレーション Method for producing tetrahydrobenzothiepines
DE10065710A1 (en) * 2000-12-29 2002-07-04 Bayer Ag Medicament containing a polyamine as an active substance
EP1448546A4 (en) 2001-11-02 2005-02-02 Searle Llc Novel mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (asbt) and taurocholate uptake
US6852753B2 (en) 2002-01-17 2005-02-08 Pharmacia Corporation Alkyl/aryl hydroxy or keto thiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
GB0221942D0 (en) * 2002-09-20 2002-10-30 Univ Strathclyde Drug delivery
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
WO2007027566A2 (en) 2005-09-02 2007-03-08 Genzyme Corporation Method for removing phosphate and polymer used therefore
CN103027896B (en) 2005-09-15 2016-01-20 基酶有限公司 The sachet formulation of amine polymer
US10231721B2 (en) 2010-06-24 2019-03-19 St. Croix Surgical Systems, Llc Failsafe percutaneous wound barrier
MA41202A (en) 2014-12-18 2017-10-24 Genzyme Corp CROSS-LINKED POLYDIALLYMINE COPOLYMERS FOR THE TREATMENT OF TYPE 2 DIABETES
CN110907543A (en) * 2019-09-29 2020-03-24 重庆健能医药开发有限公司 Experimental method for adsorbing bile acid of hydrotalcite chewable tablet

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3251778A (en) * 1960-08-04 1966-05-17 Petrolite Corp Process of preventing scale
US3332841A (en) * 1961-10-04 1967-07-25 Lilly Co Eli Method of treating hyperacidity
JPS5548221A (en) * 1978-10-04 1980-04-05 Nippon Oil Co Ltd Preparation of polyhexamethyleneimine
JPS5566513A (en) * 1978-11-14 1980-05-20 Ono Pharmaceut Co Ltd Drug for arteriosclerosis comprising high polymer compound as active constituent
JPS62243620A (en) * 1986-04-17 1987-10-24 Asahi Chem Ind Co Ltd Surface-modified wholly aromatic polyamide formed article and production thereof

Also Published As

Publication number Publication date
EP0379161B1 (en) 1994-09-21
NO900279L (en) 1990-07-23
JPH02232229A (en) 1990-09-14
FI900297A0 (en) 1990-01-18
ZA90394B (en) 1991-04-24
DE3901527A1 (en) 1990-07-26
IL93098A0 (en) 1990-11-05
DE59007178D1 (en) 1994-10-27
EP0379161A3 (en) 1991-07-31
IE65618B1 (en) 1995-11-01
PT92880B (en) 1995-12-29
PT92880A (en) 1990-07-31
AU4861890A (en) 1990-07-26
DK0379161T3 (en) 1995-01-16
AU624215B2 (en) 1992-06-04
CA2008114A1 (en) 1990-07-20
ES2063173T3 (en) 1995-01-01
ATE111931T1 (en) 1994-10-15
EP0379161A2 (en) 1990-07-25
NO900279D0 (en) 1990-01-19
NZ232149A (en) 1991-12-23

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