ZA894297B - New condensed diazepinones,processes for preparing them and pharmaceutical compositions containing these compounds - Google Patents

New condensed diazepinones,processes for preparing them and pharmaceutical compositions containing these compounds

Info

Publication number
ZA894297B
ZA894297B ZA894297A ZA894297A ZA894297B ZA 894297 B ZA894297 B ZA 894297B ZA 894297 A ZA894297 A ZA 894297A ZA 894297 A ZA894297 A ZA 894297A ZA 894297 B ZA894297 B ZA 894297B
Authority
ZA
South Africa
Prior art keywords
image
hydrogen
lower alkyl
preparing
compounds
Prior art date
Application number
ZA894297A
Inventor
Wolfhard Engel
Engel Wolfhard
Wolfgang Eberlein
Eberlein Wolfgang
Gerhard Mihm
Mihm Gerhard
Norbert Mayer
Mayer Norbert
Henri Doods
Doods Henri
Adriaan De Jonge
De Jonge Adriaan
Guenter Trummlitz
Trummlitz Guenter
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of ZA894297B publication Critical patent/ZA894297B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Condensed diazepinones of the general formula I <IMAGE> in which <IMAGE> is one of the divalent radicals <IMAGE> <IMAGE> <IMAGE> <IMAGE> or <IMAGE> X<1> and X<2> can be the =CH-group or, if <IMAGE> is the radical (S), (U) or (W), also nitrogen atoms, A is a C1 to C6-alkylene radical, R<1> and R<2> are lower alkyl radicals or R<1> and R<2> together with the nitrogen atom are also a saturated 4- to 7-membered heteroaliphatic ring, R<3> is lower alkyl or hydrogen or chlorine, R<4> and R<1><0> are hydrogen or methyl, R<5> and R<6> are hydrogen, fluorine, chlorine, bromine or lower alkyl, R<7> is hydrogen, chlorine or methyl and R<8> and R<9> are hydrogen or lower alkyl, R<9> is additionally halogen, are suitable for the treatment of bradycardias and bradyarrhythmias.
ZA894297A 1988-06-08 1989-06-07 New condensed diazepinones,processes for preparing them and pharmaceutical compositions containing these compounds ZA894297B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3819444A DE3819444A1 (en) 1988-06-08 1988-06-08 NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS

Publications (1)

Publication Number Publication Date
ZA894297B true ZA894297B (en) 1991-02-27

Family

ID=6356083

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA894297A ZA894297B (en) 1988-06-08 1989-06-07 New condensed diazepinones,processes for preparing them and pharmaceutical compositions containing these compounds

Country Status (14)

Country Link
EP (1) EP0345629B1 (en)
JP (1) JPH0232074A (en)
KR (1) KR900000366A (en)
AT (1) ATE80630T1 (en)
AU (1) AU612851B2 (en)
CA (1) CA1320198C (en)
DD (1) DD284014A5 (en)
DE (2) DE3819444A1 (en)
DK (1) DK277589A (en)
GR (1) GR3006558T3 (en)
HU (1) HU203754B (en)
IL (1) IL90549A0 (en)
NZ (1) NZ229409A (en)
ZA (1) ZA894297B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3818299A1 (en) * 1988-05-30 1989-12-07 Thomae Gmbh Dr K NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS
DE3919076A1 (en) * 1989-06-10 1990-12-13 Thomae Gmbh Dr K MEANS TO TREAT DISEASES OF THE CENTRAL NERVOUS SYSTEM AND TO PROMOTE CEREBRAL BLOOD
AU3754495A (en) * 1994-10-31 1996-05-23 Yamanouchi Pharmaceutical Co., Ltd. Novel benzodiazepinone derivative and medicinal composition thereof
DE10205219A1 (en) * 2002-02-08 2003-08-21 Bayer Ag Quinoxalinones and their use
WO2004011430A1 (en) * 2002-07-25 2004-02-05 Yamanouchi Pharmaceutical Co., Ltd. Sodium channel inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3409237A1 (en) * 1984-03-14 1985-09-19 Dr. Karl Thomae Gmbh, 7950 Biberach CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE3726908A1 (en) * 1987-08-13 1989-02-23 Thomae Gmbh Dr K NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS
DE3802334A1 (en) * 1988-01-27 1989-08-10 Thomae Gmbh Dr K NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS

Also Published As

Publication number Publication date
DE58902273D1 (en) 1992-10-22
JPH0232074A (en) 1990-02-01
EP0345629A2 (en) 1989-12-13
DK277589A (en) 1989-12-09
HU203754B (en) 1991-09-30
DK277589D0 (en) 1989-06-07
AU3613789A (en) 1990-02-01
DE3819444A1 (en) 1989-12-14
KR900000366A (en) 1990-01-30
AU612851B2 (en) 1991-07-18
HUT50470A (en) 1990-02-28
EP0345629B1 (en) 1992-09-16
NZ229409A (en) 1990-12-21
DD284014A5 (en) 1990-10-31
IL90549A0 (en) 1990-01-18
ATE80630T1 (en) 1992-10-15
CA1320198C (en) 1993-07-13
EP0345629A3 (en) 1990-08-16
GR3006558T3 (en) 1993-06-30

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